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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Sce-106224
UUCD1 version UUC-SaC-00110
Ensembl Protein ID YMR116C
UniProt Accession P38011; D6VZT9; Q6LAA5; GBLP_YEAST
Genbank Protein ID CAA89753.1; CAA89754.1; DAA10013.1
Protein Name Guanine nucleotide-binding protein subunit beta-like protein; Receptor for activated C kinase; Receptor of activated protein kinase C 1; Small ribosomal subunit protein RACK1
Genbank Nucleotide ID Z49702; Z49702; BK006946
Gene Name ASC1; CPC2; YMR116C; YM9718.15C
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YMR116C YMR116C YMR116C
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFdbPTMUniProt
PHOSIDABioGRID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.20e-34 114.0 105 135
UBD/Beta-Prp 4.00e-51 172.4 12 160
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWD 29
           gH+++v +++      +++sGs+D+tikvW 
   Q: 105  GHKSDVMSVDIdKKaSMIISGSRDKTIKVWT 135
           8**********833579*************5 PP
   

   UBD/Beta-Prp
   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkl.....lrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvls 99
           tl+gh+  v +  + + + +ll+++srd+t++ w++t  +      +rs++gh+  v+++++  dg + +++s D+t+++wd+ tg++ + + gh+++v+s
   Q: 12   TLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQkfgvpVRSFKGHSHIVQDCTLTADGAYALSASWDKTLRLWDVATGETYQRFVGHKSDVMS 112
           77888887777777799999***************99776677999******************************************************* PP
   S: 100  lsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg 149
           ++++++ + ++sGs+d+ti+vw + +gqcl  tl gh+++v+ v+v p++
   Q: 113  VDIDKKASMIISGSRDKTIKVW-TIKGQCLA-TLLGHNDWVSQVRVVPNE 160
           *****99***************.5579***9.************999986 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). Located at the head of the 40S ribosomal subunit in the vicinity of the mRNA exit channel, RACK1 serves as a scaffold protein that can recruit other proteins to the ribosome. Involved in the negative regulation of translation of a specific subset of proteins (PubMed:15340087).
 Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). Located at the head of the 40S ribosomal subunit in the vicinity of the mRNA exit channel, RACK1 serves as a scaffold protein that can recruit other proteins to the ribosome. Involved in the negative regulation of translation of a specific subset of proteins (PubMed:15340087).
Protein Sequence
(Fasta)
MASNEVLVLR GTLEGHNGWV TSLATSAGQP NLLLSASRDK TLISWKLTGD DQKFGVPVRS 60
FKGHSHIVQD CTLTADGAYA LSASWDKTLR LWDVATGETY QRFVGHKSDV MSVDIDKKAS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106224|E3,WD_repeat;UBD,Beta-Prp|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGCATCTA ACGAAGTTTT AGTTTTGAGA GGTACCTTGG AAGGTCACAA CGGTTGGGTC 60
ACATCTTTGG CTACTTCTGC TGGTCAACCA AACCTATTGT TGTCCGCTTC CCGTGATAAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106224|E3,WD_repeat;UBD,Beta-Prp|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-1017--Isopeptide bond
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0687--Ribonucleoprotein
KW-0689--Ribosomal protein
KW-0832--Ubl conjugation
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0022627--C:cytosolic small ribosomal subunit
GO:0001965--F:G-protein alpha-subunit binding
GO:0005092--F:GDP-dissociation inhibitor activity
GO:0004871--F:signal transducer activity
GO:0007186--P:G-protein coupled receptor signaling pathway
GO:0010255--P:glucose mediated signaling pathway
GO:0001403--P:invasive growth in response to glucose limitation
GO:0017148--P:negative regulation of translation
GO:2001125--P:negative regulation of translational frameshifting
KEGG sce:YMR116C
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000395 Aegilops tauschii 43.92 3.00e-67 246.00
IUUC-Aml-001935 Ailuropoda melanoleuca 53.82 1.00e-97 347.00
IUUC-Atr-002694 Amborella trichopoda 45.86 3.00e-80 289.00
IUUC-Apl-003918 Anas platyrhynchos 52.86 3.00e-84 302.00
IUUC-Aca-004869 Anolis carolinensis 53.82 1.00e-97 347.00
IUUC-Aly-005832 Arabidopsis lyrata 46.46 2.00e-83 300.00
IUUC-Ath-007105 Arabidopsis thaliana 46.77 2.00e-84 303.00
IUUC-Ago-007720 Ashbya gossypii 73.04 6.00e-146 507.00
IUUC-Acl-008156 Aspergillus clavatus 59.18 6.00e-108 381.00
IUUC-Afl-008684 Aspergillus flavus 59.18 1.00e-107 380.00
IUUC-Afu-008867 Aspergillus fumigatus 60.44 5.00e-110 388.00
IUUC-Ani-009221 Aspergillus nidulans 58.23 1.00e-106 377.00
IUUC-Ang-009843 Aspergillus niger 57.28 3.00e-105 372.00
IUUC-Aor-010193 Aspergillus oryzae 59.18 1.00e-107 380.00
IUUC-Ate-010420 Aspergillus terreus 55.36 4.00e-93 332.00
IUUC-Ame-010884 Astyanax mexicanus 54.78 6.00e-99 351.00
IUUC-Bgr-012064 Blumeria graminis 57.41 4.00e-104 369.00
IUUC-Bta-013357 Bos taurus 53.82 1.00e-97 347.00
IUUC-Bci-013862 Botrytis cinerea 58.23 2.00e-107 379.00
IUUC-Bdi-015057 Brachypodium distachyon 44.68 4.00e-77 279.00
IUUC-Bol-016005 Brassica oleracea 46.79 3.00e-84 303.00
IUUC-Bra-017817 Brassica rapa 46.32 4.00e-84 302.00
IUUC-Cel-018335 Caenorhabditis elegans 49.06 7.00e-78 281.00
IUUC-Cja-019914 Callithrix jacchus 53.82 1.00e-97 347.00
IUUC-Cfa-020755 Canis familiaris 53.82 1.00e-97 347.00
IUUC-Cpo-022377 Cavia porcellus 53.82 9.00e-98 347.00
IUUC-Cre-022909 Chlamydomonas reinhardtii 51.27 1.00e-90 324.00
IUUC-Csa-023025 Chlorocebus sabaeus 53.82 2.00e-97 346.00
IUUC-Cin-025647 Ciona intestinalis 52.68 8.00e-94 334.00
IUUC-Csv-026027 Ciona savignyi 53.00 9.00e-93 331.00
IUUC-Cgl-026718 Colletotrichum gloeosporioides 57.79 5.00e-97 345.00
IUUC-Cne-026930 Cryptococcus neoformans 51.75 1.00e-93 334.00
IUUC-Cme-027251 Cyanidioschyzon merolae 45.40 2.00e-86 309.00
IUUC-Dre-028669 Danio rerio 53.82 3.00e-97 345.00
IUUC-Dno-029470 Dasypus novemcinctus 46.82 2.00e-71 260.00
IUUC-Dor-031098 Dipodomys ordii 47.94 9.00e-69 251.00
IUUC-Dse-031255 Dothistroma septosporum 59.31 1.00e-106 377.00
IUUC-Dme-032118 Drosophila melanogaster 52.38 1.00e-91 327.00
IUUC-Ete-033182 Echinops telfairi 43.69 2.00e-46 177.00
IUUC-Eca-033296 Equus caballus 47.02 2.00e-36 142.00
IUUC-Eeu-034771 Erinaceus europaeus 51.27 1.00e-91 327.00
IUUC-Fca-036315 Felis catus 53.82 1.00e-97 347.00
IUUC-Fal-036990 Ficedula albicollis 52.94 9.00e-49 184.00
IUUC-Fox-037702 Fusarium oxysporum 58.86 7.00e-109 384.00
IUUC-Fso-038384 Fusarium solani 58.86 1.00e-108 383.00
IUUC-Gmo-039630 Gadus morhua 52.58 2.00e-93 333.00
IUUC-Ggr-039985 Gaeumannomyces graminis 59.49 9.00e-110 387.00
IUUC-Gga-040540 Gallus gallus 53.82 1.00e-97 347.00
IUUC-Gac-041316 Gasterosteus aculeatus 51.44 3.00e-93 332.00
IUUC-Gma-042872 Glycine max 46.30 3.00e-82 296.00
IUUC-Ggo-045253 Gorilla gorilla 53.82 1.00e-97 347.00
IUUC-Hsa-046809 Homo sapiens 53.82 1.00e-97 347.00
IUUC-Hvu-047641 Hordeum vulgare 44.51 1.00e-76 277.00
IUUC-Itr-048025 Ictidomys tridecemlineatus 53.82 1.00e-97 347.00
IUUC-Kpa-049214 Komagataella pastoris 59.19 2.00e-109 386.00
IUUC-Lch-049634 Latimeria chalumnae 52.55 2.00e-95 340.00
IUUC-Lpe-050762 Leersia perrieri 44.71 2.00e-77 280.00
IUUC-Loc-052163 Lepisosteus oculatus 54.14 4.00e-98 348.00
IUUC-Lma-053113 Leptosphaeria maculans 59.37 3.00e-107 379.00
IUUC-Laf-054422 Loxodonta africana 53.82 1.00e-97 347.00
IUUC-Mcc-055348 Macaca mulatta 53.82 2.00e-97 347.00
IUUC-Meu-056543 Macropus eugenii 53.82 1.00e-97 347.00
IUUC-Mor-057107 Magnaporthe oryzae 58.86 1.00e-109 387.00
IUUC-Mpo-057487 Magnaporthe poae 59.18 2.00e-109 386.00
IUUC-Mtr-058808 Medicago truncatula 45.99 2.00e-81 293.00
IUUC-Mla-058909 Melampsora laricipopulina 50.16 4.00e-92 328.00
IUUC-Mga-059387 Meleagris gallopavo 53.82 1.00e-97 347.00
IUUC-Mvi-060392 Microbotryum violaceum 50.32 6.00e-91 325.00
IUUC-Mmr-061141 Microcebus murinus 45.03 2.00e-64 237.00
IUUC-Mdo-062932 Monodelphis domestica 53.82 1.00e-97 347.00
IUUC-Mmu-064132 Mus musculus 53.82 1.00e-97 347.00
IUUC-Mac-064447 Musa acuminata 42.77 1.00e-71 260.00
IUUC-Mpu-066721 Mustela putorius furo 53.50 7.00e-96 341.00
IUUC-Mlu-068221 Myotis lucifugus 53.18 1.00e-88 317.00
IUUC-Nfi-068344 Neosartorya fischeri 60.13 2.00e-109 386.00
IUUC-Ncr-068722 Neurospora crassa 56.96 5.00e-106 375.00
IUUC-Nle-069865 Nomascus leucogenys 53.82 2.00e-97 347.00
IUUC-Opr-071100 Ochotona princeps 46.18 4.00e-74 269.00
IUUC-Ont-072287 Oreochromis niloticus 54.46 2.00e-98 350.00
IUUC-Oan-072788 Ornithorhynchus anatinus 53.82 1.00e-97 347.00
IUUC-Ocu-073844 Oryctolagus cuniculus 52.08 4.00e-93 332.00
IUUC-Oba-075652 Oryza barthii 42.48 1.00e-71 261.00
IUUC-Obr-076099 Oryza brachyantha 43.84 2.00e-76 276.00
IUUC-Ogl-077181 Oryza glaberrima 45.15 4.00e-78 282.00
IUUC-Ogu-078035 Oryza glumaepatula 45.15 4.00e-78 282.00
IUUC-Oin-079327 Oryza indica 45.15 4.00e-78 282.00
IUUC-Olo-081084 Oryza longistaminata 45.15 4.00e-78 282.00
IUUC-Ome-081612 Oryza meridionalis 45.15 4.00e-78 282.00
IUUC-Oni-082682 Oryza nivara 44.74 7.00e-78 281.00
IUUC-Opu-083308 Oryza punctata 45.15 5.00e-78 282.00
IUUC-Oru-084200 Oryza rufipogon 45.15 4.00e-78 282.00
IUUC-Osa-085488 Oryza sativa 45.15 4.00e-78 282.00
IUUC-Ola-086400 Oryzias latipes 54.14 8.00e-98 348.00
IUUC-Olu-087817 Ostreococcus lucimarinus 51.77 8.00e-93 331.00
IUUC-Oga-088811 Otolemur garnettii 53.82 1.00e-97 347.00
IUUC-Oar-089962 Ovis aries 53.82 1.00e-97 347.00
IUUC-Ptr-091340 Pan troglodytes 53.82 1.00e-97 347.00
IUUC-Pan-091946 Papio anubis 53.82 3.00e-97 346.00
IUUC-Pma-094535 Petromyzon marinus 55.10 1.00e-99 354.00
IUUC-Pno-095100 Phaeosphaeria nodorum 58.88 2.00e-69 253.00
IUUC-Ppa-095752 Physcomitrella patens 52.52 7.00e-94 334.00
IUUC-Pfo-097311 Poecilia formosa 53.82 4.00e-98 348.00
IUUC-Pab-097863 Pongo abelii 53.82 2.00e-97 347.00
IUUC-Pop-099345 Populus trichocarpa 46.95 1.00e-83 301.00
IUUC-Pca-100594 Procavia capensis 53.00 2.00e-96 343.00
IUUC-Ppe-101743 Prunus persica 46.63 4.00e-83 299.00
IUUC-Pva-102746 Pteropus vampyrus 45.69 9.00e-77 278.00
IUUC-Pgr-103375 Puccinia graminis 40.32 1.00e-61 227.00
IUUC-Ptt-103839 Puccinia triticina 49.84 2.00e-90 323.00
IUUC-Pte-104026 Pyrenophora teres 59.37 3.00e-107 379.00
IUUC-Pyt-104584 Pyrenophora triticirepentis 59.37 2.00e-107 380.00
IUUC-Rno-104964 Rattus norvegicus 53.82 1.00e-97 347.00
IUUC-Sha-107409 Sarcophilus harrisii 53.82 1.00e-97 347.00
IUUC-Sja-107971 Schizosaccharomyces japonicus 55.41 1.00e-99 353.00
IUUC-Spo-108297 Schizosaccharomyces pombe 53.50 2.00e-97 346.00
IUUC-Ssl-108479 Sclerotinia sclerotiorum 58.23 2.00e-107 379.00
IUUC-Smo-109017 Selaginella moellendorffii 47.30 2.00e-81 293.00
IUUC-Sit-110680 Setaria italica 45.43 8.00e-78 281.00
IUUC-Sly-111496 Solanum lycopersicum 46.32 2.00e-83 300.00
IUUC-Stu-112775 Solanum tuberosum 46.18 2.00e-83 300.00
IUUC-Sar-113173 Sorex araneus 53.82 1.00e-97 347.00
IUUC-Sbi-114681 Sorghum bicolor 45.15 2.00e-80 290.00
IUUC-Sre-115107 Sporisorium reilianum 52.85 3.00e-98 349.00
IUUC-Ssc-116218 Sus scrofa 52.87 4.00e-95 338.00
IUUC-Tru-118202 Takifugu rubripes 53.18 2.00e-96 343.00
IUUC-Tni-120260 Tetraodon nigroviridis 52.55 3.00e-96 342.00
IUUC-Tca-120951 Theobroma cacao 46.34 8.00e-84 301.00
IUUC-Tre-121961 Trichoderma reesei 59.18 1.00e-109 387.00
IUUC-Tvi-122447 Trichoderma virens 58.54 3.00e-108 382.00
IUUC-Tae-125589 Triticum aestivum 44.21 2.00e-76 276.00
IUUC-Tur-126335 Triticum urartu 45.35 2.00e-65 240.00
IUUC-Tme-127105 Tuber melanosporum 57.14 1.00e-100 357.00
IUUC-Tbe-128021 Tupaia belangeri 44.22 6.00e-42 161.00
IUUC-Ttr-128637 Tursiops truncatus 48.09 2.00e-81 293.00
IUUC-Uma-129634 Ustilago maydis 53.16 1.00e-98 350.00
IUUC-Vda-129923 Verticillium dahliae 59.81 7.00e-110 387.00
IUUC-Vpa-130410 Vicugna pacos 49.11 8.00e-43 164.00
IUUC-Vvi-131115 Vitis vinifera 46.32 4.00e-84 302.00
IUUC-Xtr-132105 Xenopus tropicalis 54.46 2.00e-98 349.00
IUUC-Xma-133875 Xiphophorus maculatus 53.82 1.00e-97 347.00
IUUC-Yli-134624 Yarrowia lipolytica 56.92 5.00e-108 382.00
IUUC-Zma-134711 Zea mays 45.45 2.00e-78 283.00
Created Date 25-Jun-2017

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