iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mlu-067878

Ensembl Protein ID

ENSMLUP00000006251.2

UniProt Accession

G1P7Y4; G1P7Y4_MYOLU

Genbank Protein ID

ENSMLUP00000006251

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPE02056209

Gene Name

SHARPIN

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000006847.2	ENSMLUT00000006845.2	ENSMLUP00000006251.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/ZnF/NZF	4.50e-13	48.5	336	364
ULD/UDP/UBQ/UBQ_Other	6.10e-14	51.7	217	277

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/NZF

   S: 2    eaqWaCsaCTflNePeavkCemCsrpRgc 30
           +++W C++CTf+N+P++++CemCs++R+c
   Q: 336  QPGWPCPSCTFINAPSRPGCEMCSTQRPC 364
           689*************************9 PP

ULD/UDP/UBQ/UBQ_Other

   S: 2    qvtvksldgs.eltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiL.eddktLadygl 61
           qvtv+++ +s + +l+v+p++t++ L+e++++k+g+pp+ qr+++ Gk+L  + ++La+yg+
   Q: 217  QVTVEDASSSaHVSLQVHPHCTISALQEQVFSKFGFPPAVQRWVI-GKCLcVPERSLASYGV 277
           89*******************************************.**************87 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

MAPPAGGAAA APDPGSSTVL LTVHAAVRPL AAGPDAEAQL RRLQLSADPE RPGRFRLELL 60
GAGPGAVGLE WPLESVSYTV RGPSQHELQP PPGGPGALSL RFLNPQEAQR WAALVRGATA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGCCGC CGGCGGGCGG AGCGGCGGCT GCCCCGGACC CGGGCTCGTC CACGGTGCTG 60
CTGACTGTGC ACGCCGCCGT GAGGCCGCTG GCCGCCGGAC CGGACGCTGA GGCGCAGCTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome

Interpro

IPR031912--Sharpin_PH
IPR029071--Ubiquitin-rel_dom
IPR001876--Znf_RanBP2

PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2

Pfam

PF16764--Sharpin_PH

SMART

SM00547--ZnF_RBZ

Gene Ontology

GO:0005829--C:cytosol
GO:0071797--C:LUBAC complex
GO:0008270--F:zinc ion binding
GO:0030262--P:apoptotic nuclear changes
GO:0031424--P:keratinization
GO:0007005--P:mitochondrion organization
GO:0050728--P:negative regulation of inflammatory response
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0097039--P:protein linear polyubiquitination
GO:2000348--P:regulation of CD40 signaling pathway
GO:0010803--P:regulation of tumor necrosis factor-mediated signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001223	Ailuropoda melanoleuca	83.14	3.00e-132	464.00
IUUC-Apl-004151	Anas platyrhynchos	59.26	1.00e-16	77.00
IUUC-Bta-012948	Bos taurus	84.00	5.00e-141	494.00
IUUC-Cja-019031	Callithrix jacchus	77.16	1.00e-127	449.00
IUUC-Cfa-020863	Canis familiaris	80.61	8.00e-116	410.00
IUUC-Cpo-022499	Cavia porcellus	74.59	5.00e-127	447.00
IUUC-Csa-023641	Chlorocebus sabaeus	78.90	4.00e-128	451.00
IUUC-Dre-027612	Danio rerio	37.18	6.00e-52	197.00
IUUC-Dno-029459	Dasypus novemcinctus	59.14	3.00e-62	231.00
IUUC-Dor-030914	Dipodomys ordii	62.30	9.00e-80	290.00
IUUC-Ete-032940	Echinops telfairi	67.51	3.00e-98	351.00
IUUC-Eca-033537	Equus caballus	84.97	1.00e-140	493.00
IUUC-Eeu-035176	Erinaceus europaeus	67.69	2.00e-59	223.00
IUUC-Fca-035971	Felis catus	83.28	1.00e-126	446.00
IUUC-Gmo-039219	Gadus morhua	39.39	4.00e-53	201.00
IUUC-Gac-041562	Gasterosteus aculeatus	41.05	6.00e-38	151.00
IUUC-Ggo-044678	Gorilla gorilla	77.47	6.00e-126	443.00
IUUC-Hsa-046578	Homo sapiens	80.50	4.00e-133	467.00
IUUC-Itr-047913	Ictidomys tridecemlineatus	73.77	2.00e-129	455.00
IUUC-Mcc-055686	Macaca mulatta	74.59	2.00e-130	458.00
IUUC-Meu-055912	Macropus eugenii	55.40	9.00e-62	230.00
IUUC-Mmr-060584	Microcebus murinus	77.26	3.00e-140	491.00
IUUC-Mdo-062191	Monodelphis domestica	54.55	3.00e-82	298.00
IUUC-Mmu-063740	Mus musculus	72.14	6.00e-112	397.00
IUUC-Mpu-066878	Mustela putorius furo	79.57	9.00e-114	403.00
IUUC-Nle-069748	Nomascus leucogenys	79.23	9.00e-123	432.00
IUUC-Ont-072270	Oreochromis niloticus	39.24	5.00e-52	197.00
IUUC-Oba-075102	Oryza barthii	44.44	3.00e-04	39.30
IUUC-Ogl-077291	Oryza glaberrima	44.44	3.00e-04	39.30
IUUC-Oin-079800	Oryza indica	44.90	8.00e-05	41.20
IUUC-Ome-081262	Oryza meridionalis	44.44	5.00e-04	38.50
IUUC-Oni-082829	Oryza nivara	44.90	8.00e-05	41.20
IUUC-Opu-083275	Oryza punctata	43.18	1.00e-03	37.40
IUUC-Oru-084564	Oryza rufipogon	44.44	7.00e-04	38.10
IUUC-Osa-085600	Oryza sativa	44.44	7.00e-04	38.10
IUUC-Oga-088300	Otolemur garnettii	76.55	2.00e-139	488.00
IUUC-Oar-089549	Ovis aries	84.00	6.00e-145	506.00
IUUC-Ptr-090961	Pan troglodytes	80.27	4.00e-119	421.00
IUUC-Pan-092687	Papio anubis	79.95	3.00e-131	461.00
IUUC-Pfo-096865	Poecilia formosa	36.02	1.00e-43	170.00
IUUC-Pab-097872	Pongo abelii	76.44	2.00e-119	422.00
IUUC-Pca-100363	Procavia capensis	66.67	4.00e-63	235.00
IUUC-Pva-102595	Pteropus vampyrus	81.16	2.00e-116	412.00
IUUC-Rno-105856	Rattus norvegicus	70.57	2.00e-108	385.00
IUUC-Sha-106838	Sarcophilus harrisii	54.96	4.00e-75	275.00
IUUC-Sly-111366	Solanum lycopersicum	50.00	7.00e-05	41.20
IUUC-Sar-113611	Sorex araneus	62.77	3.00e-23	102.00
IUUC-Ssc-116263	Sus scrofa	81.49	4.00e-145	507.00
IUUC-Tru-118089	Takifugu rubripes	42.19	5.00e-59	221.00
IUUC-Tni-120004	Tetraodon nigroviridis	41.40	2.00e-50	192.00
IUUC-Tbe-127471	Tupaia belangeri	67.48	3.00e-99	355.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence