iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	1.10e-26	93.0	227	300

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 1    evpeeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqawceenss 74
           ++p+++++ Is+elMr+P+++psGitydr+ Ie++l++ g+ +Pvtr+plt+e+l+Pnl+++++i+a+++en++
   Q: 227  DIPDYLCGKISFELMREPCITPSGITYDRKDIEEHLQRVGHFDPVTRSPLTQEQLIPNLAMKEVIDAFISENGW 300
           69********************************************************************9986 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MKGKEEKEGG ARLGTGGGGS PDKSPSAQEL KEQGNRLFVG RKYPEAAACY GRAITRNPLV 60
AVYYTNRALC YLKMQQPEQA LADCRRALEL DGQSVKAHFF LGQCQLEMES YDEAIANLQR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTCTCCGGG CTAAGCGAAC CCGCTCAATC CGCGAGGCTC CGCCTTTGCT CACGTGTCCC 60
CATGCCAGCC CCGCCCCACA CCGGAAGTTC CGGTGGCGGA TCGCCGACCG GGCGGAGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0677--Repeat
KW-0802--TPR repeat

Interpro

IPR023114--Elongated_TPR_rpt_dom
IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR019734--TPR_repeat
IPR003613--Ubox_domain
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50005--TPR
PS50293--TPR_REGION
PS51698--U_BOX

Pfam

PF04564--U-box

SMART

SM00028--TPR
SM00504--Ubox

Gene Ontology

GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0070062--C:extracellular exosome
GO:0042405--C:nuclear inclusion body
GO:0005654--C:nucleoplasm
GO:0000151--C:ubiquitin ligase complex
GO:0030018--C:Z disc
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0071218--P:cellular response to misfolded protein
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0006515--P:misfolded or incompletely synthesized protein catabolic process
GO:0032091--P:negative regulation of protein binding
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0090035--P:positive regulation of chaperone-mediated protein complex assembly
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0031943--P:regulation of glucocorticoid metabolic process
GO:0031647--P:regulation of protein stability
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process

