iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	Mentha
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/PH/GLUE	GLUE	19132102; 23843610

Classification

Family	E-value	Score	Start	End
UBD/PH/GLUE	1.20e-63	213.3	1	144

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/PH/GLUE

   S: 1    mdrfvytealLeinetlvirqrsvkiydgdekikfdaGellLtthRLiWir..dqkneevtlaipLsavvfieeeaaa...igksakivvhlhparsd 93
           m+rf+y+ea+L++ne++v+r+++vkiydgd+k++f++Ge++LtthRL+W+r  ++++++vtl++pLs+v++++ee++a   +g++++i++hlhp++sd
   Q: 1    MNRFAYVEARLSPNESFVSRDNRVKIYDGDQKTDFEDGEVVLTTHRLFWGRpgEIARAAVTLCLPLSYVISVSEETTAsnfFGRKTRIIMHLHPPTSD 98
           8****************************************************************************99******************* PP
   S: 94   kePGpldsskasyiklsfkekgdiefyskLseeltaRaWeelevse 139
           k+PGpld+s+a++ikls+k+++++ef+s+L+e+l+aR+We+l++se
   Q: 99   KGPGPLDTSRATHIKLSGKNGLSVEFHSALRETLNARVWEILLTSE 144
           *******************************************997 PP

Organism

Drosophila melanogaster

Functional Description
(View)

Component of the ESCRT-II complex (ensodomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex (By similarity). ESCRT-II interacts, through the Vps36 subunit, with bicoid mRNA. This interaction is required for the anterior localization of bicoid mRNA in the developing egg.

Protein Sequence
(Fasta)

MNRFAYVEAR LSPNESFVSR DNRVKIYDGD QKTDFEDGEV VLTTHRLFWG RPGEIARAAV 60
TLCLPLSYVI SVSEETTASN FFGRKTRIIM HLHPPTSDKG PGPLDTSRAT HIKLSGKNGL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGGAACGGT GGAGTCACGA AAGATGTGTC ATCTCCAGCC AGAGCCACAA CAAAACAAAT 60
ATTAAGGATA AAATAACAAA TATCTGAAAT GAATCGCTTC GCTTATGTGG AGGCCCGTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0509--mRNA transport
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0694--RNA-binding
KW-0813--Transport

Interpro

IPR007286--EAP30
IPR021648--GLUE_dom
IPR011993--PH_dom-like
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS51495--GLUE

Pfam

PF04157--EAP30
PF11605--Vps36_ESCRT-II

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005768--C:endosome
GO:0000814--C:ESCRT II complex
GO:0031902--C:late endosome membrane
GO:0043025--C:neuronal cell body
GO:0003730--F:mRNA 3'-UTR binding
GO:0032266--F:phosphatidylinositol-3-phosphate binding
GO:0043130--F:ubiquitin binding
GO:0008105--P:asymmetric protein localization
GO:0045450--P:bicoid mRNA localization
GO:0008283--P:cell proliferation
GO:0051028--P:mRNA transport
GO:0043328--P:protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0042981--P:regulation of apoptotic process
GO:0008593--P:regulation of Notch signaling pathway
GO:0019233--P:sensory perception of pain
GO:0007224--P:smoothened signaling pathway
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

KEGG

dme:Dmel_CG10711

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000963	Aegilops tauschii	39.57	1.00e-26	112.00
IUUC-Aml-002313	Ailuropoda melanoleuca	45.36	3.00e-93	334.00
IUUC-Atr-003096	Amborella trichopoda	29.46	1.00e-10	59.30
IUUC-Apl-003218	Anas platyrhynchos	46.53	2.00e-91	328.00
IUUC-Aca-004580	Anolis carolinensis	45.25	5.00e-92	330.00
IUUC-Aly-006398	Arabidopsis lyrata	34.38	1.00e-44	173.00
IUUC-Ath-006907	Arabidopsis thaliana	34.12	4.00e-43	167.00
IUUC-Ago-007840	Ashbya gossypii	23.86	3.00e-06	45.80
IUUC-Acl-008117	Aspergillus clavatus	31.45	4.00e-25	108.00
IUUC-Afl-008595	Aspergillus flavus	30.33	2.00e-25	109.00
IUUC-Afu-008918	Aspergillus fumigatus	29.48	2.00e-25	109.00
IUUC-Ani-009206	Aspergillus nidulans	31.25	7.00e-27	114.00
IUUC-Ang-009784	Aspergillus niger	31.89	1.00e-24	107.00
IUUC-Aor-010126	Aspergillus oryzae	30.33	2.00e-25	109.00
IUUC-Ate-010303	Aspergillus terreus	31.51	4.00e-28	119.00
IUUC-Ame-011190	Astyanax mexicanus	46.23	6.00e-92	330.00
IUUC-Bgr-011979	Blumeria graminis	29.41	2.00e-25	109.00
IUUC-Bta-012661	Bos taurus	45.36	3.00e-93	334.00
IUUC-Bci-013982	Botrytis cinerea	30.06	8.00e-20	91.30
IUUC-Bdi-014753	Brachypodium distachyon	37.19	3.00e-40	158.00
IUUC-Bol-015465	Brassica oleracea	37.05	6.00e-38	150.00
IUUC-Bra-016794	Brassica rapa	37.45	5.00e-39	154.00
IUUC-Cel-018514	Caenorhabditis elegans	39.36	4.00e-74	270.00
IUUC-Cja-019285	Callithrix jacchus	45.73	9.00e-83	299.00
IUUC-Cfa-020746	Canis familiaris	45.61	2.00e-93	335.00
IUUC-Cpo-022005	Cavia porcellus	46.03	9.00e-85	306.00
IUUC-Cre-022686	Chlamydomonas reinhardtii	36.56	4.00e-24	105.00
IUUC-Csa-023520	Chlorocebus sabaeus	45.11	2.00e-91	328.00
IUUC-Cho-024957	Choloepus hoffmanni	44.61	9.00e-89	319.00
IUUC-Cin-025575	Ciona intestinalis	38.10	1.00e-04	36.20
IUUC-Csv-025942	Ciona savignyi	43.39	6.00e-78	283.00
IUUC-Cgl-026558	Colletotrichum gloeosporioides	27.73	5.00e-19	88.60
IUUC-Cne-026915	Cryptococcus neoformans	24.92	1.00e-12	66.60
IUUC-Cme-027099	Cyanidioschyzon merolae	25.35	5.00e-08	51.60
IUUC-Dre-027753	Danio rerio	46.73	4.00e-92	330.00
IUUC-Dno-029922	Dasypus novemcinctus	46.12	1.00e-93	335.00
IUUC-Dor-030643	Dipodomys ordii	40.85	6.00e-82	296.00
IUUC-Dse-031368	Dothistroma septosporum	31.17	1.00e-20	94.40
IUUC-Ete-033135	Echinops telfairi	39.94	6.00e-55	206.00
IUUC-Eca-033937	Equus caballus	45.21	2.00e-82	298.00
IUUC-Eeu-034483	Erinaceus europaeus	43.53	1.00e-94	338.00
IUUC-Fca-035496	Felis catus	46.03	4.00e-84	303.00
IUUC-Fal-036743	Ficedula albicollis	44.86	6.00e-92	330.00
IUUC-Fox-037685	Fusarium oxysporum	29.34	1.00e-14	73.90
IUUC-Fso-038421	Fusarium solani	29.34	9.00e-13	67.80
IUUC-Gmo-039456	Gadus morhua	45.11	2.00e-83	301.00
IUUC-Ggr-039763	Gaeumannomyces graminis	30.41	5.00e-25	108.00
IUUC-Gga-040556	Gallus gallus	45.50	2.00e-90	325.00
IUUC-Gac-041481	Gasterosteus aculeatus	42.50	1.00e-72	265.00
IUUC-Gma-044185	Glycine max	35.77	7.00e-37	147.00
IUUC-Ggo-044849	Gorilla gorilla	45.11	2.00e-91	328.00
IUUC-Hsa-046228	Homo sapiens	45.11	2.00e-91	328.00
IUUC-Hvu-047858	Hordeum vulgare	31.07	4.00e-07	47.80
IUUC-Itr-048068	Ictidomys tridecemlineatus	43.64	1.00e-86	312.00
IUUC-Kpa-049240	Komagataella pastoris	31.52	2.00e-07	49.30
IUUC-Lch-050293	Latimeria chalumnae	53.17	2.00e-66	244.00
IUUC-Lpe-051363	Leersia perrieri	36.22	1.00e-42	166.00
IUUC-Loc-052866	Lepisosteus oculatus	45.89	1.00e-90	325.00
IUUC-Lma-053139	Leptosphaeria maculans	28.57	9.00e-21	94.40
IUUC-Laf-053881	Loxodonta africana	44.17	2.00e-89	321.00
IUUC-Mcc-055158	Macaca mulatta	44.86	5.00e-91	327.00
IUUC-Meu-056126	Macropus eugenii	39.50	3.00e-57	214.00
IUUC-Mor-057092	Magnaporthe oryzae	29.30	3.00e-20	92.80
IUUC-Mpo-057629	Magnaporthe poae	33.83	2.00e-21	95.50
IUUC-Mtr-058039	Medicago truncatula	37.19	6.00e-38	150.00
IUUC-Mla-058913	Melampsora laricipopulina	27.19	4.00e-18	85.90
IUUC-Mga-059956	Meleagris gallopavo	45.36	3.00e-91	327.00
IUUC-Mvi-060570	Microbotryum violaceum	24.51	5.00e-12	65.90
IUUC-Mmr-061769	Microcebus murinus	46.03	2.00e-83	301.00
IUUC-Mdo-062751	Monodelphis domestica	44.23	7.00e-90	323.00
IUUC-Mmu-063115	Mus musculus	44.28	6.00e-93	333.00
IUUC-Mac-064979	Musa acuminata	31.91	6.00e-39	154.00
IUUC-Mpu-066904	Mustela putorius furo	41.04	8.00e-53	199.00
IUUC-Mlu-067474	Myotis lucifugus	45.11	2.00e-90	325.00
IUUC-Nfi-068588	Neosartorya fischeri	31.91	1.00e-22	100.00
IUUC-Ncr-068855	Neurospora crassa	31.37	2.00e-18	86.70
IUUC-Nle-069660	Nomascus leucogenys	45.11	3.00e-91	327.00
IUUC-Opr-070695	Ochotona princeps	46.12	1.00e-93	335.00
IUUC-Ont-071837	Oreochromis niloticus	43.47	3.00e-80	290.00
IUUC-Oan-072903	Ornithorhynchus anatinus	44.99	1.00e-84	305.00
IUUC-Ocu-074833	Oryctolagus cuniculus	46.37	9.00e-94	336.00
IUUC-Oba-075899	Oryza barthii	41.00	3.00e-42	164.00
IUUC-Obr-076125	Oryza brachyantha	33.08	7.00e-46	177.00
IUUC-Ogl-077538	Oryza glaberrima	47.48	4.00e-28	118.00
IUUC-Ogu-078272	Oryza glumaepatula	41.00	1.00e-41	163.00
IUUC-Oin-079158	Oryza indica	40.59	2.00e-41	162.00
IUUC-Olo-080496	Oryza longistaminata	40.17	8.00e-39	152.00
IUUC-Ome-081440	Oryza meridionalis	41.57	4.00e-43	167.00
IUUC-Oni-083069	Oryza nivara	40.59	2.00e-41	162.00
IUUC-Opu-083838	Oryza punctata	42.63	8.00e-45	172.00
IUUC-Oru-084377	Oryza rufipogon	41.00	9.00e-42	163.00
IUUC-Osa-085976	Oryza sativa	41.00	9.00e-42	163.00
IUUC-Ola-086431	Oryzias latipes	44.97	1.00e-81	295.00
IUUC-Olu-087789	Ostreococcus lucimarinus	33.48	2.00e-27	114.00
IUUC-Oga-089152	Otolemur garnettii	44.61	1.00e-90	325.00
IUUC-Oar-089198	Ovis aries	46.30	2.00e-85	308.00
IUUC-Ptr-091123	Pan troglodytes	45.11	2.00e-91	328.00
IUUC-Pan-092866	Papio anubis	43.50	9.00e-86	309.00
IUUC-Psi-093384	Pelodiscus sinensis	46.12	7.00e-94	336.00
IUUC-Pno-094773	Phaeosphaeria nodorum	26.84	2.00e-12	66.20
IUUC-Ppa-095753	Physcomitrella patens	30.95	7.00e-40	157.00
IUUC-Pfo-096028	Poecilia formosa	46.46	4.00e-81	293.00
IUUC-Pop-098915	Populus trichocarpa	37.92	7.00e-39	154.00
IUUC-Pca-100422	Procavia capensis	45.48	9.00e-81	292.00
IUUC-Ppe-101564	Prunus persica	36.71	2.00e-39	155.00
IUUC-Pva-103019	Pteropus vampyrus	42.86	2.00e-82	298.00
IUUC-Pgr-103670	Puccinia graminis	26.00	3.00e-17	82.80
IUUC-Ptt-103958	Puccinia triticina	28.40	2.00e-15	76.30
IUUC-Pte-104343	Pyrenophora teres	27.67	2.00e-23	103.00
IUUC-Pyt-104554	Pyrenophora triticirepentis	27.55	4.00e-25	108.00
IUUC-Rno-105775	Rattus norvegicus	44.53	2.00e-93	334.00
IUUC-Sha-106468	Sarcophilus harrisii	46.30	4.00e-85	307.00
IUUC-Sja-107850	Schizosaccharomyces japonicus	24.27	1.00e-10	60.10
IUUC-Spo-108225	Schizosaccharomyces pombe	24.18	3.00e-09	55.80
IUUC-Ssl-108412	Sclerotinia sclerotiorum	29.33	2.00e-19	89.70
IUUC-Smo-109001	Selaginella moellendorffii	31.48	4.00e-41	161.00
IUUC-Sit-110126	Setaria italica	35.79	2.00e-37	149.00
IUUC-Sly-110884	Solanum lycopersicum	31.44	4.00e-39	154.00
IUUC-Stu-112573	Solanum tuberosum	30.79	5.00e-40	157.00
IUUC-Sar-113114	Sorex araneus	43.36	7.00e-27	113.00
IUUC-Sbi-114331	Sorghum bicolor	29.19	7.00e-29	120.00
IUUC-Sre-115135	Sporisorium reilianum	23.99	5.00e-11	62.40
IUUC-Ssc-116158	Sus scrofa	45.61	1.00e-93	335.00
IUUC-Tgu-116962	Taeniopygia guttata	45.39	3.00e-90	324.00
IUUC-Tru-117567	Takifugu rubripes	44.97	1.00e-78	285.00
IUUC-Tsy-119357	Tarsius syrichta	36.68	1.00e-57	215.00
IUUC-Tni-120047	Tetraodon nigroviridis	46.26	2.00e-70	258.00
IUUC-Tca-121097	Theobroma cacao	38.02	2.00e-40	159.00
IUUC-Tre-122075	Trichoderma reesei	31.51	4.00e-21	95.50
IUUC-Tvi-122623	Trichoderma virens	29.31	2.00e-26	113.00
IUUC-Tae-123728	Triticum aestivum	40.17	1.00e-39	156.00
IUUC-Tur-125988	Triticum urartu	39.88	4.00e-30	124.00
IUUC-Tme-126936	Tuber melanosporum	31.75	1.00e-28	120.00
IUUC-Tbe-127481	Tupaia belangeri	34.41	8.00e-48	183.00
IUUC-Ttr-128160	Tursiops truncatus	45.11	4.00e-89	320.00
IUUC-Uma-129428	Ustilago maydis	25.71	5.00e-14	72.40
IUUC-Vda-129877	Verticillium dahliae	27.86	1.00e-18	87.40
IUUC-Vpa-130358	Vicugna pacos	46.03	8.00e-84	303.00
IUUC-Vvi-131406	Vitis vinifera	33.33	3.00e-43	168.00
IUUC-Xtr-132548	Xenopus tropicalis	47.12	4.00e-93	333.00
IUUC-Xma-133352	Xiphophorus maculatus	46.46	7.00e-81	293.00
IUUC-Yli-134466	Yarrowia lipolytica	29.55	2.00e-19	89.40
IUUC-Zma-135081	Zea mays	35.44	2.00e-38	152.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence