iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mcc-055680

Ensembl Protein ID

ENSMMUP00000046713.1

UniProt Accession

G7NGE8; G7NGE8_MACMU

Genbank Protein ID

AFE65763.1; AFH27878.1; AFI35228.1; EHH24202.1

Protein Name

Protein linking IAP with cytoskeleton 1; Ubiquilin-1 isoform 1

Genbank Nucleotide ID

JSUE03015445; JU471074; JV045157; CM001267

Gene Name

UBQLN1; EGK_07819

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000005024.3	ENSMMUT00000067011.1	ENSMMUP00000046713.1
ENSMMUG00000005024.3	ENSMMUT00000056252.1	ENSMMUP00000053490.1
ENSMMUG00000005024.3	ENSMMUT00000027997.3	ENSMMUP00000026191.3
ENSMMUG00000005024.3	ENSMMUT00000077827.1	ENSMMUP00000057430.1
ENSMMUG00000005024.3	ENSMMUT00000007082.3	ENSMMUP00000006654.3
ENSMMUG00000005024.3	ENSMMUT00000007083.3	ENSMMUP00000006655.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/UBA	9.60e-10	39.4	547	584
ULD/UDP/UBQ/UBQ_PIM	9.70e-25	87.4	37	110

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGF.dreealqaLraannnleaAveyLl 39
           ++++leql +MGF +re++lqaL a++++++aA+e+Ll
   Q: 547  FQQQLEQLSAMGFlNREANLQALIATGGDINAAIERLL 584
           799**********************************9 PP

ULD/UDP/UBQ/UBQ_PIM

   S: 1    mkltvktlkgkefelevseddtveelKekiakesgvppeqqkLIyaGkiLkDdttLselgikdgsvvhlvvkksk 75
           mk+tvkt+k+ke e+ v e+++v+++Ke+i+k+++ + +q+ LI+aGkiLkD++tLs++gi+dg +vhlv+k+++
   Q: 37   MKVTVKTPKEKE-EFAVPENSSVQQFKEEISKRFKSHTDQLVLIFAGKILKDQDTLSQHGIHDGLTVHLVIKTQN 110
           99**********.***********************************************************987 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MAESGESGGP PGSQDSAAGA EGAGVPAAAA SAEPKIMKVT VKTPKEKEEF AVPENSSVQQ 60
FKEEISKRFK SHTDQLVLIF AGKILKDQDT LSQHGIHDGL TVHLVIKTQN RPQDHSAQQT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACGCGCCAGG CCCCGCCCCC GCCCCCGCCC CCGCCCCGAG GCTCTCACGC CGCCCCCTCC 60
GCCCGGGCTT CCCTCCACCC TCCGCCCGCC CGCCTGCTCG CAGCCGCGCT CTCCCCGCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR006636--STI1_HS-bd
IPR015940--UBA
IPR009060--UBA-like
IPR015496--Ubiquilin
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50030--UBA
PS50053--UBIQUITIN_2

Pfam

PF00627--UBA
PF00240--ubiquitin

SMART

SM00727--STI1
SM00165--UBA
SM00213--UBQ

Gene Ontology

GO:0016235--C:aggresome
GO:0005776--C:autophagosome
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005654--C:nucleoplasm
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0035973--P:aggrephagy
GO:0000045--P:autophagosome assembly
GO:0097352--P:autophagosome maturation
GO:0071456--P:cellular response to hypoxia
GO:1901340--P:negative regulation of store-operated calcium channel activity
GO:0034140--P:negative regulation of toll-like receptor 3 signaling pathway
GO:1903071--P:positive regulation of ER-associated ubiquitin-dependent protein catabolic process
GO:0031398--P:positive regulation of protein ubiquitination
GO:1902175--P:regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

mcc:713525

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000864	Aegilops tauschii	49.65	7.00e-38	151.00
IUUC-Aml-001461	Ailuropoda melanoleuca	96.05	0.00e+00	808.00
IUUC-Atr-002470	Amborella trichopoda	40.29	5.00e-44	172.00
IUUC-Apl-003241	Anas platyrhynchos	83.40	0.00e+00	717.00
IUUC-Aca-004511	Anolis carolinensis	80.64	0.00e+00	725.00
IUUC-Aly-005419	Arabidopsis lyrata	33.67	2.00e-51	196.00
IUUC-Ath-007350	Arabidopsis thaliana	34.43	5.00e-55	208.00
IUUC-Ago-007963	Ashbya gossypii	37.68	1.00e-08	54.30
IUUC-Bta-013048	Bos taurus	95.06	0.00e+00	827.00
IUUC-Bdi-014506	Brachypodium distachyon	36.20	3.00e-51	196.00
IUUC-Bol-015326	Brassica oleracea	33.28	4.00e-51	196.00
IUUC-Bra-018014	Brassica rapa	38.38	3.00e-41	162.00
IUUC-Cel-018631	Caenorhabditis elegans	38.73	2.00e-67	249.00
IUUC-Cja-019976	Callithrix jacchus	98.56	0.00e+00	846.00
IUUC-Cfa-020092	Canis familiaris	96.40	0.00e+00	834.00
IUUC-Cpo-022388	Cavia porcellus	96.40	0.00e+00	828.00
IUUC-Csa-024087	Chlorocebus sabaeus	99.64	0.00e+00	845.00
IUUC-Cho-024834	Choloepus hoffmanni	97.26	0.00e+00	843.00
IUUC-Cin-025136	Ciona intestinalis	50.74	6.00e-113	400.00
IUUC-Cme-027155	Cyanidioschyzon merolae	58.10	2.00e-34	140.00
IUUC-Dno-028970	Dasypus novemcinctus	77.07	0.00e+00	660.00
IUUC-Dor-030519	Dipodomys ordii	92.81	0.00e+00	803.00
IUUC-Dme-032013	Drosophila melanogaster	46.57	9.00e-115	407.00
IUUC-Ete-032273	Echinops telfairi	94.90	0.00e+00	808.00
IUUC-Eca-033667	Equus caballus	95.25	0.00e+00	835.00
IUUC-Fca-036179	Felis catus	93.35	0.00e+00	789.00
IUUC-Fal-037642	Ficedula albicollis	82.71	0.00e+00	780.00
IUUC-Gga-041264	Gallus gallus	83.57	0.00e+00	809.00
IUUC-Gma-043430	Glycine max	34.73	3.00e-44	173.00
IUUC-Ggo-044969	Gorilla gorilla	99.28	0.00e+00	824.00
IUUC-Hsa-046669	Homo sapiens	99.46	0.00e+00	857.00
IUUC-Itr-048337	Ictidomys tridecemlineatus	97.18	0.00e+00	686.00
IUUC-Lch-050192	Latimeria chalumnae	75.69	0.00e+00	675.00
IUUC-Lpe-051401	Leersia perrieri	35.43	6.00e-36	145.00
IUUC-Loc-052846	Lepisosteus oculatus	76.70	0.00e+00	668.00
IUUC-Lma-053152	Leptosphaeria maculans	28.94	2.00e-11	64.30
IUUC-Laf-054278	Loxodonta africana	94.40	0.00e+00	800.00
IUUC-Meu-056414	Macropus eugenii	79.90	5.00e-156	544.00
IUUC-Mtr-058674	Medicago truncatula	35.51	1.00e-46	181.00
IUUC-Mga-059894	Meleagris gallopavo	82.64	0.00e+00	647.00
IUUC-Mmr-061094	Microcebus murinus	97.84	0.00e+00	830.00
IUUC-Mdo-062728	Monodelphis domestica	86.36	0.00e+00	775.00
IUUC-Mmu-064088	Mus musculus	86.82	0.00e+00	840.00
IUUC-Mac-065458	Musa acuminata	33.41	2.00e-42	166.00
IUUC-Mpu-066282	Mustela putorius furo	92.63	0.00e+00	802.00
IUUC-Mlu-068158	Myotis lucifugus	94.59	0.00e+00	795.00
IUUC-Nle-069321	Nomascus leucogenys	99.28	0.00e+00	857.00
IUUC-Opr-071098	Ochotona princeps	90.32	0.00e+00	630.00
IUUC-Oan-072808	Ornithorhynchus anatinus	86.83	0.00e+00	739.00
IUUC-Ocu-074301	Oryctolagus cuniculus	88.73	0.00e+00	793.00
IUUC-Oba-074973	Oryza barthii	39.00	3.00e-42	166.00
IUUC-Obr-076444	Oryza brachyantha	50.34	2.00e-32	134.00
IUUC-Ogl-077319	Oryza glaberrima	39.33	9.00e-43	168.00
IUUC-Ogu-078074	Oryza glumaepatula	35.24	6.00e-50	191.00
IUUC-Oin-079142	Oryza indica	36.51	1.00e-42	167.00
IUUC-Olo-080565	Oryza longistaminata	35.24	5.00e-48	185.00
IUUC-Ome-081155	Oryza meridionalis	51.55	4.00e-34	139.00
IUUC-Oni-082272	Oryza nivara	36.51	1.00e-42	167.00
IUUC-Opu-083241	Oryza punctata	36.71	2.00e-50	194.00
IUUC-Oru-085257	Oryza rufipogon	36.51	1.00e-42	167.00
IUUC-Osa-086257	Oryza sativa	39.33	8.00e-43	168.00
IUUC-Ola-086802	Oryzias latipes	66.83	4.00e-135	474.00
IUUC-Olu-087597	Ostreococcus lucimarinus	32.48	4.00e-25	109.00
IUUC-Oga-088495	Otolemur garnettii	97.30	0.00e+00	805.00
IUUC-Oar-089711	Ovis aries	94.40	0.00e+00	804.00
IUUC-Ptr-091439	Pan troglodytes	99.10	0.00e+00	850.00
IUUC-Pan-092641	Papio anubis	100.00	0.00e+00	857.00
IUUC-Psi-093518	Pelodiscus sinensis	83.15	0.00e+00	719.00
IUUC-Pma-094727	Petromyzon marinus	42.92	2.00e-52	200.00
IUUC-Ppa-095193	Physcomitrella patens	52.80	2.00e-35	144.00
IUUC-Pfo-096638	Poecilia formosa	67.50	3.00e-174	605.00
IUUC-Pab-098699	Pongo abelii	96.94	0.00e+00	849.00
IUUC-Pop-099549	Populus trichocarpa	37.56	4.00e-55	209.00
IUUC-Pca-100497	Procavia capensis	84.94	5.00e-135	474.00
IUUC-Pva-102513	Pteropus vampyrus	84.14	3.00e-147	514.00
IUUC-Rno-104908	Rattus norvegicus	87.16	0.00e+00	878.00
IUUC-Sha-106881	Sarcophilus harrisii	84.51	0.00e+00	698.00
IUUC-Smo-108910	Selaginella moellendorffii	35.81	1.00e-37	151.00
IUUC-Sit-110766	Setaria italica	40.07	7.00e-36	145.00
IUUC-Sar-113648	Sorex araneus	88.31	0.00e+00	632.00
IUUC-Sbi-114307	Sorghum bicolor	38.46	5.00e-44	172.00
IUUC-Ssc-115820	Sus scrofa	97.12	0.00e+00	836.00
IUUC-Tgu-116845	Taeniopygia guttata	77.14	0.00e+00	691.00
IUUC-Tni-119780	Tetraodon nigroviridis	65.19	5.00e-171	594.00
IUUC-Tca-121558	Theobroma cacao	36.22	7.00e-55	208.00
IUUC-Tae-125518	Triticum aestivum	49.65	2.00e-38	153.00
IUUC-Tur-126783	Triticum urartu	54.41	9.00e-39	154.00
IUUC-Tbe-127379	Tupaia belangeri	83.96	0.00e+00	674.00
IUUC-Ttr-128630	Tursiops truncatus	94.43	0.00e+00	847.00
IUUC-Vpa-130413	Vicugna pacos	71.51	2.00e-159	555.00
IUUC-Vvi-131599	Vitis vinifera	38.91	1.00e-41	164.00
IUUC-Xtr-132595	Xenopus tropicalis	79.89	0.00e+00	707.00
IUUC-Xma-134155	Xiphophorus maculatus	64.50	6.00e-169	587.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence