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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046156
UUCD1 version UUC-HoS-01098
Ensembl Protein ID ENSP00000407818.2
UniProt Accession P62068; B7Z3Y7; B7Z675; B7Z7S3; G8ACC7; Q80V95; Q9H7U4; Q9H9T8; UBP46_HUMAN
Genbank Protein ID ADV57651.1; BAB14133.1; BAB14881.1; BAH12373.1; BAH13161.1; BAH13709.1; EAX05435.1; AAH37574.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 46; Deubiquitinating enzyme 46; Ubiquitin thioesterase 46; Ubiquitin-specific-processing protease 46
Genbank Nucleotide ID GU455414; AK022614; AK024318; AK296493; AK299883; AK302438; CH471057; BC037574
Gene Name USP46
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000109189.12 ENST00000441222.7 ENSP00000407818.2
ENSG00000109189.12 ENST00000451218.6 ENSP00000390102.2
ENSG00000109189.12 ENST00000503060.5 ENSP00000422018.1
ENSG00000109189.12 ENST00000508499.5 ENSP00000423244.1
ENSG00000109189.12 ENST00000512656.1 ENSP00000425806.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanmiRecordsRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/USP USP 21183687
Classification
Family E-value Score Start End
DUB/USP 4.20e-98 330.3 35 364
Active Site
Position(s) Description Evidence
44 Nucleophile ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093,
ECO:0000269|PubMed:26388029,
ECO:0000305|PubMed:22043315}
313 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsgyeqq 90
           +Gl N+gNtCY+NSvLQ+L++++++re++l  +k +      +++k++ll++l++lf+++   k+k +++ p+++++ l+ke+  f++y+qq
   Q: 35   FGLVNFGNTCYCNSVLQALYFCRPFRENVLA-YKAQ------QKKKENLLTCLADLFHSIAtqKKKVGVIPPKKFISRLRKENDLFDNYMQQ 119
           6******************************.3333......567899************976777779*********************** PP
   S: 91   DaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeet 182
           Da+Efl++ll+++ + l   ++++k+e+++ + ++ +++++ +++k + ++++++Fqg+l+++++cl+c++vss++e+fldls++v++++  
   Q: 120  DAHEFLNYLLNTIADIL---QEEKKQEKQNGKLKNGNMNEPAENNKPELTWVHEIFQGTLTNETRCLNCETVSSKDEDFLDLSVDVEQNT-- 206
           *****************...34555555555556666677788888888*****************************************.. PP
   S: 183  kkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke 274
              s+++cL++f+++e+l++e+kyyce+c++kqea+k++++kklP +L lhLkRf++ e+ ++ +k++ +v fpleL l  f+ts++  ++ 
   Q: 207  ---SITHCLRDFSNTETLCSEQKYYCETCCSKQEAQKRMRVKKLPMILALHLKRFKYMEQLHRYTKLSYRVVFPLELRL--FNTSSDA-VNL 292
           ...9**********************************************************************66555..7777554.445 PP
   S: 275  kkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetg.........staYvlfYkr 337
           ++ Y+L+avvvH G +++ GHY+++vk+ +g WllfdD+ V++++ + ++e+ g         +++Y+lfY++
   Q: 293  DRMYDLVAVVVHCGsGPNRGHYITIVKS-HGFWLLFDDDIVEKIDAQAIEEFYGltsdisknsESGYILFYQS 364
           9***************************.888*******************999*****************97 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67 (By similarity). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:19075014, PubMed:26388029). Not involved in deubiquitination of monoubiquitinated FANCD2 (PubMed:19075014).
 Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67 (By similarity). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:19075014, PubMed:26388029). Not involved in deubiquitination of monoubiquitinated FANCD2 (PubMed:19075014).
Protein Sequence
(Fasta)
MTVRNIASIC NMGTNASALE KDIGPEQFPI NEHYFGLVNF GNTCYCNSVL QALYFCRPFR 60
ENVLAYKAQQ KKKENLLTCL ADLFHSIATQ KKKVGVIPPK KFISRLRKEN DLFDNYMQQD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046156|DUB,USP|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGCTCCCTCC CCGCCCTCCC CGCGCCGCCG CCTCCTCCTC CCGGCCTCCC TCTCCCAGCC 60
AAACTGAAAG CCGGACCCCA GGCCGCCGCG CTGCCGCCCG GCCTCCCCGC CAGCGCGCCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046156|DUB,USP|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0085--Behavior
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
Pfam

PF00443--UCH
Gene Ontology

GO:0046872--F:metal ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008343--P:adult feeding behavior
GO:0001662--P:behavioral fear response
GO:0048149--P:behavioral response to ethanol
GO:0016579--P:protein deubiquitination
GO:0032228--P:regulation of synaptic transmission, GABAergic
GO:0060013--P:righting reflex
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG hsa:64854
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000193 Aegilops tauschii 60.00 9.00e-126 443.00
IUUC-Aml-002353 Ailuropoda melanoleuca 98.35 0.00e+00 704.00
IUUC-Atr-002650 Amborella trichopoda 59.56 9.00e-126 443.00
IUUC-Apl-003380 Anas platyrhynchos 95.63 0.00e+00 690.00
IUUC-Aca-005031 Anolis carolinensis 97.27 0.00e+00 750.00
IUUC-Aly-005830 Arabidopsis lyrata 58.92 1.00e-123 436.00
IUUC-Ath-006663 Arabidopsis thaliana 59.07 1.00e-126 446.00
IUUC-Ago-007871 Ashbya gossypii 38.57 1.00e-48 188.00
IUUC-Ame-010862 Astyanax mexicanus 94.85 0.00e+00 725.00
IUUC-Bta-013023 Bos taurus 98.61 0.00e+00 701.00
IUUC-Bdi-014008 Brachypodium distachyon 60.55 2.00e-125 441.00
IUUC-Bol-015138 Brassica oleracea 58.60 6.00e-125 440.00
IUUC-Bra-017483 Brassica rapa 60.34 3.00e-126 444.00
IUUC-Cel-018379 Caenorhabditis elegans 62.41 6.00e-145 507.00
IUUC-Cja-018956 Callithrix jacchus 97.55 0.00e+00 699.00
IUUC-Cfa-021064 Canis familiaris 99.44 0.00e+00 690.00
IUUC-Cpo-022443 Cavia porcellus 99.16 0.00e+00 699.00
IUUC-Cre-022711 Chlamydomonas reinhardtii 53.65 8.00e-100 357.00
IUUC-Csa-023841 Chlorocebus sabaeus 100.00 0.00e+00 724.00
IUUC-Csv-025828 Ciona savignyi 73.89 3.00e-88 319.00
IUUC-Cne-026900 Cryptococcus neoformans 41.91 4.00e-60 226.00
IUUC-Dre-028230 Danio rerio 94.34 0.00e+00 723.00
IUUC-Dno-029209 Dasypus novemcinctus 97.53 0.00e+00 702.00
IUUC-Dme-032038 Drosophila melanogaster 81.28 6.00e-100 357.00
IUUC-Eca-033721 Equus caballus 99.72 0.00e+00 696.00
IUUC-Eeu-034916 Erinaceus europaeus 98.64 3.00e-162 563.00
IUUC-Fca-036299 Felis catus 97.54 0.00e+00 701.00
IUUC-Fox-037682 Fusarium oxysporum 42.32 3.00e-74 273.00
IUUC-Fso-038299 Fusarium solani 37.07 1.00e-74 274.00
IUUC-Gmo-038611 Gadus morhua 94.63 0.00e+00 693.00
IUUC-Ggr-039806 Gaeumannomyces graminis 42.24 3.00e-75 276.00
IUUC-Gga-041157 Gallus gallus 98.63 0.00e+00 712.00
IUUC-Gac-041764 Gasterosteus aculeatus 93.94 0.00e+00 706.00
IUUC-Gma-042927 Glycine max 60.66 8.00e-128 449.00
IUUC-Ggo-044659 Gorilla gorilla 97.82 0.00e+00 702.00
IUUC-Hvu-047692 Hordeum vulgare 58.86 9.00e-124 436.00
IUUC-Itr-048157 Ictidomys tridecemlineatus 100.00 0.00e+00 724.00
IUUC-Kpa-049250 Komagataella pastoris 44.83 1.00e-69 257.00
IUUC-Lch-049969 Latimeria chalumnae 96.72 0.00e+00 685.00
IUUC-Lpe-051368 Leersia perrieri 58.70 1.00e-122 432.00
IUUC-Loc-052479 Lepisosteus oculatus 91.26 0.00e+00 694.00
IUUC-Laf-054085 Loxodonta africana 100.00 0.00e+00 724.00
IUUC-Mcc-055566 Macaca mulatta 98.08 0.00e+00 702.00
IUUC-Mor-057072 Magnaporthe oryzae 43.65 8.00e-76 278.00
IUUC-Mpo-057424 Magnaporthe poae 42.86 2.00e-75 277.00
IUUC-Mtr-057715 Medicago truncatula 60.33 4.00e-128 451.00
IUUC-Mla-059142 Melampsora laricipopulina 54.08 5.00e-96 346.00
IUUC-Mga-059575 Meleagris gallopavo 98.59 0.00e+00 686.00
IUUC-Mvi-060357 Microbotryum violaceum 53.96 2.00e-77 284.00
IUUC-Mdo-062579 Monodelphis domestica 99.73 0.00e+00 723.00
IUUC-Mmu-063611 Mus musculus 100.00 0.00e+00 724.00
IUUC-Mac-065323 Musa acuminata 60.11 3.00e-124 437.00
IUUC-Mpu-066038 Mustela putorius furo 100.00 0.00e+00 699.00
IUUC-Mlu-068183 Myotis lucifugus 98.08 0.00e+00 706.00
IUUC-Nle-069330 Nomascus leucogenys 100.00 0.00e+00 724.00
IUUC-Opr-070980 Ochotona princeps 99.72 0.00e+00 697.00
IUUC-Ont-072134 Oreochromis niloticus 95.12 0.00e+00 729.00
IUUC-Oan-073583 Ornithorhynchus anatinus 93.52 0.00e+00 686.00
IUUC-Ocu-074923 Oryctolagus cuniculus 99.72 0.00e+00 695.00
IUUC-Oba-075220 Oryza barthii 59.73 6.00e-123 434.00
IUUC-Obr-076208 Oryza brachyantha 57.65 7.00e-120 423.00
IUUC-Ogl-077216 Oryza glaberrima 59.73 6.00e-123 434.00
IUUC-Ogu-078836 Oryza glumaepatula 59.73 6.00e-123 434.00
IUUC-Oin-079522 Oryza indica 59.73 6.00e-123 434.00
IUUC-Olo-080882 Oryza longistaminata 59.73 6.00e-123 434.00
IUUC-Ome-081549 Oryza meridionalis 59.73 6.00e-123 434.00
IUUC-Oni-082982 Oryza nivara 59.73 6.00e-123 434.00
IUUC-Opu-083532 Oryza punctata 59.73 4.00e-123 434.00
IUUC-Oru-084568 Oryza rufipogon 59.73 6.00e-123 434.00
IUUC-Osa-085299 Oryza sativa 59.73 6.00e-123 434.00
IUUC-Ola-086546 Oryzias latipes 93.66 0.00e+00 705.00
IUUC-Olu-087809 Ostreococcus lucimarinus 48.44 1.00e-81 296.00
IUUC-Oga-088073 Otolemur garnettii 99.72 0.00e+00 696.00
IUUC-Oar-089248 Ovis aries 100.00 0.00e+00 698.00
IUUC-Ptr-090814 Pan troglodytes 100.00 0.00e+00 724.00
IUUC-Pan-091753 Papio anubis 100.00 0.00e+00 724.00
IUUC-Psi-094012 Pelodiscus sinensis 99.15 0.00e+00 689.00
IUUC-Pma-094388 Petromyzon marinus 89.54 0.00e+00 689.00
IUUC-Ppa-095415 Physcomitrella patens 59.03 8.00e-128 450.00
IUUC-Pfo-097369 Poecilia formosa 95.12 0.00e+00 729.00
IUUC-Pab-098594 Pongo abelii 100.00 0.00e+00 701.00
IUUC-Pop-099798 Populus trichocarpa 60.38 6.00e-127 447.00
IUUC-Pca-100913 Procavia capensis 83.66 7.00e-160 556.00
IUUC-Ppe-101474 Prunus persica 59.84 4.00e-127 447.00
IUUC-Pva-102892 Pteropus vampyrus 100.00 0.00e+00 699.00
IUUC-Pgr-103306 Puccinia graminis 52.63 2.00e-94 340.00
IUUC-Rno-104909 Rattus norvegicus 99.73 0.00e+00 723.00
IUUC-Sce-106196 Saccharomyces cerevisiae 37.80 5.00e-55 209.00
IUUC-Sha-107400 Sarcophilus harrisii 99.72 0.00e+00 697.00
IUUC-Smo-109064 Selaginella moellendorffii 60.33 6.00e-121 427.00
IUUC-Sit-110819 Setaria italica 59.73 2.00e-123 435.00
IUUC-Sly-111210 Solanum lycopersicum 59.73 1.00e-126 446.00
IUUC-Stu-112398 Solanum tuberosum 60.16 5.00e-127 447.00
IUUC-Sbi-114562 Sorghum bicolor 58.90 8.00e-124 436.00
IUUC-Sre-115197 Sporisorium reilianum 48.94 2.00e-79 290.00
IUUC-Ssc-115550 Sus scrofa 100.00 0.00e+00 699.00
IUUC-Tgu-116800 Taeniopygia guttata 98.63 0.00e+00 713.00
IUUC-Tru-118212 Takifugu rubripes 95.12 0.00e+00 731.00
IUUC-Tni-120071 Tetraodon nigroviridis 95.12 0.00e+00 730.00
IUUC-Tca-121329 Theobroma cacao 60.11 2.00e-127 448.00
IUUC-Tae-125280 Triticum aestivum 60.27 1.00e-126 446.00
IUUC-Tur-126563 Triticum urartu 60.00 3.00e-126 444.00
IUUC-Uma-129409 Ustilago maydis 49.13 3.00e-81 297.00
IUUC-Vpa-130590 Vicugna pacos 94.93 0.00e+00 652.00
IUUC-Vvi-131371 Vitis vinifera 59.84 6.00e-127 447.00
IUUC-Xma-133111 Xiphophorus maculatus 95.12 0.00e+00 729.00
IUUC-Yli-134632 Yarrowia lipolytica 45.21 6.00e-79 289.00
Created Date 25-Jun-2017

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