iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPANG00000011865.2	ENSPANT00000003249.2	ENSPANP00000008755.1
ENSPANG00000011865.2	ENSPANT00000003252.1	ENSPANP00000005162.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	6.80e-105	351.2	4117	4418
UBD/Alpha-Helix/UBA	6.30e-08	32.6	1397	1434

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrll 88
           ++++k+rl++ f+gEeg+d+gG+ re++  +s+e++np++ lf++s++d+ t+++np+s + np+hl++F+f+Gr+++ka++d+rll
   Q: 4117 PEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHC-NPNHLSYFKFVGRIVAKAVYDNRLL 4202
           6799*******************************************************86.99*********************** PP
   S: 89   dlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
           ++ +++sfyk++lgk++ + d+e+ d ++y+ l +++en   d+++lg dltfs++ +++g +++++Lkp+G+ni Vt+eNk+eYv+
   Q: 4203 ECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLEN---DVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVH 4286
           *************************************99...********************************************* PP
   S: 176  lvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           lv+++r++  i++q++af eGf+e+ip++l+s+Fte+elelli+G ++id++dlk++t+y++ y+++s +iqwFw++l++f++ +r+
   Q: 4287 LVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEYHK-YQSNSIQIQWFWRALRSFDQADRA 4372
           ************************************************************66.************************ PP
   S: 263  afLqFvTgssrlPlgGfaelk....prlfvirk.dasddrlPssnT 303
           +fLqFvTg+s++Pl+Gfa+l+     ++f+i++ d+s+drlPs++T
   Q: 4373 KFLQFVTGTSKVPLQGFAALEgmngIQKFQIHRdDRSTDRLPSAHT 4418
           *********************99998999999988899*******9 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLldg 41
           ++++l+ql++MGF+re+a +aL++   + e A+eyLl++
   Q: 1397 NQQQLQQLMDMGFTREHAMEALLN-TSTMEQATEYLLTH 1434
           89**********************.7***********98 PP

Organism

Papio anubis

Protein Sequence
(Fasta)

MKVDRTKLKK TPTEAPADCR ALIDKLKVCN DEQLLLELQQ IKTWNIGKCE LYHWVDLLDR 60
FDGILADAGQ TVENMSWMLV CDRPEREQLK MLLLAVLNFT ALLIEYSFSR HLYSSIEHLT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTAGATCTCT GAGAAGAGAG GAAGGAGTGA CAATACCAAA TAAAAACTTT GTCTAAGGTT 60
CAAGGGCAAA GTTCAACCTG AGTTGCCAGG ATGTTTATCG TTTGTCTCCC AGTATGGCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR025527--DUF4414
IPR010309--E3_Ub_ligase_DUF908
IPR010314--E3_Ub_ligase_DUF913
IPR000569--HECT_dom
IPR015940--UBA
IPR009060--UBA-like
IPR004170--WWE-dom

PROSITE

PS50237--HECT
PS50030--UBA
PS50918--WWE

Pfam

PF14377--DUF4414
PF06012--DUF908
PF06025--DUF913
PF00632--HECT
PF00627--UBA
PF02825--WWE

SMART

SM00119--HECTc
SM00165--UBA

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005654--C:nucleoplasm
GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006284--P:base-excision repair
GO:0016574--P:histone ubiquitination
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000627	Aegilops tauschii	50.00	3.00e-99	358.00
IUUC-Aml-001684	Ailuropoda melanoleuca	99.06	0.00e+00	3424.00
IUUC-Atr-003044	Amborella trichopoda	51.65	6.00e-112	400.00
IUUC-Apl-003729	Anas platyrhynchos	93.54	0.00e+00	696.00
IUUC-Aca-005263	Anolis carolinensis	92.38	0.00e+00	3125.00
IUUC-Aly-006083	Arabidopsis lyrata	50.24	2.00e-111	399.00
IUUC-Ath-007472	Arabidopsis thaliana	50.24	1.00e-111	399.00
IUUC-Ago-008005	Ashbya gossypii	44.69	2.00e-115	412.00
IUUC-Acl-008254	Aspergillus clavatus	45.42	6.00e-121	431.00
IUUC-Afl-008712	Aspergillus flavus	44.70	2.00e-123	436.00
IUUC-Afu-009022	Aspergillus fumigatus	45.62	2.00e-121	432.00
IUUC-Ani-009412	Aspergillus nidulans	46.02	1.00e-122	436.00
IUUC-Ang-009771	Aspergillus niger	45.82	2.00e-121	432.00
IUUC-Aor-010186	Aspergillus oryzae	44.70	2.00e-123	437.00
IUUC-Ate-010253	Aspergillus terreus	45.98	2.00e-121	432.00
IUUC-Ame-011067	Astyanax mexicanus	80.34	0.00e+00	3670.00
IUUC-Bgr-012043	Blumeria graminis	45.38	2.00e-125	446.00
IUUC-Bta-012813	Bos taurus	98.80	0.00e+00	3456.00
IUUC-Bci-013995	Botrytis cinerea	44.69	4.00e-124	441.00
IUUC-Bdi-014884	Brachypodium distachyon	51.15	8.00e-114	407.00
IUUC-Bra-016637	Brassica rapa	42.67	8.00e-109	390.00
IUUC-Cel-018179	Caenorhabditis elegans	60.25	8.00e-168	586.00
IUUC-Cja-018741	Callithrix jacchus	99.37	0.00e+00	3449.00
IUUC-Cfa-020083	Canis familiaris	99.21	0.00e+00	3437.00
IUUC-Cpo-021923	Cavia porcellus	97.85	0.00e+00	3390.00
IUUC-Cre-022900	Chlamydomonas reinhardtii	48.21	4.00e-108	384.00
IUUC-Csa-023853	Chlorocebus sabaeus	99.90	0.00e+00	3457.00
IUUC-Cho-024718	Choloepus hoffmanni	100.00	0.00e+00	741.00
IUUC-Cin-025627	Ciona intestinalis	39.47	0.00e+00	1321.00
IUUC-Csv-025824	Ciona savignyi	43.98	0.00e+00	886.00
IUUC-Cgl-026647	Colletotrichum gloeosporioides	52.64	8.00e-124	440.00
IUUC-Cne-027095	Cryptococcus neoformans	40.73	3.00e-95	345.00
IUUC-Cme-027267	Cyanidioschyzon merolae	48.70	3.00e-101	364.00
IUUC-Dre-028525	Danio rerio	81.47	0.00e+00	3649.00
IUUC-Dno-029680	Dasypus novemcinctus	97.80	0.00e+00	3360.00
IUUC-Dor-030902	Dipodomys ordii	96.05	0.00e+00	1215.00
IUUC-Dse-031197	Dothistroma septosporum	45.94	1.00e-124	443.00
IUUC-Dme-032122	Drosophila melanogaster	67.85	0.00e+00	737.00
IUUC-Ete-032690	Echinops telfairi	90.89	0.00e+00	1260.00
IUUC-Eca-033915	Equus caballus	98.48	0.00e+00	3432.00
IUUC-Eeu-034963	Erinaceus europaeus	93.48	0.00e+00	2786.00
IUUC-Fca-035824	Felis catus	99.11	0.00e+00	3432.00
IUUC-Fox-037756	Fusarium oxysporum	53.09	4.00e-124	441.00
IUUC-Fso-038464	Fusarium solani	54.10	1.00e-123	439.00
IUUC-Gmo-039073	Gadus morhua	81.21	0.00e+00	2764.00
IUUC-Ggr-039946	Gaeumannomyces graminis	52.49	6.00e-122	434.00
IUUC-Gga-040309	Gallus gallus	98.91	4.00e-169	587.00
IUUC-Gac-042430	Gasterosteus aculeatus	81.61	0.00e+00	2823.00
IUUC-Gma-043129	Glycine max	46.25	4.00e-113	404.00
IUUC-Ggo-044785	Gorilla gorilla	99.58	0.00e+00	3405.00
IUUC-Hsa-046879	Homo sapiens	99.63	0.00e+00	3409.00
IUUC-Hvu-047697	Hordeum vulgare	43.88	2.00e-114	408.00
IUUC-Itr-048430	Ictidomys tridecemlineatus	99.23	0.00e+00	1412.00
IUUC-Kpa-049228	Komagataella pastoris	47.48	3.00e-126	448.00
IUUC-Lch-050252	Latimeria chalumnae	88.09	0.00e+00	2959.00
IUUC-Lpe-051550	Leersia perrieri	50.89	3.00e-113	404.00
IUUC-Loc-052472	Lepisosteus oculatus	83.16	0.00e+00	3762.00
IUUC-Lma-053159	Leptosphaeria maculans	45.00	4.00e-124	441.00
IUUC-Laf-054154	Loxodonta africana	98.06	0.00e+00	3394.00
IUUC-Mcc-055085	Macaca mulatta	99.95	0.00e+00	3459.00
IUUC-Meu-056727	Macropus eugenii	91.88	0.00e+00	1845.00
IUUC-Mor-057201	Magnaporthe oryzae	45.64	2.00e-122	436.00
IUUC-Mpo-057597	Magnaporthe poae	45.23	1.00e-120	430.00
IUUC-Mtr-058273	Medicago truncatula	51.65	1.00e-113	406.00
IUUC-Mla-058888	Melampsora laricipopulina	47.40	5.00e-100	357.00
IUUC-Mvi-060320	Microbotryum violaceum	39.79	5.00e-111	397.00
IUUC-Mmr-060820	Microcebus murinus	98.80	0.00e+00	3386.00
IUUC-Mdo-062930	Monodelphis domestica	92.84	0.00e+00	3194.00
IUUC-Mmu-063601	Mus musculus	98.22	0.00e+00	3285.00
IUUC-Mac-065557	Musa acuminata	50.76	8.00e-110	393.00
IUUC-Mpu-066653	Mustela putorius furo	96.81	0.00e+00	3308.00
IUUC-Mlu-067418	Myotis lucifugus	98.01	0.00e+00	3470.00
IUUC-Nfi-068278	Neosartorya fischeri	45.82	6.00e-122	434.00
IUUC-Ncr-068813	Neurospora crassa	45.64	2.00e-123	439.00
IUUC-Nle-069418	Nomascus leucogenys	99.11	0.00e+00	3374.00
IUUC-Opr-070187	Ochotona princeps	84.10	0.00e+00	835.00
IUUC-Ont-071300	Oreochromis niloticus	81.79	0.00e+00	2789.00
IUUC-Oan-073046	Ornithorhynchus anatinus	88.56	0.00e+00	4425.00
IUUC-Ocu-074178	Oryctolagus cuniculus	98.48	0.00e+00	3455.00
IUUC-Oba-075757	Oryza barthii	50.64	4.00e-113	404.00
IUUC-Obr-076553	Oryza brachyantha	43.85	3.00e-112	401.00
IUUC-Ogl-077520	Oryza glaberrima	50.64	4.00e-113	404.00
IUUC-Ogu-078278	Oryza glumaepatula	50.64	4.00e-113	404.00
IUUC-Oin-079767	Oryza indica	50.64	4.00e-113	404.00
IUUC-Olo-080380	Oryza longistaminata	50.13	3.00e-111	398.00
IUUC-Ome-081925	Oryza meridionalis	50.13	2.00e-111	399.00
IUUC-Oni-082619	Oryza nivara	50.64	4.00e-113	404.00
IUUC-Opu-083684	Oryza punctata	50.13	1.00e-111	399.00
IUUC-Oru-084501	Oryza rufipogon	50.64	3.00e-113	404.00
IUUC-Osa-086251	Oryza sativa	50.64	7.00e-112	398.00
IUUC-Ola-087437	Oryzias latipes	84.99	0.00e+00	1894.00
IUUC-Olu-087813	Ostreococcus lucimarinus	49.59	7.00e-103	367.00
IUUC-Oga-088903	Otolemur garnettii	98.85	0.00e+00	3388.00
IUUC-Oar-090210	Ovis aries	98.90	0.00e+00	3425.00
IUUC-Ptr-090502	Pan troglodytes	99.69	0.00e+00	3404.00
IUUC-Pma-094246	Petromyzon marinus	74.50	0.00e+00	1295.00
IUUC-Pno-094871	Phaeosphaeria nodorum	52.50	2.00e-122	435.00
IUUC-Ppa-095657	Physcomitrella patens	50.25	2.00e-111	399.00
IUUC-Pfo-096232	Poecilia formosa	80.47	0.00e+00	3685.00
IUUC-Pab-098583	Pongo abelii	99.69	0.00e+00	3411.00
IUUC-Pop-099613	Populus trichocarpa	51.91	5.00e-114	407.00
IUUC-Pca-100310	Procavia capensis	94.55	0.00e+00	1323.00
IUUC-Ppe-102109	Prunus persica	51.40	6.00e-113	404.00
IUUC-Pva-102116	Pteropus vampyrus	98.53	0.00e+00	3461.00
IUUC-Pgr-103465	Puccinia graminis	41.62	5.00e-111	397.00
IUUC-Ptt-103813	Puccinia triticina	39.39	1.00e-98	356.00
IUUC-Pte-104018	Pyrenophora teres	52.25	2.00e-121	432.00
IUUC-Pyt-104713	Pyrenophora triticirepentis	52.12	5.00e-121	431.00
IUUC-Rno-105889	Rattus norvegicus	88.36	0.00e+00	2883.00
IUUC-Sce-106449	Saccharomyces cerevisiae	43.12	2.00e-111	399.00
IUUC-Sha-106961	Sarcophilus harrisii	90.53	0.00e+00	3127.00
IUUC-Sja-107814	Schizosaccharomyces japonicus	43.41	1.00e-111	399.00
IUUC-Spo-108024	Schizosaccharomyces pombe	43.55	3.00e-115	411.00
IUUC-Smo-109428	Selaginella moellendorffii	50.24	3.00e-117	418.00
IUUC-Sit-110598	Setaria italica	51.40	9.00e-114	406.00
IUUC-Sly-111706	Solanum lycopersicum	46.47	3.00e-115	411.00
IUUC-Sar-113291	Sorex araneus	93.22	0.00e+00	2755.00
IUUC-Sbi-114042	Sorghum bicolor	51.40	3.00e-114	408.00
IUUC-Sre-114958	Sporisorium reilianum	55.27	2.00e-123	436.00
IUUC-Ssc-115754	Sus scrofa	99.37	0.00e+00	3436.00
IUUC-Tru-118570	Takifugu rubripes	81.20	0.00e+00	2843.00
IUUC-Tsy-119159	Tarsius syrichta	98.79	0.00e+00	2041.00
IUUC-Tni-120836	Tetraodon nigroviridis	77.77	0.00e+00	2009.00
IUUC-Tca-121646	Theobroma cacao	50.48	8.00e-113	403.00
IUUC-Tre-121909	Trichoderma reesei	53.20	1.00e-120	429.00
IUUC-Tvi-122370	Trichoderma virens	53.20	7.00e-121	430.00
IUUC-Tae-125214	Triticum aestivum	50.13	7.00e-112	399.00
IUUC-Tme-127172	Tuber melanosporum	46.18	1.00e-125	446.00
IUUC-Tbe-127506	Tupaia belangeri	96.15	0.00e+00	1506.00
IUUC-Ttr-129253	Tursiops truncatus	91.48	0.00e+00	2206.00
IUUC-Uma-129355	Ustilago maydis	47.40	4.00e-125	441.00
IUUC-Vda-129886	Verticillium dahliae	46.45	2.00e-125	445.00
IUUC-Vpa-130708	Vicugna pacos	97.86	0.00e+00	2915.00
IUUC-Vvi-131170	Vitis vinifera	49.64	1.00e-112	401.00
IUUC-Xtr-132123	Xenopus tropicalis	83.09	0.00e+00	5349.00
IUUC-Xma-133869	Xiphophorus maculatus	80.47	0.00e+00	3697.00
IUUC-Yli-134657	Yarrowia lipolytica	43.70	3.00e-115	411.00
IUUC-Zma-135570	Zea mays	43.27	2.00e-114	408.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence