iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000002715.2	ENSLACT00000026586.1	ENSLACP00000022645.1
ENSLACG00000002715.2	ENSLACT00000003061.1	ENSLACP00000003034.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	9.40e-134	446.2	542	873

Active Site

Position(s)	Description	Evidence
843	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++ lk+rl++ef+ E+gld+gGv+re+++llske++np++glf+ys++d++tlq+n++sgl+n++hl++F+f+Gr+ g+a+++g+lld 
   Q: 542  PDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINSNSGLCNEDHLSYFKFIGRVAGMAVFHGKLLDG 630
           57899************************************************************************************ PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
           ++ ++fyk++lgk +sl+d+e+vd+e+y+slk+i+en   d +e  ldl+f+++ee++g+t++++Lkp+G++  VtneNk+eY++lv++
   Q: 631  FFIRPFYKMMLGKLISLKDMESVDSEYYNSLKWILEN---DPTE--LDLRFCIDEENFGQTYQVDLKPNGSELVVTNENKREYIDLVIQ 714
           ***********************************99...6666..7****************************************** PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +++++q++ f eGf+e+ip +++++F+e+elell+cG  ++dv+d++++t yk+gy +++paiqwFw+++  +++e+r ++LqFv
   Q: 715  WRFVNRVQKQMNGFLEGFTELIPSDIIKIFDENELELLMCGLGDVDVNDWRQHTIYKNGYCPNHPAIQWFWKAVLLMDAEKRIRLLQFV 803
           ***************************************************************************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           Tg+sr+P++Gfael     p+lf+i++++s+++lP+++TCfn+L+LP+Y+s e+l+ekLl+A+e+++gFe
   Q: 804  TGTSRVPMNGFAELYgsngPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYESFEELREKLLMAVENAQGFE 873
           *********************************************************************8 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

MTRDDFLGQV DVPLNHLPTE DPAMERPYTF KDFLLRPRSH KSRVKGFLRL KMAYLPKNGG 60
QEEENGEQRE DSEHGWDVVD PTDSGSQRQQ QVPAPLPPGW EEKTDNLGRT YYVNHNNRTT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCAGAGACTG CTGTTTGAAG TTTTTGATGA AAACAGATTG GTAAGTGTTT AGTTCAACAC 60
ATTGTACTAA ACACATACTT TTATAAACTG AGGCTTAGCA GTCTGTGTTA GGATTTATTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001314	Ailuropoda melanoleuca	85.11	0.00e+00	1426.00
IUUC-Apl-003893	Anas platyrhynchos	86.70	0.00e+00	1489.00
IUUC-Aca-004744	Anolis carolinensis	85.00	0.00e+00	1440.00
IUUC-Acl-008273	Aspergillus clavatus	49.17	1.00e-161	563.00
IUUC-Afl-008713	Aspergillus flavus	48.83	4.00e-159	555.00
IUUC-Afu-009103	Aspergillus fumigatus	49.50	2.00e-161	563.00
IUUC-Ani-009259	Aspergillus nidulans	49.33	6.00e-161	561.00
IUUC-Ang-009738	Aspergillus niger	49.16	1.00e-160	560.00
IUUC-Aor-010053	Aspergillus oryzae	57.05	6.00e-100	357.00
IUUC-Ate-010529	Aspergillus terreus	49.33	5.00e-162	564.00
IUUC-Ame-010810	Astyanax mexicanus	70.94	0.00e+00	1125.00
IUUC-Bgr-012148	Blumeria graminis	47.67	1.00e-152	533.00
IUUC-Bta-012679	Bos taurus	86.80	0.00e+00	1466.00
IUUC-Bci-013785	Botrytis cinerea	47.58	3.00e-155	542.00
IUUC-Cel-018564	Caenorhabditis elegans	52.51	2.00e-180	625.00
IUUC-Cja-018732	Callithrix jacchus	86.93	0.00e+00	1494.00
IUUC-Cfa-021226	Canis familiaris	86.59	0.00e+00	1475.00
IUUC-Cpo-021671	Cavia porcellus	85.36	0.00e+00	1439.00
IUUC-Csa-023344	Chlorocebus sabaeus	84.86	0.00e+00	1472.00
IUUC-Cho-024832	Choloepus hoffmanni	95.74	0.00e+00	717.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	48.17	6.00e-155	541.00
IUUC-Dre-027770	Danio rerio	79.40	0.00e+00	1288.00
IUUC-Dno-029466	Dasypus novemcinctus	86.82	0.00e+00	1488.00
IUUC-Dor-030138	Dipodomys ordii	84.59	0.00e+00	1385.00
IUUC-Dse-031241	Dothistroma septosporum	47.74	1.00e-157	550.00
IUUC-Ete-033145	Echinops telfairi	79.49	0.00e+00	1159.00
IUUC-Eca-033445	Equus caballus	86.69	0.00e+00	1442.00
IUUC-Eeu-035247	Erinaceus europaeus	79.66	0.00e+00	1276.00
IUUC-Fca-035489	Felis catus	84.63	0.00e+00	1410.00
IUUC-Fal-037604	Ficedula albicollis	84.19	0.00e+00	1480.00
IUUC-Fox-037774	Fusarium oxysporum	46.96	7.00e-156	544.00
IUUC-Fso-038393	Fusarium solani	47.58	5.00e-153	535.00
IUUC-Gmo-039674	Gadus morhua	76.86	0.00e+00	1251.00
IUUC-Gga-040703	Gallus gallus	86.82	0.00e+00	1488.00
IUUC-Gac-042020	Gasterosteus aculeatus	80.59	0.00e+00	1299.00
IUUC-Ggo-045332	Gorilla gorilla	85.57	0.00e+00	1462.00
IUUC-Hsa-045968	Homo sapiens	86.70	0.00e+00	1487.00
IUUC-Loc-052662	Lepisosteus oculatus	83.05	0.00e+00	1306.00
IUUC-Laf-053850	Loxodonta africana	85.57	0.00e+00	1464.00
IUUC-Mcc-055821	Macaca mulatta	86.82	0.00e+00	1487.00
IUUC-Meu-056712	Macropus eugenii	72.62	5.00e-180	624.00
IUUC-Mor-057097	Magnaporthe oryzae	44.88	7.00e-158	550.00
IUUC-Mla-058996	Melampsora laricipopulina	53.94	3.00e-149	522.00
IUUC-Mvi-060395	Microbotryum violaceum	53.70	1.00e-149	523.00
IUUC-Mmr-060798	Microcebus murinus	82.90	0.00e+00	1368.00
IUUC-Mdo-062173	Monodelphis domestica	85.21	0.00e+00	1486.00
IUUC-Mmu-064136	Mus musculus	86.27	0.00e+00	1459.00
IUUC-Mpu-066765	Mustela putorius furo	86.59	0.00e+00	1466.00
IUUC-Mlu-067565	Myotis lucifugus	87.49	0.00e+00	1468.00
IUUC-Nfi-068427	Neosartorya fischeri	49.50	1.00e-161	563.00
IUUC-Ncr-068918	Neurospora crassa	47.40	1.00e-156	546.00
IUUC-Nle-069070	Nomascus leucogenys	83.20	0.00e+00	1400.00
IUUC-Opr-071044	Ochotona princeps	88.87	0.00e+00	1120.00
IUUC-Ont-072044	Oreochromis niloticus	79.80	0.00e+00	1354.00
IUUC-Oan-073032	Ornithorhynchus anatinus	83.79	0.00e+00	1321.00
IUUC-Ocu-074160	Oryctolagus cuniculus	84.01	0.00e+00	1408.00
IUUC-Ola-087467	Oryzias latipes	80.90	0.00e+00	1301.00
IUUC-Oga-088460	Otolemur garnettii	84.19	0.00e+00	1430.00
IUUC-Oar-090198	Ovis aries	86.25	0.00e+00	1452.00
IUUC-Ptr-090939	Pan troglodytes	86.70	0.00e+00	1487.00
IUUC-Pan-092284	Papio anubis	86.59	0.00e+00	1484.00
IUUC-Psi-093645	Pelodiscus sinensis	86.48	0.00e+00	1478.00
IUUC-Pma-094364	Petromyzon marinus	83.16	0.00e+00	837.00
IUUC-Pno-095118	Phaeosphaeria nodorum	49.00	4.00e-161	561.00
IUUC-Pab-098088	Pongo abelii	86.93	0.00e+00	1490.00
IUUC-Pca-100714	Procavia capensis	71.46	0.00e+00	1139.00
IUUC-Pva-102354	Pteropus vampyrus	85.23	0.00e+00	1430.00
IUUC-Ptt-103806	Puccinia triticina	53.62	2.00e-122	433.00
IUUC-Pte-104016	Pyrenophora teres	48.01	2.00e-158	552.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	48.01	2.00e-158	552.00
IUUC-Rno-105318	Rattus norvegicus	86.38	0.00e+00	1459.00
IUUC-Sce-106289	Saccharomyces cerevisiae	48.91	3.00e-162	565.00
IUUC-Sha-107482	Sarcophilus harrisii	87.43	0.00e+00	1484.00
IUUC-Sja-107786	Schizosaccharomyces japonicus	47.91	4.00e-152	531.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	47.41	2.00e-156	545.00
IUUC-Ssc-115950	Sus scrofa	66.25	0.00e+00	1093.00
IUUC-Tgu-117130	Taeniopygia guttata	86.25	0.00e+00	1487.00
IUUC-Tru-118610	Takifugu rubripes	80.61	0.00e+00	1338.00
IUUC-Tsy-119492	Tarsius syrichta	84.94	0.00e+00	1446.00
IUUC-Tni-120113	Tetraodon nigroviridis	75.78	0.00e+00	1266.00
IUUC-Tvi-122595	Trichoderma virens	45.91	1.00e-152	533.00
IUUC-Ttr-128235	Tursiops truncatus	93.53	0.00e+00	1043.00
IUUC-Vda-129753	Verticillium dahliae	47.16	3.00e-155	541.00
IUUC-Xtr-132859	Xenopus tropicalis	86.72	0.00e+00	1470.00
IUUC-Xma-133797	Xiphophorus maculatus	82.09	0.00e+00	1331.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence