iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ncr-068844

Ensembl Protein ID

EAA29275

UniProt Accession

Q7S1P9; RAD5_NEUCR

Genbank Protein ID

EAA29275.2

Protein Name

DNA repair protein rad5; Mutagen-sensitive protein 41

Genbank Nucleotide ID

CM002238

Gene Name

mus-41; rad5; NCU09516

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
NCU09516	EAA29275	EAA29275

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	32.41	6.00e-136	483.00	IUUC-Ath-007517
E3 activity/RING/RING	33.71	6.00e-150	526.00	IUUC-Sce-106396
E3 activity/RING/RING	38.31	0.00e+00	662.00	IUUC-Spo-108026

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Neurospora crassa

Functional Description
(View)

Probable helicase, member of the UBC2/RAD6 epistasis group. Functions with DNA repair protein uvs-2/rad18 in error-free postreplication DNA repair. Involved in the maintenance of wild-type rates of instability of simple repetitive sequences such as poly(GT) repeats. Seems to be involved in maintaining a balance which acts in favor of error-prone non-homologous joining during DNA double-strand breaks repairs (By similarity).

Protein Sequence
(Fasta)

MDRHDTMDFT NEPLSKKRRF LGDQGDSDHV AGGPSSSPQF SAPPSSPPRK KLLQDPNSEV 60
QPRVSKDADH NDDDDDDDDD DDEERPRFFT DDGTLTPHAT KICAPWLNDM PKPDPRKGYL 120

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Nucleotide Sequence
(Fasta)

CCAAAGTTTC ACGGTTGCCA CGGCACAGTC GCGTCTCACA GGCGCAACAC TGAAGTTCAC 60
CATTGCAGTT GGTGCATTCG AGTCGGTTGG GTGACAGTAG CTGACTGATA CCGTACACCC 120

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Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0347--Helicase
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR014905--HIRAN
IPR027417--P-loop_NTPase
IPR000330--SNF2_N
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER
PS50089--ZF_RING_2

Pfam

PF00271--Helicase_C
PF08797--HIRAN
PF00176--SNF2_N
PF00097--zf-C3HC4

SMART

SM00487--DEXDc
SM00490--HELICc
SM00910--HIRAN

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0003677--F:DNA binding
GO:0004386--F:helicase activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair

KEGG

ncr:NCU09516

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000167	Aegilops tauschii	32.31	5.00e-122	430.00
IUUC-Atr-003139	Amborella trichopoda	32.84	9.00e-133	466.00
IUUC-Aly-006331	Arabidopsis lyrata	31.99	3.00e-132	464.00
IUUC-Ath-007517	Arabidopsis thaliana	32.22	1.00e-134	472.00
IUUC-Ago-007997	Ashbya gossypii	34.13	6.00e-138	483.00
IUUC-Acl-008022	Aspergillus clavatus	54.65	0.00e+00	1139.00
IUUC-Afl-008514	Aspergillus flavus	52.45	0.00e+00	1119.00
IUUC-Afu-009055	Aspergillus fumigatus	55.46	0.00e+00	1151.00
IUUC-Ani-009340	Aspergillus nidulans	53.07	0.00e+00	1073.00
IUUC-Ang-009785	Aspergillus niger	53.27	0.00e+00	1109.00
IUUC-Aor-010158	Aspergillus oryzae	52.45	0.00e+00	1119.00
IUUC-Ate-010536	Aspergillus terreus	53.82	0.00e+00	1068.00
IUUC-Bgr-012147	Blumeria graminis	60.02	0.00e+00	1249.00
IUUC-Bci-013741	Botrytis cinerea	64.95	0.00e+00	1371.00
IUUC-Bdi-014646	Brachypodium distachyon	36.68	2.00e-129	455.00
IUUC-Bol-015995	Brassica oleracea	33.30	2.00e-134	471.00
IUUC-Bra-017004	Brassica rapa	36.30	2.00e-128	451.00
IUUC-Cre-022824	Chlamydomonas reinhardtii	26.29	6.00e-51	194.00
IUUC-Csv-026168	Ciona savignyi	25.33	1.00e-50	192.00
IUUC-Cgl-026606	Colletotrichum gloeosporioides	61.64	0.00e+00	1426.00
IUUC-Cne-026886	Cryptococcus neoformans	35.02	2.00e-174	605.00
IUUC-Cme-027110	Cyanidioschyzon merolae	32.35	4.00e-94	338.00
IUUC-Dre-027867	Danio rerio	35.48	4.00e-92	330.00
IUUC-Dor-030651	Dipodomys ordii	33.44	3.00e-39	155.00
IUUC-Dse-031471	Dothistroma septosporum	57.07	0.00e+00	1197.00
IUUC-Fal-037486	Ficedula albicollis	27.89	3.00e-59	221.00
IUUC-Fox-038039	Fusarium oxysporum	65.04	0.00e+00	1397.00
IUUC-Fso-038179	Fusarium solani	67.53	0.00e+00	1392.00
IUUC-Ggr-039735	Gaeumannomyces graminis	65.97	0.00e+00	1382.00
IUUC-Gma-042995	Glycine max	32.41	1.00e-133	469.00
IUUC-Hvu-047747	Hordeum vulgare	32.24	3.00e-125	441.00
IUUC-Kpa-049087	Komagataella pastoris	33.30	9.00e-141	492.00
IUUC-Lpe-051123	Leersia perrieri	33.37	6.00e-130	456.00
IUUC-Loc-052785	Lepisosteus oculatus	35.37	3.00e-94	338.00
IUUC-Lma-052956	Leptosphaeria maculans	57.68	0.00e+00	1193.00
IUUC-Mor-057210	Magnaporthe oryzae	61.97	0.00e+00	1347.00
IUUC-Mpo-057407	Magnaporthe poae	65.17	0.00e+00	1432.00
IUUC-Mtr-058565	Medicago truncatula	31.84	6.00e-130	456.00
IUUC-Mla-058867	Melampsora laricipopulina	34.35	8.00e-84	303.00
IUUC-Mvi-060322	Microbotryum violaceum	35.44	5.00e-131	460.00
IUUC-Mac-064548	Musa acuminata	31.97	7.00e-120	423.00
IUUC-Nfi-068354	Neosartorya fischeri	55.08	0.00e+00	1143.00
IUUC-Ont-071782	Oreochromis niloticus	33.84	3.00e-87	315.00
IUUC-Oba-075316	Oryza barthii	33.23	2.00e-123	435.00
IUUC-Obr-076403	Oryza brachyantha	36.11	2.00e-124	438.00
IUUC-Ogl-077573	Oryza glaberrima	33.62	1.00e-129	456.00
IUUC-Ogu-078083	Oryza glumaepatula	32.68	4.00e-129	454.00
IUUC-Oin-079146	Oryza indica	33.62	3.00e-129	454.00
IUUC-Olo-080615	Oryza longistaminata	34.19	1.00e-132	465.00
IUUC-Ome-081448	Oryza meridionalis	32.56	2.00e-117	415.00
IUUC-Oni-082773	Oryza nivara	32.68	1.00e-128	452.00
IUUC-Opu-083675	Oryza punctata	33.27	7.00e-133	466.00
IUUC-Oru-084543	Oryza rufipogon	32.68	2.00e-127	449.00
IUUC-Osa-085686	Oryza sativa	36.11	1.00e-124	438.00
IUUC-Pan-091844	Papio anubis	33.89	5.00e-40	158.00
IUUC-Pno-094916	Phaeosphaeria nodorum	57.72	0.00e+00	1195.00
IUUC-Ppa-095877	Physcomitrella patens	35.89	6.00e-128	450.00
IUUC-Pop-099320	Populus trichocarpa	34.43	2.00e-127	448.00
IUUC-Ppe-101820	Prunus persica	32.25	2.00e-128	451.00
IUUC-Pgr-103454	Puccinia graminis	35.21	2.00e-128	451.00
IUUC-Ptt-103829	Puccinia triticina	33.50	6.00e-136	477.00
IUUC-Pte-104242	Pyrenophora teres	54.93	0.00e+00	1213.00
IUUC-Pyt-104728	Pyrenophora triticirepentis	59.86	0.00e+00	1190.00
IUUC-Sce-106396	Saccharomyces cerevisiae	37.55	5.00e-138	483.00
IUUC-Sja-107985	Schizosaccharomyces japonicus	40.69	0.00e+00	693.00
IUUC-Spo-108026	Schizosaccharomyces pombe	38.24	0.00e+00	665.00
IUUC-Ssl-108388	Sclerotinia sclerotiorum	64.57	0.00e+00	1393.00
IUUC-Sit-110076	Setaria italica	35.56	2.00e-125	441.00
IUUC-Sly-111031	Solanum lycopersicum	33.41	5.00e-130	457.00
IUUC-Stu-112600	Solanum tuberosum	33.19	2.00e-129	455.00
IUUC-Sbi-113927	Sorghum bicolor	35.88	3.00e-123	434.00
IUUC-Sre-115131	Sporisorium reilianum	39.93	6.00e-151	526.00
IUUC-Tca-121137	Theobroma cacao	32.99	7.00e-133	466.00
IUUC-Tre-121896	Trichoderma reesei	65.90	0.00e+00	1343.00
IUUC-Tvi-122597	Trichoderma virens	65.32	0.00e+00	1373.00
IUUC-Tae-123334	Triticum aestivum	36.40	8.00e-129	453.00
IUUC-Tur-125999	Triticum urartu	36.34	3.00e-121	427.00
IUUC-Tme-126953	Tuber melanosporum	52.11	0.00e+00	1010.00
IUUC-Tbe-127642	Tupaia belangeri	32.77	5.00e-32	131.00
IUUC-Uma-129629	Ustilago maydis	39.52	7.00e-154	536.00
IUUC-Vda-129849	Verticillium dahliae	59.58	0.00e+00	1338.00
IUUC-Vvi-131508	Vitis vinifera	33.62	7.00e-126	443.00
IUUC-Yli-134588	Yarrowia lipolytica	35.21	6.00e-173	599.00
IUUC-Zma-135801	Zea mays	35.77	2.00e-120	425.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence