iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000147364.16	ENST00000350302.7	ENSP00000342077.3
ENSG00000147364.16	ENST00000382824.5	ENSP00000372274.2
ENSG00000147364.16	ENST00000276326.9	ENSP00000276326.6

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	16714087; 23940030

Reviewed

Classification

Family	Identity	E-value	Score	Source Orthology
E3 adaptor/Cullin RING/SCF/F-box	26.61	5.00e-35	144.00	IUUC-Cel-018348

Organism

Homo sapiens

Functional Description
(View)

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity).

Protein Sequence
(Fasta)

MPFLGQDWRS PGWSWIKTED GWKRCESCSQ KLERENNRCN ISHSIILNSE DGEIFNNEEH 60
EYASKKRKKD HFRNDTNTQS FYREKWIYVH KESTKERHGY CTLGEAFNRL DFSSAIQDIR 120

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Nucleotide Sequence
(Fasta)

GTGTGAGCGC GCAGTGATGC CCTAGAGTGC AGTCATCCCG GGCTTGGCGC CCAGCGGGTG 60
GAAATACGGC CGCAGGGTGG AAATGCGGCG GCGGGGCTGC CCAGGCTCCT GTGGGACCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0009--Actin-binding
KW-0025--Alternative splicing
KW-0160--Chromosomal rearrangement
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR001810--F-box_dom

Gene Ontology

GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0000151--C:ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0016567--P:protein ubiquitination

KEGG

hsa:26260

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-004153	Anas platyrhynchos	82.93	2.00e-171	595.00
IUUC-Cel-018348	Caenorhabditis elegans	26.82	6.00e-36	145.00
IUUC-Cho-024976	Choloepus hoffmanni	93.33	1.00e-119	421.00
IUUC-Dre-028818	Danio rerio	76.54	3.00e-165	574.00
IUUC-Ete-032333	Echinops telfairi	78.26	5.00e-129	453.00
IUUC-Eca-033813	Equus caballus	87.43	0.00e+00	634.00
IUUC-Eeu-034622	Erinaceus europaeus	91.61	4.00e-176	610.00
IUUC-Fca-035902	Felis catus	88.83	0.00e+00	668.00
IUUC-Fal-036982	Ficedula albicollis	83.51	4.00e-175	607.00
IUUC-Gmo-039533	Gadus morhua	60.92	1.00e-126	446.00
IUUC-Gga-040549	Gallus gallus	83.93	3.00e-174	604.00
IUUC-Mga-059743	Meleagris gallopavo	84.44	2.00e-175	608.00
IUUC-Mmr-061578	Microcebus murinus	92.10	2.00e-178	618.00
IUUC-Mpu-065933	Mustela putorius furo	87.19	0.00e+00	669.00
IUUC-Opr-070514	Ochotona princeps	82.56	2.00e-40	159.00
IUUC-Ogu-078178	Oryza glumaepatula	31.94	6.00e-03	35.00
IUUC-Oin-079543	Oryza indica	31.94	6.00e-03	35.00
IUUC-Oni-082751	Oryza nivara	31.94	6.00e-03	35.00
IUUC-Oru-084545	Oryza rufipogon	31.94	6.00e-03	35.00
IUUC-Osa-085485	Oryza sativa	31.94	6.00e-03	35.00
IUUC-Pan-092053	Papio anubis	99.16	0.00e+00	723.00
IUUC-Psi-093922	Pelodiscus sinensis	86.63	0.00e+00	631.00
IUUC-Pab-097940	Pongo abelii	99.44	0.00e+00	719.00
IUUC-Rno-105568	Rattus norvegicus	78.77	2.00e-166	578.00
IUUC-Sha-107281	Sarcophilus harrisii	92.46	0.00e+00	662.00
IUUC-Tgu-116518	Taeniopygia guttata	85.87	3.00e-178	617.00
IUUC-Tsy-119123	Tarsius syrichta	79.74	8.00e-127	446.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence