iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ncr-068813

Ensembl Protein ID

EAA34194

UniProt Accession

Q9P4Z1; TOM1_NEUCR

Genbank Protein ID

CAB92704.2; EAA34194.3

Protein Name

E3 ubiquitin-protein ligase TOM1-like; HECT-type E3 ubiquitin transferase TOM1-like

Genbank Nucleotide ID

AL356834; CM002237

Gene Name

B11B22.010; NCU08501

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
NCU08501	EAA34194	EAA34194

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.10e-118	395.5	3747	4074

Active Site

Position(s)	Description	Evidence
4043	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 7    krlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfyklllgkkl 105
            +l+++f+gEeg+d+gGvtre+++ ls+++++p++ lf+  ++d++t++pn+ s + n ehl +F+f+Gr++gkal++grll++ +s+++yk++lgk++
   Q: 3747 GKLNIRFQGEEGVDAGGVTREWFQVLSRQMFDPNYVLFVPVSSDRTTFHPNKLSPI-NDEHLPFFKFIGRIIGKALYEGRLLECYFSRAVYKRILGKPV 3844
           5899***************************************************9.56**************************************** PP
   S: 106  sledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviple 204
           s++d+e++dp++yksl +++en   di+++ ++ tfsv+++++ge+k+++L+++G+nipVt+eNk+eYv+l+ve++l +++k q++af  Gf+e+ip+e
   Q: 3845 SVKDMESFDPDYYKSLVWMLEN---DITDI-ITETFSVEDDVFGEVKVVDLIENGRNIPVTEENKHEYVRLIVEHKLITSVKDQMKAFLTGFHEIIPEE 3939
           ********************99...99999.999***************************************************************** PP
   S: 205  llslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelk....prlfvirk.dasddrl 298
           l+++F+e+elelli+G ++id++d+k++t+y++ y++  p+iqwFw+++++f++ee +++LqFvTg+s++Pl+Gf+el+     ++f i++ ++s+drl
   Q: 3940 LIAIFNEQELELLISGLPDIDIDDWKANTEYHN-YSAGAPQIQWFWRAVRSFDKEELAKLLQFVTGTSKVPLNGFKELEgmngVSRFNIHRdYGSKDRL 4037
           *******************************66.*********************************************99996667777769999*** PP
   S: 299  PssnTCfnyLkLPeYsskeilkekLlyAieet.kgFe 334
           Pss+TCfn+L+LPeY+++e+l+++Ll Ai+ + + F+
   Q: 4038 PSSHTCFNQLDLPEYENYETLRSQLLKAITAGsDYFG 4074
           *****************************99866665 PP

Organism

Neurospora crassa

Functional Description
(View)

Probable ubiquitin ligase protein, which may be involved in mRNA export. E3 ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. Participates in mRNA export from the nucleus by regulating the transport of hnRNP proteins.

Protein Sequence
(Fasta)

MGKITKTMQQ KHRDTLSPWL KEFVDTASSA PLPLILQRLD EFPRRWMFPR GDLYHWIPLL 60
NRFDNILESI CATYELSKGP QTRDFGRDVL LNNGGPSLEY RDEPWTVERL AEAGYKEDGD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACCGGATCTC CATCGAAACT TTGCAACTTG CAGGTGCCTT GCCCAACCTC AACAACACCT 60
TCCCGGACCA TCACTCACCT CCACGATCAC GACTCAGAGA CCGACACTCT CAACTACTAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0509--mRNA transport
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0813--Transport
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR025527--DUF4414
IPR010309--E3_Ub_ligase_DUF908
IPR010314--E3_Ub_ligase_DUF913
IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF14377--DUF4414
PF06012--DUF908
PF06025--DUF913
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0051028--P:mRNA transport

KEGG

ncr:NCU08501

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000627	Aegilops tauschii	32.07	4.00e-130	459.00
IUUC-Aml-001684	Ailuropoda melanoleuca	54.37	4.00e-136	479.00
IUUC-Atr-003044	Amborella trichopoda	38.40	1.00e-142	501.00
IUUC-Apl-003729	Anas platyrhynchos	52.11	5.00e-101	358.00
IUUC-Aca-005263	Anolis carolinensis	54.85	2.00e-137	483.00
IUUC-Aly-006157	Arabidopsis lyrata	41.77	2.00e-143	503.00
IUUC-Ath-007160	Arabidopsis thaliana	43.70	5.00e-143	502.00
IUUC-Ago-008005	Ashbya gossypii	56.33	0.00e+00	728.00
IUUC-Acl-008254	Aspergillus clavatus	34.31	0.00e+00	1123.00
IUUC-Afl-008712	Aspergillus flavus	58.94	0.00e+00	1245.00
IUUC-Afu-009022	Aspergillus fumigatus	57.89	0.00e+00	1253.00
IUUC-Ani-009412	Aspergillus nidulans	58.37	0.00e+00	1222.00
IUUC-Ang-009771	Aspergillus niger	58.13	0.00e+00	1256.00
IUUC-Aor-010186	Aspergillus oryzae	56.98	0.00e+00	1215.00
IUUC-Ate-010253	Aspergillus terreus	58.30	0.00e+00	1268.00
IUUC-Ame-011067	Astyanax mexicanus	53.65	1.00e-136	481.00
IUUC-Bgr-012043	Blumeria graminis	38.71	0.00e+00	1410.00
IUUC-Bta-012813	Bos taurus	54.37	4.00e-136	479.00
IUUC-Bci-013995	Botrytis cinerea	39.75	0.00e+00	1494.00
IUUC-Bdi-014884	Brachypodium distachyon	34.65	6.00e-144	504.00
IUUC-Bol-016533	Brassica oleracea	58.55	2.00e-96	343.00
IUUC-Bra-016726	Brassica rapa	41.96	3.00e-145	509.00
IUUC-Cel-018179	Caenorhabditis elegans	52.96	3.00e-132	466.00
IUUC-Cja-018741	Callithrix jacchus	54.25	4.00e-135	476.00
IUUC-Cfa-020083	Canis familiaris	54.37	5.00e-136	479.00
IUUC-Cpo-021923	Cavia porcellus	43.99	1.00e-98	355.00
IUUC-Cre-022900	Chlamydomonas reinhardtii	51.77	3.00e-135	473.00
IUUC-Csa-023853	Chlorocebus sabaeus	54.37	3.00e-136	479.00
IUUC-Cho-024718	Choloepus hoffmanni	57.94	6.00e-126	445.00
IUUC-Cin-025627	Ciona intestinalis	53.74	3.00e-136	479.00
IUUC-Csv-025872	Ciona savignyi	53.66	2.00e-132	464.00
IUUC-Cgl-026647	Colletotrichum gloeosporioides	46.18	0.00e+00	1850.00
IUUC-Cne-027095	Cryptococcus neoformans	43.24	1.00e-159	556.00
IUUC-Cme-027267	Cyanidioschyzon merolae	52.14	2.00e-124	439.00
IUUC-Dre-028525	Danio rerio	53.47	3.00e-123	436.00
IUUC-Dno-029680	Dasypus novemcinctus	54.37	4.00e-136	479.00
IUUC-Dor-030902	Dipodomys ordii	48.94	2.00e-115	410.00
IUUC-Dse-031197	Dothistroma septosporum	53.84	0.00e+00	1125.00
IUUC-Dme-032122	Drosophila melanogaster	53.66	2.00e-132	467.00
IUUC-Eca-033915	Equus caballus	53.79	5.00e-135	476.00
IUUC-Eeu-034963	Erinaceus europaeus	54.01	7.00e-134	472.00
IUUC-Fca-035824	Felis catus	54.37	4.00e-136	479.00
IUUC-Fox-037756	Fusarium oxysporum	45.52	0.00e+00	1790.00
IUUC-Fso-038464	Fusarium solani	46.53	0.00e+00	1847.00
IUUC-Gmo-039073	Gadus morhua	54.37	1.00e-136	481.00
IUUC-Ggr-039946	Gaeumannomyces graminis	47.53	0.00e+00	1938.00
IUUC-Gga-040309	Gallus gallus	59.28	1.00e-107	380.00
IUUC-Gac-042430	Gasterosteus aculeatus	54.37	2.00e-136	480.00
IUUC-Gma-043112	Glycine max	40.50	8.00e-145	508.00
IUUC-Hsa-046879	Homo sapiens	54.37	5.00e-136	479.00
IUUC-Hvu-047697	Hordeum vulgare	34.04	3.00e-151	529.00
IUUC-Itr-048430	Ictidomys tridecemlineatus	54.37	2.00e-136	479.00
IUUC-Kpa-049228	Komagataella pastoris	57.48	0.00e+00	743.00
IUUC-Lch-050252	Latimeria chalumnae	54.72	4.00e-136	479.00
IUUC-Lpe-051550	Leersia perrieri	44.88	7.00e-142	498.00
IUUC-Loc-052472	Lepisosteus oculatus	54.85	2.00e-137	483.00
IUUC-Lma-053159	Leptosphaeria maculans	56.53	0.00e+00	1209.00
IUUC-Laf-054154	Loxodonta africana	54.37	3.00e-136	479.00
IUUC-Mcc-055085	Macaca mulatta	54.37	4.00e-136	479.00
IUUC-Mor-057201	Magnaporthe oryzae	46.37	0.00e+00	1892.00
IUUC-Mpo-057597	Magnaporthe poae	47.00	0.00e+00	1900.00
IUUC-Mtr-057633	Medicago truncatula	39.77	4.00e-145	508.00
IUUC-Mla-058888	Melampsora laricipopulina	56.76	1.00e-143	500.00
IUUC-Mvi-060320	Microbotryum violaceum	50.53	0.00e+00	674.00
IUUC-Mmr-060820	Microcebus murinus	54.37	3.00e-136	479.00
IUUC-Mdo-062930	Monodelphis domestica	54.61	9.00e-137	481.00
IUUC-Mmu-063601	Mus musculus	54.37	5.00e-136	479.00
IUUC-Mac-065229	Musa acuminata	34.79	7.00e-158	551.00
IUUC-Mpu-066653	Mustela putorius furo	54.37	4.00e-136	479.00
IUUC-Mlu-067418	Myotis lucifugus	54.37	3.00e-136	479.00
IUUC-Nfi-068278	Neosartorya fischeri	57.89	0.00e+00	1267.00
IUUC-Nle-069418	Nomascus leucogenys	54.37	5.00e-136	479.00
IUUC-Ont-071300	Oreochromis niloticus	54.37	3.00e-136	479.00
IUUC-Oan-073046	Ornithorhynchus anatinus	54.59	6.00e-136	478.00
IUUC-Ocu-074178	Oryctolagus cuniculus	54.37	2.00e-136	480.00
IUUC-Oba-075757	Oryza barthii	33.73	7.00e-154	538.00
IUUC-Obr-076553	Oryza brachyantha	44.63	1.00e-144	507.00
IUUC-Ogl-077520	Oryza glaberrima	33.73	8.00e-154	538.00
IUUC-Ogu-078278	Oryza glumaepatula	44.12	3.00e-144	506.00
IUUC-Oin-079767	Oryza indica	33.70	5.00e-152	531.00
IUUC-Olo-080380	Oryza longistaminata	32.93	2.00e-148	520.00
IUUC-Ome-081925	Oryza meridionalis	33.47	6.00e-151	528.00
IUUC-Oni-082619	Oryza nivara	33.76	8.00e-154	538.00
IUUC-Opu-083684	Oryza punctata	32.79	2.00e-148	520.00
IUUC-Oru-084501	Oryza rufipogon	33.70	9.00e-152	531.00
IUUC-Osa-086251	Oryza sativa	44.12	5.00e-143	499.00
IUUC-Olu-087813	Ostreococcus lucimarinus	48.40	7.00e-121	425.00
IUUC-Oga-088903	Otolemur garnettii	54.37	5.00e-136	479.00
IUUC-Oar-090210	Ovis aries	54.37	4.00e-136	479.00
IUUC-Pan-092368	Papio anubis	53.73	2.00e-123	437.00
IUUC-Pno-094871	Phaeosphaeria nodorum	56.31	0.00e+00	1197.00
IUUC-Ppa-095834	Physcomitrella patens	39.48	6.00e-145	508.00
IUUC-Pfo-096232	Poecilia formosa	54.37	1.00e-136	481.00
IUUC-Pab-098583	Pongo abelii	54.37	5.00e-136	479.00
IUUC-Ppe-101641	Prunus persica	46.07	4.00e-143	502.00
IUUC-Pva-102116	Pteropus vampyrus	50.59	9.00e-122	431.00
IUUC-Pgr-103465	Puccinia graminis	47.34	0.00e+00	647.00
IUUC-Ptt-103813	Puccinia triticina	44.72	1.00e-170	594.00
IUUC-Pte-104018	Pyrenophora teres	55.83	0.00e+00	1201.00
IUUC-Pyt-104713	Pyrenophora triticirepentis	56.18	0.00e+00	1194.00
IUUC-Sce-106449	Saccharomyces cerevisiae	55.57	0.00e+00	712.00
IUUC-Sha-106961	Sarcophilus harrisii	54.61	1.00e-136	481.00
IUUC-Sja-107814	Schizosaccharomyces japonicus	44.74	0.00e+00	855.00
IUUC-Spo-108024	Schizosaccharomyces pombe	43.65	0.00e+00	867.00
IUUC-Smo-109640	Selaginella moellendorffii	41.29	4.00e-145	509.00
IUUC-Sit-110598	Setaria italica	35.62	4.00e-148	519.00
IUUC-Sly-111706	Solanum lycopersicum	41.11	4.00e-144	505.00
IUUC-Stu-112894	Solanum tuberosum	33.79	7.00e-56	210.00
IUUC-Sar-113291	Sorex araneus	54.57	2.00e-132	467.00
IUUC-Sbi-114042	Sorghum bicolor	33.79	6.00e-155	541.00
IUUC-Sre-114958	Sporisorium reilianum	57.12	5.00e-177	612.00
IUUC-Ssc-115754	Sus scrofa	54.37	4.00e-136	479.00
IUUC-Tru-118570	Takifugu rubripes	54.37	1.00e-136	481.00
IUUC-Tni-120836	Tetraodon nigroviridis	53.43	3.00e-132	466.00
IUUC-Tca-121479	Theobroma cacao	32.30	2.00e-158	553.00
IUUC-Tre-121909	Trichoderma reesei	45.51	0.00e+00	1879.00
IUUC-Tvi-122370	Trichoderma virens	46.09	0.00e+00	1847.00
IUUC-Tae-125214	Triticum aestivum	32.75	7.00e-149	520.00
IUUC-Tur-126774	Triticum urartu	30.40	1.00e-52	199.00
IUUC-Tme-127172	Tuber melanosporum	68.82	0.00e+00	933.00
IUUC-Ttr-129253	Tursiops truncatus	54.37	6.00e-136	479.00
IUUC-Uma-129355	Ustilago maydis	56.95	2.00e-179	620.00
IUUC-Vda-129886	Verticillium dahliae	45.38	0.00e+00	1816.00
IUUC-Vpa-130708	Vicugna pacos	54.37	2.00e-135	477.00
IUUC-Vvi-131078	Vitis vinifera	46.36	9.00e-141	494.00
IUUC-Xtr-132123	Xenopus tropicalis	52.48	1.00e-127	451.00
IUUC-Xma-133869	Xiphophorus maculatus	54.37	1.00e-136	481.00
IUUC-Yli-134657	Yarrowia lipolytica	57.93	0.00e+00	780.00
IUUC-Zma-135570	Zea mays	33.85	6.00e-155	541.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence