• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063943
UUCD1 version UUC-MuM-00308
Ensembl Protein ID ENSMUSP00000108203.1
UniProt Accession P41230; O54995; Q3TYU8; Q3U1X6; Q3U282; Q6ZQF8; Q80XQ9; Q9CVI4; Q9D0C3; Q9QVR8; Q9R039; KDM5C_MOUSE
Genbank Protein ID AAD53049.1; BAB25462.1; BAE33161.1; BAE33260.1; BAE33367.1; BAE34464.1; AAH43096.1; AAH54550.1; CAA82759.1; BAC97906.1; AAA62384.1; AAB96762.1
Protein Name Lysine-specific demethylase 5C; Histone demethylase JARID1C; Jumonji/ARID domain-containing protein 1C; Protein SmcX; Protein Xe169
Genbank Nucleotide ID AF127245; AK008105; AK155279; AK155427; AK155651; AK158340; AK011577; BC054550; Z29651; AK129096; L29563; AF039894
Gene Name Kdm5c; Jarid1c; Kiaa0234; Smcx; Xe169
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000025332.14 ENSMUST00000112584.7 ENSMUSP00000108203.1
ENSMUSG00000025332.14 ENSMUST00000112588.8 ENSMUSP00000108207.2
ENSMUSG00000025332.14 ENSMUST00000082177.12 ENSMUSP00000080814.6
ENSMUSG00000025332.14 ENSMUST00000156114.1 ENSMUSP00000122750.1
ENSMUSG00000025332.14 ENSMUST00000155793.1 ENSMUSP00000123364.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
circBasemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDPINAHINT
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 8.40e-13 49.4 326 372
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           vC +C +g+ed+ +l+ C+ C++++H  Cl ++  +e p+   w CpkC 
   Q: 326  VCRMCSRGDEDD-KLLLCDGCDDNYHIFCLLPP-LPEIPKGV-WRCPKCV 372
           8*********88.6*******************.*******8.******6 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements (By similarity). Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2.
 Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements (By similarity). Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2.
Protein Sequence
(Fasta)
MELGSDDFLP PPECPVFEPS WAEFRDPLGY IAKIRPIAEK SGICKIRPPA DWQPPFAVEV 60
DNFRFTPRIQ RLNELEAQTR VKLNYLDQIA KFWEIQGSSL KIPNVERRIL DLYSLSKIVV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063943|E3,PHD|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TTGTTCTTCC GCCAATGAAA TGAACTATTT TCTCTTAGCC TGAGAAATGT TTTTAACTAA 60
CCACCTCCAA ATAAGGGACA TATACAACCC GATTTCTTTC GGTCATCACA TGATGAAGGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063943|E3,PHD|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0090--Biological rhythms
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0408--Iron
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001606--ARID_dom
IPR003347--JmjC_dom
IPR003349--JmjN
IPR013637--Lys_sp_deMease-like_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR004198--Znf_C5HC2
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51011--ARID
PS51184--JMJC
PS51183--JMJN
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF01388--ARID
PF02373--JmjC
PF02375--JmjN
PF00628--PHD
PF08429--PLU-1
PF02928--zf-C5HC2
SMART

SM00501--BRIGHT
SM00558--JmjC
SM00545--JmjN
SM00249--PHD
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0032453--F:histone demethylase activity (H3-K4 specific)
GO:0042802--F:identical protein binding
GO:0016706--F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0001085--F:RNA polymerase II transcription factor binding
GO:0008270--F:zinc ion binding
GO:0034720--P:histone H3-K4 demethylation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0042752--P:regulation of circadian rhythm
GO:0009636--P:response to toxic substance
GO:0048511--P:rhythmic process
GO:0006351--P:transcription, DNA-templated
KEGG mmu:20591
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001327 Ailuropoda melanoleuca 94.91 0.00e+00 2597.00
IUUC-Aca-004712 Anolis carolinensis 79.77 0.00e+00 1993.00
IUUC-Acl-008162 Aspergillus clavatus 31.00 9.00e-113 402.00
IUUC-Afu-008796 Aspergillus fumigatus 30.97 2.00e-114 408.00
IUUC-Bgr-012241 Blumeria graminis 29.46 2.00e-110 394.00
IUUC-Bta-013099 Bos taurus 93.65 0.00e+00 2568.00
IUUC-Bci-013992 Botrytis cinerea 29.74 2.00e-107 384.00
IUUC-Cja-018723 Callithrix jacchus 91.76 0.00e+00 2499.00
IUUC-Cfa-020954 Canis familiaris 95.63 0.00e+00 2580.00
IUUC-Cpo-021718 Cavia porcellus 97.38 0.00e+00 1364.00
IUUC-Csa-023946 Chlorocebus sabaeus 95.62 0.00e+00 2563.00
IUUC-Cne-026851 Cryptococcus neoformans 29.97 1.00e-110 395.00
IUUC-Dre-028238 Danio rerio 62.93 0.00e+00 1858.00
IUUC-Dno-029435 Dasypus novemcinctus 92.27 0.00e+00 2562.00
IUUC-Dor-030226 Dipodomys ordii 89.63 0.00e+00 1786.00
IUUC-Dse-031479 Dothistroma septosporum 29.49 1.00e-116 415.00
IUUC-Eca-033834 Equus caballus 94.20 0.00e+00 2632.00
IUUC-Eeu-034692 Erinaceus europaeus 92.52 0.00e+00 1967.00
IUUC-Fca-035766 Felis catus 92.41 0.00e+00 2463.00
IUUC-Fso-038127 Fusarium solani 30.76 1.00e-115 412.00
IUUC-Gmo-039140 Gadus morhua 64.89 0.00e+00 1782.00
IUUC-Gac-041825 Gasterosteus aculeatus 63.54 0.00e+00 1779.00
IUUC-Ggo-045492 Gorilla gorilla 95.23 0.00e+00 2642.00
IUUC-Hsa-046737 Homo sapiens 95.16 0.00e+00 2625.00
IUUC-Itr-048348 Ictidomys tridecemlineatus 95.42 0.00e+00 2715.00
IUUC-Lch-050517 Latimeria chalumnae 74.88 0.00e+00 2101.00
IUUC-Laf-054098 Loxodonta africana 87.48 0.00e+00 2352.00
IUUC-Mcc-055740 Macaca mulatta 95.04 0.00e+00 2638.00
IUUC-Meu-056643 Macropus eugenii 84.38 0.00e+00 2267.00
IUUC-Mmr-061032 Microcebus murinus 96.16 0.00e+00 2586.00
IUUC-Mdo-062754 Monodelphis domestica 80.43 0.00e+00 2185.00
IUUC-Mpu-066800 Mustela putorius furo 94.07 0.00e+00 2600.00
IUUC-Mlu-067109 Myotis lucifugus 93.54 0.00e+00 2576.00
IUUC-Ncr-068763 Neurospora crassa 28.44 2.00e-139 491.00
IUUC-Nle-069569 Nomascus leucogenys 96.65 0.00e+00 2525.00
IUUC-Ont-072274 Oreochromis niloticus 65.49 0.00e+00 1840.00
IUUC-Oan-073160 Ornithorhynchus anatinus 85.87 0.00e+00 2262.00
IUUC-Ocu-074440 Oryctolagus cuniculus 94.85 0.00e+00 2612.00
IUUC-Oin-079273 Oryza indica 37.84 1.00e-13 69.30
IUUC-Ola-087059 Oryzias latipes 65.79 0.00e+00 1867.00
IUUC-Oga-088191 Otolemur garnettii 95.27 0.00e+00 2619.00
IUUC-Oar-090027 Ovis aries 95.08 0.00e+00 2559.00
IUUC-Ptr-091415 Pan troglodytes 85.17 0.00e+00 2335.00
IUUC-Pan-091829 Papio anubis 94.71 0.00e+00 2621.00
IUUC-Pma-094137 Petromyzon marinus 51.65 0.00e+00 1366.00
IUUC-Pno-094879 Phaeosphaeria nodorum 29.35 3.00e-113 404.00
IUUC-Pfo-096645 Poecilia formosa 59.90 0.00e+00 1809.00
IUUC-Pab-097582 Pongo abelii 94.45 0.00e+00 2345.00
IUUC-Pca-100446 Procavia capensis 91.41 0.00e+00 2563.00
IUUC-Pva-102553 Pteropus vampyrus 94.05 0.00e+00 1636.00
IUUC-Pgr-103434 Puccinia graminis 36.36 7.00e-30 124.00
IUUC-Sha-106769 Sarcophilus harrisii 87.82 0.00e+00 2144.00
IUUC-Ssl-108489 Sclerotinia sclerotiorum 30.40 8.00e-118 419.00
IUUC-Sre-115161 Sporisorium reilianum 30.40 2.00e-131 465.00
IUUC-Ssc-116354 Sus scrofa 95.32 0.00e+00 2693.00
IUUC-Tru-117667 Takifugu rubripes 65.20 0.00e+00 1654.00
IUUC-Tni-119920 Tetraodon nigroviridis 65.28 0.00e+00 1801.00
IUUC-Tca-121478 Theobroma cacao 32.52 3.00e-107 384.00
IUUC-Tre-122213 Trichoderma reesei 29.12 5.00e-110 393.00
IUUC-Tvi-122263 Trichoderma virens 28.31 2.00e-103 371.00
IUUC-Tbe-128040 Tupaia belangeri 99.10 0.00e+00 1082.00
IUUC-Ttr-128979 Tursiops truncatus 95.35 0.00e+00 2621.00
IUUC-Vpa-130433 Vicugna pacos 98.52 0.00e+00 1800.00
IUUC-Vvi-131071 Vitis vinifera 32.41 1.00e-86 315.00
IUUC-Xtr-132324 Xenopus tropicalis 68.50 0.00e+00 1913.00
IUUC-Xma-134315 Xiphophorus maculatus 65.30 0.00e+00 1870.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved