iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Spo-108177

Ensembl Protein ID

SPBC4B4.10c.1:pep

UniProt Accession

O74971; ATG5_SCHPO

Genbank Protein ID

CAA19290.1

Protein Name

Autophagy protein 5; Meiotically up-regulated gene 77 protein

Genbank Nucleotide ID

CU329671

Gene Name

atg5; mug77; SPBC4B4.10c

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPBC4B4.10c	SPBC4B4.10c.1	SPBC4B4.10c.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
iRefIndex
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/Other	26.83	2.00e-18	87.40	IUUC-Sce-106216

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Schizosaccharomyces pombe

Functional Description
(View)

Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with atg12, through a ubiquitin-like conjugating system involving atg7 as an E1-like activating enzyme and atg10 as an E2-like conjugating enzyme, is essential for its function. The atg12-atg5 conjugate acts as an E3-like enzyme which is required for lipidation of atg8 and atg8 association to the vesicle membranes (By similarity). Has a role in meiosis and sporulation.

Protein Sequence
(Fasta)

MNVDNNKGNI PELLWNGTIS VRIDYEGNSL AYLANVPRQS YFAQILPNVQ RLLAPSIPLS 60
ECWLDYNGVP LKWHWPVGLL FDLLTVFDPD TPRAPVLWRI QLRSGLFPTT KILQMETMDT 120

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Nucleotide Sequence
(Fasta)

AAGTCCCTTG AATATCTCAA ACTTCTACTT CCGAAAAGTC ATTACGTGTC TATTAACTAA 60
TCAATACAGT GAATCTACAA ATTCCTAATT GCGGTTTTTG TATAGCAGGA ACTCGTATTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0469--Meiosis
KW-0472--Membrane
KW-0539--Nucleus
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0832--Ubl conjugation

Interpro

IPR007239--Atg5

Pfam

PF04106--APG5

Gene Ontology

GO:0034274--C:Atg12-Atg5-Atg16 complex
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0000407--C:pre-autophagosomal structure
GO:0034045--C:pre-autophagosomal structure membrane
GO:0000045--P:autophagosome assembly
GO:0006914--P:autophagy
GO:0006501--P:C-terminal protein lipidation
GO:0006995--P:cellular response to nitrogen starvation
GO:0016236--P:macroautophagy
GO:0051321--P:meiotic cell cycle
GO:0000422--P:mitophagy
GO:0044804--P:nucleophagy
GO:0015031--P:protein transport

KEGG

spo:SPBC4B4.10c

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000583	Aegilops tauschii	28.06	1.00e-14	73.60
IUUC-Aml-002403	Ailuropoda melanoleuca	27.89	3.00e-20	90.10
IUUC-Atr-002645	Amborella trichopoda	26.49	4.00e-17	80.10
IUUC-Apl-003611	Anas platyrhynchos	27.31	2.00e-22	97.10
IUUC-Aca-004411	Anolis carolinensis	26.59	6.00e-19	85.90
IUUC-Aly-005636	Arabidopsis lyrata	33.03	4.00e-15	73.20
IUUC-Ath-006959	Arabidopsis thaliana	29.11	4.00e-15	73.60
IUUC-Ago-007978	Ashbya gossypii	29.84	4.00e-18	83.20
IUUC-Acl-008328	Aspergillus clavatus	26.38	2.00e-24	104.00
IUUC-Afl-008638	Aspergillus flavus	25.79	3.00e-28	116.00
IUUC-Afu-009042	Aspergillus fumigatus	27.51	2.00e-28	117.00
IUUC-Ani-009364	Aspergillus nidulans	30.65	8.00e-22	95.50
IUUC-Aor-009889	Aspergillus oryzae	25.79	1.00e-28	118.00
IUUC-Ate-010511	Aspergillus terreus	29.81	1.00e-09	53.10
IUUC-Ame-011644	Astyanax mexicanus	31.71	5.00e-03	30.00
IUUC-Bgr-012153	Blumeria graminis	32.44	2.00e-25	107.00
IUUC-Bta-012360	Bos taurus	29.71	3.00e-14	69.30
IUUC-Bci-013723	Botrytis cinerea	27.72	3.00e-25	106.00
IUUC-Bdi-014520	Brachypodium distachyon	27.93	4.00e-13	66.60
IUUC-Bol-016053	Brassica oleracea	28.99	4.00e-16	76.60
IUUC-Bra-017072	Brassica rapa	27.12	3.00e-16	77.40
IUUC-Cel-018529	Caenorhabditis elegans	25.30	7.00e-15	72.40
IUUC-Cja-019569	Callithrix jacchus	28.11	1.00e-21	94.40
IUUC-Cfa-020473	Canis familiaris	28.11	2.00e-21	94.40
IUUC-Cpo-021421	Cavia porcellus	28.11	5.00e-21	92.80
IUUC-Cre-022862	Chlamydomonas reinhardtii	30.86	9.00e-14	68.20
IUUC-Csa-024197	Chlorocebus sabaeus	28.11	2.00e-21	94.00
IUUC-Cho-024521	Choloepus hoffmanni	28.03	3.00e-20	89.70
IUUC-Cin-025119	Ciona intestinalis	27.21	2.00e-18	83.60
IUUC-Csv-026192	Ciona savignyi	26.02	3.00e-17	80.10
IUUC-Cgl-026686	Colletotrichum gloeosporioides	24.92	2.00e-17	80.50
IUUC-Dre-028466	Danio rerio	26.79	4.00e-21	92.80
IUUC-Dse-031228	Dothistroma septosporum	27.63	5.00e-34	135.00
IUUC-Dme-031703	Drosophila melanogaster	23.40	1.00e-17	81.60
IUUC-Ete-032482	Echinops telfairi	28.03	8.00e-20	88.20
IUUC-Eca-034036	Equus caballus	28.11	2.00e-21	94.40
IUUC-Eeu-035235	Erinaceus europaeus	29.71	5.00e-14	69.30
IUUC-Fca-036263	Felis catus	28.11	3.00e-21	93.60
IUUC-Fal-037064	Ficedula albicollis	27.71	5.00e-23	99.40
IUUC-Fox-037813	Fusarium oxysporum	29.35	4.00e-25	106.00
IUUC-Fso-038139	Fusarium solani	29.82	2.00e-26	110.00
IUUC-Gmo-039509	Gadus morhua	25.79	1.00e-15	74.30
IUUC-Ggr-040111	Gaeumannomyces graminis	28.88	3.00e-17	80.50
IUUC-Gga-040517	Gallus gallus	28.11	3.00e-23	99.80
IUUC-Gac-042270	Gasterosteus aculeatus	26.09	1.00e-15	75.10
IUUC-Gma-044400	Glycine max	33.07	1.00e-17	81.30
IUUC-Ggo-045048	Gorilla gorilla	28.11	2.00e-21	94.00
IUUC-Hsa-046744	Homo sapiens	28.11	1.00e-21	94.40
IUUC-Kpa-049174	Komagataella pastoris	26.44	5.00e-26	109.00
IUUC-Lch-049475	Latimeria chalumnae	27.60	3.00e-23	100.00
IUUC-Lpe-051283	Leersia perrieri	25.60	8.00e-13	67.40
IUUC-Loc-052446	Lepisosteus oculatus	25.70	2.00e-20	90.50
IUUC-Lma-053278	Leptosphaeria maculans	27.85	5.00e-33	132.00
IUUC-Laf-054020	Loxodonta africana	27.89	2.00e-20	90.50
IUUC-Mcc-055176	Macaca mulatta	28.11	1.00e-21	94.40
IUUC-Mor-057164	Magnaporthe oryzae	29.09	2.00e-24	103.00
IUUC-Mpo-057428	Magnaporthe poae	28.71	1.00e-15	75.10
IUUC-Mtr-058424	Medicago truncatula	31.71	4.00e-16	76.30
IUUC-Mla-058872	Melampsora laricipopulina	25.41	4.00e-20	90.50
IUUC-Mga-059859	Meleagris gallopavo	28.11	3.00e-23	99.80
IUUC-Mmr-061482	Microcebus murinus	28.11	1.00e-21	94.70
IUUC-Mdo-062371	Monodelphis domestica	28.51	3.00e-24	103.00
IUUC-Mmu-063139	Mus musculus	28.11	2.00e-21	93.60
IUUC-Mac-065332	Musa acuminata	29.01	3.00e-16	77.40
IUUC-Mpu-066783	Mustela putorius furo	28.11	3.00e-21	93.60
IUUC-Mlu-068165	Myotis lucifugus	28.29	2.00e-20	90.90
IUUC-Nfi-068578	Neosartorya fischeri	26.54	2.00e-27	114.00
IUUC-Ncr-068636	Neurospora crassa	27.86	5.00e-21	93.20
IUUC-Nle-069740	Nomascus leucogenys	28.11	2.00e-21	94.40
IUUC-Opr-070802	Ochotona princeps	28.85	3.00e-14	70.10
IUUC-Ont-072222	Oreochromis niloticus	25.70	5.00e-20	89.40
IUUC-Oan-072760	Ornithorhynchus anatinus	27.59	2.00e-17	80.50
IUUC-Ocu-074844	Oryctolagus cuniculus	26.67	8.00e-11	58.20
IUUC-Oba-075834	Oryza barthii	23.19	4.00e-13	67.00
IUUC-Obr-076230	Oryza brachyantha	23.76	5.00e-08	49.70
IUUC-Ogl-077554	Oryza glaberrima	23.19	5.00e-13	66.60
IUUC-Ogu-078687	Oryza glumaepatula	23.19	3.00e-13	67.40
IUUC-Oin-079677	Oryza indica	23.91	2.00e-13	68.20
IUUC-Olo-081078	Oryza longistaminata	24.46	4.00e-14	70.50
IUUC-Ome-081548	Oryza meridionalis	21.89	6.00e-14	70.90
IUUC-Oni-082050	Oryza nivara	23.91	2.00e-13	67.80
IUUC-Opu-083609	Oryza punctata	23.91	2.00e-13	68.20
IUUC-Oru-085057	Oryza rufipogon	23.91	2.00e-13	68.20
IUUC-Osa-085917	Oryza sativa	23.91	2.00e-13	67.80
IUUC-Ola-087032	Oryzias latipes	24.50	7.00e-18	82.40
IUUC-Oga-088468	Otolemur garnettii	28.29	9.00e-23	98.60
IUUC-Oar-089751	Ovis aries	28.11	2.00e-21	94.00
IUUC-Ptr-091064	Pan troglodytes	28.11	1.00e-21	94.40
IUUC-Pan-092505	Papio anubis	27.89	2.00e-20	90.90
IUUC-Psi-093086	Pelodiscus sinensis	27.20	2.00e-21	94.40
IUUC-Pma-094129	Petromyzon marinus	40.00	6.70e+00	21.60
IUUC-Pno-094825	Phaeosphaeria nodorum	30.45	1.00e-34	137.00
IUUC-Ppa-095419	Physcomitrella patens	26.63	3.00e-15	74.30
IUUC-Pfo-096224	Poecilia formosa	25.10	2.00e-19	87.40
IUUC-Pab-098501	Pongo abelii	28.11	2.00e-21	94.40
IUUC-Pop-099243	Populus trichocarpa	30.00	1.00e-14	72.00
IUUC-Ppe-101255	Prunus persica	26.63	3.00e-15	74.30
IUUC-Pva-102828	Pteropus vampyrus	28.11	2.00e-21	93.60
IUUC-Pgr-103672	Puccinia graminis	24.67	3.00e-18	84.30
IUUC-Ptt-104013	Puccinia triticina	23.10	6.00e-16	76.30
IUUC-Pyt-104615	Pyrenophora triticirepentis	28.05	2.00e-29	120.00
IUUC-Rno-106089	Rattus norvegicus	27.98	8.00e-21	91.70
IUUC-Sce-106216	Saccharomyces cerevisiae	26.83	2.00e-19	87.40
IUUC-Sha-106484	Sarcophilus harrisii	28.51	4.00e-24	102.00
IUUC-Sja-107699	Schizosaccharomyces japonicus	42.91	4.00e-66	242.00
IUUC-Ssl-108475	Sclerotinia sclerotiorum	29.02	1.00e-27	114.00
IUUC-Smo-109473	Selaginella moellendorffii	29.91	2.00e-12	64.30
IUUC-Sit-110736	Setaria italica	24.26	8.00e-15	72.40
IUUC-Sly-111657	Solanum lycopersicum	26.16	2.00e-16	78.20
IUUC-Sar-113050	Sorex araneus	24.69	2.00e-15	73.90
IUUC-Sbi-114258	Sorghum bicolor	26.21	3.00e-15	73.90
IUUC-Sre-114902	Sporisorium reilianum	28.51	2.00e-18	85.10
IUUC-Ssc-116166	Sus scrofa	28.11	1.00e-20	91.70
IUUC-Tgu-116814	Taeniopygia guttata	27.71	7.00e-23	98.60
IUUC-Tru-118172	Takifugu rubripes	27.89	1.00e-21	94.70
IUUC-Tsy-119010	Tarsius syrichta	24.50	3.00e-17	80.10
IUUC-Tni-120397	Tetraodon nigroviridis	25.44	5.00e-14	68.90
IUUC-Tca-121283	Theobroma cacao	24.85	3.00e-14	70.50
IUUC-Tvi-122545	Trichoderma virens	26.57	1.00e-20	91.30
IUUC-Tae-122685	Triticum aestivum	25.00	2.00e-14	71.20
IUUC-Tur-126407	Triticum urartu	27.59	4.00e-15	73.20
IUUC-Tme-126913	Tuber melanosporum	30.82	4.00e-37	145.00
IUUC-Tbe-127738	Tupaia belangeri	27.78	2.00e-14	69.70
IUUC-Ttr-128528	Tursiops truncatus	28.11	2.00e-21	94.00
IUUC-Uma-129625	Ustilago maydis	28.77	1.00e-20	92.00
IUUC-Vda-129906	Verticillium dahliae	27.24	4.00e-19	85.90
IUUC-Vpa-130223	Vicugna pacos	27.94	6.00e-21	92.40
IUUC-Vvi-131617	Vitis vinifera	24.73	3.00e-15	73.90
IUUC-Xtr-132288	Xenopus tropicalis	26.91	9.00e-23	98.60
IUUC-Xma-134214	Xiphophorus maculatus	24.85	5.00e-13	65.50
IUUC-Yli-134377	Yarrowia lipolytica	31.00	6.00e-18	82.40
IUUC-Zma-135108	Zea mays	25.90	1.00e-14	72.40

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence