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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Sce-106438
UUCD1 version UUC-SaC-00020
Ensembl Protein ID YKL034W
UniProt Accession P36096; D6VXQ1; TUL1_YEAST
Genbank Protein ID CAA49298.1; CAA81869.1; DAA09121.1
Protein Name Transmembrane E3 ubiquitin-protein ligase 1; RING-type E3 ubiquitin transferase TUL1
Genbank Nucleotide ID X71622; Z28034; BK006944
Gene Name TUL1; YKL034W; YKL247
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YKL034W YKL034W YKL034W
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Post-translational Modifications (PTMs)
BioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 17344478; 19394298
Classification
Family E-value Score Start End
E3 activity/RING/RING 6.60e-11 41.0 699 752
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf..............kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           CaiC++d               ++ ++v+pC+Hvfh++Cl++w       + + +CP+Cr
   Q: 699  CAICMSDVpiyieeipethkvdQHSYMVTPCNHVFHTSCLENW------MNYKLQCPVCR 752
           ******9988888887777666445889***************......9999******8 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     E3 ubiquitin ligase protein that mediates ubiquitination of vacuolar proteins such as CPS1, PPN1, PEP12 and other proteins containing exposed hydrophilic residues within their transmembrane domains (TMDs). Ubiquitination of such proteins mediates their sorting into internal vesicles in late endosomes.
 E3 ubiquitin ligase protein that mediates ubiquitination of vacuolar proteins such as CPS1, PPN1, PEP12 and other proteins containing exposed hydrophilic residues within their transmembrane domains (TMDs). Ubiquitination of such proteins mediates their sorting into internal vesicles in late endosomes.
Protein Sequence
(Fasta)
MEIDGNTLVF IIVILFLFFS SPGGDGVSSQ YEFNQLQRLK QQFRTEHNTF VNMTYTDSFR 60
NITGLKLSYQ DMLNNPLQNA TYPLPGKDYD RWFPNQNYMV LPNDVIEAIN TEVWNTSNDD 120
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Protein Fasta Sequence


>IUUC-Sce-106438|E3,RING|Saccharomyces cerevisiae
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Nucleotide Sequence
(Fasta)
ATGGAAATCG ATGGCAACAC TCTGGTGTTC ATAATAGTGA TCCTTTTCCT ATTTTTCTCC 60
TCACCGGGTG GTGATGGTGT GTCTTCTCAA TATGAGTTCA ATCAACTCCA GAGACTCAAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106438|E3,RING|Saccharomyces cerevisiae
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Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0732--Signal
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR024766--Znf_RING_H2
PROSITE

PS50089--ZF_RING_2
Pfam

PF12678--zf-rbx1
SMART

SM00184--RING
Gene Ontology

GO:0044695--C:Dsc E3 ubiquitin ligase complex
GO:0005794--C:Golgi apparatus
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0005634--C:nucleus
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
KEGG sce:YKL034W
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000147 Aegilops tauschii 28.93 7.00e-28 115.00
IUUC-Atr-003038 Amborella trichopoda 30.09 9.00e-39 152.00
IUUC-Aly-006319 Arabidopsis lyrata 28.65 3.00e-35 141.00
IUUC-Ath-007176 Arabidopsis thaliana 28.07 1.00e-35 142.00
IUUC-Ago-007897 Ashbya gossypii 54.00 0.00e+00 853.00
IUUC-Acl-008354 Aspergillus clavatus 26.73 8.00e-56 209.00
IUUC-Afl-008715 Aspergillus flavus 26.15 4.00e-52 197.00
IUUC-Afu-008993 Aspergillus fumigatus 28.03 6.00e-58 217.00
IUUC-Ani-009159 Aspergillus nidulans 26.60 3.00e-54 204.00
IUUC-Ang-009736 Aspergillus niger 26.15 2.00e-54 205.00
IUUC-Aor-010205 Aspergillus oryzae 25.99 6.00e-52 196.00
IUUC-Ate-010380 Aspergillus terreus 26.82 1.00e-55 209.00
IUUC-Bgr-012261 Blumeria graminis 33.84 9.00e-30 123.00
IUUC-Bta-012763 Bos taurus 34.78 2.00e-08 52.40
IUUC-Bci-013822 Botrytis cinerea 34.44 3.00e-33 135.00
IUUC-Bdi-014178 Brachypodium distachyon 27.87 8.00e-36 142.00
IUUC-Bol-015718 Brassica oleracea 27.01 1.00e-33 135.00
IUUC-Bra-017095 Brassica rapa 28.37 3.00e-35 140.00
IUUC-Cel-018589 Caenorhabditis elegans 35.94 4.00e-08 48.50
IUUC-Cre-022642 Chlamydomonas reinhardtii 25.54 1.00e-10 58.20
IUUC-Cgl-026705 Colletotrichum gloeosporioides 33.08 2.00e-35 142.00
IUUC-Cne-027078 Cryptococcus neoformans 28.22 7.00e-17 80.90
IUUC-Cme-027308 Cyanidioschyzon merolae 29.40 3.00e-34 137.00
IUUC-Dre-028637 Danio rerio 35.94 4.00e-08 48.90
IUUC-Dse-031227 Dothistroma septosporum 30.86 6.00e-36 144.00
IUUC-Eeu-035349 Erinaceus europaeus 33.33 1.00e-06 45.80
IUUC-Fox-037716 Fusarium oxysporum 33.21 1.00e-32 132.00
IUUC-Fso-038434 Fusarium solani 34.76 7.00e-21 93.60
IUUC-Gmo-038545 Gadus morhua 30.77 6.00e-08 47.80
IUUC-Ggr-039796 Gaeumannomyces graminis 30.40 1.00e-25 110.00
IUUC-Gga-041003 Gallus gallus 29.51 8.00e-08 47.80
IUUC-Gac-041731 Gasterosteus aculeatus 43.59 4.00e-07 47.80
IUUC-Gma-044142 Glycine max 29.34 1.00e-37 148.00
IUUC-Hvu-047407 Hordeum vulgare 27.17 2.00e-29 121.00
IUUC-Kpa-049246 Komagataella pastoris 33.46 1.00e-114 405.00
IUUC-Lch-050499 Latimeria chalumnae 33.87 5.00e-07 47.80
IUUC-Lpe-050804 Leersia perrieri 26.75 4.00e-30 124.00
IUUC-Loc-052517 Lepisosteus oculatus 30.77 2.00e-08 49.30
IUUC-Lma-052994 Leptosphaeria maculans 28.42 1.00e-31 129.00
IUUC-Mor-057007 Magnaporthe oryzae 26.74 2.00e-32 132.00
IUUC-Mpo-057296 Magnaporthe poae 31.45 4.00e-28 117.00
IUUC-Mtr-057662 Medicago truncatula 30.17 2.00e-39 155.00
IUUC-Mvi-060396 Microbotryum violaceum 33.96 2.00e-22 99.40
IUUC-Mdo-063045 Monodelphis domestica 33.87 3.00e-07 48.10
IUUC-Mac-065213 Musa acuminata 30.75 6.00e-35 140.00
IUUC-Nfi-068252 Neosartorya fischeri 26.99 2.00e-57 215.00
IUUC-Ncr-068860 Neurospora crassa 25.37 5.00e-18 84.70
IUUC-Oba-075543 Oryza barthii 22.59 5.00e-15 73.60
IUUC-Obr-076427 Oryza brachyantha 28.08 1.00e-34 138.00
IUUC-Ogl-077281 Oryza glaberrima 27.59 8.00e-35 139.00
IUUC-Ogu-078135 Oryza glumaepatula 23.57 7.00e-15 73.60
IUUC-Oin-079565 Oryza indica 27.59 8.00e-35 139.00
IUUC-Olo-080765 Oryza longistaminata 26.44 3.00e-29 120.00
IUUC-Ome-081704 Oryza meridionalis 23.57 6.00e-15 73.60
IUUC-Oni-082520 Oryza nivara 22.14 7.00e-14 69.30
IUUC-Opu-083443 Oryza punctata 23.65 3.00e-13 67.80
IUUC-Oru-085261 Oryza rufipogon 22.59 7.00e-15 73.20
IUUC-Osa-085322 Oryza sativa 24.89 1.00e-10 58.90
IUUC-Ola-087147 Oryzias latipes 30.77 6.00e-08 48.10
IUUC-Olu-087584 Ostreococcus lucimarinus 28.61 5.00e-28 115.00
IUUC-Oar-089523 Ovis aries 34.78 3.00e-08 51.60
IUUC-Pno-095138 Phaeosphaeria nodorum 30.19 5.00e-35 141.00
IUUC-Ppa-095903 Physcomitrella patens 28.65 2.00e-35 142.00
IUUC-Pfo-096899 Poecilia formosa 30.77 6.00e-08 48.10
IUUC-Pop-098898 Populus trichocarpa 30.17 2.00e-41 161.00
IUUC-Pca-100472 Procavia capensis 33.80 3.00e-07 48.50
IUUC-Ppe-102081 Prunus persica 29.60 9.00e-40 155.00
IUUC-Pgr-103658 Puccinia graminis 63.89 1.00e-11 63.20
IUUC-Ptt-103835 Puccinia triticina 24.12 5.00e-11 61.20
IUUC-Pte-104066 Pyrenophora teres 29.14 2.00e-13 70.50
IUUC-Pyt-104574 Pyrenophora triticirepentis 28.52 4.00e-29 121.00
IUUC-Sja-107916 Schizosaccharomyces japonicus 38.71 4.00e-10 57.40
IUUC-Spo-108066 Schizosaccharomyces pombe 28.26 2.00e-38 152.00
IUUC-Ssl-108517 Sclerotinia sclerotiorum 23.96 4.00e-30 124.00
IUUC-Smo-109376 Selaginella moellendorffii 29.80 1.00e-34 139.00
IUUC-Sit-109719 Setaria italica 27.30 4.00e-35 140.00
IUUC-Sly-111887 Solanum lycopersicum 28.74 3.00e-40 157.00
IUUC-Stu-112706 Solanum tuberosum 29.18 7.00e-36 143.00
IUUC-Sbi-114347 Sorghum bicolor 27.01 1.00e-34 139.00
IUUC-Sre-114925 Sporisorium reilianum 28.57 1.00e-11 63.20
IUUC-Ssc-115345 Sus scrofa 27.47 1.00e-07 49.30
IUUC-Tgu-117105 Taeniopygia guttata 35.59 6.00e-08 47.40
IUUC-Tru-118255 Takifugu rubripes 29.58 5.00e-08 48.10
IUUC-Tni-120104 Tetraodon nigroviridis 29.36 2.00e-07 47.80
IUUC-Tca-121160 Theobroma cacao 28.57 2.00e-33 135.00
IUUC-Tre-121878 Trichoderma reesei 32.83 5.00e-38 150.00
IUUC-Tvi-122299 Trichoderma virens 32.33 5.00e-38 150.00
IUUC-Tae-125659 Triticum aestivum 27.59 2.00e-35 141.00
IUUC-Tur-126740 Triticum urartu 24.68 3.00e-23 100.00
IUUC-Tme-126915 Tuber melanosporum 28.48 5.00e-67 247.00
IUUC-Uma-129430 Ustilago maydis 26.53 2.00e-20 92.40
IUUC-Vda-129918 Verticillium dahliae 29.28 2.00e-29 122.00
IUUC-Vvi-131478 Vitis vinifera 29.31 5.00e-38 150.00
IUUC-Xma-134115 Xiphophorus maculatus 30.77 6.00e-08 48.10
IUUC-Yli-134449 Yarrowia lipolytica 28.90 2.00e-73 268.00
IUUC-Zma-135016 Zea mays 23.21 6.00e-15 73.60
Created Date 25-Jun-2017

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