iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/MINDY	1.20e-62	209.9	158	280

Active Site

Position(s)	Description	Evidence
151	Nucleophile	{ECO:0000250\|UniProtKB:Q8N5J2}
333	Proton acceptor	{ECO:0000250\|UniProtKB:Q8N5J2}

Domain Profile

DUB/MINDY

   S: 1    nilllswkvklvpkkevitleelievlgdilldvkdkekseiselnyeqnvddalsllpklaeGldvnvrftGvrsfeytkecsvfdll 89
           nil+l+wkvkl+p+kevit++el+ +lg++ll++k++ekse+++ln++qnv da+++lpkla+GldvnvrftGv++feyt+ecsvfdll
   Q: 158  NILFLQWKVKLPPQKEVITSDELLTHLGNCLLSIKPQEKSEGLQLNFQQNVGDAMTVLPKLATGLDVNVRFTGVSDFEYTPECSVFDLL 246
           9**************************************************************************************** PP
   S: 90   didlyhGWlvdsqideavkavgklsyeqlveril 123
           +++lyhGWlvd+q++eav avgklsy+qlve+i+
   Q: 247  GVPLYHGWLVDPQSPEAVSAVGKLSYNQLVEKII 280
           *********************************8 PP

Organism

Rattus norvegicus

Functional Description
(View)

Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

Protein Sequence
(Fasta)

MEQPQAECPA PSKTNSAETV ESEKHEALSG PEKHPQDKDG ADAAPEKHPQ DKDGADAHGE 60
AGKQKSGDQT LPPVQDGGNL ECPPPEASSS PPGPACGIPS EVETTEACSR PQQLPQSPRI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACCCTGTTCA CTTTGTCTTT TCTTGTTTCC TTTGCTCTAT AATTCAATGA CCTTATTGGC 60
CAGGTCCTTT TGCACACTAG AATAGCCCTA GGCAAGGTCT CTGAGGTCAC AGAGCAACTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR007518--MINDY
IPR033979--MINDY_domain

Pfam

PF04424--MINDY_DUB

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0016807--F:cysteine-type carboxypeptidase activity
GO:0036435--F:K48-linked polyubiquitin binding
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity

KEGG

rno:310665

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-136378	Aegilops tauschii	43.33	3.00e-26	114.00
IUUC-Aml-136381	Ailuropoda melanoleuca	74.07	2.00e-173	602.00
IUUC-Atr-136384	Amborella trichopoda	39.07	2.00e-31	130.00
IUUC-Apl-136388	Anas platyrhynchos	85.76	4.00e-147	514.00
IUUC-Aly-136393	Arabidopsis lyrata	47.44	2.00e-36	147.00
IUUC-Ath-136397	Arabidopsis thaliana	43.09	5.00e-37	149.00
IUUC-Ago-136399	Ashbya gossypii	30.22	3.00e-27	115.00
IUUC-Afu-136402	Aspergillus fumigatus	31.63	8.00e-26	112.00
IUUC-Ani-136403	Aspergillus nidulans	31.13	8.00e-28	119.00
IUUC-Ang-136404	Aspergillus niger	30.38	1.00e-27	118.00
IUUC-Aor-136405	Aspergillus oryzae	32.44	8.00e-26	112.00
IUUC-Ame-136409	Astyanax mexicanus	65.92	1.00e-127	449.00
IUUC-Bgr-136410	Blumeria graminis	31.83	4.00e-26	113.00
IUUC-Bta-136413	Bos taurus	79.09	3.00e-177	614.00
IUUC-Bci-136415	Botrytis cinerea	28.90	1.00e-26	115.00
IUUC-Bdi-136417	Brachypodium distachyon	44.30	4.00e-35	142.00
IUUC-Bol-136420	Brassica oleracea	46.67	3.00e-39	156.00
IUUC-Bra-136422	Brassica rapa	46.45	5.00e-40	159.00
IUUC-Cel-136423	Caenorhabditis elegans	41.57	2.00e-49	189.00
IUUC-Cja-136426	Callithrix jacchus	81.61	0.00e+00	667.00
IUUC-Cfa-136431	Canis familiaris	77.28	1.00e-165	575.00
IUUC-Cpo-136435	Cavia porcellus	78.63	0.00e+00	671.00
IUUC-Cre-136437	Chlamydomonas reinhardtii	34.15	4.00e-28	120.00
IUUC-Csa-136440	Chlorocebus sabaeus	76.19	0.00e+00	629.00
IUUC-Cho-136442	Choloepus hoffmanni	65.05	2.00e-59	223.00
IUUC-Cin-136446	Ciona intestinalis	34.55	2.00e-04	37.00
IUUC-Cme-136451	Cyanidioschyzon merolae	33.95	1.00e-22	100.00
IUUC-Dre-136455	Danio rerio	69.19	5.00e-129	454.00
IUUC-Dno-136458	Dasypus novemcinctus	79.30	0.00e+00	662.00
IUUC-Dor-136460	Dipodomys ordii	54.84	4.00e-90	324.00
IUUC-Dse-136464	Dothistroma septosporum	29.43	2.00e-28	121.00
IUUC-Eca-136474	Equus caballus	80.54	0.00e+00	639.00
IUUC-Eeu-136475	Erinaceus europaeus	87.92	6.00e-133	466.00
IUUC-Fca-136480	Felis catus	78.63	0.00e+00	634.00
IUUC-Gga-136494	Gallus gallus	83.62	3.00e-147	514.00
IUUC-Gac-136498	Gasterosteus aculeatus	75.39	2.00e-119	422.00
IUUC-Gma-136500	Glycine max	45.10	2.00e-34	140.00
IUUC-Ggo-136504	Gorilla gorilla	81.40	0.00e+00	687.00
IUUC-Hsa-136506	Homo sapiens	80.79	0.00e+00	655.00
IUUC-Hvu-136509	Hordeum vulgare	45.03	4.00e-37	149.00
IUUC-Itr-136512	Ictidomys tridecemlineatus	81.12	0.00e+00	696.00
IUUC-Kpa-136513	Komagataella pastoris	28.45	3.00e-22	99.80
IUUC-Lch-136516	Latimeria chalumnae	68.62	2.00e-120	425.00
IUUC-Lpe-136519	Leersia perrieri	44.97	1.00e-36	148.00
IUUC-Loc-136523	Lepisosteus oculatus	68.66	1.00e-125	443.00
IUUC-Laf-136529	Loxodonta africana	75.31	0.00e+00	626.00
IUUC-Mcc-136533	Macaca mulatta	79.55	2.00e-180	625.00
IUUC-Meu-136536	Macropus eugenii	76.73	1.00e-173	602.00
IUUC-Mor-136537	Magnaporthe oryzae	30.22	2.00e-25	111.00
IUUC-Mtr-136539	Medicago truncatula	44.81	1.00e-36	147.00
IUUC-Mla-136542	Melampsora laricipopulina	36.84	2.00e-15	76.60
IUUC-Mvi-136546	Microbotryum violaceum	31.49	5.00e-30	126.00
IUUC-Mmr-136550	Microcebus murinus	81.54	0.00e+00	664.00
IUUC-Mdo-136554	Monodelphis domestica	75.97	2.00e-176	611.00
IUUC-Mmu-136557	Mus musculus	87.76	0.00e+00	683.00
IUUC-Mac-136560	Musa acuminata	42.95	1.00e-32	134.00
IUUC-Mpu-136564	Mustela putorius furo	78.01	0.00e+00	651.00
IUUC-Mlu-136567	Myotis lucifugus	79.88	0.00e+00	630.00
IUUC-Nfi-136569	Neosartorya fischeri	29.43	6.00e-27	115.00
IUUC-Nle-136574	Nomascus leucogenys	81.03	0.00e+00	670.00
IUUC-Opr-136578	Ochotona princeps	76.76	1.00e-175	608.00
IUUC-Ont-136581	Oreochromis niloticus	66.94	2.00e-128	452.00
IUUC-Ocu-136587	Oryctolagus cuniculus	75.78	2.00e-164	571.00
IUUC-Oba-136590	Oryza barthii	42.76	1.00e-35	144.00
IUUC-Obr-136591	Oryza brachyantha	43.92	2.00e-35	144.00
IUUC-Ogl-136594	Oryza glaberrima	42.76	2.00e-35	144.00
IUUC-Ogu-136596	Oryza glumaepatula	42.76	2.00e-35	144.00
IUUC-Oin-136598	Oryza indica	42.76	1.00e-35	144.00
IUUC-Olo-136600	Oryza longistaminata	43.05	4.00e-35	143.00
IUUC-Ome-136601	Oryza meridionalis	42.76	2.00e-35	144.00
IUUC-Oni-136603	Oryza nivara	42.76	2.00e-35	144.00
IUUC-Opu-136605	Oryza punctata	42.76	1.00e-35	144.00
IUUC-Oru-136607	Oryza rufipogon	42.76	2.00e-35	144.00
IUUC-Osa-136609	Oryza sativa	42.76	1.00e-35	144.00
IUUC-Ola-136612	Oryzias latipes	63.22	1.00e-112	399.00
IUUC-Oga-136618	Otolemur garnettii	79.67	0.00e+00	654.00
IUUC-Oar-136621	Ovis aries	76.60	0.00e+00	627.00
IUUC-Ptr-136625	Pan troglodytes	81.40	0.00e+00	659.00
IUUC-Pan-136630	Papio anubis	79.75	0.00e+00	626.00
IUUC-Psi-136634	Pelodiscus sinensis	75.61	2.00e-159	555.00
IUUC-Ppa-136640	Physcomitrella patens	47.44	8.00e-39	155.00
IUUC-Pfo-136643	Poecilia formosa	65.64	6.00e-133	466.00
IUUC-Pab-136648	Pongo abelii	80.79	0.00e+00	672.00
IUUC-Pop-136649	Populus trichocarpa	47.01	3.00e-30	124.00
IUUC-Pca-136654	Procavia capensis	70.09	1.00e-129	456.00
IUUC-Ppe-136657	Prunus persica	44.44	2.00e-34	141.00
IUUC-Pva-136661	Pteropus vampyrus	78.93	0.00e+00	660.00
IUUC-Pgr-136662	Puccinia graminis	26.41	6.00e-16	79.00
IUUC-Sha-136673	Sarcophilus harrisii	73.65	1.00e-173	602.00
IUUC-Sja-136675	Schizosaccharomyces japonicus	27.70	8.00e-17	81.30
IUUC-Spo-136676	Schizosaccharomyces pombe	28.83	3.00e-18	86.30
IUUC-Ssl-136677	Sclerotinia sclerotiorum	29.38	2.00e-28	121.00
IUUC-Smo-136679	Selaginella moellendorffii	48.39	2.00e-37	150.00
IUUC-Sit-136681	Setaria italica	46.62	1.00e-31	131.00
IUUC-Sly-136682	Solanum lycopersicum	45.39	1.00e-34	141.00
IUUC-Stu-136684	Solanum tuberosum	45.39	2.00e-34	140.00
IUUC-Sar-136687	Sorex araneus	70.67	1.00e-121	429.00
IUUC-Sbi-136689	Sorghum bicolor	46.36	5.00e-38	152.00
IUUC-Sre-136690	Sporisorium reilianum	30.03	2.00e-32	134.00
IUUC-Ssc-136693	Sus scrofa	80.54	0.00e+00	679.00
IUUC-Tru-136701	Takifugu rubripes	71.57	4.00e-127	447.00
IUUC-Tsy-136705	Tarsius syrichta	67.45	4.00e-118	418.00
IUUC-Tni-136708	Tetraodon nigroviridis	67.65	5.00e-118	417.00
IUUC-Tca-136710	Theobroma cacao	47.06	3.00e-32	134.00
IUUC-Tae-136715	Triticum aestivum	45.03	7.00e-37	149.00
IUUC-Tur-136717	Triticum urartu	37.91	8.00e-27	115.00
IUUC-Tme-136718	Tuber melanosporum	32.78	5.00e-28	119.00
IUUC-Ttr-136725	Tursiops truncatus	79.25	0.00e+00	640.00
IUUC-Uma-136726	Ustilago maydis	30.12	3.00e-30	127.00
IUUC-Vvi-136733	Vitis vinifera	44.87	7.00e-34	139.00
IUUC-Xtr-136737	Xenopus tropicalis	73.13	4.00e-141	494.00
IUUC-Xma-136740	Xiphophorus maculatus	65.37	1.00e-132	466.00
IUUC-Yli-136742	Yarrowia lipolytica	31.79	1.00e-31	131.00
IUUC-Zma-136744	Zea mays	43.86	7.00e-39	155.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence