iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Sce-106149

UUCD1 version

UUC-SaC-00070

Ensembl Protein ID

YDL008W

UniProt Accession

Q12157; D6VRX9; APC11_YEAST

Genbank Protein ID

CAA98564.1; CAA88351.1; DAA11839.1

Protein Name

Anaphase-promoting complex subunit 11

Genbank Nucleotide ID

Z74056; Z48432; BK006938

Gene Name

APC11; YDL008W; D2900

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
YDL008W	YDL008W	YDL008W

Annotation

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/APC_C/APC_C	APC_C	21107322; 16763193

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	9.30e-05	21.4	41	95

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf............kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC+ ++            +++++++ C H fh +C+++w + +  +sk  +CP Cr
   Q: 41   CGICRASYngtcpsckfpgdQCPLVIGLCHHNFHDHCIYRWLDTP--TSKG-LCPMCR 95
           7788777777666666677555455555*************3333..5555.5****8 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Probably catalytic subunit of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication. APC11 is required to recruit the ubiquitin-conjugating enzyme E2 to the APC/C.

Protein Sequence
(Fasta)

MKVKINEVHS VFAWSWHIPS TSDEDAANND PIGNDEDEDV CGICRASYNG TCPSCKFPGD 60
QCPLVIGLCH HNFHDHCIYR WLDTPTSKGL CPMCRQTFQL QKGLAINDAH VQKFVEIVSR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAAAGTTA AAATAAACGA AGTGCACAGT GTGTTTGCTT GGTCATGGCA CATCCCTAGC 60
ACATCTGATG AGGACGCAGC CAATAACGAT CCAATTGGCA ATGATGAAGA CGAGGATGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0436--Ligase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR024991--Apc11
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF12861--zf-ANAPC11

Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0016567--P:protein ubiquitination

KEGG

sce:YDL008W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002323	Ailuropoda melanoleuca	44.12	1.00e-20	88.60
IUUC-Aly-006393	Arabidopsis lyrata	40.95	3.00e-22	93.60
IUUC-Ath-006698	Arabidopsis thaliana	40.95	3.00e-22	93.60
IUUC-Ago-007824	Ashbya gossypii	46.34	3.00e-43	165.00
IUUC-Acl-008180	Aspergillus clavatus	40.80	4.00e-25	104.00
IUUC-Afl-008622	Aspergillus flavus	46.94	6.00e-25	103.00
IUUC-Afu-008844	Aspergillus fumigatus	46.94	5.00e-25	103.00
IUUC-Ani-009260	Aspergillus nidulans	46.15	5.00e-25	103.00
IUUC-Ang-009794	Aspergillus niger	47.92	5.00e-25	107.00
IUUC-Ame-011274	Astyanax mexicanus	45.63	1.00e-22	95.50
IUUC-Bgr-012017	Blumeria graminis	43.30	5.00e-19	83.60
IUUC-Bta-012644	Bos taurus	43.14	2.00e-20	87.80
IUUC-Bci-013779	Botrytis cinerea	48.48	2.00e-23	98.20
IUUC-Bdi-014975	Brachypodium distachyon	43.56	4.00e-24	99.80
IUUC-Bol-016184	Brassica oleracea	39.18	1.00e-20	88.60
IUUC-Bra-016983	Brassica rapa	38.24	2.00e-21	92.40
IUUC-Cel-018191	Caenorhabditis elegans	37.25	4.00e-19	84.70
IUUC-Cja-019909	Callithrix jacchus	44.12	2.00e-20	87.40
IUUC-Cfa-020306	Canis familiaris	44.12	1.00e-20	88.60
IUUC-Cpo-021773	Cavia porcellus	44.12	1.00e-20	88.60
IUUC-Cre-022961	Chlamydomonas reinhardtii	37.86	2.00e-19	84.70
IUUC-Csa-024274	Chlorocebus sabaeus	44.12	2.00e-20	87.40
IUUC-Cgl-026398	Colletotrichum gloeosporioides	45.54	3.00e-24	100.00
IUUC-Cne-027036	Cryptococcus neoformans	43.93	1.00e-16	76.30
IUUC-Cme-027263	Cyanidioschyzon merolae	41.18	3.00e-22	94.00
IUUC-Dre-027617	Danio rerio	46.60	3.00e-23	97.40
IUUC-Dse-031304	Dothistroma septosporum	46.94	5.00e-24	99.80
IUUC-Dme-031897	Drosophila melanogaster	44.00	5.00e-20	86.30
IUUC-Fca-036297	Felis catus	44.12	8.00e-21	89.70
IUUC-Fal-037228	Ficedula albicollis	42.16	2.00e-21	90.90
IUUC-Fox-037929	Fusarium oxysporum	43.24	1.00e-14	68.20
IUUC-Fso-038194	Fusarium solani	46.88	5.00e-23	96.70
IUUC-Gmo-039638	Gadus morhua	51.06	3.00e-11	57.40
IUUC-Gga-040897	Gallus gallus	42.16	2.00e-20	87.80
IUUC-Gac-041644	Gasterosteus aculeatus	51.06	3.00e-11	57.40
IUUC-Gma-043111	Glycine max	39.00	4.00e-22	94.00
IUUC-Hsa-046268	Homo sapiens	44.12	2.00e-20	87.40
IUUC-Hvu-047356	Hordeum vulgare	43.56	3.00e-24	100.00
IUUC-Itr-048453	Ictidomys tridecemlineatus	44.12	1.00e-20	88.60
IUUC-Kpa-049388	Komagataella pastoris	40.51	2.00e-28	115.00
IUUC-Lch-049838	Latimeria chalumnae	41.18	2.00e-19	84.30
IUUC-Lpe-050878	Leersia perrieri	41.98	2.00e-17	77.80
IUUC-Lma-053166	Leptosphaeria maculans	45.79	3.00e-25	104.00
IUUC-Laf-054221	Loxodonta africana	44.12	1.00e-20	88.60
IUUC-Mor-056930	Magnaporthe oryzae	47.00	2.00e-24	101.00
IUUC-Mpo-057352	Magnaporthe poae	36.59	1.00e-11	58.90
IUUC-Mtr-058104	Medicago truncatula	40.86	1.00e-20	89.00
IUUC-Mla-059079	Melampsora laricipopulina	39.64	5.00e-21	90.90
IUUC-Mvi-060446	Microbotryum violaceum	37.60	9.00e-20	87.40
IUUC-Mmu-064301	Mus musculus	44.12	1.00e-20	88.60
IUUC-Mac-064936	Musa acuminata	42.57	5.00e-23	97.40
IUUC-Mpu-066041	Mustela putorius furo	44.12	1.00e-20	88.60
IUUC-Mlu-067360	Myotis lucifugus	43.14	2.00e-20	87.80
IUUC-Ncr-068931	Neurospora crassa	45.45	2.00e-24	102.00
IUUC-Ont-072502	Oreochromis niloticus	43.69	6.00e-22	92.80
IUUC-Ocu-074751	Oryctolagus cuniculus	40.59	1.00e-16	75.10
IUUC-Oba-075026	Oryza barthii	46.53	1.00e-23	98.60
IUUC-Obr-076888	Oryza brachyantha	44.55	5.00e-24	100.00
IUUC-Ogl-077825	Oryza glaberrima	45.54	2.00e-24	100.00
IUUC-Ogu-078290	Oryza glumaepatula	45.54	2.00e-24	100.00
IUUC-Oin-079835	Oryza indica	45.54	2.00e-24	100.00
IUUC-Ome-081297	Oryza meridionalis	45.68	2.00e-18	83.60
IUUC-Oni-082739	Oryza nivara	46.53	9.00e-24	100.00
IUUC-Opu-083502	Oryza punctata	45.68	3.00e-18	80.90
IUUC-Oru-084838	Oryza rufipogon	44.55	5.00e-24	100.00
IUUC-Osa-086037	Oryza sativa	45.54	2.00e-24	100.00
IUUC-Ola-087572	Oryzias latipes	44.12	2.00e-21	90.90
IUUC-Olu-087765	Ostreococcus lucimarinus	34.65	5.00e-15	69.70
IUUC-Oga-088853	Otolemur garnettii	44.12	1.00e-20	88.60
IUUC-Oar-089687	Ovis aries	44.12	1.00e-20	88.60
IUUC-Ptr-091674	Pan troglodytes	44.12	2.00e-20	87.40
IUUC-Psi-093124	Pelodiscus sinensis	44.12	2.00e-21	90.90
IUUC-Pno-094852	Phaeosphaeria nodorum	48.48	3.00e-25	104.00
IUUC-Ppa-095866	Physcomitrella patens	38.54	9.00e-20	85.50
IUUC-Pfo-096410	Poecilia formosa	45.10	5.00e-22	92.80
IUUC-Pop-099204	Populus trichocarpa	37.74	8.00e-21	89.70
IUUC-Ppe-101903	Prunus persica	41.58	4.00e-23	96.70
IUUC-Pte-104160	Pyrenophora teres	47.62	3.00e-25	104.00
IUUC-Rno-104979	Rattus norvegicus	44.12	1.00e-20	88.60
IUUC-Sja-107930	Schizosaccharomyces japonicus	45.00	4.00e-22	93.60
IUUC-Spo-108296	Schizosaccharomyces pombe	46.94	3.00e-22	94.00
IUUC-Ssl-108464	Sclerotinia sclerotiorum	39.18	2.00e-14	67.80
IUUC-Smo-109289	Selaginella moellendorffii	36.00	2.00e-19	84.30
IUUC-Sit-109777	Setaria italica	43.56	6.00e-24	99.80
IUUC-Sly-111381	Solanum lycopersicum	43.14	3.00e-08	47.40
IUUC-Stu-112287	Solanum tuberosum	47.06	8.00e-20	86.70
IUUC-Sbi-113803	Sorghum bicolor	43.56	6.00e-24	99.40
IUUC-Sre-115018	Sporisorium reilianum	38.83	5.00e-17	77.00
IUUC-Ssc-116403	Sus scrofa	46.88	9.00e-20	85.50
IUUC-Tgu-117375	Taeniopygia guttata	42.16	2.00e-21	90.90
IUUC-Tru-118064	Takifugu rubripes	45.92	9.00e-21	89.00
IUUC-Tni-120387	Tetraodon nigroviridis	43.14	3.00e-21	90.50
IUUC-Tca-121186	Theobroma cacao	49.09	3.00e-15	70.50
IUUC-Tre-122153	Trichoderma reesei	46.88	4.00e-23	96.70
IUUC-Tvi-122412	Trichoderma virens	47.52	6.00e-25	103.00
IUUC-Tae-125184	Triticum aestivum	43.56	6.00e-24	99.40
IUUC-Tur-126516	Triticum urartu	43.56	7.00e-25	102.00
IUUC-Tme-127121	Tuber melanosporum	46.00	3.00e-26	107.00
IUUC-Uma-129529	Ustilago maydis	39.80	1.00e-16	75.50
IUUC-Vvi-131191	Vitis vinifera	39.78	3.00e-20	88.60
IUUC-Xma-133275	Xiphophorus maculatus	45.10	7.00e-22	92.40
IUUC-Yli-134369	Yarrowia lipolytica	52.53	8.00e-27	109.00
IUUC-Zma-134869	Zea mays	43.56	4.00e-24	100.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence