iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
RAID2
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.90e-91	305.7	4499	4833
E3 adaptor/Cullin RING/DCX/DWD	1.40e-14	54.0	3419	3449

Active Site

Position(s)	Description	Evidence
4802	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 6    kkrle.vefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgr 86
            +r++ v++vgE + d+gGv+ ++++++++el++  + l+  s+n ++++ +n+d++l +p     ehl  F+flG+l+g+a+++++
   Q: 4499 PSRAWkVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFLFSPsacldEHLMQFKFLGILMGVAIRTKK 4585
           466666*****************************************************99************************** PP
   S: 87   lldlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeee..LkpgGenipVtneNke 171
           +ldl+l++ ++k+l+ ++l+ledleevd  ++++l++i++ ++s i+e++++ ++  ++ + ++++ ++  ++pgG++ip t +N++
   Q: 4586 PLDLHLAPLVWKQLCCVPLTLEDLEEVDLLYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADGKMvpIIPGGNSIPLTFSNRK 4672
           *******************************************************9999887777766666**************** PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefss 258
           eYv++ +eyrl+e +++qv+a+reG+++++p  llsl+t+++le+++cG++ei v+ lkk  +y++ + e+++ +qw+w++leefs+
   Q: 4673 EYVERAIEYRLHE-MDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEICVDVLKKVVRYRE-VDEQHQLVQWLWRTLEEFSN 4757
           *************.**************************************************88.******************** PP
   S: 259  eerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           eer  f++Fv+g+srlP+ + a+++ ++f+i k d+  d+lP+s+TCf++L+LP+Yss+ ++ e+L+yAi++++++++
   Q: 4758 EERVLFMRFVSGRSRLPA-NTADIS-QRFQIMKvDRPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSIDM 4833
           *****************6.899999.679999956666***********************************99987 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 3    tds.vtclaf.sd.tllvsGsdDgtikvWDlr 31
           +++ +tc+ + +  +ll+++++Dgti+vW+++
   Q: 3419 QNRvMTCV-WcNKkGLLATSGNDGTIRVWNVT 3449
           55416677.*9778****************97 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MATMVPPVKL KWLEHLNSSW ITEDSESIAT REGVTVLYSK LVSNKEVVPL PQQVLCLKGP 60
QLPDFERESL SSDEQDHYLD ALLSSQLALA KMVCSDSPFA GALRKRLLVL QRVFYALSNK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGAGAGTTCC CCACAAGTCC CGCGAGACTC GCCTGCCGCT GCCGCCGCCG CCTCTTACGT 60
CTTTCCCTTT GACAAGTCGC CGCCGCTGCA GCAAAAATAT AAAGGACGCG GCTAGCGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR001870--B30.2/SPRY
IPR016186--C-type_lectin-like/link
IPR013320--ConA-like_dom
IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR003877--SPRY_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50188--B302_SPRY
PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00632--HECT
PF00415--RCC1
PF00622--SPRY
PF00400--WD40

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc
SM00449--SPRY
SM00320--WD40

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0021702--P:cerebellar Purkinje cell differentiation
GO:0010507--P:negative regulation of autophagy
GO:0050885--P:neuromuscular process controlling balance
GO:0031175--P:neuron projection development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001830	Ailuropoda melanoleuca	97.02	0.00e+00	8752.00
IUUC-Apl-003461	Anas platyrhynchos	92.54	0.00e+00	8366.00
IUUC-Aca-004452	Anolis carolinensis	85.03	0.00e+00	7398.00
IUUC-Aly-006545	Arabidopsis lyrata	36.36	1.00e-48	188.00
IUUC-Ame-011268	Astyanax mexicanus	60.89	0.00e+00	2243.00
IUUC-Bta-013213	Bos taurus	97.28	0.00e+00	8726.00
IUUC-Bra-017584	Brassica rapa	34.72	2.00e-50	194.00
IUUC-Cja-019298	Callithrix jacchus	96.95	0.00e+00	8762.00
IUUC-Cfa-021213	Canis familiaris	96.96	0.00e+00	8814.00
IUUC-Cpo-021674	Cavia porcellus	96.02	0.00e+00	5917.00
IUUC-Cre-023014	Chlamydomonas reinhardtii	38.76	3.00e-50	192.00
IUUC-Csa-023341	Chlorocebus sabaeus	96.97	0.00e+00	8762.00
IUUC-Cho-024567	Choloepus hoffmanni	95.28	0.00e+00	1783.00
IUUC-Dre-028289	Danio rerio	78.89	0.00e+00	7124.00
IUUC-Dno-029988	Dasypus novemcinctus	96.46	0.00e+00	8690.00
IUUC-Dor-030636	Dipodomys ordii	94.80	0.00e+00	2149.00
IUUC-Ete-032598	Echinops telfairi	85.06	0.00e+00	1370.00
IUUC-Eca-033754	Equus caballus	97.12	0.00e+00	8757.00
IUUC-Eeu-034702	Erinaceus europaeus	91.83	0.00e+00	1507.00
IUUC-Fca-035900	Felis catus	97.45	0.00e+00	8805.00
IUUC-Fal-037034	Ficedula albicollis	90.95	0.00e+00	7233.00
IUUC-Gmo-039260	Gadus morhua	74.92	0.00e+00	1248.00
IUUC-Gga-040321	Gallus gallus	92.60	0.00e+00	8436.00
IUUC-Gac-042444	Gasterosteus aculeatus	58.18	0.00e+00	2226.00
IUUC-Gma-043808	Glycine max	33.68	2.00e-46	181.00
IUUC-Ggo-045134	Gorilla gorilla	92.17	0.00e+00	4735.00
IUUC-Hsa-046516	Homo sapiens	96.81	0.00e+00	8719.00
IUUC-Itr-048914	Ictidomys tridecemlineatus	97.68	0.00e+00	2573.00
IUUC-Lch-049903	Latimeria chalumnae	86.98	0.00e+00	7899.00
IUUC-Lpe-051165	Leersia perrieri	34.08	6.00e-51	194.00
IUUC-Loc-052149	Lepisosteus oculatus	85.21	0.00e+00	5455.00
IUUC-Laf-053426	Loxodonta africana	96.65	0.00e+00	8772.00
IUUC-Mcc-055826	Macaca mulatta	97.00	0.00e+00	8778.00
IUUC-Meu-056521	Macropus eugenii	85.01	0.00e+00	2237.00
IUUC-Mga-059567	Meleagris gallopavo	95.60	0.00e+00	2118.00
IUUC-Mmr-061512	Microcebus murinus	96.83	0.00e+00	8692.00
IUUC-Mdo-062177	Monodelphis domestica	91.92	0.00e+00	8287.00
IUUC-Mmu-064373	Mus musculus	99.14	0.00e+00	8905.00
IUUC-Mpu-066148	Mustela putorius furo	96.83	0.00e+00	8762.00
IUUC-Mlu-067680	Myotis lucifugus	96.65	0.00e+00	8686.00
IUUC-Nle-069633	Nomascus leucogenys	96.73	0.00e+00	8702.00
IUUC-Opr-070609	Ochotona princeps	95.44	0.00e+00	1453.00
IUUC-Ont-071249	Oreochromis niloticus	81.56	0.00e+00	7479.00
IUUC-Oan-073157	Ornithorhynchus anatinus	93.22	0.00e+00	8382.00
IUUC-Ocu-074841	Oryctolagus cuniculus	97.32	0.00e+00	8843.00
IUUC-Oba-075262	Oryza barthii	33.92	5.00e-49	188.00
IUUC-Obr-076115	Oryza brachyantha	34.10	1.00e-48	187.00
IUUC-Ogl-077586	Oryza glaberrima	33.92	6.00e-49	188.00
IUUC-Ogu-078796	Oryza glumaepatula	33.67	3.00e-48	186.00
IUUC-Oin-079298	Oryza indica	33.67	2.00e-48	186.00
IUUC-Oni-082049	Oryza nivara	33.67	3.00e-48	186.00
IUUC-Opu-083608	Oryza punctata	33.75	3.00e-49	189.00
IUUC-Oru-084712	Oryza rufipogon	33.67	3.00e-48	186.00
IUUC-Osa-086078	Oryza sativa	33.67	3.00e-48	186.00
IUUC-Ola-086889	Oryzias latipes	80.09	0.00e+00	7306.00
IUUC-Oga-088459	Otolemur garnettii	96.26	0.00e+00	8702.00
IUUC-Oar-089888	Ovis aries	97.30	0.00e+00	8699.00
IUUC-Ptr-091114	Pan troglodytes	96.85	0.00e+00	8753.00
IUUC-Pan-092442	Papio anubis	97.16	0.00e+00	8786.00
IUUC-Psi-093833	Pelodiscus sinensis	92.13	0.00e+00	5491.00
IUUC-Pma-094275	Petromyzon marinus	77.23	0.00e+00	1737.00
IUUC-Ppa-095790	Physcomitrella patens	35.80	7.00e-55	207.00
IUUC-Pfo-097262	Poecilia formosa	80.24	0.00e+00	7156.00
IUUC-Pab-097760	Pongo abelii	97.20	0.00e+00	4994.00
IUUC-Pop-099121	Populus trichocarpa	36.63	7.00e-52	199.00
IUUC-Pca-100465	Procavia capensis	95.62	0.00e+00	4571.00
IUUC-Ppe-101345	Prunus persica	34.02	4.00e-52	200.00
IUUC-Pva-102950	Pteropus vampyrus	96.31	0.00e+00	4111.00
IUUC-Sha-106633	Sarcophilus harrisii	93.29	0.00e+00	8283.00
IUUC-Smo-108827	Selaginella moellendorffii	35.14	2.00e-51	198.00
IUUC-Sly-111155	Solanum lycopersicum	36.24	1.00e-53	204.00
IUUC-Stu-112166	Solanum tuberosum	31.97	2.00e-49	191.00
IUUC-Sar-113251	Sorex araneus	86.92	0.00e+00	2477.00
IUUC-Ssc-116391	Sus scrofa	97.24	0.00e+00	8760.00
IUUC-Tgu-116554	Taeniopygia guttata	92.01	0.00e+00	8353.00
IUUC-Tru-118695	Takifugu rubripes	80.99	0.00e+00	7441.00
IUUC-Tsy-119647	Tarsius syrichta	90.67	0.00e+00	5643.00
IUUC-Tni-120707	Tetraodon nigroviridis	80.99	0.00e+00	7412.00
IUUC-Tbe-127346	Tupaia belangeri	89.87	0.00e+00	2601.00
IUUC-Ttr-128542	Tursiops truncatus	93.36	0.00e+00	5929.00
IUUC-Vpa-130611	Vicugna pacos	96.90	0.00e+00	4002.00
IUUC-Xtr-131933	Xenopus tropicalis	85.12	0.00e+00	7665.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence