iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Itr-047966

Ensembl Protein ID

ENSSTOP00000006521.2

UniProt Accession

I3M9G1; I3M9G1_ICTTR

Genbank Protein ID

ENSSTOP00000006521

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTP01048063

Gene Name

TRAF6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000007303.2	ENSSTOT00000007300.2	ENSSTOP00000006521.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	4.60e-07	29.8	66	127

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrli 65
           + + CpI l   r+ v +p+G+ + +++I k +++ g++cPv+++ l e++l P ++ +r i
   Q: 66   SKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREI 127
           5689*****************************999999*****************999977 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

MSLLNCENSC GSSQSESNCC AAMANSCSTA IKDDSVSGSA STGNLSSSFM EEIQGYDVEF 60
DPPLESKYEC PICLMALREA VQTPCGHRFC KACIIKSIRD AGHKCPVDNE ILLENQLFPD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCTTAGCCG GCGGAGAAGG CGGAAGAAAG CGGCGTCAGA GACTGGGGCT GGGGCTCCCG 60
GCGGCCCGCG GACGCGGCGG CCTTCGGCCC TGGAGATTGG CCTGCGGGCC GTCTCGCCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002083--MATH/TRAF_dom
IPR012227--TNF_rcpt--assoc_TRAF
IPR008974--TRAF-like
IPR027139--TRAF6
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF

PROSITE

PS50144--MATH
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF

Pfam

PF02176--zf-TRAF

SMART

SM00061--MATH
SM00184--RING

Gene Ontology

GO:0035631--C:CD40 receptor complex
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0005829--C:cytosol
GO:0005811--C:lipid particle
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0043234--C:protein complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007250--P:activation of NF-kappaB-inducing kinase activity
GO:0019886--P:antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0045453--P:bone resorption
GO:0048468--P:cell development
GO:0071222--P:cellular response to lipopolysaccharide
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0070498--P:interleukin-1-mediated signaling pathway
GO:0043011--P:myeloid dendritic cell differentiation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0001843--P:neural tube closure
GO:0042475--P:odontogenesis of dentin-containing tooth
GO:0001503--P:ossification
GO:0030316--P:osteoclast differentiation
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045084--P:positive regulation of interleukin-12 biosynthetic process
GO:0032743--P:positive regulation of interleukin-2 production
GO:0045410--P:positive regulation of interleukin-6 biosynthetic process
GO:0043507--P:positive regulation of JUN kinase activity
GO:0031666--P:positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0045672--P:positive regulation of osteoclast differentiation
GO:0002726--P:positive regulation of T cell cytokine production
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:2000679--P:positive regulation of transcription regulatory region DNA binding
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042981--P:regulation of apoptotic process
GO:0051023--P:regulation of immunoglobulin secretion
GO:0050852--P:T cell receptor signaling pathway
GO:0042088--P:T-helper 1 type immune response

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001262	Ailuropoda melanoleuca	90.02	0.00e+00	956.00
IUUC-Apl-004062	Anas platyrhynchos	72.78	0.00e+00	840.00
IUUC-Aca-004636	Anolis carolinensis	71.90	0.00e+00	783.00
IUUC-Ame-011682	Astyanax mexicanus	52.34	4.00e-165	574.00
IUUC-Bta-012692	Bos taurus	87.82	0.00e+00	972.00
IUUC-Bci-013998	Botrytis cinerea	22.74	8.00e-13	68.20
IUUC-Bdi-014180	Brachypodium distachyon	25.14	1.00e-07	50.80
IUUC-Cja-019426	Callithrix jacchus	91.32	0.00e+00	978.00
IUUC-Cfa-020948	Canis familiaris	88.75	0.00e+00	848.00
IUUC-Cpo-021378	Cavia porcellus	89.69	0.00e+00	966.00
IUUC-Csa-024045	Chlorocebus sabaeus	91.32	0.00e+00	988.00
IUUC-Cho-024973	Choloepus hoffmanni	76.59	8.00e-109	387.00
IUUC-Csv-026300	Ciona savignyi	39.53	3.00e-47	181.00
IUUC-Dre-027557	Danio rerio	55.62	5.00e-176	610.00
IUUC-Dno-030032	Dasypus novemcinctus	85.28	3.00e-148	517.00
IUUC-Dor-030790	Dipodomys ordii	91.51	0.00e+00	984.00
IUUC-Dse-031478	Dothistroma septosporum	24.03	1.00e-09	57.80
IUUC-Dme-031921	Drosophila melanogaster	27.43	3.00e-41	162.00
IUUC-Ete-032952	Echinops telfairi	85.37	8.00e-167	579.00
IUUC-Eca-033924	Equus caballus	85.27	0.00e+00	878.00
IUUC-Eeu-034734	Erinaceus europaeus	83.99	0.00e+00	870.00
IUUC-Fca-036222	Felis catus	82.29	0.00e+00	845.00
IUUC-Fal-036834	Ficedula albicollis	73.57	0.00e+00	739.00
IUUC-Fox-037935	Fusarium oxysporum	28.57	1.00e-22	100.00
IUUC-Gmo-039061	Gadus morhua	55.78	1.00e-90	326.00
IUUC-Ggr-040084	Gaeumannomyces graminis	28.16	3.00e-12	66.60
IUUC-Gga-040599	Gallus gallus	72.84	0.00e+00	845.00
IUUC-Gac-041977	Gasterosteus aculeatus	55.09	1.00e-169	588.00
IUUC-Ggo-044508	Gorilla gorilla	85.71	0.00e+00	905.00
IUUC-Hsa-046349	Homo sapiens	91.89	0.00e+00	1018.00
IUUC-Lch-049821	Latimeria chalumnae	66.55	0.00e+00	756.00
IUUC-Loc-051995	Lepisosteus oculatus	59.77	0.00e+00	635.00
IUUC-Laf-054115	Loxodonta africana	84.29	0.00e+00	938.00
IUUC-Mcc-055298	Macaca mulatta	90.94	0.00e+00	983.00
IUUC-Mor-057263	Magnaporthe oryzae	26.67	2.00e-18	86.70
IUUC-Mpo-057517	Magnaporthe poae	28.37	5.00e-14	72.40
IUUC-Mga-059340	Meleagris gallopavo	72.84	0.00e+00	823.00
IUUC-Mvi-060553	Microbotryum violaceum	28.12	3.00e-15	76.30
IUUC-Mmr-061063	Microcebus murinus	90.99	0.00e+00	969.00
IUUC-Mdo-062075	Monodelphis domestica	80.56	0.00e+00	909.00
IUUC-Mmu-063780	Mus musculus	90.62	0.00e+00	939.00
IUUC-Mpu-065748	Mustela putorius furo	89.28	0.00e+00	967.00
IUUC-Mlu-067888	Myotis lucifugus	88.64	0.00e+00	957.00
IUUC-Ncr-068632	Neurospora crassa	26.82	3.00e-18	86.70
IUUC-Nle-069234	Nomascus leucogenys	91.89	0.00e+00	993.00
IUUC-Opr-070393	Ochotona princeps	95.77	2.00e-122	432.00
IUUC-Ont-072459	Oreochromis niloticus	53.53	5.00e-177	613.00
IUUC-Oan-073578	Ornithorhynchus anatinus	81.80	0.00e+00	914.00
IUUC-Ocu-074201	Oryctolagus cuniculus	91.87	0.00e+00	993.00
IUUC-Ola-087319	Oryzias latipes	57.79	7.00e-90	324.00
IUUC-Olu-087748	Ostreococcus lucimarinus	21.31	3.00e-09	55.80
IUUC-Oga-087936	Otolemur garnettii	88.48	0.00e+00	957.00
IUUC-Oar-089379	Ovis aries	87.64	0.00e+00	974.00
IUUC-Ptr-090758	Pan troglodytes	92.26	0.00e+00	993.00
IUUC-Pan-092590	Papio anubis	91.13	0.00e+00	984.00
IUUC-Psi-093948	Pelodiscus sinensis	72.03	0.00e+00	818.00
IUUC-Pma-094434	Petromyzon marinus	42.73	1.00e-125	442.00
IUUC-Pfo-096912	Poecilia formosa	55.75	2.00e-170	592.00
IUUC-Pab-097651	Pongo abelii	92.26	0.00e+00	997.00
IUUC-Pca-100958	Procavia capensis	85.83	0.00e+00	701.00
IUUC-Pva-103247	Pteropus vampyrus	92.46	3.00e-132	464.00
IUUC-Pte-104279	Pyrenophora teres	26.89	2.00e-13	71.20
IUUC-Rno-104994	Rattus norvegicus	88.56	0.00e+00	951.00
IUUC-Sha-106494	Sarcophilus harrisii	82.86	0.00e+00	931.00
IUUC-Ssl-108580	Sclerotinia sclerotiorum	24.88	6.00e-12	65.10
IUUC-Sar-113375	Sorex araneus	87.38	0.00e+00	931.00
IUUC-Sre-115218	Sporisorium reilianum	26.84	2.00e-15	77.00
IUUC-Ssc-115417	Sus scrofa	89.30	0.00e+00	977.00
IUUC-Tgu-117232	Taeniopygia guttata	72.21	0.00e+00	792.00
IUUC-Tru-118321	Takifugu rubripes	54.14	1.00e-169	589.00
IUUC-Tni-120475	Tetraodon nigroviridis	53.45	3.00e-165	574.00
IUUC-Tbe-127719	Tupaia belangeri	79.51	0.00e+00	823.00
IUUC-Ttr-129264	Tursiops truncatus	90.51	6.00e-128	450.00
IUUC-Uma-129620	Ustilago maydis	27.52	5.00e-18	85.90
IUUC-Vpa-130244	Vicugna pacos	91.30	1.00e-132	466.00
IUUC-Xtr-131948	Xenopus tropicalis	64.70	0.00e+00	744.00
IUUC-Xma-133132	Xiphophorus maculatus	56.05	1.00e-170	592.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence