iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
circBase	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
Phospho.ELM	UniProt	PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	16709668

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBA	1.10e-08	36.0	4	42
ULD/UDP/UFD/UBX	1.50e-20	74.7	210	291

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraa.nnnleaAveyLldg 41
             +le l+eMGF+r +a +aL+ + n  +eaA+++L+++
   Q: 4    LTALESLIEMGFPRGRAEKALALTgNQGIEAAMDWLMEH 42
           5689********************************987 PP

ULD/UDP/UFD/UBX

   S: 2    tteqatlqiRlpdGkrlvrkFpssttleqiyqfve....yllvessdpFeLvspfPrrtlkpeehmstlqeagLvpsgsllv 79
           +++q+++q+RlpdG  l+++F+++++l +++ +ve    ++ ++++dp +L+s+fPrr +++ ++++ lqe+gLvps++l+v
   Q: 210  EYDQCRIQVRLPDGTSLTQTFRAREQLAAVRLYVElhrgEEPGQDQDPVQLLSGFPRRAFSEADMERPLQELGLVPSAVLIV 291
           578*****************************************************************************98 PP

Organism

Mus musculus

Functional Description
(View)

Ubiquitin-binding protein that interacts with the BRCA1-BARD1 heterodimer, and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer (By similarity) Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. Involved in ubiquitin-proteasome systems.

Protein Sequence
(Fasta)

MAELTALESL IEMGFPRGRA EKALALTGNQ GIEAAMDWLM EHEDDPDVDE PLETPLSHVL 60
GREPTPSEQV GPEGSGSAAG ESRPILTEEE RQEQTKRMLE LVAQKQRERE EREEREALER 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCCCTCGTC CCTGGGTCTC CCGCCCCGTG AGTTAGCGAG CGCCGGGAGG GCGGCGTCGC 60
GGGCGGAGTC GCCCCGGGCT GACCCTTGCG GTCTTCCTTC TGGTCCCCGC AGGTCCCCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0597--Phosphoprotein
KW-1185--Reference proteome

Interpro

IPR015940--UBA
IPR009060--UBA-like
IPR029071--Ubiquitin-rel_dom
IPR001012--UBX_dom

PROSITE

PS50030--UBA
PS50033--UBX

Pfam

PF00627--UBA
PF00789--UBX

SMART

SM00165--UBA
SM00166--UBX

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0030425--C:dendrite
GO:0005783--C:endoplasmic reticulum
GO:0043025--C:neuronal cell body
GO:0005634--C:nucleus
GO:0000502--C:proteasome complex
GO:0034098--C:VCP-NPL4-UFD1 AAA ATPase complex
GO:0051117--F:ATPase binding
GO:0036435--F:K48-linked polyubiquitin binding
GO:0071796--F:K6-linked polyubiquitin binding
GO:0031593--F:polyubiquitin binding
GO:0043130--F:ubiquitin binding
GO:0031625--F:ubiquitin protein ligase binding
GO:1904293--P:negative regulation of ERAD pathway
GO:0032435--P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:1903094--P:negative regulation of protein K48-linked deubiquitination
GO:0031397--P:negative regulation of protein ubiquitination
GO:2000157--P:negative regulation of ubiquitin-specific protease activity

KEGG

mmu:225896

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002325	Ailuropoda melanoleuca	92.86	1.00e-111	395.00
IUUC-Atr-002907	Amborella trichopoda	43.75	1.00e-09	57.80
IUUC-Aca-004329	Anolis carolinensis	72.51	7.00e-51	193.00
IUUC-Aly-005639	Arabidopsis lyrata	50.91	6.00e-12	65.10
IUUC-Ath-006887	Arabidopsis thaliana	41.67	8.00e-12	64.70
IUUC-Ago-007989	Ashbya gossypii	35.90	6.00e-06	44.70
IUUC-Ame-011399	Astyanax mexicanus	55.05	5.00e-65	241.00
IUUC-Bta-013151	Bos taurus	91.92	1.00e-123	435.00
IUUC-Bdi-014311	Brachypodium distachyon	54.55	1.00e-09	57.80
IUUC-Bol-016537	Brassica oleracea	50.91	9.00e-12	64.70
IUUC-Bra-017906	Brassica rapa	59.09	2.00e-11	63.90
IUUC-Cel-018300	Caenorhabditis elegans	34.85	4.00e-13	68.60
IUUC-Cja-019084	Callithrix jacchus	92.61	9.00e-100	356.00
IUUC-Cfa-020997	Canis familiaris	89.79	1.00e-89	322.00
IUUC-Cpo-021736	Cavia porcellus	80.47	4.00e-83	301.00
IUUC-Csa-024040	Chlorocebus sabaeus	93.94	6.00e-101	360.00
IUUC-Cho-024543	Choloepus hoffmanni	92.61	3.00e-70	258.00
IUUC-Cin-025719	Ciona intestinalis	39.66	2.00e-40	159.00
IUUC-Csv-025854	Ciona savignyi	38.00	7.00e-39	154.00
IUUC-Cme-027235	Cyanidioschyzon merolae	47.73	4.00e-08	52.80
IUUC-Dre-027745	Danio rerio	53.51	2.00e-61	228.00
IUUC-Dno-029598	Dasypus novemcinctus	89.23	2.00e-101	362.00
IUUC-Dor-030917	Dipodomys ordii	80.99	3.00e-89	321.00
IUUC-Dme-032055	Drosophila melanogaster	41.95	2.00e-24	106.00
IUUC-Ete-032960	Echinops telfairi	75.18	4.00e-77	281.00
IUUC-Eca-034294	Equus caballus	92.59	1.00e-111	395.00
IUUC-Eeu-034906	Erinaceus europaeus	88.77	3.00e-105	374.00
IUUC-Fca-035653	Felis catus	91.20	4.00e-95	341.00
IUUC-Gmo-038755	Gadus morhua	51.29	1.00e-58	219.00
IUUC-Gac-042481	Gasterosteus aculeatus	54.52	1.00e-57	216.00
IUUC-Gma-042684	Glycine max	52.27	2.00e-10	60.10
IUUC-Ggo-044821	Gorilla gorilla	92.25	3.00e-94	338.00
IUUC-Hsa-046797	Homo sapiens	92.93	2.00e-102	365.00
IUUC-Itr-048850	Ictidomys tridecemlineatus	95.96	2.00e-116	411.00
IUUC-Lch-049508	Latimeria chalumnae	53.37	4.00e-57	214.00
IUUC-Laf-053932	Loxodonta africana	91.92	5.00e-127	446.00
IUUC-Mcc-055300	Macaca mulatta	94.28	5.00e-101	360.00
IUUC-Mtr-058774	Medicago truncatula	50.00	8.00e-10	57.80
IUUC-Mla-059083	Melampsora laricipopulina	27.57	6.00e-14	71.60
IUUC-Mvi-060245	Microbotryum violaceum	40.48	6.00e-12	64.70
IUUC-Mmr-060979	Microcebus murinus	91.25	1.00e-106	379.00
IUUC-Mdo-062299	Monodelphis domestica	82.75	5.00e-94	337.00
IUUC-Mac-065072	Musa acuminata	60.53	1.00e-10	60.80
IUUC-Mpu-066540	Mustela putorius furo	92.93	3.00e-112	398.00
IUUC-Mlu-067589	Myotis lucifugus	91.58	9.00e-106	376.00
IUUC-Nle-069045	Nomascus leucogenys	93.15	2.00e-75	275.00
IUUC-Opr-070772	Ochotona princeps	87.28	5.00e-89	320.00
IUUC-Ont-072006	Oreochromis niloticus	54.60	1.00e-57	216.00
IUUC-Oan-073244	Ornithorhynchus anatinus	60.71	5.00e-46	177.00
IUUC-Ocu-074333	Oryctolagus cuniculus	91.58	5.00e-103	367.00
IUUC-Oba-075451	Oryza barthii	49.06	6.00e-11	62.00
IUUC-Obr-076923	Oryza brachyantha	55.10	2.00e-11	63.90
IUUC-Ogl-077259	Oryza glaberrima	28.40	4.00e-10	59.30
IUUC-Ogu-078589	Oryza glumaepatula	49.06	5.00e-11	62.00
IUUC-Oin-079151	Oryza indica	49.06	5.00e-11	62.00
IUUC-Olo-080934	Oryza longistaminata	45.90	2.00e-10	60.50
IUUC-Ome-081253	Oryza meridionalis	49.06	5.00e-11	62.40
IUUC-Oni-082110	Oryza nivara	39.73	2.00e-10	59.70
IUUC-Opu-083336	Oryza punctata	49.06	6.00e-11	62.00
IUUC-Oru-085235	Oryza rufipogon	49.06	6.00e-11	62.00
IUUC-Osa-085611	Oryza sativa	49.06	6.00e-11	62.00
IUUC-Ola-086781	Oryzias latipes	54.19	4.00e-54	204.00
IUUC-Oga-088429	Otolemur garnettii	92.59	1.00e-102	365.00
IUUC-Oar-089885	Ovis aries	91.25	5.00e-123	433.00
IUUC-Ptr-091315	Pan troglodytes	91.90	5.00e-94	337.00
IUUC-Pan-092885	Papio anubis	93.94	6.00e-101	360.00
IUUC-Psi-093299	Pelodiscus sinensis	71.60	4.00e-66	244.00
IUUC-Pma-094221	Petromyzon marinus	64.37	2.00e-28	117.00
IUUC-Ppa-095484	Physcomitrella patens	51.11	2.00e-10	60.10
IUUC-Pfo-096188	Poecilia formosa	54.40	1.00e-55	209.00
IUUC-Pab-097881	Pongo abelii	87.21	5.00e-99	353.00
IUUC-Pop-098863	Populus trichocarpa	59.09	8.00e-12	65.10
IUUC-Pca-100977	Procavia capensis	89.55	7.00e-103	367.00
IUUC-Ppe-101243	Prunus persica	47.06	6.00e-10	58.20
IUUC-Pva-102169	Pteropus vampyrus	92.96	6.00e-99	353.00
IUUC-Rno-105459	Rattus norvegicus	97.31	7.00e-125	439.00
IUUC-Sha-107526	Sarcophilus harrisii	85.19	2.00e-94	338.00
IUUC-Ssl-108389	Sclerotinia sclerotiorum	28.26	3.00e-06	46.60
IUUC-Sit-110434	Setaria italica	31.35	4.00e-10	58.50
IUUC-Sly-111766	Solanum lycopersicum	47.54	5.00e-11	62.40
IUUC-Stu-112122	Solanum tuberosum	47.54	5.00e-11	62.40
IUUC-Sar-112945	Sorex araneus	90.48	2.00e-68	251.00
IUUC-Sbi-114159	Sorghum bicolor	31.89	9.00e-12	64.30
IUUC-Ssc-116114	Sus scrofa	92.59	3.00e-99	355.00
IUUC-Tru-117839	Takifugu rubripes	54.02	2.00e-59	222.00
IUUC-Tsy-118813	Tarsius syrichta	70.42	6.00e-97	347.00
IUUC-Tni-120504	Tetraodon nigroviridis	57.19	2.00e-60	225.00
IUUC-Tur-126615	Triticum urartu	41.27	3.00e-09	56.20
IUUC-Tbe-128034	Tupaia belangeri	92.96	2.00e-104	372.00
IUUC-Ttr-128468	Tursiops truncatus	86.82	7.00e-103	366.00
IUUC-Uma-129569	Ustilago maydis	33.33	3.00e-04	39.30
IUUC-Vpa-130179	Vicugna pacos	86.58	2.00e-76	278.00
IUUC-Vvi-131064	Vitis vinifera	44.78	2.00e-10	60.50
IUUC-Xtr-132119	Xenopus tropicalis	63.76	3.00e-67	248.00
IUUC-Xma-134067	Xiphophorus maculatus	54.22	2.00e-56	212.00
IUUC-Zma-134709	Zea mays	30.98	2.00e-10	59.70

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence