iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
iRefIndex	PINA	HINT	Mentha
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	20152813

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	7.00e-06	26.9	18	86
E3 activity/RING/RING	2.00e-09	38.7	21	75

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 5    eflCpIslelMrdPvvlpsGitydrssIekwl.asggk...............tcPvtrqplteedlvPn 58
           +f C I l+  rdPvv+ +G+ +   +I+kw  a +++               +cPv+++ ++e +lvP 
   Q: 18   DFDCNICLDQVRDPVVTLCGHLFCWPCIHKWTyA-SNNsrqrvdqydhkreppKCPVCKSDVSEATLVPI 86
           69******************************63.3333678999************************7 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkw..........pglknssskefrCPlCr 46
           C iCl+  +d p+v+ CgH+f+  C++kw          +++++ ++   +CP+C+
   Q: 21   CNICLDQVRD-PVVTLCGHLFCWPCIHKWtyasnnsrqrVDQYDHKREPPKCPVCK 75
           99********.999***************9888888888777778888888****7 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of the auxin-binding protein ERABP1.

Protein Sequence
(Fasta)

MEIEKDEDDT TLVDSGGDFD CNICLDQVRD PVVTLCGHLF CWPCIHKWTY ASNNSRQRVD 60
QYDHKREPPK CPVCKSDVSE ATLVPIYGRG QKAPQSGSNV PSRPTGPVYD LRGVGQRLGE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTTTTTTCA ACATACAATT TTATTCAAAC TAAAATAAAT ATTTTTCTAT AAATATATAT 60
TTAGTTGTGT ATAAATAATT ATATTATCTT GTTTACTTTT TTTTAAAACG ATGCTATCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR027370--Znf-RING_LisH
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13445--zf-RING_UBOX

SMART

SM00184--RING

Gene Ontology

GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0005783--C:endoplasmic reticulum
GO:0016021--C:integral component of membrane
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:0044390--F:ubiquitin-like protein conjugating enzyme binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0071712--P:ER-associated misfolded protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

ath:AT4G28270

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-005578	Arabidopsis lyrata	94.97	3.00e-100	356.00
IUUC-Bci-013671	Botrytis cinerea	33.68	1.00e-10	60.50
IUUC-Bol-016203	Brassica oleracea	82.97	7.00e-87	311.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence