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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-105318
UUCD1 version UUC-RaN-00763
Ensembl Protein ID ENSRNOP00000070352.1
UniProt Accession A0A0G2JXP3; A0A0G2JXP3_RAT
Genbank Protein ID ENSRNOP00000070352
Protein Name Neural precursor cell-expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
Genbank Nucleotide ID AABR07032297
Gene Name Nedd4l
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000017610.7 ENSRNOT00000023890.7 ENSRNOP00000023890.7
ENSRNOG00000017610.7 ENSRNOT00000088624.1 ENSRNOP00000070352.1
ENSRNOG00000017610.7 ENSRNOT00000083363.1 ENSRNOP00000069274.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
TRANSFACRAID2
Post-translational Modifications (PTMs)
dbPAFBioGRID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 4.20e-135 450.8 627 958
Active Site
Position(s) Description Evidence
928 Glycyl thioester intermediate {ECO:0000256|PIRSR:PIRSR001569-1,
ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++ lk+rl++ef+ E+gld+gGv+re+++llske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld 
   Q: 627  PDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDG 715
           57899************************************************************************************ PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
           ++ ++fyk++lgk+++l+d+e+vd+e+y+slk+i+en   d +e  ldl+f+++ee++g+t++++Lkp+G++i+VtneNk+eY++lv++
   Q: 716  FFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILEN---DPTE--LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQ 799
           ***********************************99...6666..7****************************************** PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +++++q++af eGf+e++p++l+++F+e+elell+cG  ++dv+d++++  yk+gy +++p+iqwFw+++  +++e+r ++LqFv
   Q: 800  WRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFV 888
           ***************************************************************************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           Tg+sr+P++Gfael     p+lf+i++++s+++lP+++TCfn+L+LP+Y++ e l+ekLl+A+e+++gFe
   Q: 889  TGTSRVPMNGFAELYgsngPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 958
           *********************************************************************8 PP
   
Organism Rattus norvegicus
Protein Sequence
(Fasta)
QGESRILRVK VVSGLTSPKS EPFPCSDPYV KLSLYVADEN RELALVQTKT IKKTLNPKWN 60
EEFYFRVNPS NHRLLFEVFD ENRLTRDDFL GQVDVPLSHL PTEDPTMERP YTFKDFLLRP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105318|E3,HECT|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTCTTATTGG TGTGTTGCTC TGCCAAAAAG GGGGGTGGGA GGCCTGTCGC GGGCGCGGAG 60
TGACAGGCAG GCTGGATGGA GCAGGTAGGA GTGGTTCACC ATCTGGCGGG GTGCGCGCCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105318|E3,HECT|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom
PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2
Pfam

PF00168--C2
PF00632--HECT
PF00397--WW
SMART

SM00239--C2
SM00119--HECTc
SM00456--WW
Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0019870--F:potassium channel inhibitor activity
GO:0019871--F:sodium channel inhibitor activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:1901017--P:negative regulation of potassium ion transmembrane transporter activity
GO:2000009--P:negative regulation of protein localization to cell surface
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:1903861--P:positive regulation of dendrite extension
GO:0045732--P:positive regulation of protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0006513--P:protein monoubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0003254--P:regulation of membrane depolarization
GO:0060306--P:regulation of membrane repolarization
GO:0010038--P:response to metal ion
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001314 Ailuropoda melanoleuca 95.33 0.00e+00 1699.00
IUUC-Apl-003893 Anas platyrhynchos 93.96 0.00e+00 1701.00
IUUC-Aca-004744 Anolis carolinensis 89.79 0.00e+00 1637.00
IUUC-Ago-007742 Ashbya gossypii 49.08 5.00e-162 565.00
IUUC-Acl-008273 Aspergillus clavatus 49.26 1.00e-163 570.00
IUUC-Afl-008713 Aspergillus flavus 49.01 2.00e-161 562.00
IUUC-Afu-009103 Aspergillus fumigatus 49.02 9.00e-164 570.00
IUUC-Ani-009259 Aspergillus nidulans 49.16 1.00e-161 563.00
IUUC-Ang-009738 Aspergillus niger 49.33 3.00e-162 565.00
IUUC-Aor-010053 Aspergillus oryzae 58.05 1.00e-101 362.00
IUUC-Ate-010529 Aspergillus terreus 49.42 3.00e-164 572.00
IUUC-Ame-010810 Astyanax mexicanus 72.35 0.00e+00 1260.00
IUUC-Bgr-012148 Blumeria graminis 47.91 1.00e-154 540.00
IUUC-Bta-012679 Bos taurus 97.04 0.00e+00 1605.00
IUUC-Bci-013785 Botrytis cinerea 47.99 2.00e-156 546.00
IUUC-Cja-018732 Callithrix jacchus 97.09 0.00e+00 1786.00
IUUC-Cfa-021226 Canis familiaris 96.57 0.00e+00 1783.00
IUUC-Cpo-021671 Cavia porcellus 95.21 0.00e+00 1732.00
IUUC-Csa-023344 Chlorocebus sabaeus 95.20 0.00e+00 1769.00
IUUC-Cho-024832 Choloepus hoffmanni 100.00 0.00e+00 744.00
IUUC-Csv-026098 Ciona savignyi 59.22 0.00e+00 655.00
IUUC-Cgl-026642 Colletotrichum gloeosporioides 47.66 9.00e-156 544.00
IUUC-Cne-026849 Cryptococcus neoformans 48.58 1.00e-158 553.00
IUUC-Dre-027770 Danio rerio 77.62 0.00e+00 1397.00
IUUC-Dno-029466 Dasypus novemcinctus 97.71 0.00e+00 1802.00
IUUC-Dor-030138 Dipodomys ordii 92.62 0.00e+00 1644.00
IUUC-Dse-031241 Dothistroma septosporum 47.86 2.00e-160 559.00
IUUC-Dme-032166 Drosophila melanogaster 67.09 0.00e+00 713.00
IUUC-Ete-033145 Echinops telfairi 89.05 0.00e+00 1285.00
IUUC-Eca-033445 Equus caballus 97.61 0.00e+00 1592.00
IUUC-Eeu-035247 Erinaceus europaeus 88.51 0.00e+00 1497.00
IUUC-Fca-035489 Felis catus 93.90 0.00e+00 1538.00
IUUC-Fal-037604 Ficedula albicollis 91.00 0.00e+00 1691.00
IUUC-Fox-037774 Fusarium oxysporum 48.76 4.00e-159 555.00
IUUC-Fso-038393 Fusarium solani 47.41 3.00e-154 538.00
IUUC-Gmo-039674 Gadus morhua 76.47 0.00e+00 1371.00
IUUC-Ggr-040107 Gaeumannomyces graminis 47.75 2.00e-156 546.00
IUUC-Gga-040703 Gallus gallus 92.70 0.00e+00 1715.00
IUUC-Gac-042020 Gasterosteus aculeatus 79.73 0.00e+00 1399.00
IUUC-Ggo-045332 Gorilla gorilla 96.16 0.00e+00 1730.00
IUUC-Hsa-045968 Homo sapiens 97.09 0.00e+00 1783.00
IUUC-Lch-050443 Latimeria chalumnae 86.88 0.00e+00 1437.00
IUUC-Lpe-050915 Leersia perrieri 44.33 1.00e-91 333.00
IUUC-Loc-052662 Lepisosteus oculatus 79.80 0.00e+00 1414.00
IUUC-Laf-053850 Loxodonta africana 95.73 0.00e+00 1766.00
IUUC-Mcc-055821 Macaca mulatta 96.98 0.00e+00 1776.00
IUUC-Meu-056712 Macropus eugenii 81.61 0.00e+00 771.00
IUUC-Mor-057097 Magnaporthe oryzae 44.54 2.00e-157 549.00
IUUC-Mpo-057442 Magnaporthe poae 52.16 9.00e-146 511.00
IUUC-Mla-058996 Melampsora laricipopulina 47.32 2.00e-155 543.00
IUUC-Mvi-060395 Microbotryum violaceum 53.70 4.00e-150 525.00
IUUC-Mmr-060798 Microcebus murinus 93.25 0.00e+00 1659.00
IUUC-Mdo-062173 Monodelphis domestica 94.18 0.00e+00 1774.00
IUUC-Mmu-064136 Mus musculus 98.54 0.00e+00 1776.00
IUUC-Mpu-066765 Mustela putorius furo 96.56 0.00e+00 1762.00
IUUC-Mlu-067565 Myotis lucifugus 95.00 0.00e+00 1573.00
IUUC-Nfi-068427 Neosartorya fischeri 49.02 6.00e-164 571.00
IUUC-Ncr-068918 Neurospora crassa 47.57 1.00e-157 550.00
IUUC-Nle-069070 Nomascus leucogenys 93.14 0.00e+00 1685.00
IUUC-Opr-071044 Ochotona princeps 96.43 0.00e+00 1202.00
IUUC-Ont-072044 Oreochromis niloticus 77.05 0.00e+00 1428.00
IUUC-Oan-073032 Ornithorhynchus anatinus 92.53 0.00e+00 1441.00
IUUC-Ocu-074160 Oryctolagus cuniculus 93.66 0.00e+00 1709.00
IUUC-Oba-075252 Oryza barthii 44.58 8.00e-91 330.00
IUUC-Oin-079663 Oryza indica 44.58 6.00e-91 331.00
IUUC-Olo-080326 Oryza longistaminata 44.33 6.00e-90 327.00
IUUC-Oni-082342 Oryza nivara 44.58 8.00e-91 330.00
IUUC-Oru-084559 Oryza rufipogon 44.58 6.00e-91 330.00
IUUC-Ola-087467 Oryzias latipes 78.67 0.00e+00 1415.00
IUUC-Oga-088460 Otolemur garnettii 93.39 0.00e+00 1570.00
IUUC-Oar-090198 Ovis aries 95.94 0.00e+00 1748.00
IUUC-Ptr-090939 Pan troglodytes 97.09 0.00e+00 1783.00
IUUC-Pan-092284 Papio anubis 97.19 0.00e+00 1786.00
IUUC-Psi-093645 Pelodiscus sinensis 92.92 0.00e+00 1712.00
IUUC-Pma-094364 Petromyzon marinus 82.63 0.00e+00 862.00
IUUC-Pno-095118 Phaeosphaeria nodorum 48.17 2.00e-164 573.00
IUUC-Pfo-097145 Poecilia formosa 61.48 0.00e+00 1105.00
IUUC-Pab-098088 Pongo abelii 97.19 0.00e+00 1783.00
IUUC-Pca-100714 Procavia capensis 76.68 0.00e+00 1305.00
IUUC-Pva-102354 Pteropus vampyrus 95.61 0.00e+00 1693.00
IUUC-Pgr-103620 Puccinia graminis 53.53 4.00e-148 518.00
IUUC-Ptt-103806 Puccinia triticina 53.38 7.00e-123 434.00
IUUC-Pte-104016 Pyrenophora teres 49.00 3.00e-162 565.00
IUUC-Pyt-104550 Pyrenophora triticirepentis 49.00 3.00e-162 565.00
IUUC-Sce-106289 Saccharomyces cerevisiae 49.25 3.00e-164 572.00
IUUC-Sha-107482 Sarcophilus harrisii 96.60 0.00e+00 1622.00
IUUC-Sja-107786 Schizosaccharomyces japonicus 54.23 2.00e-150 526.00
IUUC-Ssl-108514 Sclerotinia sclerotiorum 48.49 7.00e-158 551.00
IUUC-Stu-112582 Solanum tuberosum 35.81 5.00e-55 209.00
IUUC-Sbi-113794 Sorghum bicolor 44.50 1.00e-92 336.00
IUUC-Ssc-115950 Sus scrofa 71.08 0.00e+00 1182.00
IUUC-Tgu-117130 Taeniopygia guttata 93.24 0.00e+00 1720.00
IUUC-Tru-118610 Takifugu rubripes 79.71 0.00e+00 1444.00
IUUC-Tsy-119492 Tarsius syrichta 92.53 0.00e+00 1642.00
IUUC-Tni-120113 Tetraodon nigroviridis 75.23 0.00e+00 1352.00
IUUC-Tre-122203 Trichoderma reesei 45.12 8.00e-153 534.00
IUUC-Tvi-122595 Trichoderma virens 47.44 1.00e-154 540.00
IUUC-Tme-126897 Tuber melanosporum 52.69 9.00e-148 517.00
IUUC-Tbe-127441 Tupaia belangeri 90.04 0.00e+00 793.00
IUUC-Ttr-128235 Tursiops truncatus 99.28 0.00e+00 1088.00
IUUC-Vda-129753 Verticillium dahliae 47.85 2.00e-157 549.00
IUUC-Xtr-132859 Xenopus tropicalis 88.80 0.00e+00 1648.00
IUUC-Xma-133797 Xiphophorus maculatus 80.70 0.00e+00 1430.00
IUUC-Yli-134668 Yarrowia lipolytica 46.42 3.00e-162 565.00
Created Date 25-Jun-2017

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