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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046843
UUCD1 version UUC-HoS-01253
Ensembl Protein ID ENSP00000297579.5
UniProt Accession Q9NV06; Q3MII9; Q8NCH8; Q8TC51; Q96JY7; Q9NZX3; DCA13_HUMAN
Genbank Protein ID AAF29036.1; BAA91955.1; BAB55377.1; BAC11163.1; AAH26067.2; AAI01811.1; AAI12043.1
Protein Name DDB1- and CUL4-associated factor 13; WD repeat and SOF domain-containing protein 1
Genbank Nucleotide ID AF161549; AK001874; AK027799; AK074725; BC026067; BC101810; BC112042
Gene Name DCAF13; WDSOF1; HSPC064
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000164934.13 ENST00000297579.9 ENSP00000297579.5
ENSG00000164934.13 ENST00000521971.5 ENSP00000430883.2
ENSG00000164934.13 ENST00000519682.5 ENSP00000430411.2
ENSG00000164934.13 ENST00000618975.1 ENSP00000480810.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 17588513
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 6.80e-21 75.1 216 255
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sdtl..lvsGsdDgtikvWDlrtgvllk 37
           gH d+v+cla  +++l  ++sG+ Dg +++W+l++ ++++
   Q: 216  GHRDGVNCLAKhPEKLatVLSGACDGEVRIWNLTQRNCIR 255
           8********855653344899**************99987 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Possible role in ribosomal RNA processing (By similarity). May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
 Possible role in ribosomal RNA processing (By similarity). May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
Protein Sequence
(Fasta)
MQWPPPWRRS PLVSATPPPG PTRGLLCPRR VSEAGDSSTE GARTGHRHYV TPAESAMEGR 60
SQPLPSLRPA SPTNAPAHGR GSDCTAKEPP LANVCRQNYG AAQDPVEPAG RRSASHVTGS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046843|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AAAAGACGGA GGAGATCCAG TTCGGGCTGA CAGTGAGAGG ATGCAGCCCG GTGTCTGGGC 60
GGGCTCTTAC CGGCGAAGCG GATCTTCACG AGGTCGAGCG GATGCAGCGC AAGGTTGGAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046843|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0687--Ribonucleoprotein
KW-0690--Ribosome biogenesis
KW-0698--rRNA processing
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
Interpro

IPR007287--Sof1
IPR013979--TIF_beta_prop-like
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF08662--eIF2A
PF04158--Sof1
PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0030054--C:cell junction
GO:0005813--C:centrosome
GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0032040--C:small-subunit processome
GO:0030331--F:estrogen receptor binding
GO:0003723--F:RNA binding
GO:0000462--P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0016567--P:protein ubiquitination
GO:0006364--P:rRNA processing
KEGG hsa:25879
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002178 Ailuropoda melanoleuca 95.43 0.00e+00 881.00
IUUC-Atr-002799 Amborella trichopoda 47.95 3.00e-131 461.00
IUUC-Apl-003675 Anas platyrhynchos 85.09 0.00e+00 769.00
IUUC-Aca-004792 Anolis carolinensis 86.44 0.00e+00 817.00
IUUC-Aly-005998 Arabidopsis lyrata 47.60 1.00e-128 452.00
IUUC-Ath-007526 Arabidopsis thaliana 47.60 4.00e-128 451.00
IUUC-Ago-007774 Ashbya gossypii 46.59 1.00e-116 413.00
IUUC-Acl-008024 Aspergillus clavatus 44.20 3.00e-105 375.00
IUUC-Afu-008930 Aspergillus fumigatus 43.42 2.00e-103 369.00
IUUC-Ani-009370 Aspergillus nidulans 42.99 4.00e-104 371.00
IUUC-Ang-009827 Aspergillus niger 45.18 4.00e-108 385.00
IUUC-Aor-010060 Aspergillus oryzae 43.98 2.00e-100 359.00
IUUC-Ate-010434 Aspergillus terreus 45.15 6.00e-91 327.00
IUUC-Ame-011967 Astyanax mexicanus 73.49 0.00e+00 701.00
IUUC-Bgr-011989 Blumeria graminis 44.68 7.00e-107 380.00
IUUC-Bta-013291 Bos taurus 68.56 5.00e-177 613.00
IUUC-Bci-013868 Botrytis cinerea 42.99 2.00e-103 369.00
IUUC-Bdi-014343 Brachypodium distachyon 49.43 1.00e-124 439.00
IUUC-Bol-015740 Brassica oleracea 46.00 8.00e-119 420.00
IUUC-Bra-016689 Brassica rapa 45.77 5.00e-117 414.00
IUUC-Cel-018536 Caenorhabditis elegans 49.64 1.00e-121 430.00
IUUC-Cja-018779 Callithrix jacchus 97.70 0.00e+00 905.00
IUUC-Cfa-020105 Canis familiaris 97.01 0.00e+00 897.00
IUUC-Cpo-021538 Cavia porcellus 92.73 0.00e+00 848.00
IUUC-Cre-022798 Chlamydomonas reinhardtii 51.63 3.00e-45 174.00
IUUC-Csa-023492 Chlorocebus sabaeus 98.20 0.00e+00 927.00
IUUC-Cho-024497 Choloepus hoffmanni 84.47 1.00e-154 539.00
IUUC-Cin-025524 Ciona intestinalis 62.39 4.00e-169 587.00
IUUC-Csv-026197 Ciona savignyi 63.30 3.00e-172 598.00
IUUC-Cgl-026745 Colletotrichum gloeosporioides 39.72 4.00e-92 331.00
IUUC-Cne-026840 Cryptococcus neoformans 36.72 2.00e-78 288.00
IUUC-Cme-027111 Cyanidioschyzon merolae 35.13 2.00e-73 270.00
IUUC-Dre-027471 Danio rerio 74.42 0.00e+00 721.00
IUUC-Dno-029790 Dasypus novemcinctus 91.14 0.00e+00 698.00
IUUC-Dor-030971 Dipodomys ordii 65.76 0.00e+00 713.00
IUUC-Dse-031563 Dothistroma septosporum 44.37 4.00e-103 368.00
IUUC-Dme-032161 Drosophila melanogaster 58.49 2.00e-159 555.00
IUUC-Ete-033127 Echinops telfairi 77.46 0.00e+00 882.00
IUUC-Eca-033531 Equus caballus 95.89 0.00e+00 844.00
IUUC-Eeu-034663 Erinaceus europaeus 68.58 0.00e+00 758.00
IUUC-Fca-036258 Felis catus 97.24 0.00e+00 900.00
IUUC-Fal-037456 Ficedula albicollis 87.82 0.00e+00 778.00
IUUC-Fox-038025 Fusarium oxysporum 43.39 6.00e-102 364.00
IUUC-Fso-038344 Fusarium solani 43.95 3.00e-99 355.00
IUUC-Gmo-039643 Gadus morhua 75.40 0.00e+00 731.00
IUUC-Ggr-039816 Gaeumannomyces graminis 44.58 1.00e-102 366.00
IUUC-Gga-040143 Gallus gallus 88.74 0.00e+00 813.00
IUUC-Gac-041665 Gasterosteus aculeatus 76.67 0.00e+00 740.00
IUUC-Gma-043073 Glycine max 47.37 1.00e-124 439.00
IUUC-Ggo-045058 Gorilla gorilla 96.63 0.00e+00 1137.00
IUUC-Hvu-047654 Hordeum vulgare 50.00 6.00e-74 270.00
IUUC-Itr-048822 Ictidomys tridecemlineatus 95.40 0.00e+00 883.00
IUUC-Kpa-049232 Komagataella pastoris 46.95 1.00e-119 422.00
IUUC-Lch-050542 Latimeria chalumnae 78.35 0.00e+00 780.00
IUUC-Lpe-051622 Leersia perrieri 49.43 5.00e-127 447.00
IUUC-Loc-052674 Lepisosteus oculatus 75.28 0.00e+00 714.00
IUUC-Lma-053108 Leptosphaeria maculans 42.69 5.00e-103 368.00
IUUC-Laf-053385 Loxodonta africana 94.94 0.00e+00 863.00
IUUC-Mcc-055151 Macaca mulatta 97.93 0.00e+00 908.00
IUUC-Meu-056230 Macropus eugenii 90.95 3.00e-119 422.00
IUUC-Mor-057013 Magnaporthe oryzae 42.79 4.00e-98 351.00
IUUC-Mpo-057530 Magnaporthe poae 44.58 2.00e-103 369.00
IUUC-Mtr-058187 Medicago truncatula 47.83 1.00e-126 446.00
IUUC-Mla-058964 Melampsora laricipopulina 39.96 1.00e-93 337.00
IUUC-Mga-059712 Meleagris gallopavo 88.25 0.00e+00 773.00
IUUC-Mvi-060370 Microbotryum violaceum 40.14 5.00e-67 248.00
IUUC-Mmr-061340 Microcebus murinus 79.93 0.00e+00 862.00
IUUC-Mdo-062978 Monodelphis domestica 88.05 0.00e+00 827.00
IUUC-Mmu-063439 Mus musculus 93.10 0.00e+00 865.00
IUUC-Mac-065129 Musa acuminata 47.61 5.00e-129 454.00
IUUC-Mpu-066548 Mustela putorius furo 86.39 0.00e+00 704.00
IUUC-Mlu-067660 Myotis lucifugus 96.09 0.00e+00 894.00
IUUC-Nfi-068455 Neosartorya fischeri 44.69 7.00e-107 380.00
IUUC-Ncr-068848 Neurospora crassa 42.43 9.00e-94 337.00
IUUC-Nle-069923 Nomascus leucogenys 95.74 0.00e+00 1160.00
IUUC-Opr-070279 Ochotona princeps 81.58 2.00e-89 323.00
IUUC-Ont-072234 Oreochromis niloticus 77.47 0.00e+00 743.00
IUUC-Oan-073713 Ornithorhynchus anatinus 83.51 1.00e-101 361.00
IUUC-Ocu-073782 Oryctolagus cuniculus 95.17 0.00e+00 880.00
IUUC-Oba-075161 Oryza barthii 49.43 3.00e-127 448.00
IUUC-Obr-076868 Oryza brachyantha 49.54 4.00e-127 447.00
IUUC-Ogl-077062 Oryza glaberrima 49.43 3.00e-127 448.00
IUUC-Ogu-078308 Oryza glumaepatula 49.43 2.00e-127 448.00
IUUC-Oin-079378 Oryza indica 49.43 2.00e-127 448.00
IUUC-Olo-080638 Oryza longistaminata 46.92 3.00e-117 415.00
IUUC-Oni-082368 Oryza nivara 49.43 2.00e-127 448.00
IUUC-Opu-083628 Oryza punctata 49.43 2.00e-127 448.00
IUUC-Oru-085226 Oryza rufipogon 49.20 7.00e-127 447.00
IUUC-Osa-085368 Oryza sativa 44.65 5.00e-68 250.00
IUUC-Ola-086836 Oryzias latipes 79.08 0.00e+00 759.00
IUUC-Olu-087755 Ostreococcus lucimarinus 45.54 5.00e-125 441.00
IUUC-Oga-088170 Otolemur garnettii 95.40 0.00e+00 887.00
IUUC-Oar-089388 Ovis aries 91.85 0.00e+00 879.00
IUUC-Ptr-090494 Pan troglodytes 93.36 0.00e+00 1134.00
IUUC-Pan-091697 Papio anubis 94.28 0.00e+00 1011.00
IUUC-Psi-093916 Pelodiscus sinensis 83.45 0.00e+00 762.00
IUUC-Pno-095004 Phaeosphaeria nodorum 40.55 5.00e-93 334.00
IUUC-Ppa-095514 Physcomitrella patens 48.98 2.00e-131 462.00
IUUC-Pfo-097432 Poecilia formosa 78.74 0.00e+00 734.00
IUUC-Pab-098423 Pongo abelii 98.65 0.00e+00 929.00
IUUC-Pop-099649 Populus trichocarpa 48.51 4.00e-129 454.00
IUUC-Pca-100365 Procavia capensis 76.79 0.00e+00 863.00
IUUC-Ppe-101379 Prunus persica 46.68 3.00e-125 441.00
IUUC-Pva-102845 Pteropus vampyrus 81.79 0.00e+00 940.00
IUUC-Pgr-103469 Puccinia graminis 35.27 8.00e-83 301.00
IUUC-Ptt-103980 Puccinia triticina 37.28 3.00e-62 232.00
IUUC-Pte-104111 Pyrenophora teres 42.05 8.00e-100 357.00
IUUC-Pyt-104610 Pyrenophora triticirepentis 42.18 4.00e-100 358.00
IUUC-Rno-105082 Rattus norvegicus 92.64 0.00e+00 867.00
IUUC-Sce-106340 Saccharomyces cerevisiae 45.63 1.00e-117 417.00
IUUC-Sha-106584 Sarcophilus harrisii 88.51 0.00e+00 831.00
IUUC-Sja-107703 Schizosaccharomyces japonicus 43.48 1.00e-100 359.00
IUUC-Spo-108046 Schizosaccharomyces pombe 45.89 1.00e-104 373.00
IUUC-Ssl-108574 Sclerotinia sclerotiorum 43.45 3.00e-104 372.00
IUUC-Smo-109548 Selaginella moellendorffii 46.68 7.00e-126 444.00
IUUC-Sit-110242 Setaria italica 48.29 1.00e-123 436.00
IUUC-Sly-111762 Solanum lycopersicum 47.37 4.00e-125 441.00
IUUC-Stu-112156 Solanum tuberosum 47.37 3.00e-124 438.00
IUUC-Sbi-114739 Sorghum bicolor 49.66 2.00e-125 442.00
IUUC-Sre-114951 Sporisorium reilianum 39.92 8.00e-103 367.00
IUUC-Ssc-115510 Sus scrofa 96.09 0.00e+00 890.00
IUUC-Tgu-117234 Taeniopygia guttata 87.62 0.00e+00 733.00
IUUC-Tru-117986 Takifugu rubripes 76.99 0.00e+00 742.00
IUUC-Tsy-119252 Tarsius syrichta 82.76 0.00e+00 936.00
IUUC-Tni-119785 Tetraodon nigroviridis 77.46 0.00e+00 718.00
IUUC-Tca-121222 Theobroma cacao 47.14 8.00e-124 437.00
IUUC-Tre-122243 Trichoderma reesei 43.72 5.00e-101 361.00
IUUC-Tvi-122293 Trichoderma virens 43.49 5.00e-99 354.00
IUUC-Tae-124591 Triticum aestivum 47.48 4.00e-112 398.00
IUUC-Tur-126098 Triticum urartu 46.33 6.00e-108 384.00
IUUC-Tme-127200 Tuber melanosporum 47.30 2.00e-121 429.00
IUUC-Tbe-127568 Tupaia belangeri 96.90 3.00e-134 471.00
IUUC-Ttr-129185 Tursiops truncatus 80.04 0.00e+00 825.00
IUUC-Uma-129353 Ustilago maydis 40.33 2.00e-102 365.00
IUUC-Vda-129768 Verticillium dahliae 42.66 2.00e-97 349.00
IUUC-Vpa-130572 Vicugna pacos 82.71 0.00e+00 986.00
IUUC-Vvi-131555 Vitis vinifera 47.83 2.00e-125 442.00
IUUC-Xtr-132263 Xenopus tropicalis 80.22 0.00e+00 640.00
IUUC-Xma-133925 Xiphophorus maculatus 78.97 0.00e+00 737.00
IUUC-Yli-134384 Yarrowia lipolytica 46.15 1.00e-112 400.00
IUUC-Zma-135616 Zea mays 49.43 1.00e-124 440.00
Created Date 25-Jun-2017

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