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Tag Content
UUCD2 ID IUUC-Itr-048918
UUCD1 version UUC-SpT-00557
Ensembl Protein ID ENSSTOP00000013270.2
UniProt Accession I3MNL8; I3MNL8_ICTTR
Genbank Protein ID ENSSTOP00000013270
Protein Name E3 ubiquitin-protein ligase
Genbank Nucleotide ID AGTP01059868
Gene Name Itch
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSSTOG00000014804.2 ENSSTOT00000014815.2 ENSSTOP00000013270.2
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 1.40e-136 455.3 522 854
Active Site
Position(s) Description Evidence
823 Glycyl thioester intermediate {ECO:0000256|PIRSR:PIRSR001569-1,
ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f gEegld+gGv+re+++lls+e+ np+++lf+y  +d+++lq+np+s++ np+hlk+F+f+Gr++++al++g+++d+
   Q: 522  PQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYI-NPDHLKYFRFIGRFIAMALFHGKFIDT 609
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+k++ l+dle++dpe+y+sl ++ken   +iee+gl++ fsv++eilge+k+++Lkp+G ni Vt+eNkeeY++ v+e
   Q: 610  GFSLPFYKCILNKPVGLKDLESIDPEFYNSLIWVKEN---NIEECGLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAE 695
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +rl +g++eq++af eGfne++p++ l++F+++ele+l+cG++eid++d+++++ y++ yt++s++i wFw++++e+++e+r ++LqFv
   Q: 696  WRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRH-YTRTSKQIMWFWQFVKEIDNEKRMRLLQFV 783
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfa+l+    p++f+i+k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 784  TGTCRLPVGGFADLMgingPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 854
           *********************************************************************96 PP
   
Organism Ictidomys tridecemlineatus
Protein Sequence
(Fasta)
MSDSGSLIMK SQLQVTVISA KLKENKKNWF GPSPYVEVTV DGQSKKTEKC NNTNSPKWKQ 60
PLTVIVTPVS KLHFRVWSHQ TLKSDVLLGT AALDIYETLK SNNMKLEEVI VTLQLAGDKE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Itr-048918|E3,HECT|Ictidomys tridecemlineatus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CAAGAAACTC TCAGCTGAGC TATATCCCCA GCCCCAGGTA GTGAGTATTT GTGTACAACG 60
TTTTGTGAGG AGTGTGTTTT CAGTTCCTAG GTTATATATC TAGGAGTTGA ATTGATGAAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Itr-048918|E3,HECT|Ictidomys tridecemlineatus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom
PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2
Pfam

PF00168--C2
PF00632--HECT
PF00397--WW
SMART

SM00239--C2
SM00119--HECTc
SM00456--WW
Gene Ontology

GO:0005938--C:cell cortex
GO:0031410--C:cytoplasmic vesicle
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0016874--F:ligase activity
GO:0043021--F:ribonucleoprotein complex binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0046642--P:negative regulation of alpha-beta T cell proliferation
GO:0043066--P:negative regulation of apoptotic process
GO:0050687--P:negative regulation of defense response to virus
GO:0046329--P:negative regulation of JNK cascade
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0045732--P:positive regulation of protein catabolic process
GO:0002669--P:positive regulation of T cell anergy
GO:0035519--P:protein K29-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0090085--P:regulation of protein deubiquitination
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002302 Ailuropoda melanoleuca 96.34 0.00e+00 1610.00
IUUC-Apl-003752 Anas platyrhynchos 83.43 0.00e+00 1446.00
IUUC-Aca-005338 Anolis carolinensis 82.31 0.00e+00 1417.00
IUUC-Ago-007742 Ashbya gossypii 48.71 3.00e-162 565.00
IUUC-Acl-008273 Aspergillus clavatus 47.98 1.00e-156 546.00
IUUC-Afl-008713 Aspergillus flavus 47.14 1.00e-153 536.00
IUUC-Afu-009103 Aspergillus fumigatus 48.15 7.00e-158 550.00
IUUC-Ani-009259 Aspergillus nidulans 47.32 3.00e-154 538.00
IUUC-Ang-009738 Aspergillus niger 47.32 7.00e-154 537.00
IUUC-Ate-010529 Aspergillus terreus 44.94 2.00e-155 543.00
IUUC-Ame-010601 Astyanax mexicanus 87.22 0.00e+00 1112.00
IUUC-Bgr-012148 Blumeria graminis 46.19 7.00e-151 527.00
IUUC-Bta-012782 Bos taurus 95.82 0.00e+00 1567.00
IUUC-Bci-013785 Botrytis cinerea 46.92 2.00e-152 533.00
IUUC-Cja-018899 Callithrix jacchus 93.24 0.00e+00 1572.00
IUUC-Cfa-020648 Canis familiaris 95.29 0.00e+00 1577.00
IUUC-Cpo-022073 Cavia porcellus 96.52 0.00e+00 1620.00
IUUC-Csa-023252 Chlorocebus sabaeus 95.82 0.00e+00 1615.00
IUUC-Cho-024695 Choloepus hoffmanni 88.37 0.00e+00 1588.00
IUUC-Cgl-026642 Colletotrichum gloeosporioides 47.37 5.00e-155 541.00
IUUC-Cne-026849 Cryptococcus neoformans 46.09 1.00e-158 553.00
IUUC-Dre-028809 Danio rerio 87.95 0.00e+00 1108.00
IUUC-Dno-029884 Dasypus novemcinctus 94.90 0.00e+00 1635.00
IUUC-Dse-031241 Dothistroma septosporum 47.55 2.00e-155 543.00
IUUC-Eca-033793 Equus caballus 96.06 0.00e+00 1619.00
IUUC-Eeu-034716 Erinaceus europaeus 92.58 0.00e+00 886.00
IUUC-Fca-035605 Felis catus 96.46 0.00e+00 1641.00
IUUC-Fal-037126 Ficedula albicollis 82.65 0.00e+00 1429.00
IUUC-Fox-037774 Fusarium oxysporum 47.03 2.00e-154 539.00
IUUC-Fso-038393 Fusarium solani 47.04 1.00e-153 536.00
IUUC-Gmo-038596 Gadus morhua 80.20 0.00e+00 1008.00
IUUC-Ggr-040107 Gaeumannomyces graminis 47.68 7.00e-154 537.00
IUUC-Gga-040832 Gallus gallus 84.25 0.00e+00 1456.00
IUUC-Gac-041658 Gasterosteus aculeatus 86.15 0.00e+00 1114.00
IUUC-Ggo-044535 Gorilla gorilla 93.33 0.00e+00 1583.00
IUUC-Hsa-046564 Homo sapiens 92.14 0.00e+00 1606.00
IUUC-Kpa-049273 Komagataella pastoris 49.05 3.00e-163 568.00
IUUC-Lch-050454 Latimeria chalumnae 77.40 0.00e+00 1387.00
IUUC-Loc-052647 Lepisosteus oculatus 74.42 0.00e+00 1343.00
IUUC-Laf-054383 Loxodonta africana 96.29 0.00e+00 1622.00
IUUC-Mcc-055532 Macaca mulatta 95.82 0.00e+00 1617.00
IUUC-Mor-057097 Magnaporthe oryzae 47.27 8.00e-155 540.00
IUUC-Mpo-057442 Magnaporthe poae 50.93 1.00e-143 503.00
IUUC-Mla-058996 Melampsora laricipopulina 51.45 4.00e-147 515.00
IUUC-Mga-059661 Meleagris gallopavo 84.25 0.00e+00 1444.00
IUUC-Mvi-060395 Microbotryum violaceum 50.83 8.00e-148 517.00
IUUC-Mmr-061135 Microcebus murinus 96.73 0.00e+00 1646.00
IUUC-Mdo-062505 Monodelphis domestica 86.88 0.00e+00 1494.00
IUUC-Mmu-063375 Mus musculus 94.79 0.00e+00 1578.00
IUUC-Mpu-066203 Mustela putorius furo 96.58 0.00e+00 1613.00
IUUC-Mlu-067837 Myotis lucifugus 95.79 0.00e+00 1614.00
IUUC-Nfi-068427 Neosartorya fischeri 48.15 2.00e-157 549.00
IUUC-Ncr-068918 Neurospora crassa 46.89 2.00e-151 529.00
IUUC-Nle-069244 Nomascus leucogenys 95.14 0.00e+00 1605.00
IUUC-Opr-070585 Ochotona princeps 89.48 0.00e+00 1553.00
IUUC-Ont-071798 Oreochromis niloticus 87.11 0.00e+00 1135.00
IUUC-Ocu-074298 Oryctolagus cuniculus 95.95 0.00e+00 1607.00
IUUC-Ola-086526 Oryzias latipes 85.07 0.00e+00 1115.00
IUUC-Oga-088167 Otolemur garnettii 90.36 0.00e+00 1510.00
IUUC-Oar-090316 Ovis aries 80.28 0.00e+00 1197.00
IUUC-Ptr-090819 Pan troglodytes 91.35 0.00e+00 1566.00
IUUC-Pan-092454 Papio anubis 95.82 0.00e+00 1617.00
IUUC-Psi-093319 Pelodiscus sinensis 81.86 0.00e+00 1426.00
IUUC-Pno-095118 Phaeosphaeria nodorum 46.92 4.00e-151 528.00
IUUC-Pfo-096937 Poecilia formosa 88.53 0.00e+00 1123.00
IUUC-Pab-097580 Pongo abelii 85.60 0.00e+00 1449.00
IUUC-Pca-100923 Procavia capensis 77.15 0.00e+00 1330.00
IUUC-Pva-103209 Pteropus vampyrus 94.55 0.00e+00 1562.00
IUUC-Pgr-103620 Puccinia graminis 51.04 3.00e-145 508.00
IUUC-Pte-104016 Pyrenophora teres 46.75 1.00e-151 530.00
IUUC-Pyt-104550 Pyrenophora triticirepentis 46.75 1.00e-151 530.00
IUUC-Rno-104924 Rattus norvegicus 94.21 0.00e+00 1581.00
IUUC-Sce-106289 Saccharomyces cerevisiae 48.64 2.00e-161 562.00
IUUC-Sha-107175 Sarcophilus harrisii 87.69 0.00e+00 1491.00
IUUC-Sja-107941 Schizosaccharomyces japonicus 44.81 2.00e-160 559.00
IUUC-Spo-108171 Schizosaccharomyces pombe 50.80 2.00e-162 565.00
IUUC-Ssl-108514 Sclerotinia sclerotiorum 47.17 5.00e-152 531.00
IUUC-Sar-113761 Sorex araneus 86.23 0.00e+00 1486.00
IUUC-Tgu-116632 Taeniopygia guttata 80.09 0.00e+00 1327.00
IUUC-Tru-118442 Takifugu rubripes 88.24 0.00e+00 1112.00
IUUC-Tsy-119198 Tarsius syrichta 89.47 0.00e+00 1501.00
IUUC-Tni-120168 Tetraodon nigroviridis 86.17 0.00e+00 1054.00
IUUC-Tme-126897 Tuber melanosporum 47.33 2.00e-143 502.00
IUUC-Tbe-127756 Tupaia belangeri 76.85 0.00e+00 1287.00
IUUC-Ttr-128504 Tursiops truncatus 89.38 0.00e+00 1170.00
IUUC-Vda-129753 Verticillium dahliae 46.77 4.00e-154 538.00
IUUC-Vpa-130103 Vicugna pacos 81.53 0.00e+00 1375.00
IUUC-Xtr-132885 Xenopus tropicalis 76.35 0.00e+00 1364.00
IUUC-Xma-133987 Xiphophorus maculatus 88.53 0.00e+00 1125.00
Created Date 25-Jun-2017

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