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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046307
UUCD1 version UUC-HoS-00061
Ensembl Protein ID ENSP00000349543.4
UniProt Accession P28328; Q567S6; Q9BW41; PEX2_HUMAN
Genbank Protein ID AAC12785.1; AAF97687.1; AAA60141.1; AAH05375.1; AAH93043.1
Protein Name Peroxisome biogenesis factor 2; 35 kDa peroxisomal membrane protein; Peroxin-2; Peroxisomal membrane protein 3; Peroxisome assembly factor 1; RING finger protein 72
Genbank Nucleotide ID M86852; AF133826; M85038; AC090810; BC093043
Gene Name PEX2; PAF1; PMP3; PMP35; PXMP3; RNF72
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000164751.14 ENST00000357039.8 ENSP00000349543.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
ClinVarOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 19687296
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.38 13.0 244 283
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           Ca+C e +   p++ +C H+f+  C      ++ +    f+CP C
   Q: 244  CALCGEWPTM-PHTIGCEHIFCYFCA----KSSFLFDVYFTCPKC 283
           ****998877.**************5....444677777899988 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Belongs to the pex2/pex10/pex12 family.
 Belongs to the pex2/pex10/pex12 family.
Protein Sequence
(Fasta)
MASRKENAKS ANRVLRISQL DALELNKALE QLVWSQFTQC FHGFKPGLLA RFEPEVKACL 60
WVFLWRFTIY SKNATVGQSV LNIKYKNDFS PNLRYQPPSK NQKIWYAVCT IGGRWLEERC 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046307|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGAGGTAAGA ACTAAGACGT TCTTAAACCC TACTACGTGC TGGAATCCTG AAGTGCCTGC 60
CATCATTCAA ACTTAAGCAC TAACTCTCTA GAGAGACACT GCCATTCATA CCACAGAACG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046307|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0472--Membrane
KW-0479--Metal-binding
KW-0576--Peroxisome
KW-0962--Peroxisome biogenesis
KW-0958--Peroxisome biogenesis disorder
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0861--Zellweger syndrome
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR006845--Pex_N
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF04757--Pex2_Pex12
PF00097--zf-C3HC4
SMART

SM00184--RING
Gene Ontology

GO:0016593--C:Cdc73/Paf1 complex
GO:0005779--C:integral component of peroxisomal membrane
GO:0016020--C:membrane
GO:0005778--C:peroxisomal membrane
GO:0008270--F:zinc ion binding
GO:0006635--P:fatty acid beta-oxidation
GO:0050680--P:negative regulation of epithelial cell proliferation
GO:0048147--P:negative regulation of fibroblast proliferation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0007031--P:peroxisome organization
GO:0031648--P:protein destabilization
GO:0016558--P:protein import into peroxisome matrix
GO:0000038--P:very long-chain fatty acid metabolic process
KEGG hsa:5828
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000106 Aegilops tauschii 28.78 2.00e-20 92.80
IUUC-Aml-001595 Ailuropoda melanoleuca 89.84 3.00e-161 560.00
IUUC-Atr-002766 Amborella trichopoda 28.23 5.00e-32 131.00
IUUC-Apl-004019 Anas platyrhynchos 73.36 1.00e-135 475.00
IUUC-Aca-004791 Anolis carolinensis 70.39 5.00e-119 420.00
IUUC-Aly-005607 Arabidopsis lyrata 29.22 4.00e-33 135.00
IUUC-Ath-006880 Arabidopsis thaliana 28.90 4.00e-33 135.00
IUUC-Ago-007841 Ashbya gossypii 23.92 1.00e-08 53.90
IUUC-Acl-008272 Aspergillus clavatus 29.11 2.00e-23 103.00
IUUC-Afl-008698 Aspergillus flavus 31.46 3.00e-24 106.00
IUUC-Afu-008859 Aspergillus fumigatus 31.05 2.00e-24 106.00
IUUC-Ani-009210 Aspergillus nidulans 30.00 5.00e-23 102.00
IUUC-Ang-009515 Aspergillus niger 29.76 6.00e-23 102.00
IUUC-Aor-009913 Aspergillus oryzae 31.46 3.00e-24 106.00
IUUC-Ate-010581 Aspergillus terreus 29.61 1.00e-23 104.00
IUUC-Ame-010951 Astyanax mexicanus 54.08 2.00e-88 318.00
IUUC-Bgr-012274 Blumeria graminis 27.27 1.00e-20 94.40
IUUC-Bta-012949 Bos taurus 86.51 8.00e-155 539.00
IUUC-Bci-013654 Botrytis cinerea 28.16 9.00e-17 81.60
IUUC-Bdi-014062 Brachypodium distachyon 30.23 5.00e-34 138.00
IUUC-Bra-016860 Brassica rapa 30.27 2.00e-33 135.00
IUUC-Cel-018250 Caenorhabditis elegans 23.31 1.00e-18 87.00
IUUC-Cja-019623 Callithrix jacchus 95.41 1.00e-175 608.00
IUUC-Cfa-020899 Canis familiaris 89.84 4.00e-167 580.00
IUUC-Cpo-021971 Cavia porcellus 89.18 7.00e-164 569.00
IUUC-Cre-022853 Chlamydomonas reinhardtii 34.43 2.00e-04 39.70
IUUC-Csa-023552 Chlorocebus sabaeus 97.38 8.00e-179 619.00
IUUC-Cho-024309 Choloepus hoffmanni 91.15 1.00e-169 588.00
IUUC-Csv-025909 Ciona savignyi 28.52 2.00e-23 103.00
IUUC-Cgl-026469 Colletotrichum gloeosporioides 27.84 5.00e-21 95.90
IUUC-Cne-027011 Cryptococcus neoformans 24.43 7.00e-14 71.60
IUUC-Cme-027206 Cyanidioschyzon merolae 26.18 3.00e-15 75.90
IUUC-Dre-027627 Danio rerio 57.05 1.00e-97 349.00
IUUC-Dno-029220 Dasypus novemcinctus 91.15 2.00e-168 584.00
IUUC-Dor-030828 Dipodomys ordii 87.87 5.00e-166 576.00
IUUC-Dse-031469 Dothistroma septosporum 30.34 1.00e-15 78.60
IUUC-Dme-031865 Drosophila melanogaster 28.87 5.00e-33 134.00
IUUC-Ete-033020 Echinops telfairi 68.52 3.00e-105 374.00
IUUC-Eca-034078 Equus caballus 89.84 8.00e-167 579.00
IUUC-Fca-036406 Felis catus 88.52 3.00e-164 570.00
IUUC-Fal-037365 Ficedula albicollis 72.70 2.00e-124 438.00
IUUC-Fox-037825 Fusarium oxysporum 31.33 4.00e-21 95.90
IUUC-Fso-038458 Fusarium solani 31.33 4.00e-20 92.80
IUUC-Gmo-038729 Gadus morhua 55.36 1.00e-25 110.00
IUUC-Ggr-039992 Gaeumannomyces graminis 31.98 9.00e-15 75.10
IUUC-Gga-040364 Gallus gallus 74.01 6.00e-137 479.00
IUUC-Gac-041501 Gasterosteus aculeatus 50.00 3.00e-67 248.00
IUUC-Gma-044174 Glycine max 30.00 2.00e-31 129.00
IUUC-Ggo-045248 Gorilla gorilla 98.69 5.00e-180 623.00
IUUC-Hvu-047618 Hordeum vulgare 30.56 9.00e-34 137.00
IUUC-Itr-048006 Ictidomys tridecemlineatus 90.13 1.00e-167 582.00
IUUC-Kpa-049382 Komagataella pastoris 23.68 1.00e-14 74.30
IUUC-Lch-049694 Latimeria chalumnae 68.90 3.00e-120 424.00
IUUC-Lpe-050779 Leersia perrieri 29.67 1.00e-26 114.00
IUUC-Loc-052253 Lepisosteus oculatus 56.48 6.00e-100 357.00
IUUC-Lma-053100 Leptosphaeria maculans 32.00 5.00e-14 72.40
IUUC-Laf-053543 Loxodonta africana 91.15 2.00e-168 584.00
IUUC-Mcc-055435 Macaca mulatta 97.70 4.00e-179 620.00
IUUC-Meu-056096 Macropus eugenii 83.55 7.00e-157 546.00
IUUC-Mor-057285 Magnaporthe oryzae 27.43 3.00e-22 99.80
IUUC-Mtr-058501 Medicago truncatula 28.52 1.00e-27 117.00
IUUC-Mla-059178 Melampsora laricipopulina 24.05 4.00e-12 65.50
IUUC-Mga-060125 Meleagris gallopavo 72.04 2.00e-134 471.00
IUUC-Mvi-060252 Microbotryum violaceum 40.79 3.00e-13 70.10
IUUC-Mmr-061696 Microcebus murinus 92.13 5.00e-170 589.00
IUUC-Mdo-062789 Monodelphis domestica 82.57 1.00e-154 539.00
IUUC-Mmu-063391 Mus musculus 87.87 2.00e-162 565.00
IUUC-Mac-064555 Musa acuminata 30.82 1.00e-34 140.00
IUUC-Mpu-065832 Mustela putorius furo 89.84 2.00e-167 580.00
IUUC-Mlu-067811 Myotis lucifugus 85.57 7.00e-162 562.00
IUUC-Nfi-068362 Neosartorya fischeri 30.43 3.00e-19 89.70
IUUC-Ncr-068621 Neurospora crassa 32.60 9.00e-19 89.00
IUUC-Nle-069980 Nomascus leucogenys 97.70 7.00e-179 619.00
IUUC-Opr-070196 Ochotona princeps 89.51 1.00e-166 578.00
IUUC-Ont-071826 Oreochromis niloticus 52.03 2.00e-77 282.00
IUUC-Oan-072999 Ornithorhynchus anatinus 56.98 3.00e-26 110.00
IUUC-Ocu-074466 Oryctolagus cuniculus 90.82 8.00e-168 582.00
IUUC-Oba-075893 Oryza barthii 29.45 1.00e-27 117.00
IUUC-Obr-076621 Oryza brachyantha 30.23 1.00e-33 137.00
IUUC-Ogl-077881 Oryza glaberrima 29.24 1.00e-32 133.00
IUUC-Ogu-078407 Oryza glumaepatula 29.53 7.00e-33 134.00
IUUC-Oin-080063 Oryza indica 29.24 1.00e-32 133.00
IUUC-Olo-080529 Oryza longistaminata 29.33 1.00e-23 103.00
IUUC-Ome-081350 Oryza meridionalis 29.09 1.00e-27 117.00
IUUC-Oni-082647 Oryza nivara 29.33 1.00e-23 103.00
IUUC-Opu-083358 Oryza punctata 28.78 5.00e-27 115.00
IUUC-Oru-084263 Oryza rufipogon 29.08 7.00e-25 107.00
IUUC-Osa-085561 Oryza sativa 29.24 1.00e-32 133.00
IUUC-Ola-087048 Oryzias latipes 48.98 2.00e-66 246.00
IUUC-Olu-087782 Ostreococcus lucimarinus 27.15 4.00e-15 75.10
IUUC-Oga-088107 Otolemur garnettii 91.48 2.00e-169 587.00
IUUC-Oar-089967 Ovis aries 87.17 9.00e-155 539.00
IUUC-Ptr-091627 Pan troglodytes 98.69 8.00e-180 622.00
IUUC-Pan-091754 Papio anubis 97.38 2.00e-179 620.00
IUUC-Psi-093286 Pelodiscus sinensis 73.11 4.00e-127 447.00
IUUC-Pma-094543 Petromyzon marinus 45.30 4.00e-66 244.00
IUUC-Pno-094850 Phaeosphaeria nodorum 28.91 7.00e-18 85.50
IUUC-Ppa-095816 Physcomitrella patens 30.87 5.00e-29 121.00
IUUC-Pfo-097377 Poecilia formosa 48.68 1.00e-75 276.00
IUUC-Pab-097671 Pongo abelii 98.03 5.00e-179 619.00
IUUC-Pop-099692 Populus trichocarpa 30.54 1.00e-33 137.00
IUUC-Ppe-101194 Prunus persica 29.21 4.00e-28 118.00
IUUC-Pva-102697 Pteropus vampyrus 83.61 3.00e-156 543.00
IUUC-Pgr-103472 Puccinia graminis 44.90 5.00e-05 42.40
IUUC-Pte-104058 Pyrenophora teres 28.30 2.00e-23 103.00
IUUC-Pyt-104435 Pyrenophora triticirepentis 29.49 1.00e-20 94.70
IUUC-Rno-105925 Rattus norvegicus 87.87 2.00e-163 567.00
IUUC-Sce-106321 Saccharomyces cerevisiae 21.53 2.00e-07 49.30
IUUC-Sha-106928 Sarcophilus harrisii 82.57 1.00e-154 539.00
IUUC-Ssl-108434 Sclerotinia sclerotiorum 27.85 6.00e-17 82.00
IUUC-Smo-108998 Selaginella moellendorffii 28.57 5.00e-27 115.00
IUUC-Sit-110018 Setaria italica 29.57 2.00e-32 133.00
IUUC-Sly-111670 Solanum lycopersicum 31.62 2.00e-36 146.00
IUUC-Stu-112190 Solanum tuberosum 31.06 5.00e-36 145.00
IUUC-Sar-112920 Sorex araneus 82.62 1.00e-153 535.00
IUUC-Sbi-114300 Sorghum bicolor 29.34 2.00e-33 136.00
IUUC-Sre-115019 Sporisorium reilianum 29.27 1.00e-11 64.70
IUUC-Ssc-116289 Sus scrofa 85.25 8.00e-154 536.00
IUUC-Tgu-116936 Taeniopygia guttata 73.36 5.00e-135 473.00
IUUC-Tru-118611 Takifugu rubripes 46.69 8.00e-81 293.00
IUUC-Tsy-119073 Tarsius syrichta 92.13 2.00e-169 587.00
IUUC-Tni-119824 Tetraodon nigroviridis 45.28 4.00e-70 258.00
IUUC-Tca-121117 Theobroma cacao 28.85 2.00e-33 136.00
IUUC-Tre-122081 Trichoderma reesei 28.64 1.00e-21 97.40
IUUC-Tvi-122454 Trichoderma virens 24.85 8.00e-22 98.20
IUUC-Tae-123108 Triticum aestivum 30.56 9.00e-34 137.00
IUUC-Tur-125989 Triticum urartu 28.70 1.00e-18 87.00
IUUC-Tme-127082 Tuber melanosporum 29.66 2.00e-21 97.40
IUUC-Tbe-127229 Tupaia belangeri 90.49 2.00e-166 577.00
IUUC-Ttr-129251 Tursiops truncatus 87.21 9.00e-163 565.00
IUUC-Vda-130008 Verticillium dahliae 32.16 6.00e-15 75.50
IUUC-Vpa-130084 Vicugna pacos 89.18 1.00e-154 538.00
IUUC-Vvi-130953 Vitis vinifera 31.06 9.00e-36 144.00
IUUC-Xtr-132429 Xenopus tropicalis 65.69 1.00e-121 429.00
IUUC-Xma-133897 Xiphophorus maculatus 49.17 1.00e-72 266.00
IUUC-Yli-134504 Yarrowia lipolytica 25.95 2.00e-14 73.60
IUUC-Zma-135123 Zea mays 27.76 2.00e-30 126.00
Created Date 25-Jun-2017

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