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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Sce-106215
UUCD1 version UUC-SaC-00165
Ensembl Protein ID YLR323C
UniProt Accession P53769; D6VYW5; CWC24_YEAST
Genbank Protein ID AAB64511.1; DAA09631.1
Protein Name Pre-mRNA-splicing factor CWC24; Complexed with CEF1 protein 24
Genbank Nucleotide ID U20618; BK006945
Gene Name CWC24; YLR323C; L8543.3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YLR323C YLR323C YLR323C
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDB
Post-translational Modifications (PTMs)
dbPAFdbPTMUniProtPHOSIDA
BioGRID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 1.00e-05 24.4 199 236
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           C +C+ed+k  p+v++CgH f+ +C+ k        +k  +C +C
   Q: 199  CTLCKEDYKS-PVVTNCGHYFCGSCFAKD------MKKGTKCFIC 236
           9*******99.999************555......5666667777 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Belongs to the CWC complex (or CEF1-associated complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1, CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2.
 Belongs to the CWC complex (or CEF1-associated complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1, CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2.
Protein Sequence
(Fasta)
MFRKRLVNKS SSDEKNQKKR QKINFSEEKL VASDEEKGSS DLMSLAKSGN SRTLQLSHEN 60
EGKLQKKGED LDKYTLTVND DSTKEDLLNF ERKELAEKAK KRRPSDDNEL VLNMSGKNKR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106215|E3,RING|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGTTCAGAA AGAGATTAGT GAACAAAAGC TCTTCTGATG AAAAGAACCA GAAAAAGAGG 60
CAGAAAATTA ATTTTAGCGA AGAGAAACTA GTGGCCAGCG ATGAAGAAAA GGGTTCCAGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106215|E3,RING|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0747--Spliceosome
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000571--Znf_CCCH
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50103--ZF_C3H1
PS50089--ZF_RING_2
Pfam

PF00642--zf-CCCH
SMART

SM00184--RING
SM00356--ZnF_C3H1
Gene Ontology

GO:0005634--C:nucleus
GO:0005681--C:spliceosomal complex
GO:0005684--C:U2-type spliceosomal complex
GO:0003677--F:DNA binding
GO:0008270--F:zinc ion binding
GO:0000349--P:generation of catalytic spliceosome for first transesterification step
GO:0045292--P:mRNA cis splicing, via spliceosome
GO:0000398--P:mRNA splicing, via spliceosome
GO:0034247--P:snoRNA splicing
KEGG sce:YLR323C
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000118 Aegilops tauschii 42.86 3.00e-34 137.00
IUUC-Aml-002002 Ailuropoda melanoleuca 42.14 4.00e-36 143.00
IUUC-Atr-003145 Amborella trichopoda 38.82 9.00e-32 128.00
IUUC-Apl-003440 Anas platyrhynchos 47.97 8.00e-37 145.00
IUUC-Aca-004421 Anolis carolinensis 47.15 2.00e-36 143.00
IUUC-Aly-006121 Arabidopsis lyrata 40.82 2.00e-34 137.00
IUUC-Ath-007493 Arabidopsis thaliana 41.50 5.00e-34 135.00
IUUC-Ago-007731 Ashbya gossypii 56.41 3.00e-45 172.00
IUUC-Acl-008186 Aspergillus clavatus 39.45 1.00e-39 154.00
IUUC-Afl-008484 Aspergillus flavus 42.28 4.00e-33 133.00
IUUC-Afu-008971 Aspergillus fumigatus 38.39 1.00e-39 154.00
IUUC-Ani-009499 Aspergillus nidulans 44.59 2.00e-36 144.00
IUUC-Ang-009717 Aspergillus niger 45.00 9.00e-34 135.00
IUUC-Aor-009898 Aspergillus oryzae 42.31 5.00e-33 132.00
IUUC-Ate-010508 Aspergillus terreus 42.38 2.00e-34 137.00
IUUC-Ame-011925 Astyanax mexicanus 45.59 4.00e-38 149.00
IUUC-Bgr-012259 Blumeria graminis 45.58 6.00e-38 149.00
IUUC-Bta-012958 Bos taurus 42.86 7.00e-38 149.00
IUUC-Bci-013882 Botrytis cinerea 45.16 4.00e-39 153.00
IUUC-Bdi-014084 Brachypodium distachyon 43.36 1.00e-34 138.00
IUUC-Bol-016607 Brassica oleracea 41.78 5.00e-34 136.00
IUUC-Bra-017747 Brassica rapa 41.78 3.00e-34 136.00
IUUC-Cel-018698 Caenorhabditis elegans 39.46 2.00e-29 121.00
IUUC-Cja-019434 Callithrix jacchus 42.86 2.00e-36 144.00
IUUC-Cfa-020902 Canis familiaris 42.86 2.00e-36 144.00
IUUC-Cpo-021645 Cavia porcellus 37.50 1.00e-06 45.10
IUUC-Cre-022885 Chlamydomonas reinhardtii 41.10 7.00e-30 122.00
IUUC-Csa-023933 Chlorocebus sabaeus 42.34 2.00e-33 134.00
IUUC-Cho-024587 Choloepus hoffmanni 48.24 6.00e-24 102.00
IUUC-Cin-025328 Ciona intestinalis 41.43 8.00e-34 135.00
IUUC-Csv-026148 Ciona savignyi 45.04 3.00e-36 143.00
IUUC-Cgl-026700 Colletotrichum gloeosporioides 41.61 9.00e-32 128.00
IUUC-Cne-026816 Cryptococcus neoformans 36.54 6.00e-34 135.00
IUUC-Dre-027744 Danio rerio 42.86 2.00e-38 150.00
IUUC-Dse-031155 Dothistroma septosporum 50.36 5.00e-37 145.00
IUUC-Dme-031788 Drosophila melanogaster 46.76 6.00e-36 142.00
IUUC-Ete-033013 Echinops telfairi 43.07 2.00e-35 140.00
IUUC-Eca-033460 Equus caballus 42.86 1.00e-36 144.00
IUUC-Fca-035525 Felis catus 42.86 1.00e-36 144.00
IUUC-Fal-037206 Ficedula albicollis 45.19 3.00e-37 146.00
IUUC-Fox-037959 Fusarium oxysporum 40.00 7.00e-31 125.00
IUUC-Fso-038348 Fusarium solani 45.00 8.00e-34 135.00
IUUC-Gmo-038718 Gadus morhua 38.67 3.00e-35 140.00
IUUC-Ggr-040114 Gaeumannomyces graminis 44.38 9.00e-39 151.00
IUUC-Gga-041037 Gallus gallus 46.04 3.00e-38 150.00
IUUC-Gac-042103 Gasterosteus aculeatus 41.10 2.00e-36 144.00
IUUC-Gma-043581 Glycine max 39.22 3.00e-34 136.00
IUUC-Ggo-044906 Gorilla gorilla 42.86 2.00e-36 144.00
IUUC-Hsa-047000 Homo sapiens 42.86 2.00e-36 144.00
IUUC-Hvu-047578 Hordeum vulgare 35.45 1.00e-16 76.60
IUUC-Itr-048102 Ictidomys tridecemlineatus 42.14 4.00e-36 143.00
IUUC-Kpa-049320 Komagataella pastoris 51.30 6.00e-41 158.00
IUUC-Lch-050488 Latimeria chalumnae 43.17 5.00e-37 146.00
IUUC-Lpe-051156 Leersia perrieri 38.67 3.00e-29 120.00
IUUC-Loc-052670 Lepisosteus oculatus 42.86 2.00e-38 150.00
IUUC-Lma-053326 Leptosphaeria maculans 43.37 5.00e-40 156.00
IUUC-Laf-053570 Loxodonta africana 41.43 5.00e-36 142.00
IUUC-Mcc-055375 Macaca mulatta 42.86 2.00e-36 144.00
IUUC-Meu-056191 Macropus eugenii 45.26 1.00e-37 148.00
IUUC-Mor-057193 Magnaporthe oryzae 42.77 2.00e-36 144.00
IUUC-Mpo-057603 Magnaporthe poae 42.24 5.00e-38 149.00
IUUC-Mtr-058182 Medicago truncatula 41.50 2.00e-33 134.00
IUUC-Mla-058921 Melampsora laricipopulina 43.48 3.00e-26 108.00
IUUC-Mga-059281 Meleagris gallopavo 45.93 8.00e-38 148.00
IUUC-Mvi-060317 Microbotryum violaceum 44.03 8.00e-30 122.00
IUUC-Mmr-061744 Microcebus murinus 43.57 2.00e-36 144.00
IUUC-Mdo-062958 Monodelphis domestica 37.78 3.00e-06 43.10
IUUC-Mmu-063426 Mus musculus 43.17 3.00e-37 146.00
IUUC-Mac-065265 Musa acuminata 39.86 8.00e-30 122.00
IUUC-Mpu-066867 Mustela putorius furo 42.86 1.00e-36 144.00
IUUC-Mlu-067828 Myotis lucifugus 43.17 1.00e-36 144.00
IUUC-Nfi-068575 Neosartorya fischeri 37.05 1.00e-35 141.00
IUUC-Ncr-068828 Neurospora crassa 41.45 9.00e-32 129.00
IUUC-Nle-069137 Nomascus leucogenys 42.86 2.00e-36 144.00
IUUC-Ont-071497 Oreochromis niloticus 45.26 3.00e-38 150.00
IUUC-Oan-073182 Ornithorhynchus anatinus 41.43 5.00e-36 142.00
IUUC-Ocu-073949 Oryctolagus cuniculus 43.80 1.00e-35 141.00
IUUC-Oba-075693 Oryza barthii 40.14 3.00e-30 123.00
IUUC-Obr-076128 Oryza brachyantha 38.26 3.00e-29 120.00
IUUC-Ogl-077323 Oryza glaberrima 40.14 3.00e-30 123.00
IUUC-Ogu-078766 Oryza glumaepatula 40.14 3.00e-30 123.00
IUUC-Oin-080054 Oryza indica 40.14 3.00e-30 123.00
IUUC-Olo-080325 Oryza longistaminata 37.78 2.00e-25 107.00
IUUC-Ome-081331 Oryza meridionalis 40.14 2.00e-30 124.00
IUUC-Oni-082786 Oryza nivara 40.14 3.00e-30 123.00
IUUC-Opu-083855 Oryza punctata 40.14 3.00e-30 123.00
IUUC-Oru-084304 Oryza rufipogon 40.14 3.00e-30 123.00
IUUC-Osa-086166 Oryza sativa 39.46 3.00e-30 123.00
IUUC-Ola-086368 Oryzias latipes 46.51 7.00e-37 145.00
IUUC-Olu-087624 Ostreococcus lucimarinus 40.62 5.00e-32 128.00
IUUC-Oga-088080 Otolemur garnettii 42.86 2.00e-36 144.00
IUUC-Oar-089545 Ovis aries 42.86 1.00e-37 148.00
IUUC-Ptr-090827 Pan troglodytes 42.86 2.00e-36 144.00
IUUC-Pan-092245 Papio anubis 42.86 2.00e-36 144.00
IUUC-Psi-093790 Pelodiscus sinensis 44.29 6.00e-38 148.00
IUUC-Pma-094326 Petromyzon marinus 44.60 8.00e-37 145.00
IUUC-Pno-095057 Phaeosphaeria nodorum 42.67 1.00e-37 147.00
IUUC-Ppa-095690 Physcomitrella patens 41.01 4.00e-33 133.00
IUUC-Pfo-097026 Poecilia formosa 42.03 6.00e-37 145.00
IUUC-Pab-098689 Pongo abelii 42.86 2.00e-36 144.00
IUUC-Pop-100044 Populus trichocarpa 40.38 2.00e-08 51.60
IUUC-Pca-100687 Procavia capensis 43.17 4.00e-35 139.00
IUUC-Ppe-101155 Prunus persica 41.10 4.00e-34 136.00
IUUC-Pgr-103440 Puccinia graminis 33.81 5.00e-36 142.00
IUUC-Ptt-103893 Puccinia triticina 30.39 2.00e-21 94.00
IUUC-Pte-104377 Pyrenophora teres 43.71 1.00e-36 144.00
IUUC-Pyt-104731 Pyrenophora triticirepentis 43.71 1.00e-36 144.00
IUUC-Rno-105967 Rattus norvegicus 42.86 7.00e-37 145.00
IUUC-Sha-107587 Sarcophilus harrisii 42.86 2.00e-34 137.00
IUUC-Sja-107955 Schizosaccharomyces japonicus 45.07 7.00e-36 142.00
IUUC-Spo-108336 Schizosaccharomyces pombe 34.48 2.00e-37 148.00
IUUC-Smo-108930 Selaginella moellendorffii 42.86 4.00e-35 139.00
IUUC-Sit-110234 Setaria italica 40.14 4.00e-30 123.00
IUUC-Sly-111790 Solanum lycopersicum 39.19 2.00e-33 133.00
IUUC-Stu-111994 Solanum tuberosum 40.28 2.00e-34 137.00
IUUC-Sar-113374 Sorex araneus 44.53 2.00e-36 144.00
IUUC-Sbi-114766 Sorghum bicolor 40.40 4.00e-32 129.00
IUUC-Sre-115021 Sporisorium reilianum 45.93 1.00e-36 144.00
IUUC-Ssc-115474 Sus scrofa 42.86 1.00e-36 145.00
IUUC-Tgu-116649 Taeniopygia guttata 45.00 6.00e-38 149.00
IUUC-Tru-117701 Takifugu rubripes 45.32 3.00e-38 149.00
IUUC-Tni-120607 Tetraodon nigroviridis 44.60 1.00e-36 144.00
IUUC-Tca-121278 Theobroma cacao 37.76 8.00e-29 119.00
IUUC-Tre-122006 Trichoderma reesei 39.19 2.00e-30 124.00
IUUC-Tvi-122670 Trichoderma virens 42.76 1.00e-35 141.00
IUUC-Tae-122716 Triticum aestivum 43.36 4.00e-34 136.00
IUUC-Tur-126208 Triticum urartu 41.72 6.00e-34 135.00
IUUC-Tme-126908 Tuber melanosporum 48.18 9.00e-38 148.00
IUUC-Tbe-127394 Tupaia belangeri 42.86 2.00e-36 144.00
IUUC-Uma-129339 Ustilago maydis 45.71 5.00e-36 142.00
IUUC-Vda-129895 Verticillium dahliae 46.67 9.00e-38 148.00
IUUC-Vpa-130519 Vicugna pacos 41.43 1.00e-35 141.00
IUUC-Vvi-131382 Vitis vinifera 35.81 1.00e-28 118.00
IUUC-Xtr-131923 Xenopus tropicalis 44.29 5.00e-38 149.00
IUUC-Xma-133705 Xiphophorus maculatus 41.43 3.00e-37 146.00
IUUC-Yli-134518 Yarrowia lipolytica 38.59 3.00e-34 136.00
IUUC-Zma-135029 Zea mays 40.29 3.00e-29 120.00
Created Date 25-Jun-2017

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