KEGG

rno:287155

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000537	Aegilops tauschii	34.73	5.00e-38	150.00
IUUC-Aml-001350	Ailuropoda melanoleuca	97.60	2.00e-140	491.00
IUUC-Atr-003168	Amborella trichopoda	35.38	1.00e-30	126.00
IUUC-Apl-003736	Anas platyrhynchos	86.85	2.00e-125	441.00
IUUC-Aca-004751	Anolis carolinensis	84.86	5.00e-136	476.00
IUUC-Aly-006292	Arabidopsis lyrata	33.33	1.00e-43	169.00
IUUC-Ath-007012	Arabidopsis thaliana	33.69	1.00e-40	159.00
IUUC-Acl-008025	Aspergillus clavatus	32.52	7.00e-33	134.00
IUUC-Afl-008721	Aspergillus flavus	31.47	4.00e-31	128.00
IUUC-Afu-008853	Aspergillus fumigatus	33.10	1.00e-32	133.00
IUUC-Ani-009349	Aspergillus nidulans	31.85	5.00e-32	131.00
IUUC-Ang-009674	Aspergillus niger	33.33	2.00e-29	122.00
IUUC-Aor-010014	Aspergillus oryzae	29.89	1.00e-25	109.00
IUUC-Ate-010467	Aspergillus terreus	30.64	1.00e-26	113.00
IUUC-Ame-011215	Astyanax mexicanus	60.14	2.00e-87	315.00
IUUC-Bgr-011971	Blumeria graminis	29.39	3.00e-24	105.00
IUUC-Bta-013025	Bos taurus	96.03	2.00e-160	558.00
IUUC-Bci-013945	Botrytis cinerea	39.51	6.00e-15	74.70
IUUC-Bdi-014483	Brachypodium distachyon	38.04	9.00e-44	170.00
IUUC-Bol-015676	Brassica oleracea	35.05	1.00e-44	173.00
IUUC-Bra-017897	Brassica rapa	32.06	5.00e-28	117.00
IUUC-Cel-018323	Caenorhabditis elegans	40.79	2.00e-54	205.00
IUUC-Cja-019657	Callithrix jacchus	96.84	5.00e-161	559.00
IUUC-Cfa-020470	Canis familiaris	96.97	4.00e-128	449.00
IUUC-Cpo-022033	Cavia porcellus	97.37	1.00e-165	575.00
IUUC-Cre-022896	Chlamydomonas reinhardtii	27.59	2.00e-27	115.00
IUUC-Csa-023038	Chlorocebus sabaeus	97.89	2.00e-159	554.00
IUUC-Cin-025381	Ciona intestinalis	53.38	1.00e-85	309.00
IUUC-Cgl-026524	Colletotrichum gloeosporioides	32.26	3.00e-38	151.00
IUUC-Dre-027610	Danio rerio	78.60	1.00e-130	458.00
IUUC-Dno-030087	Dasypus novemcinctus	94.08	6.00e-161	559.00
IUUC-Dor-031029	Dipodomys ordii	91.93	2.00e-151	528.00
IUUC-Dse-031275	Dothistroma septosporum	32.31	2.00e-25	108.00
IUUC-Dme-031856	Drosophila melanogaster	58.06	2.00e-93	335.00
IUUC-Ete-033087	Echinops telfairi	91.21	2.00e-131	461.00
IUUC-Eca-033512	Equus caballus	97.60	1.00e-140	491.00
IUUC-Eeu-034763	Erinaceus europaeus	90.76	2.00e-91	327.00
IUUC-Fca-036460	Felis catus	97.43	1.00e-153	535.00
IUUC-Fal-037441	Ficedula albicollis	86.71	7.00e-143	499.00
IUUC-Fox-038028	Fusarium oxysporum	30.72	5.00e-37	147.00
IUUC-Fso-038323	Fusarium solani	31.91	5.00e-28	117.00
IUUC-Gmo-038511	Gadus morhua	76.49	2.00e-124	437.00
IUUC-Ggr-039964	Gaeumannomyces graminis	31.25	2.00e-25	109.00
IUUC-Gga-040854	Gallus gallus	87.06	2.00e-142	498.00
IUUC-Gac-042175	Gasterosteus aculeatus	73.10	8.00e-121	426.00
IUUC-Gma-044046	Glycine max	35.14	2.00e-41	162.00
IUUC-Ggo-044512	Gorilla gorilla	97.89	2.00e-159	554.00
IUUC-Hsa-046872	Homo sapiens	97.89	2.00e-159	554.00
IUUC-Hvu-047661	Hordeum vulgare	33.33	1.00e-38	153.00
IUUC-Itr-048871	Ictidomys tridecemlineatus	97.89	5.00e-163	566.00
IUUC-Lch-049988	Latimeria chalumnae	78.67	1.00e-130	458.00
IUUC-Lpe-050693	Leersia perrieri	34.42	6.00e-42	164.00
IUUC-Loc-052195	Lepisosteus oculatus	77.65	1.00e-111	395.00
IUUC-Lma-053207	Leptosphaeria maculans	30.29	2.00e-27	117.00
IUUC-Laf-054584	Loxodonta africana	94.08	1.00e-160	558.00
IUUC-Mcc-054689	Macaca mulatta	97.89	2.00e-159	554.00
IUUC-Meu-055998	Macropus eugenii	88.95	2.00e-80	292.00
IUUC-Mor-057116	Magnaporthe oryzae	34.16	2.00e-39	155.00
IUUC-Mtr-057684	Medicago truncatula	32.00	8.00e-38	150.00
IUUC-Mga-059332	Meleagris gallopavo	87.25	4.00e-125	440.00
IUUC-Mmr-061377	Microcebus murinus	97.89	5.00e-159	553.00
IUUC-Mdo-061963	Monodelphis domestica	90.21	2.00e-144	504.00
IUUC-Mmu-063146	Mus musculus	99.34	2.00e-164	571.00
IUUC-Mac-064932	Musa acuminata	33.66	8.00e-27	113.00
IUUC-Mpu-066418	Mustela putorius furo	97.54	1.00e-161	561.00
IUUC-Mlu-067066	Myotis lucifugus	96.05	7.00e-163	566.00
IUUC-Nfi-068601	Neosartorya fischeri	33.10	2.00e-32	132.00
IUUC-Ncr-068761	Neurospora crassa	41.67	4.00e-17	82.00
IUUC-Nle-069374	Nomascus leucogenys	97.89	2.00e-159	554.00
IUUC-Opr-070765	Ochotona princeps	93.44	7.00e-98	348.00
IUUC-Ont-071996	Oreochromis niloticus	79.65	2.00e-128	451.00
IUUC-Oba-075967	Oryza barthii	35.38	6.00e-43	167.00
IUUC-Obr-076440	Oryza brachyantha	33.18	1.00e-29	125.00
IUUC-Ogl-077495	Oryza glaberrima	35.38	6.00e-43	167.00
IUUC-Ogu-078247	Oryza glumaepatula	35.57	3.00e-39	155.00
IUUC-Oin-079376	Oryza indica	35.38	6.00e-43	167.00
IUUC-Olo-081083	Oryza longistaminata	30.18	2.00e-29	122.00
IUUC-Ome-081935	Oryza meridionalis	28.30	5.00e-20	94.00
IUUC-Oni-082535	Oryza nivara	35.57	3.00e-39	155.00
IUUC-Opu-083794	Oryza punctata	34.47	1.00e-42	166.00
IUUC-Oru-085153	Oryza rufipogon	35.38	1.00e-42	166.00
IUUC-Osa-085936	Oryza sativa	35.82	2.00e-16	79.00
IUUC-Ola-087081	Oryzias latipes	77.89	1.00e-128	452.00
IUUC-Olu-087790	Ostreococcus lucimarinus	31.18	9.00e-31	126.00
IUUC-Oga-088331	Otolemur garnettii	97.04	4.00e-162	563.00
IUUC-Oar-089987	Ovis aries	91.80	7.00e-135	473.00
IUUC-Ptr-090855	Pan troglodytes	97.89	2.00e-159	554.00
IUUC-Pan-092801	Papio anubis	92.28	6.00e-154	536.00
IUUC-Psi-093393	Pelodiscus sinensis	86.06	3.00e-124	437.00
IUUC-Pma-094680	Petromyzon marinus	68.57	5.00e-109	387.00
IUUC-Pno-094913	Phaeosphaeria nodorum	32.77	3.00e-33	135.00
IUUC-Ppa-095508	Physcomitrella patens	32.27	1.00e-40	160.00
IUUC-Pfo-096850	Poecilia formosa	78.25	5.00e-126	443.00
IUUC-Pab-097963	Pongo abelii	97.89	2.00e-159	554.00
IUUC-Pop-098805	Populus trichocarpa	42.86	7.00e-25	106.00
IUUC-Pca-100788	Procavia capensis	95.07	1.00e-162	565.00
IUUC-Ppe-101221	Prunus persica	33.81	8.00e-44	170.00
IUUC-Pva-103076	Pteropus vampyrus	95.39	2.00e-162	564.00
IUUC-Pte-104237	Pyrenophora teres	31.47	3.00e-32	132.00
IUUC-Pyt-104468	Pyrenophora triticirepentis	31.47	2.00e-32	132.00
IUUC-Sha-106579	Sarcophilus harrisii	85.55	2.00e-124	437.00
IUUC-Smo-109525	Selaginella moellendorffii	35.77	5.00e-41	160.00
IUUC-Sit-110072	Setaria italica	35.02	2.00e-40	159.00
IUUC-Sly-111473	Solanum lycopersicum	35.59	2.00e-43	169.00
IUUC-Stu-112353	Solanum tuberosum	34.98	6.00e-42	164.00
IUUC-Sbi-114250	Sorghum bicolor	35.19	1.00e-43	169.00
IUUC-Ssc-115416	Sus scrofa	96.05	2.00e-162	564.00
IUUC-Tgu-117272	Taeniopygia guttata	92.59	3.00e-56	209.00
IUUC-Tru-117777	Takifugu rubripes	78.25	6.00e-127	446.00
IUUC-Tni-120572	Tetraodon nigroviridis	79.30	5.00e-128	450.00
IUUC-Tca-121149	Theobroma cacao	37.05	2.00e-47	182.00
IUUC-Tre-122230	Trichoderma reesei	32.85	3.00e-32	131.00
IUUC-Tvi-122678	Trichoderma virens	35.61	4.00e-41	161.00
IUUC-Tae-122986	Triticum aestivum	34.56	1.00e-41	163.00
IUUC-Tur-126009	Triticum urartu	34.40	3.00e-37	148.00
IUUC-Tme-126948	Tuber melanosporum	35.84	2.00e-40	158.00
IUUC-Ttr-129031	Tursiops truncatus	93.75	2.00e-160	557.00
IUUC-Vda-130023	Verticillium dahliae	32.97	7.00e-38	150.00
IUUC-Vvi-131091	Vitis vinifera	48.31	4.00e-25	106.00
IUUC-Xtr-132871	Xenopus tropicalis	82.86	3.00e-129	454.00
IUUC-Xma-134220	Xiphophorus maculatus	78.60	1.00e-126	445.00
IUUC-Yli-134462	Yarrowia lipolytica	28.27	4.00e-28	118.00
IUUC-Zma-135773	Zea mays	36.26	5.00e-44	171.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence