iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Dse-031164

Ensembl Protein ID

EME44855

UniProt Accession

N1PR65; N1PR65_DOTSN

Genbank Protein ID

EME44855.1

Protein Name

Nuclear distribution protein PAC1; Lissencephaly-1 homolog; nudF homolog

Genbank Nucleotide ID

KB446538

Gene Name

PAC1; LIS1; DOTSEDRAFT_70794

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
DOTSEDRAFT_70794	EME44855	EME44855

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.20e-46	153.1	202	249
UBD/Beta-Prp	3.20e-60	203.2	114	308

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..........sdtllvsGsdDgtikvWDlrtgvllks 38
           gH  sv+c++f          s++ll+s+s+D++i++WD++tg +l++
   Q: 202  GHDHSVSCVRFipsgaagaplSGNLLASASRDKSIRIWDVTTGYCLRT 249
           8*******************877********************99875 PP

UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfs.pdgk.ilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsfsp 104
           ++h ++it+v+f+p  s la+gs+d tik+wd++ g l r+l++h+++v +v+f  p+g+ +l+++s+D tik+wd+   +k ++tl gh++sv +++f p
   Q: 114  QSHRQPITSVAFHPLFSSLASGSEDCTIKIWDYELGELERTLKSHTKAVLDVDFGgPRGNtLLASCSSDLTIKLWDPAeEYKNIRTLPGHDHSVSCVRFIP 214
           45666999999999999999999999999999999999999999999999999963444479999999999999965439999999999999999999999 PP
   S: 105  ........sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl...ktgkllrtltgghtdsvyslsfd 189
                   sg+ l+s+s+d+ ir+wd+ tg+cl+ tl+gh ++v++++   dg+ lvs s D+  r+Wdl    ++   +t+   h++ v++++f 
   Q: 215  sgaagaplSGNLLASASRDKSIRIWDVTTGYCLR-TLRGHADWVRSLAPTMDGRWLVSTSSDQSARMWDLsqpDSNAQKQTFMA-HEHVVECTAFA 308
           8888888889999999999999999999999999.9999999999999999999999999999999999977777777888887.99999998874 PP

Organism

Dothistroma septosporum

Functional Description
(View)

Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.

Protein Sequence
(Fasta)

MSALLTSRQA EELHKSLIAY LLSTGHGNSA QVLREDLNLP ESDFDAATAK KYEGLIEKKW 60
TSVVRLQKKI MDLEAKSQQL QSELDSATPT SLAARKNHDP TTWLPRAPAR HTLQSHRQPI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCACCACGG ACCTCACGTC ACATAGTATA CAAGATCACG CCAGCTTCTA CCGCCTGATC 60
CATTGGCTGC TACTGAAGAT CTCTTGCTTG ACCAGCCGGC CCATCCACCT CCTGCACGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0000922--C:spindle pole
GO:0051301--P:cell division
GO:0000132--P:establishment of mitotic spindle orientation
GO:0007067--P:mitotic nuclear division
GO:0006810--P:transport

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001589	Ailuropoda melanoleuca	43.42	2.00e-99	353.00
IUUC-Apl-004024	Anas platyrhynchos	43.58	3.00e-102	363.00
IUUC-Aca-004564	Anolis carolinensis	43.58	9.00e-101	358.00
IUUC-Ago-007862	Ashbya gossypii	27.38	5.00e-39	153.00
IUUC-Acl-008360	Aspergillus clavatus	65.90	3.00e-174	603.00
IUUC-Afl-008502	Aspergillus flavus	56.12	3.00e-151	526.00
IUUC-Afu-008848	Aspergillus fumigatus	68.15	0.00e+00	643.00
IUUC-Ani-009173	Aspergillus nidulans	56.83	9.00e-151	524.00
IUUC-Ang-009873	Aspergillus niger	55.34	4.00e-148	516.00
IUUC-Aor-009973	Aspergillus oryzae	54.19	1.00e-147	514.00
IUUC-Ate-010523	Aspergillus terreus	57.52	4.00e-152	529.00
IUUC-Ame-011154	Astyanax mexicanus	43.83	9.00e-103	365.00
IUUC-Bgr-011972	Blumeria graminis	65.31	0.00e+00	624.00
IUUC-Bta-013106	Bos taurus	43.58	1.00e-102	364.00
IUUC-Bci-013615	Botrytis cinerea	69.23	0.00e+00	636.00
IUUC-Cel-018459	Caenorhabditis elegans	42.30	2.00e-92	331.00
IUUC-Cja-018755	Callithrix jacchus	42.62	8.00e-100	355.00
IUUC-Cfa-020749	Canis familiaris	43.58	1.00e-102	364.00
IUUC-Cpo-022371	Cavia porcellus	43.58	1.00e-102	364.00
IUUC-Csa-023524	Chlorocebus sabaeus	43.64	5.00e-85	305.00
IUUC-Cho-024764	Choloepus hoffmanni	41.55	5.00e-85	306.00
IUUC-Cin-025753	Ciona intestinalis	44.53	6.00e-96	342.00
IUUC-Csv-025817	Ciona savignyi	43.52	8.00e-96	342.00
IUUC-Cgl-026529	Colletotrichum gloeosporioides	69.11	2.00e-180	623.00
IUUC-Cne-027087	Cryptococcus neoformans	52.67	8.00e-111	392.00
IUUC-Dre-027554	Danio rerio	43.10	1.00e-100	357.00
IUUC-Dno-029050	Dasypus novemcinctus	43.58	2.00e-102	364.00
IUUC-Dor-030222	Dipodomys ordii	40.79	2.00e-94	337.00
IUUC-Dme-031745	Drosophila melanogaster	44.04	3.00e-92	330.00
IUUC-Ete-032508	Echinops telfairi	43.80	9.00e-66	242.00
IUUC-Eca-034288	Equus caballus	42.93	3.00e-98	350.00
IUUC-Eeu-034984	Erinaceus europaeus	40.54	3.00e-93	333.00
IUUC-Fca-036498	Felis catus	43.58	1.00e-102	364.00
IUUC-Fal-036920	Ficedula albicollis	43.58	3.00e-102	363.00
IUUC-Fox-037996	Fusarium oxysporum	66.31	0.00e+00	647.00
IUUC-Fso-038160	Fusarium solani	64.79	2.00e-178	617.00
IUUC-Gmo-038983	Gadus morhua	43.10	3.00e-101	360.00
IUUC-Ggr-040051	Gaeumannomyces graminis	62.02	2.00e-169	587.00
IUUC-Gga-040623	Gallus gallus	43.58	3.00e-102	363.00
IUUC-Gac-041613	Gasterosteus aculeatus	43.38	3.00e-101	360.00
IUUC-Ggo-045410	Gorilla gorilla	40.71	2.00e-82	297.00
IUUC-Hsa-046358	Homo sapiens	43.58	2.00e-102	363.00
IUUC-Itr-047890	Ictidomys tridecemlineatus	43.58	1.00e-102	364.00
IUUC-Kpa-049351	Komagataella pastoris	29.80	2.00e-46	178.00
IUUC-Lch-049936	Latimeria chalumnae	43.10	9.00e-102	362.00
IUUC-Loc-052476	Lepisosteus oculatus	43.18	6.00e-99	352.00
IUUC-Lma-053170	Leptosphaeria maculans	69.96	0.00e+00	629.00
IUUC-Laf-053713	Loxodonta africana	43.60	2.00e-100	357.00
IUUC-Mcc-054628	Macaca mulatta	43.58	2.00e-102	363.00
IUUC-Meu-055927	Macropus eugenii	36.06	2.00e-47	181.00
IUUC-Mor-056962	Magnaporthe oryzae	61.56	1.00e-172	597.00
IUUC-Mpo-057583	Magnaporthe poae	62.37	1.00e-164	570.00
IUUC-Mla-058819	Melampsora laricipopulina	45.18	7.00e-112	395.00
IUUC-Mga-059945	Meleagris gallopavo	43.34	6.00e-102	362.00
IUUC-Mvi-060403	Microbotryum violaceum	48.82	6.00e-123	432.00
IUUC-Mmr-061289	Microcebus murinus	43.07	3.00e-99	353.00
IUUC-Mdo-061912	Monodelphis domestica	43.38	9.00e-102	361.00
IUUC-Mmu-063253	Mus musculus	43.58	1.00e-102	364.00
IUUC-Mpu-066638	Mustela putorius furo	43.58	1.00e-102	364.00
IUUC-Mlu-067267	Myotis lucifugus	42.72	1.00e-99	355.00
IUUC-Nfi-068571	Neosartorya fischeri	62.21	3.00e-168	582.00
IUUC-Ncr-068895	Neurospora crassa	67.46	0.00e+00	625.00
IUUC-Nle-069087	Nomascus leucogenys	42.50	2.00e-82	297.00
IUUC-Opr-070579	Ochotona princeps	43.58	2.00e-102	364.00
IUUC-Ont-072432	Oreochromis niloticus	43.34	8.00e-102	362.00
IUUC-Oan-073072	Ornithorhynchus anatinus	43.58	1.00e-102	364.00
IUUC-Ocu-074180	Oryctolagus cuniculus	43.58	2.00e-102	364.00
IUUC-Ola-086815	Oryzias latipes	43.83	2.00e-102	363.00
IUUC-Oga-088219	Otolemur garnettii	42.86	4.00e-100	356.00
IUUC-Oar-090394	Ovis aries	43.58	1.00e-102	364.00
IUUC-Ptr-091517	Pan troglodytes	43.58	1.00e-102	364.00
IUUC-Pan-092421	Papio anubis	43.58	2.00e-102	363.00
IUUC-Psi-093370	Pelodiscus sinensis	43.58	5.00e-102	362.00
IUUC-Pma-094319	Petromyzon marinus	43.73	4.00e-84	302.00
IUUC-Pno-094815	Phaeosphaeria nodorum	68.52	0.00e+00	640.00
IUUC-Pfo-097089	Poecilia formosa	43.58	6.00e-102	362.00
IUUC-Pab-098421	Pongo abelii	43.58	1.00e-102	364.00
IUUC-Pca-100120	Procavia capensis	36.06	1.00e-57	214.00
IUUC-Pva-102960	Pteropus vampyrus	43.34	4.00e-101	359.00
IUUC-Pgr-103538	Puccinia graminis	47.67	5.00e-115	405.00
IUUC-Ptt-103990	Puccinia triticina	43.89	6.00e-43	167.00
IUUC-Pte-104261	Pyrenophora teres	69.66	0.00e+00	641.00
IUUC-Pyt-104780	Pyrenophora triticirepentis	69.87	0.00e+00	643.00
IUUC-Rno-105123	Rattus norvegicus	43.58	1.00e-102	364.00
IUUC-Sce-106208	Saccharomyces cerevisiae	30.20	2.00e-37	148.00
IUUC-Sha-107010	Sarcophilus harrisii	43.38	8.00e-102	362.00
IUUC-Sja-107899	Schizosaccharomyces japonicus	36.02	5.00e-67	246.00
IUUC-Ssl-108571	Sclerotinia sclerotiorum	68.87	5.00e-178	615.00
IUUC-Sar-113309	Sorex araneus	42.68	2.00e-96	344.00
IUUC-Sre-115003	Sporisorium reilianum	46.97	9.00e-119	418.00
IUUC-Ssc-116148	Sus scrofa	43.58	1.00e-102	364.00
IUUC-Tgu-117299	Taeniopygia guttata	43.34	2.00e-101	360.00
IUUC-Tru-118179	Takifugu rubripes	43.10	4.00e-101	359.00
IUUC-Tsy-119493	Tarsius syrichta	43.58	2.00e-101	360.00
IUUC-Tni-120355	Tetraodon nigroviridis	42.89	2.00e-99	353.00
IUUC-Tre-121977	Trichoderma reesei	58.37	3.00e-157	546.00
IUUC-Tvi-122661	Trichoderma virens	59.49	9.00e-159	551.00
IUUC-Tme-127031	Tuber melanosporum	61.35	2.00e-164	570.00
IUUC-Tbe-127492	Tupaia belangeri	37.17	1.00e-46	178.00
IUUC-Ttr-128929	Tursiops truncatus	43.58	3.00e-102	363.00
IUUC-Uma-129347	Ustilago maydis	49.03	8.00e-118	415.00
IUUC-Vda-129837	Verticillium dahliae	66.95	1.00e-174	604.00
IUUC-Vpa-130532	Vicugna pacos	37.84	1.00e-83	301.00
IUUC-Xtr-131985	Xenopus tropicalis	43.83	1.00e-102	364.00
IUUC-Xma-133314	Xiphophorus maculatus	43.58	6.00e-102	362.00
IUUC-Yli-134403	Yarrowia lipolytica	40.25	6.00e-93	332.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence