iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pab-098699

Ensembl Protein ID

ENSPPYP00000021651.2

UniProt Accession

H2PSI2; H2PSI2_PONAB

Genbank Protein ID

ENSPPYP00000021651

Protein Name

Ubiquilin-1

Genbank Nucleotide ID

ABGA01125763

Gene Name

UBQLN1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000019323.2	ENSPPYT00000022537.2	ENSPPYP00000021651.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/UBA	4.50e-10	39.4	535	572
ULD/UDP/UBQ/UBQ_PIM	4.60e-25	87.5	37	110

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGF.dreealqaLraannnleaAveyLl 39
           ++++leql +MGF +re++lqaL a++++++aA+e+Ll
   Q: 535  FQQQLEQLSAMGFlNREANLQALIATGGDINAAIERLL 572
           799**********************************9 PP

ULD/UDP/UBQ/UBQ_PIM

   S: 1    mkltvktlkgkefelevseddtveelKekiakesgvppeqqkLIyaGkiLkDdttLselgikdgsvvhlvvkksk 75
           mk+tvkt+k+ke e+ v e+++v+++Ke+i+k+++ + +q+ LI+aGkiLkD++tLs++gi+dg +vhlv+k+++
   Q: 37   MKVTVKTPKEKE-EFAVPENSSVQQFKEEISKRFKSHTDQLVLIFAGKILKDQDTLSQHGIHDGLTVHLVIKTQN 110
           99**********.***********************************************************987 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

MAESGESGGP PGSQDSAAGA EGAGAPAAAA SAEPKIMKVT VKTPKEKEEF AVPENSSVQQ 60
FKEEISKRFK SHTDQLVLIF AGKILKDQDT LSQHGIHDGL TVHLVIKTQN RPQDHSAQQT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACCGTGACGT CATCTCGGTG CGCCGTTACA GCGCTTAACT GGAAGGTGCG ATTTAGTTTT 60
TGGTGAAAGG AGTGGGTAAA AAACCATGAA CTGACCTACC CCGCCCCATT TTGCTTTTAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR006636--STI1_HS-bd
IPR015940--UBA
IPR009060--UBA-like
IPR015496--Ubiquilin
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50030--UBA
PS50053--UBIQUITIN_2

Pfam

PF00627--UBA
PF00240--ubiquitin

SMART

SM00727--STI1
SM00165--UBA
SM00213--UBQ

Gene Ontology

GO:0016235--C:aggresome
GO:0005776--C:autophagosome
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005654--C:nucleoplasm
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0035973--P:aggrephagy
GO:0000045--P:autophagosome assembly
GO:0097352--P:autophagosome maturation
GO:0071456--P:cellular response to hypoxia
GO:1901340--P:negative regulation of store-operated calcium channel activity
GO:0034140--P:negative regulation of toll-like receptor 3 signaling pathway
GO:1903071--P:positive regulation of ER-associated ubiquitin-dependent protein catabolic process
GO:0031398--P:positive regulation of protein ubiquitination
GO:1902175--P:regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:0030433--P:ubiquitin-dependent ERAD pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000864	Aegilops tauschii	49.65	6.00e-38	152.00
IUUC-Aml-001461	Ailuropoda melanoleuca	93.81	0.00e+00	803.00
IUUC-Atr-002470	Amborella trichopoda	39.38	9.00e-45	174.00
IUUC-Apl-003241	Anas platyrhynchos	83.21	0.00e+00	715.00
IUUC-Aca-004511	Anolis carolinensis	77.92	0.00e+00	725.00
IUUC-Aly-005736	Arabidopsis lyrata	37.13	2.00e-55	209.00
IUUC-Ath-007350	Arabidopsis thaliana	35.66	1.00e-57	217.00
IUUC-Ago-007963	Ashbya gossypii	37.68	1.00e-08	53.90
IUUC-Bta-013048	Bos taurus	92.50	0.00e+00	821.00
IUUC-Bdi-014506	Brachypodium distachyon	36.32	2.00e-53	203.00
IUUC-Bol-015326	Brassica oleracea	34.45	9.00e-55	207.00
IUUC-Bra-018014	Brassica rapa	40.00	1.00e-43	170.00
IUUC-Cel-018631	Caenorhabditis elegans	39.14	1.00e-69	257.00
IUUC-Cja-019976	Callithrix jacchus	95.68	0.00e+00	837.00
IUUC-Cfa-020092	Canis familiaris	94.05	0.00e+00	828.00
IUUC-Cpo-022388	Cavia porcellus	93.87	0.00e+00	823.00
IUUC-Csa-024087	Chlorocebus sabaeus	96.90	0.00e+00	839.00
IUUC-Cho-024834	Choloepus hoffmanni	94.52	0.00e+00	839.00
IUUC-Cin-025136	Ciona intestinalis	51.88	4.00e-115	408.00
IUUC-Cme-027155	Cyanidioschyzon merolae	58.10	1.00e-34	141.00
IUUC-Dno-028970	Dasypus novemcinctus	77.84	0.00e+00	672.00
IUUC-Dor-030519	Dipodomys ordii	90.29	0.00e+00	798.00
IUUC-Dme-032013	Drosophila melanogaster	47.97	5.00e-118	417.00
IUUC-Ete-032273	Echinops telfairi	93.19	0.00e+00	806.00
IUUC-Eca-033667	Equus caballus	93.21	0.00e+00	830.00
IUUC-Fca-036179	Felis catus	90.65	0.00e+00	783.00
IUUC-Fal-037642	Ficedula albicollis	81.93	0.00e+00	773.00
IUUC-Gga-041264	Gallus gallus	82.80	0.00e+00	803.00
IUUC-Gma-043430	Glycine max	36.75	4.00e-47	182.00
IUUC-Ggo-044969	Gorilla gorilla	97.30	0.00e+00	818.00
IUUC-Hsa-046669	Homo sapiens	97.48	0.00e+00	850.00
IUUC-Itr-048337	Ictidomys tridecemlineatus	93.90	0.00e+00	681.00
IUUC-Lch-050192	Latimeria chalumnae	78.83	0.00e+00	677.00
IUUC-Lpe-051401	Leersia perrieri	39.25	1.00e-38	154.00
IUUC-Loc-052846	Lepisosteus oculatus	76.43	0.00e+00	671.00
IUUC-Lma-053152	Leptosphaeria maculans	27.11	8.00e-12	65.10
IUUC-Laf-054278	Loxodonta africana	89.81	0.00e+00	794.00
IUUC-Mcc-055680	Macaca mulatta	96.94	0.00e+00	850.00
IUUC-Meu-056414	Macropus eugenii	77.86	2.00e-155	542.00
IUUC-Mtr-058674	Medicago truncatula	37.23	1.00e-50	193.00
IUUC-Mga-059894	Meleagris gallopavo	81.20	0.00e+00	644.00
IUUC-Mmr-061094	Microcebus murinus	95.50	0.00e+00	828.00
IUUC-Mdo-062728	Monodelphis domestica	84.85	0.00e+00	769.00
IUUC-Mmu-064088	Mus musculus	85.47	0.00e+00	835.00
IUUC-Mac-065458	Musa acuminata	37.56	2.00e-47	183.00
IUUC-Mpu-066282	Mustela putorius furo	90.11	0.00e+00	796.00
IUUC-Mlu-068158	Myotis lucifugus	90.97	0.00e+00	793.00
IUUC-Nle-069321	Nomascus leucogenys	97.30	0.00e+00	850.00
IUUC-Opr-071098	Ochotona princeps	86.43	0.00e+00	626.00
IUUC-Oan-072808	Ornithorhynchus anatinus	85.90	0.00e+00	737.00
IUUC-Ocu-074301	Oryctolagus cuniculus	85.95	0.00e+00	781.00
IUUC-Oba-074973	Oryza barthii	40.96	5.00e-46	178.00
IUUC-Obr-076444	Oryza brachyantha	49.70	7.00e-33	135.00
IUUC-Ogl-077319	Oryza glaberrima	40.96	1.00e-46	180.00
IUUC-Ogu-078074	Oryza glumaepatula	36.28	1.00e-53	204.00
IUUC-Oin-079142	Oryza indica	40.27	2.00e-46	180.00
IUUC-Olo-080565	Oryza longistaminata	36.28	7.00e-52	197.00
IUUC-Ome-081155	Oryza meridionalis	45.15	2.00e-35	144.00
IUUC-Oni-082272	Oryza nivara	40.27	2.00e-46	180.00
IUUC-Opu-083241	Oryza punctata	37.99	5.00e-54	205.00
IUUC-Oru-085257	Oryza rufipogon	40.27	2.00e-46	180.00
IUUC-Osa-086257	Oryza sativa	40.96	1.00e-46	180.00
IUUC-Olu-087597	Ostreococcus lucimarinus	33.96	5.00e-27	115.00
IUUC-Oga-088495	Otolemur garnettii	94.95	0.00e+00	805.00
IUUC-Oar-089711	Ovis aries	89.47	0.00e+00	801.00
IUUC-Ptr-091439	Pan troglodytes	97.30	0.00e+00	845.00
IUUC-Pan-092641	Papio anubis	96.94	0.00e+00	850.00
IUUC-Psi-093518	Pelodiscus sinensis	81.84	0.00e+00	716.00
IUUC-Pma-094727	Petromyzon marinus	42.69	6.00e-54	205.00
IUUC-Ppa-095193	Physcomitrella patens	52.80	1.00e-35	144.00
IUUC-Pfo-096638	Poecilia formosa	66.97	6.00e-174	603.00
IUUC-Pop-099549	Populus trichocarpa	38.02	2.00e-55	209.00
IUUC-Pca-100497	Procavia capensis	80.40	6.00e-133	467.00
IUUC-Ppe-101901	Prunus persica	36.45	9.00e-59	221.00
IUUC-Pva-102513	Pteropus vampyrus	95.99	2.00e-134	472.00
IUUC-Rno-104908	Rattus norvegicus	84.46	0.00e+00	872.00
IUUC-Sha-106881	Sarcophilus harrisii	82.84	0.00e+00	696.00
IUUC-Smo-109502	Selaginella moellendorffii	36.71	8.00e-40	158.00
IUUC-Sit-110766	Setaria italica	42.03	4.00e-40	159.00
IUUC-Sly-111731	Solanum lycopersicum	35.06	4.00e-45	176.00
IUUC-Stu-112263	Solanum tuberosum	37.32	2.00e-49	189.00
IUUC-Sar-113648	Sorex araneus	85.18	0.00e+00	627.00
IUUC-Sbi-114307	Sorghum bicolor	39.93	2.00e-47	183.00
IUUC-Ssc-115820	Sus scrofa	94.41	0.00e+00	831.00
IUUC-Tgu-116845	Taeniopygia guttata	78.20	0.00e+00	684.00
IUUC-Tni-119780	Tetraodon nigroviridis	64.34	5.00e-172	597.00
IUUC-Tca-121558	Theobroma cacao	37.24	1.00e-55	210.00
IUUC-Tae-125518	Triticum aestivum	49.65	2.00e-38	153.00
IUUC-Tur-126783	Triticum urartu	54.41	8.00e-39	154.00
IUUC-Tbe-127379	Tupaia belangeri	81.13	0.00e+00	668.00
IUUC-Ttr-128630	Tursiops truncatus	91.55	0.00e+00	833.00
IUUC-Vpa-130413	Vicugna pacos	68.37	2.00e-157	548.00
IUUC-Vvi-131599	Vitis vinifera	40.07	7.00e-44	171.00
IUUC-Xtr-132595	Xenopus tropicalis	78.85	0.00e+00	707.00
IUUC-Xma-134155	Xiphophorus maculatus	64.30	3.00e-169	588.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence