iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-074951

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AAGW02040226

Gene Name

USP27X

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000000066.2	ENSOCUT00000000066.2	ENSOCUP00000000058.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.20e-90	304.2	189	531

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqq 90
           Gl NlgNtC+mN+++Q+L+++p lr+++l+ ++++++    ++p+ +l++++ +lf+el++++ +   p +ll+ ++  a+++ gy+qq
   Q: 189  GLINLGNTCFMNCIVQALTHTPILRDFFLS-DRHRCEM---PSPELCLVCEMSSLFRELYSGNPSPHVPYKLLHLVWIHARHLAGYRQQ 273
           9*****************************.9999987...589********************************************* PP
   S: 91   DaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgk 179
           Da+Efl   ld l++++k                  +  +  +++++ +++i+++F g l+s+++c++c+ vs++ +p +d+sl++pg+
   Q: 274  DAHEFLIAALDVLHRHCKG----------------DDVGKAANNPNHCNCIIDQIFTGGLQSDVTCQACHGVSTTIDPCWDISLDLPGS 346
           *****************22................2344668899999***************************************** PP
   S: 180  eetkke...................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksreki 249
           +++  +                   +l+dcL+ ft++e+l ++ k++c  c+++qe++k+l+++klP v ++h+kRf  +++ k+r+ki
   Q: 347  STSFWPmspgressvngeshlpgisTLTDCLRRFTRPEHLGSSAKIKCGGCQSYQESTKQLTMNKLPVVACFHFKRF--EHSAKQRRKI 433
           *877779**********************************************************************..55667999** PP
   S: 250  nkkvefpleLdlspfcts............peekqke.....kkkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeee 321
           +++++fpleLd++pf++s            p     +     ++kY+L+avv+H+G+l+sGHY+++++++k++W+++dD  +t+ + ++
   Q: 434  TTYISFPLELDMTPFMASskesringqlqlP-----TnsgsnENKYSLFAVVNHQGTLESGHYTSFIRHHKDQWFKCDDAVITKASIKD 517
           ******************5555555555554.....055555*********************************************** PP
   S: 322  vleetgstaYvlfYkrr 338
           vl    s++Y+lfY+++
   Q: 518  VLD---SEGYLLFYHKQ 531
           ***...********985 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

LKLEPEPEPV RGPGGGCLDV DFALGPPGCS HVNSFKVGEN WRQELRVIYQ CFVWCGTPET 60
RKSKAKSCVC HVCGAHLNRL HSCLSCVFFG CFTEKHIHEH AEAKQHTLAV DLYYGGIYCF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCAAGCTGG AGCCCGAACC CGAGCCGGTA CGGGAGGCGG AGCAGGAGCC GGAGGGGGAG 60
CCGAAGCAGG AGCTGGAGGA TGAGGACCCA GCGCGGAGCG GCGGTGGCTG CAGCGGCGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0061578--F:Lys63-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0043065--P:positive regulation of apoptotic process
GO:0050821--P:protein stabilization
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002084	Ailuropoda melanoleuca	96.78	0.00e+00	1077.00
IUUC-Aly-006565	Arabidopsis lyrata	37.44	2.00e-72	266.00
IUUC-Ath-007536	Arabidopsis thaliana	34.86	7.00e-74	271.00
IUUC-Ago-007811	Ashbya gossypii	28.81	5.00e-51	195.00
IUUC-Bgr-012150	Blumeria graminis	30.97	1.00e-47	184.00
IUUC-Bdi-014171	Brachypodium distachyon	35.97	6.00e-75	275.00
IUUC-Cja-019954	Callithrix jacchus	86.98	0.00e+00	937.00
IUUC-Cfa-020956	Canis familiaris	94.43	0.00e+00	994.00
IUUC-Cpo-022014	Cavia porcellus	97.14	0.00e+00	1075.00
IUUC-Dno-029905	Dasypus novemcinctus	94.37	0.00e+00	838.00
IUUC-Dor-030832	Dipodomys ordii	95.34	3.00e-109	388.00
IUUC-Dme-032074	Drosophila melanogaster	49.81	4.00e-132	464.00
IUUC-Eca-033957	Equus caballus	95.25	0.00e+00	1054.00
IUUC-Fca-035768	Felis catus	96.59	0.00e+00	1075.00
IUUC-Fox-038046	Fusarium oxysporum	30.89	3.00e-54	206.00
IUUC-Ggr-040044	Gaeumannomyces graminis	32.68	4.00e-56	212.00
IUUC-Gma-043933	Glycine max	36.47	2.00e-87	316.00
IUUC-Ggo-044925	Gorilla gorilla	97.15	0.00e+00	1077.00
IUUC-Hvu-047739	Hordeum vulgare	37.78	2.00e-68	252.00
IUUC-Kpa-049135	Komagataella pastoris	34.12	4.00e-68	252.00
IUUC-Lpe-050969	Leersia perrieri	39.95	4.00e-71	261.00
IUUC-Laf-053947	Loxodonta africana	95.80	0.00e+00	1064.00
IUUC-Mpo-057621	Magnaporthe poae	33.19	4.00e-56	212.00
IUUC-Mtr-057894	Medicago truncatula	36.12	5.00e-83	302.00
IUUC-Mvi-060530	Microbotryum violaceum	32.65	6.00e-57	214.00
IUUC-Mpu-066433	Mustela putorius furo	95.68	0.00e+00	1066.00
IUUC-Mlu-067330	Myotis lucifugus	96.02	0.00e+00	1066.00
IUUC-Nle-069084	Nomascus leucogenys	95.31	0.00e+00	847.00
IUUC-Oba-075688	Oryza barthii	35.73	2.00e-75	276.00
IUUC-Obr-076652	Oryza brachyantha	40.05	1.00e-72	266.00
IUUC-Ogl-077910	Oryza glaberrima	35.83	2.00e-76	280.00
IUUC-Ogu-078479	Oryza glumaepatula	35.63	2.00e-76	280.00
IUUC-Olo-080811	Oryza longistaminata	40.28	2.00e-52	199.00
IUUC-Ome-081706	Oryza meridionalis	35.83	5.00e-76	278.00
IUUC-Oni-083070	Oryza nivara	35.22	2.00e-76	279.00
IUUC-Opu-083605	Oryza punctata	38.74	2.00e-65	242.00
IUUC-Oru-084522	Oryza rufipogon	35.83	2.00e-76	280.00
IUUC-Osa-085351	Oryza sativa	37.84	2.00e-73	269.00
IUUC-Olu-087695	Ostreococcus lucimarinus	31.49	1.00e-48	186.00
IUUC-Oga-088771	Otolemur garnettii	94.84	0.00e+00	1041.00
IUUC-Oar-089610	Ovis aries	94.63	0.00e+00	996.00
IUUC-Pan-092253	Papio anubis	95.23	0.00e+00	1003.00
IUUC-Ppa-095413	Physcomitrella patens	34.24	4.00e-82	298.00
IUUC-Pab-098324	Pongo abelii	96.97	0.00e+00	1078.00
IUUC-Pop-099558	Populus trichocarpa	35.93	5.00e-88	318.00
IUUC-Pca-100329	Procavia capensis	96.01	0.00e+00	1064.00
IUUC-Ppe-102020	Prunus persica	37.48	3.00e-92	332.00
IUUC-Pva-102721	Pteropus vampyrus	91.92	0.00e+00	986.00
IUUC-Sce-106247	Saccharomyces cerevisiae	30.66	3.00e-50	192.00
IUUC-Sja-107656	Schizosaccharomyces japonicus	34.60	2.00e-64	239.00
IUUC-Spo-108226	Schizosaccharomyces pombe	32.48	4.00e-59	221.00
IUUC-Smo-109310	Selaginella moellendorffii	36.45	3.00e-87	316.00
IUUC-Sit-109716	Setaria italica	36.18	2.00e-78	286.00
IUUC-Sly-111077	Solanum lycopersicum	37.11	3.00e-80	292.00
IUUC-Stu-112203	Solanum tuberosum	38.62	2.00e-75	276.00
IUUC-Sar-113174	Sorex araneus	90.65	0.00e+00	936.00
IUUC-Sbi-114205	Sorghum bicolor	35.81	3.00e-79	289.00
IUUC-Sre-115195	Sporisorium reilianum	27.74	2.00e-54	207.00
IUUC-Ssc-115315	Sus scrofa	95.03	0.00e+00	1041.00
IUUC-Tca-121154	Theobroma cacao	39.38	2.00e-92	333.00
IUUC-Tvi-122599	Trichoderma virens	31.09	1.00e-53	204.00
IUUC-Tae-125608	Triticum aestivum	34.00	9.00e-84	304.00
IUUC-Ttr-129006	Tursiops truncatus	96.33	0.00e+00	1052.00
IUUC-Vda-129829	Verticillium dahliae	33.11	4.00e-35	141.00
IUUC-Vvi-131477	Vitis vinifera	37.26	2.00e-77	283.00
IUUC-Yli-134357	Yarrowia lipolytica	30.26	3.00e-47	182.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence