iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mcc-054935

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

JSUE03026990

Gene Name

AIRE

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000004168.3	ENSMMUT00000005921.3	ENSMMUP00000005576.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	4.40e-10	40.7	297	341

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           + C+vC++gge    l++C+ C ++fH aCl+++  +e p+ + w C+ C 
   Q: 297  DECAVCRDGGE----LICCDGCPRAFHLACLSPP-LREIPSGT-WRCSGCL 341
           57*********....*******************.*******6.******6 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MAADAALRQL LRLHRTEIAV AVDSAFPLLH ALADHDVVPE DKFQETLRLK EKEGCPQAFH 60
ALLSWLLTQD STVILDFWRV LFKDYNLERY GRLQPILDSF PKDVDLSQSR KGRKLPTIPK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCTCCTCCC ACAGCCCCAG GCGGGCCTCT GAGTAGGGGC TTTCAGCTTG TGTGGAGGTT 60
CCCCAGGGAC ACCACCCCGA TCCAGCCTCC ATGGAGGCTC TTGCCGGCCA CTGGGAGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR008087--AIRE
IPR004865--HSR_dom
IPR000770--SAND_dom
IPR010919--SAND_dom-like
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51414--HSR
PS50864--SAND
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF03172--HSR
PF00628--PHD
PF01342--SAND

PRINTS

PR01711--AIREGULATOR

SMART

SM00249--PHD
SM00258--SAND

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016604--C:nuclear body
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0042393--F:histone binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003712--F:transcription cofactor activity
GO:0045182--F:translation regulator activity
GO:0008270--F:zinc ion binding
GO:0002509--P:central tolerance induction to self antigen
GO:0032602--P:chemokine production
GO:0006959--P:humoral immune response
GO:0006955--P:immune response
GO:0045060--P:negative thymic T cell selection
GO:0002458--P:peripheral T cell tolerance induction
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:2000410--P:regulation of thymocyte migration
GO:0097536--P:thymus epithelium morphogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001612	Ailuropoda melanoleuca	75.41	0.00e+00	634.00
IUUC-Aca-004543	Anolis carolinensis	69.35	8.00e-24	101.00
IUUC-Bta-012988	Bos taurus	75.09	0.00e+00	650.00
IUUC-Bci-013636	Botrytis cinerea	44.44	2.00e-09	58.50
IUUC-Bdi-014663	Brachypodium distachyon	48.48	1.00e-13	72.80
IUUC-Cja-019486	Callithrix jacchus	83.69	3.00e-116	411.00
IUUC-Cfa-021069	Canis familiaris	73.46	7.00e-172	597.00
IUUC-Cpo-021649	Cavia porcellus	67.92	3.00e-165	575.00
IUUC-Csa-023960	Chlorocebus sabaeus	95.68	0.00e+00	800.00
IUUC-Dre-028583	Danio rerio	40.83	6.00e-58	218.00
IUUC-Dno-029869	Dasypus novemcinctus	64.57	9.00e-132	463.00
IUUC-Dor-030263	Dipodomys ordii	86.02	3.00e-45	175.00
IUUC-Ete-032778	Echinops telfairi	90.91	1.00e-55	210.00
IUUC-Eca-034328	Equus caballus	75.45	1.00e-179	622.00
IUUC-Fca-035400	Felis catus	71.27	8.00e-173	600.00
IUUC-Fal-036644	Ficedula albicollis	51.01	3.00e-74	272.00
IUUC-Ggo-045250	Gorilla gorilla	90.99	0.00e+00	754.00
IUUC-Hsa-046603	Homo sapiens	91.24	0.00e+00	761.00
IUUC-Hvu-047073	Hordeum vulgare	45.45	1.00e-13	72.80
IUUC-Itr-048977	Ictidomys tridecemlineatus	73.20	3.00e-176	611.00
IUUC-Lch-050310	Latimeria chalumnae	42.61	7.00e-96	344.00
IUUC-Loc-052508	Lepisosteus oculatus	48.98	2.00e-81	296.00
IUUC-Laf-054028	Loxodonta africana	67.44	4.00e-160	558.00
IUUC-Mga-059318	Meleagris gallopavo	41.82	7.00e-55	207.00
IUUC-Mmr-061557	Microcebus murinus	65.08	7.00e-146	510.00
IUUC-Mdo-062475	Monodelphis domestica	49.72	2.00e-121	429.00
IUUC-Mmu-063994	Mus musculus	69.35	0.00e+00	670.00
IUUC-Mac-065614	Musa acuminata	42.03	2.00e-11	65.10
IUUC-Mpu-066347	Mustela putorius furo	76.12	0.00e+00	694.00
IUUC-Mlu-068239	Myotis lucifugus	60.68	3.00e-84	305.00
IUUC-Nle-069544	Nomascus leucogenys	83.08	2.00e-27	115.00
IUUC-Opr-071199	Ochotona princeps	76.98	1.00e-77	283.00
IUUC-Ont-072571	Oreochromis niloticus	33.05	2.00e-39	156.00
IUUC-Oan-073739	Ornithorhynchus anatinus	53.54	1.00e-149	523.00
IUUC-Ogl-077865	Oryza glaberrima	43.94	4.00e-13	70.90
IUUC-Olo-080499	Oryza longistaminata	43.94	4.00e-13	71.20
IUUC-Opu-083209	Oryza punctata	43.94	4.00e-13	71.20
IUUC-Ola-086528	Oryzias latipes	35.10	8.00e-42	164.00
IUUC-Oga-088353	Otolemur garnettii	77.63	0.00e+00	690.00
IUUC-Oar-090065	Ovis aries	77.66	6.00e-150	523.00
IUUC-Ptr-091347	Pan troglodytes	91.83	0.00e+00	730.00
IUUC-Pan-092423	Papio anubis	96.64	0.00e+00	820.00
IUUC-Psi-093798	Pelodiscus sinensis	53.32	5.00e-135	474.00
IUUC-Pfo-096145	Poecilia formosa	71.70	6.00e-21	95.50
IUUC-Pab-098369	Pongo abelii	89.85	2.00e-133	469.00
IUUC-Pca-100537	Procavia capensis	72.25	3.00e-178	618.00
IUUC-Ppe-101215	Prunus persica	60.42	4.00e-14	73.60
IUUC-Pva-102639	Pteropus vampyrus	74.77	1.00e-179	622.00
IUUC-Rno-105285	Rattus norvegicus	68.72	0.00e+00	644.00
IUUC-Sha-107159	Sarcophilus harrisii	49.82	6.00e-126	444.00
IUUC-Sit-110355	Setaria italica	47.14	9.00e-13	69.70
IUUC-Sbi-113930	Sorghum bicolor	58.33	9.00e-13	70.10
IUUC-Ssc-115773	Sus scrofa	73.75	1.00e-179	623.00
IUUC-Tgu-116922	Taeniopygia guttata	49.71	1.00e-72	266.00
IUUC-Tru-118263	Takifugu rubripes	31.35	4.00e-58	219.00
IUUC-Tsy-119270	Tarsius syrichta	73.93	2.00e-94	339.00
IUUC-Tni-120138	Tetraodon nigroviridis	30.73	1.00e-58	220.00
IUUC-Tca-121757	Theobroma cacao	57.14	9.00e-14	73.60
IUUC-Tae-124715	Triticum aestivum	45.45	1.00e-13	73.20
IUUC-Tur-126422	Triticum urartu	53.19	1.00e-11	66.20
IUUC-Tme-127204	Tuber melanosporum	55.32	7.00e-14	73.20
IUUC-Tbe-128077	Tupaia belangeri	70.80	0.00e+00	637.00
IUUC-Ttr-128781	Tursiops truncatus	83.70	8.00e-79	287.00
IUUC-Xma-133054	Xiphophorus maculatus	31.41	1.00e-57	218.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence