iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-013260

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

F-box only protein 3

Genbank Nucleotide ID

BC146250

Gene Name

FBXO3; FBX3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000010071.4	ENSBTAT00000013287.3	ENSBTAP00000013287.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/SCF/F-box	98.80	0.00e+00	808.00	IUUC-Hsa-047002
E3 adaptor/Cullin RING/SCF/F-box	31.03	2.00e-03	38.50	IUUC-Sce-106220

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Bos taurus

Functional Description
(View)

Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation (By similarity).

Protein Sequence
(Fasta)

MAAMDTESAP LTLESLPTDP LLLILSFLDY RDLINCCYVS RRLSQLSSHD PLWRRHCKKY 60
WLISEEEKTQ KNQCWKSLFI DTYSDVGRYI DHYAAIKKAW DDLKKYLEPR CPRMVLSLKE 120

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Nucleotide Sequence
(Fasta)

CTGGGCCAGG CAAGATGGCG GCCATGGATA CCGAGTCGGC GCCCCTAACC CTAGAATCGC 60
TGCCCACCGA CCCCCTGCTC CTCATCTTAT CCTTCTTGGA CTACCGGGAC CTAATCAAGT 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR007474--ApaG_domain
IPR001810--F-box_dom
IPR018958--SMI1/KNR4-like_dom

PROSITE

PS51087--APAG
PS50181--FBOX

Pfam

PF04379--DUF525
PF12937--F-box-like
PF09346--SMI1_KNR4

SMART

SM00256--FBOX
SM00860--SMI1_KNR4

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm

KEGG

bta:534287

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001541	Ailuropoda melanoleuca	99.50	0.00e+00	783.00
IUUC-Afl-008734	Aspergillus flavus	29.69	3.00e-03	36.60
IUUC-Ani-009404	Aspergillus nidulans	29.69	3.00e-03	36.60
IUUC-Ang-009604	Aspergillus niger	31.03	7.00e-04	38.90
IUUC-Aor-009932	Aspergillus oryzae	29.69	3.00e-03	37.00
IUUC-Bdi-014986	Brachypodium distachyon	23.96	2.00e-13	70.10
IUUC-Bol-015263	Brassica oleracea	25.29	1.00e-17	84.30
IUUC-Cja-019627	Callithrix jacchus	98.80	0.00e+00	808.00
IUUC-Cfa-020598	Canis familiaris	99.04	0.00e+00	810.00
IUUC-Cpo-021355	Cavia porcellus	99.00	0.00e+00	777.00
IUUC-Csa-023967	Chlorocebus sabaeus	98.56	0.00e+00	806.00
IUUC-Cin-025228	Ciona intestinalis	33.50	2.00e-46	179.00
IUUC-Csv-026017	Ciona savignyi	30.92	1.00e-49	190.00
IUUC-Dno-029157	Dasypus novemcinctus	99.34	6.00e-166	576.00
IUUC-Dor-030275	Dipodomys ordii	96.60	0.00e+00	725.00
IUUC-Ete-032638	Echinops telfairi	95.54	2.00e-156	545.00
IUUC-Eca-034324	Equus caballus	95.96	0.00e+00	745.00
IUUC-Eeu-034676	Erinaceus europaeus	84.50	0.00e+00	655.00
IUUC-Fca-035703	Felis catus	99.04	0.00e+00	810.00
IUUC-Fso-038271	Fusarium solani	34.48	4.00e-05	42.70
IUUC-Ggo-044501	Gorilla gorilla	98.80	0.00e+00	808.00
IUUC-Hsa-047002	Homo sapiens	98.80	0.00e+00	808.00
IUUC-Itr-048749	Ictidomys tridecemlineatus	99.34	6.00e-166	576.00
IUUC-Laf-054310	Loxodonta africana	99.04	0.00e+00	810.00
IUUC-Mcc-055406	Macaca mulatta	98.32	0.00e+00	803.00
IUUC-Mmr-061614	Microcebus murinus	98.55	0.00e+00	799.00
IUUC-Mmu-063540	Mus musculus	95.20	0.00e+00	784.00
IUUC-Mpu-066040	Mustela putorius furo	99.04	0.00e+00	810.00
IUUC-Mlu-067763	Myotis lucifugus	93.42	0.00e+00	813.00
IUUC-Nfi-068290	Neosartorya fischeri	31.25	6.00e-04	38.90
IUUC-Nle-069186	Nomascus leucogenys	98.80	0.00e+00	808.00
IUUC-Opr-070860	Ochotona princeps	83.92	9.00e-80	290.00
IUUC-Ocu-074378	Oryctolagus cuniculus	76.25	2.00e-65	242.00
IUUC-Oba-075362	Oryza barthii	24.71	9.00e-13	67.40
IUUC-Ogl-077469	Oryza glaberrima	22.89	1.00e-11	64.70
IUUC-Oin-079080	Oryza indica	22.89	7.00e-11	62.00
IUUC-Ome-081119	Oryza meridionalis	23.68	1.00e-12	67.40
IUUC-Opu-084117	Oryza punctata	23.31	9.00e-12	64.70
IUUC-Osa-085783	Oryza sativa	22.89	5.00e-11	62.40
IUUC-Oga-088925	Otolemur garnettii	96.88	0.00e+00	796.00
IUUC-Oar-090074	Ovis aries	99.76	0.00e+00	814.00
IUUC-Ptr-091462	Pan troglodytes	98.80	0.00e+00	808.00
IUUC-Pan-092326	Papio anubis	98.32	0.00e+00	803.00
IUUC-Psi-093898	Pelodiscus sinensis	87.38	1.00e-146	512.00
IUUC-Pab-097597	Pongo abelii	98.80	0.00e+00	808.00
IUUC-Pva-102622	Pteropus vampyrus	99.04	0.00e+00	809.00
IUUC-Pte-104405	Pyrenophora teres	37.88	7.00e-04	39.70
IUUC-Rno-105168	Rattus norvegicus	95.44	0.00e+00	788.00
IUUC-Sce-106220	Saccharomyces cerevisiae	31.03	9.00e-04	38.50
IUUC-Sit-110738	Setaria italica	23.38	5.00e-08	52.40
IUUC-Stu-112725	Solanum tuberosum	34.67	1.00e-04	40.80
IUUC-Ssc-115881	Sus scrofa	98.88	3.00e-161	560.00
IUUC-Tca-121476	Theobroma cacao	25.45	2.00e-18	87.40
IUUC-Tur-126848	Triticum urartu	24.43	1.00e-12	68.20
IUUC-Ttr-128934	Tursiops truncatus	98.53	0.00e+00	701.00
IUUC-Uma-129413	Ustilago maydis	34.09	7.40e-02	33.50
IUUC-Vpa-130081	Vicugna pacos	99.48	0.00e+00	744.00
IUUC-Vvi-131081	Vitis vinifera	32.94	1.00e-04	42.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence