iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089756

Ensembl Protein ID

ENSOARP00000014159.1

UniProt Accession

W5PUM7; W5PUM7_SHEEP

Genbank Protein ID

ENSOARP00000014159

Protein Name

Nitric oxide synthase-interacting protein

Genbank Nucleotide ID

AMGL01029332

Gene Name

NOSIP

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000013215.1	ENSOART00000014366.1	ENSOARP00000014159.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	2.90e-14	53.1	40	79

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwlasggk 41
           v ++ +C +sl++ +dPvv+p+G+ y+r++I +++ +++k
   Q: 40   VKDFDCCCLSLQPCHDPVVTPDGYLYEREAILEYILHQKK 79
           567789*****************************98887 PP

Organism

Ovis aries

Functional Description
(View)

Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.

Protein Sequence
(Fasta)

MTRHGKNCTA GAVYTYHEKK KDTAASGYGT QNIRLSRDAV KDFDCCCLSL QPCHDPVVTP 60
DGYLYEREAI LEYILHQKKE IARQMKAYEK QRGARREEQK EAQDHVRGFL EKEAAIVSRP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTCCCCATC AGGTCAGATC AGGAACCATA AAGATCCAGT CCTCTCTTGG GCTCCCTCCG 60
GTCACCACCA CCTTGCAGCT ACCTCTTCCT CCCCCCGGGG ATGACGCGGC ACGGCAAGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome

Interpro

IPR016818--Nitric_oxide_synth-interacting
IPR031790--Znf-NOSIP
IPR013083--Znf_RING/FYVE/PHD

Pfam

PF15906--zf-NOSIP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003723--F:RNA binding
GO:0051001--P:negative regulation of nitric-oxide synthase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000769	Aegilops tauschii	46.51	1.00e-16	81.30
IUUC-Aml-002069	Ailuropoda melanoleuca	89.21	3.00e-155	540.00
IUUC-Atr-002661	Amborella trichopoda	30.93	3.00e-27	115.00
IUUC-Aca-004630	Anolis carolinensis	72.85	2.00e-128	451.00
IUUC-Aly-006316	Arabidopsis lyrata	30.84	1.00e-28	119.00
IUUC-Ath-007000	Arabidopsis thaliana	29.87	6.00e-28	117.00
IUUC-Acl-008175	Aspergillus clavatus	32.43	9.00e-06	44.70
IUUC-Afl-008440	Aspergillus flavus	32.74	9.00e-06	44.70
IUUC-Afu-009012	Aspergillus fumigatus	31.97	2.00e-06	47.00
IUUC-Ani-009153	Aspergillus nidulans	43.59	6.00e-03	35.40
IUUC-Ang-009556	Aspergillus niger	25.00	2.00e-07	49.70
IUUC-Aor-009892	Aspergillus oryzae	32.74	9.00e-06	44.70
IUUC-Ate-010473	Aspergillus terreus	31.82	1.00e-04	42.40
IUUC-Ame-011874	Astyanax mexicanus	62.66	2.00e-102	365.00
IUUC-Bgr-012090	Blumeria graminis	26.06	1.00e-06	47.40
IUUC-Bta-012956	Bos taurus	96.37	2.00e-168	584.00
IUUC-Bci-013897	Botrytis cinerea	42.50	8.00e-10	57.80
IUUC-Bdi-014968	Brachypodium distachyon	29.49	1.00e-30	126.00
IUUC-Bol-015578	Brassica oleracea	31.49	8.00e-33	134.00
IUUC-Bra-017234	Brassica rapa	31.49	8.00e-33	134.00
IUUC-Cel-018637	Caenorhabditis elegans	43.04	3.00e-53	201.00
IUUC-Cja-019632	Callithrix jacchus	90.76	3.00e-157	547.00
IUUC-Cfa-020192	Canis familiaris	91.75	3.00e-158	551.00
IUUC-Cpo-021939	Cavia porcellus	87.13	3.00e-143	500.00
IUUC-Cre-023005	Chlamydomonas reinhardtii	34.32	3.00e-38	152.00
IUUC-Csa-023802	Chlorocebus sabaeus	90.76	3.00e-157	547.00
IUUC-Cho-024637	Choloepus hoffmanni	73.06	9.00e-71	259.00
IUUC-Cin-025180	Ciona intestinalis	49.83	2.00e-80	291.00
IUUC-Csv-026206	Ciona savignyi	44.97	2.00e-40	158.00
IUUC-Cgl-026696	Colletotrichum gloeosporioides	26.10	8.00e-12	64.70
IUUC-Cne-026827	Cryptococcus neoformans	36.36	9.00e-07	47.80
IUUC-Dre-028092	Danio rerio	63.49	1.00e-109	389.00
IUUC-Dno-029501	Dasypus novemcinctus	81.91	5.00e-135	473.00
IUUC-Dor-030542	Dipodomys ordii	87.21	1.00e-149	521.00
IUUC-Dse-031188	Dothistroma septosporum	24.16	3.00e-12	66.20
IUUC-Dme-031734	Drosophila melanogaster	47.92	8.00e-76	276.00
IUUC-Eca-033577	Equus caballus	93.40	4.00e-162	563.00
IUUC-Fca-035761	Felis catus	92.74	2.00e-160	557.00
IUUC-Fox-037703	Fusarium oxysporum	37.04	2.00e-07	49.70
IUUC-Fso-038208	Fusarium solani	25.71	3.00e-06	45.80
IUUC-Gmo-038523	Gadus morhua	61.14	1.00e-59	222.00
IUUC-Ggr-040087	Gaeumannomyces graminis	41.03	6.00e-10	58.20
IUUC-Gac-042621	Gasterosteus aculeatus	57.86	1.00e-101	362.00
IUUC-Gma-042698	Glycine max	29.90	4.00e-29	121.00
IUUC-Ggo-045357	Gorilla gorilla	90.76	3.00e-157	547.00
IUUC-Hsa-046195	Homo sapiens	90.76	3.00e-157	547.00
IUUC-Hvu-047174	Hordeum vulgare	29.49	3.00e-31	128.00
IUUC-Itr-048487	Ictidomys tridecemlineatus	88.45	5.00e-150	523.00
IUUC-Lch-050569	Latimeria chalumnae	66.03	2.00e-108	385.00
IUUC-Lpe-050992	Leersia perrieri	33.66	3.00e-19	89.70
IUUC-Loc-052522	Lepisosteus oculatus	66.23	2.00e-108	385.00
IUUC-Lma-053254	Leptosphaeria maculans	25.17	2.00e-10	60.50
IUUC-Laf-053397	Loxodonta africana	91.80	3.00e-157	547.00
IUUC-Mcc-054681	Macaca mulatta	90.76	5.00e-157	547.00
IUUC-Meu-056723	Macropus eugenii	80.33	8.00e-140	489.00
IUUC-Mor-056961	Magnaporthe oryzae	39.47	1.00e-10	60.50
IUUC-Mpo-057359	Magnaporthe poae	25.84	3.00e-06	45.80
IUUC-Mtr-058063	Medicago truncatula	30.82	2.00e-30	126.00
IUUC-Mla-059004	Melampsora laricipopulina	31.63	3.00e-26	112.00
IUUC-Mvi-060460	Microbotryum violaceum	29.26	1.00e-24	106.00
IUUC-Mmr-060847	Microcebus murinus	93.07	8.00e-161	559.00
IUUC-Mdo-062480	Monodelphis domestica	81.31	2.00e-141	494.00
IUUC-Mmu-063809	Mus musculus	88.45	5.00e-152	530.00
IUUC-Mac-064870	Musa acuminata	29.90	2.00e-30	126.00
IUUC-Mpu-066322	Mustela putorius furo	93.44	4.00e-161	560.00
IUUC-Mlu-067556	Myotis lucifugus	89.84	2.00e-146	511.00
IUUC-Nfi-068440	Neosartorya fischeri	31.97	2.00e-06	46.60
IUUC-Ncr-068898	Neurospora crassa	38.46	9.00e-08	51.20
IUUC-Nle-070049	Nomascus leucogenys	91.09	1.00e-157	548.00
IUUC-Opr-070972	Ochotona princeps	86.32	3.00e-146	510.00
IUUC-Ont-071682	Oreochromis niloticus	65.02	1.00e-108	385.00
IUUC-Oan-073296	Ornithorhynchus anatinus	98.31	1.00e-32	131.00
IUUC-Ocu-074218	Oryctolagus cuniculus	83.69	5.00e-123	433.00
IUUC-Oba-075284	Oryza barthii	31.65	9.00e-31	127.00
IUUC-Obr-076651	Oryza brachyantha	30.58	5.00e-33	134.00
IUUC-Ogl-077899	Oryza glaberrima	31.65	9.00e-31	127.00
IUUC-Ogu-078477	Oryza glumaepatula	32.66	3.00e-31	129.00
IUUC-Oin-080011	Oryza indica	31.65	1.00e-30	127.00
IUUC-Olo-080545	Oryza longistaminata	31.18	1.00e-23	103.00
IUUC-Ome-081543	Oryza meridionalis	31.65	1.00e-30	127.00
IUUC-Oni-082955	Oryza nivara	31.65	1.00e-30	127.00
IUUC-Opu-083565	Oryza punctata	31.65	4.00e-31	128.00
IUUC-Oru-084474	Oryza rufipogon	31.65	1.00e-30	127.00
IUUC-Osa-085913	Oryza sativa	31.65	1.00e-30	127.00
IUUC-Ola-086851	Oryzias latipes	64.90	2.00e-113	401.00
IUUC-Olu-087724	Ostreococcus lucimarinus	33.01	5.00e-12	65.10
IUUC-Oga-087970	Otolemur garnettii	92.11	1.00e-158	551.00
IUUC-Ptr-091485	Pan troglodytes	89.77	9.00e-154	535.00
IUUC-Pan-091832	Papio anubis	91.09	9.00e-158	548.00
IUUC-Pma-094551	Petromyzon marinus	60.91	2.00e-102	365.00
IUUC-Pno-094830	Phaeosphaeria nodorum	32.35	2.00e-05	43.10
IUUC-Ppa-095255	Physcomitrella patens	30.41	6.00e-29	121.00
IUUC-Pfo-096373	Poecilia formosa	63.40	1.00e-110	392.00
IUUC-Pab-098247	Pongo abelii	90.76	4.00e-157	546.00
IUUC-Pop-099186	Populus trichocarpa	30.69	7.00e-28	117.00
IUUC-Pca-100677	Procavia capensis	87.36	8.00e-127	446.00
IUUC-Ppe-101403	Prunus persica	28.42	2.00e-27	116.00
IUUC-Pva-103000	Pteropus vampyrus	92.41	2.00e-160	557.00
IUUC-Pgr-103663	Puccinia graminis	29.45	7.00e-29	121.00
IUUC-Ptt-103712	Puccinia triticina	40.00	5.00e-09	54.70
IUUC-Pte-104287	Pyrenophora teres	27.21	3.00e-14	72.80
IUUC-Pyt-104579	Pyrenophora triticirepentis	25.62	4.00e-12	65.50
IUUC-Rno-106069	Rattus norvegicus	88.78	2.00e-152	531.00
IUUC-Sha-106553	Sarcophilus harrisii	80.33	3.00e-140	491.00
IUUC-Smo-108874	Selaginella moellendorffii	31.44	1.00e-35	143.00
IUUC-Sit-110307	Setaria italica	30.58	8.00e-30	124.00
IUUC-Sly-111094	Solanum lycopersicum	30.72	6.00e-30	124.00
IUUC-Stu-112363	Solanum tuberosum	31.54	2.00e-29	122.00
IUUC-Sar-113480	Sorex araneus	91.09	2.00e-146	511.00
IUUC-Sbi-113939	Sorghum bicolor	30.93	2.00e-30	125.00
IUUC-Ssc-115644	Sus scrofa	94.06	6.00e-163	566.00
IUUC-Tru-118781	Takifugu rubripes	63.84	2.00e-113	401.00
IUUC-Tni-119672	Tetraodon nigroviridis	74.71	4.00e-35	138.00
IUUC-Tca-121795	Theobroma cacao	30.33	3.00e-32	132.00
IUUC-Tre-122037	Trichoderma reesei	36.36	3.00e-08	52.80
IUUC-Tvi-122524	Trichoderma virens	26.32	5.00e-15	75.10
IUUC-Tae-122828	Triticum aestivum	29.83	2.00e-31	129.00
IUUC-Tur-126387	Triticum urartu	29.57	2.00e-24	107.00
IUUC-Tme-127111	Tuber melanosporum	40.00	1.00e-09	57.00
IUUC-Ttr-128227	Tursiops truncatus	93.73	1.00e-161	562.00
IUUC-Vda-129924	Verticillium dahliae	26.28	4.00e-14	72.00
IUUC-Vpa-130802	Vicugna pacos	96.63	8.00e-45	173.00
IUUC-Vvi-131105	Vitis vinifera	31.62	7.00e-30	124.00
IUUC-Xtr-132830	Xenopus tropicalis	63.35	2.00e-114	404.00
IUUC-Xma-133618	Xiphophorus maculatus	64.14	3.00e-105	374.00
IUUC-Zma-135389	Zea mays	30.58	1.00e-29	123.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence