iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000005399.1	ENSOART00000005893.1	ENSOARP00000005804.1
ENSOARG00000005399.1	ENSOART00000005898.1	ENSOARP00000005809.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.20e-135	450.6	694	1025

Active Site

Position(s)	Description	Evidence
995	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrll 88
           ++ lk+rl++ef+ E+gld+gGv+re+++llske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+ll
   Q: 694  PDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLL 780
           57899********************************************************************************** PP
   S: 89   dlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
           d ++ ++fyk++lgk+++l+d+e+vd+e+y+slk+i+en   d +e  ldl+f+++ee++g+t++++Lkp+G++i+VtneNk+eY++
   Q: 781  DGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILEN---DPTE--LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYID 862
           *************************************99...6666..7************************************** PP
   S: 176  lvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           lv+++r+ +++++q++af eGf+e++p++l+++F+e+elell+cG  ++dv+d++++  yk+gy +++p+iqwFw+++  +++e+r 
   Q: 863  LVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRI 949
           *************************************************************************************** PP
   S: 263  afLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           ++LqFvTg+sr+P++Gfael     p+lf+i++++s+++lP+++TCfn+L+LP+Y++ e l+ekLl+A+e+++gFe
   Q: 950  RLLQFVTGTSRVPMNGFAELYgsngPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 1025
           ***************************************************************************8 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MAFLAPTTNK IFLVLLWLII YILLIFGKTR CKNRGLKQRK GESSSGCENG RISWETRLAL 60
VLPKRMKMKG ESRILRVKVV SGIDLAKKDI FGASDPYVKL SLYVADENRE LALVQTKTIK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTTTTC TGGCTCCTAC TACTAATAAA ATATTTCTAG TATTGCTCTG GCTAATTATT 60
TACATTTTAC TGATCTTCGG GAAAACAAGA TGTAAAAACA GAGGGCTTAA ACAAAGGAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

PRINTS

PR00360--C2DOMAIN

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0019870--F:potassium channel inhibitor activity
GO:0019871--F:sodium channel inhibitor activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:1901017--P:negative regulation of potassium ion transmembrane transporter activity
GO:2000009--P:negative regulation of protein localization to cell surface
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:1903861--P:positive regulation of dendrite extension
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0003254--P:regulation of membrane depolarization
GO:0060306--P:regulation of membrane repolarization
GO:0010038--P:response to metal ion

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001314	Ailuropoda melanoleuca	95.65	0.00e+00	1692.00
IUUC-Apl-003893	Anas platyrhynchos	93.95	0.00e+00	1698.00
IUUC-Aca-004744	Anolis carolinensis	89.99	0.00e+00	1640.00
IUUC-Ago-007742	Ashbya gossypii	48.91	1.00e-161	563.00
IUUC-Acl-008273	Aspergillus clavatus	48.77	1.00e-163	570.00
IUUC-Afl-008713	Aspergillus flavus	49.09	4.00e-161	561.00
IUUC-Afu-009103	Aspergillus fumigatus	49.02	5.00e-164	571.00
IUUC-Ani-009259	Aspergillus nidulans	48.78	4.00e-162	565.00
IUUC-Ang-009738	Aspergillus niger	49.67	4.00e-162	565.00
IUUC-Aor-010053	Aspergillus oryzae	58.05	1.00e-101	362.00
IUUC-Ate-010529	Aspergillus terreus	49.59	5.00e-164	571.00
IUUC-Ame-010810	Astyanax mexicanus	71.56	0.00e+00	1248.00
IUUC-Bgr-012148	Blumeria graminis	47.83	4.00e-154	538.00
IUUC-Bta-012679	Bos taurus	99.20	0.00e+00	1618.00
IUUC-Cel-018564	Caenorhabditis elegans	52.69	0.00e+00	634.00
IUUC-Cja-018732	Callithrix jacchus	97.51	0.00e+00	1797.00
IUUC-Cfa-021226	Canis familiaris	97.50	0.00e+00	1791.00
IUUC-Cpo-021671	Cavia porcellus	95.94	0.00e+00	1735.00
IUUC-Csa-023344	Chlorocebus sabaeus	95.60	0.00e+00	1781.00
IUUC-Cho-024832	Choloepus hoffmanni	100.00	0.00e+00	743.00
IUUC-Csv-026098	Ciona savignyi	59.04	0.00e+00	654.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	47.41	4.00e-156	545.00
IUUC-Cne-026849	Cryptococcus neoformans	47.21	5.00e-159	555.00
IUUC-Dre-027770	Danio rerio	78.40	0.00e+00	1414.00
IUUC-Dno-029466	Dasypus novemcinctus	97.50	0.00e+00	1800.00
IUUC-Dor-030138	Dipodomys ordii	92.29	0.00e+00	1628.00
IUUC-Dse-031241	Dothistroma septosporum	47.70	3.00e-160	558.00
IUUC-Dme-032166	Drosophila melanogaster	67.09	0.00e+00	712.00
IUUC-Ete-033145	Echinops telfairi	88.50	0.00e+00	1281.00
IUUC-Eca-033445	Equus caballus	97.95	0.00e+00	1588.00
IUUC-Eeu-035247	Erinaceus europaeus	88.79	0.00e+00	1496.00
IUUC-Fca-035489	Felis catus	94.80	0.00e+00	1536.00
IUUC-Fal-037604	Ficedula albicollis	90.67	0.00e+00	1714.00
IUUC-Fox-037774	Fusarium oxysporum	48.43	5.00e-158	551.00
IUUC-Fso-038393	Fusarium solani	47.16	3.00e-154	538.00
IUUC-Gmo-039674	Gadus morhua	77.40	0.00e+00	1385.00
IUUC-Ggr-040107	Gaeumannomyces graminis	47.18	2.00e-155	542.00
IUUC-Gga-040703	Gallus gallus	93.32	0.00e+00	1731.00
IUUC-Gac-042020	Gasterosteus aculeatus	79.94	0.00e+00	1408.00
IUUC-Ggo-045332	Gorilla gorilla	95.52	0.00e+00	1722.00
IUUC-Hsa-045968	Homo sapiens	97.71	0.00e+00	1793.00
IUUC-Kpa-049273	Komagataella pastoris	44.86	4.00e-162	565.00
IUUC-Lch-050443	Latimeria chalumnae	86.25	0.00e+00	1431.00
IUUC-Loc-052662	Lepisosteus oculatus	80.49	0.00e+00	1437.00
IUUC-Laf-053850	Loxodonta africana	95.83	0.00e+00	1776.00
IUUC-Mcc-055821	Macaca mulatta	96.11	0.00e+00	1793.00
IUUC-Meu-056712	Macropus eugenii	80.18	0.00e+00	768.00
IUUC-Mor-057097	Magnaporthe oryzae	47.45	4.00e-155	541.00
IUUC-Mpo-057442	Magnaporthe poae	52.16	7.00e-146	511.00
IUUC-Mvi-060395	Microbotryum violaceum	53.70	3.00e-150	525.00
IUUC-Mmr-060798	Microcebus murinus	93.56	0.00e+00	1668.00
IUUC-Mdo-062173	Monodelphis domestica	94.08	0.00e+00	1781.00
IUUC-Mmu-064136	Mus musculus	96.57	0.00e+00	1762.00
IUUC-Mpu-066765	Mustela putorius furo	98.12	0.00e+00	1779.00
IUUC-Mlu-067565	Myotis lucifugus	95.11	0.00e+00	1566.00
IUUC-Nfi-068427	Neosartorya fischeri	49.02	3.00e-164	572.00
IUUC-Ncr-068918	Neurospora crassa	47.24	6.00e-157	548.00
IUUC-Nle-069070	Nomascus leucogenys	93.86	0.00e+00	1698.00
IUUC-Opr-071044	Ochotona princeps	95.66	0.00e+00	1199.00
IUUC-Ont-072044	Oreochromis niloticus	78.02	0.00e+00	1449.00
IUUC-Oan-073032	Ornithorhynchus anatinus	92.16	0.00e+00	1428.00
IUUC-Ocu-074160	Oryctolagus cuniculus	95.11	0.00e+00	1726.00
IUUC-Ola-087467	Oryzias latipes	79.53	0.00e+00	1433.00
IUUC-Oga-088460	Otolemur garnettii	92.70	0.00e+00	1556.00
IUUC-Ptr-090939	Pan troglodytes	97.71	0.00e+00	1793.00
IUUC-Pan-092284	Papio anubis	97.40	0.00e+00	1790.00
IUUC-Psi-093645	Pelodiscus sinensis	94.15	0.00e+00	1729.00
IUUC-Pma-094364	Petromyzon marinus	82.63	0.00e+00	863.00
IUUC-Pno-095118	Phaeosphaeria nodorum	47.86	6.00e-164	571.00
IUUC-Pab-098088	Pongo abelii	97.71	0.00e+00	1795.00
IUUC-Pca-100714	Procavia capensis	74.84	0.00e+00	1308.00
IUUC-Pva-102354	Pteropus vampyrus	95.72	0.00e+00	1684.00
IUUC-Pgr-103620	Puccinia graminis	53.53	4.00e-148	518.00
IUUC-Ptt-103806	Puccinia triticina	53.38	7.00e-123	434.00
IUUC-Pte-104016	Pyrenophora teres	49.17	3.00e-163	568.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	49.17	3.00e-163	568.00
IUUC-Rno-105318	Rattus norvegicus	95.84	0.00e+00	1743.00
IUUC-Sce-106289	Saccharomyces cerevisiae	49.42	7.00e-163	567.00
IUUC-Sha-107482	Sarcophilus harrisii	95.35	0.00e+00	1613.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	47.91	2.00e-158	552.00
IUUC-Sre-114929	Sporisorium reilianum	47.41	3.00e-155	542.00
IUUC-Ssc-115950	Sus scrofa	71.92	0.00e+00	1188.00
IUUC-Tgu-117130	Taeniopygia guttata	94.26	0.00e+00	1738.00
IUUC-Tru-118610	Takifugu rubripes	80.31	0.00e+00	1458.00
IUUC-Tsy-119492	Tarsius syrichta	91.52	0.00e+00	1637.00
IUUC-Tni-120113	Tetraodon nigroviridis	74.71	0.00e+00	1344.00
IUUC-Tvi-122595	Trichoderma virens	47.18	2.00e-153	536.00
IUUC-Tbe-127441	Tupaia belangeri	90.02	0.00e+00	783.00
IUUC-Ttr-128235	Tursiops truncatus	88.43	0.00e+00	1521.00
IUUC-Vda-129753	Verticillium dahliae	47.68	5.00e-156	544.00
IUUC-Xtr-132859	Xenopus tropicalis	89.53	0.00e+00	1655.00
IUUC-Xma-133797	Xiphophorus maculatus	80.69	0.00e+00	1447.00
IUUC-Yli-134668	Yarrowia lipolytica	46.42	4.00e-162	565.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence