iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000015479.1	ENSONIT00000019495.1	ENSONIP00000019478.1
ENSONIG00000015479.1	ENSONIT00000019496.1	ENSONIP00000019479.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.30e-98	330.9	426	762

Active Site

Position(s)	Description	Evidence
730	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpl 92
           dlkk+l+v+fvgE+gld+gG+t+e++ ll+++++++d+g+f+y ++++++++ + +      ++ + F+++G+l+g+a++++  ld+++
   Q: 426  DLKKKLRVTFVGEAGLDMGGLTKEWFLLLVRQIFHTDYGMFTYMKDSRCHWFSSWKC-----DNYSEFQLVGTLMGLAVYNSIALDIHF 509
           89************************************************9976655.....789************************ PP
   S: 93   sksfyklllgk..............klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtn 167
           +  +y++ll+               + +l+dl++++pel++ l e++++ e ++ee  + ltf+v +e++g +k+++LkpgG++ipVt+
   Q: 510  PLYCYRKLLTPptvpcdqnalvgmaNATLDDLQQIMPELAHGLGELLSY-EGNVEED-FYLTFQVFQEEMGMVKSYNLKPGGDKIPVTK 596
           ********999666666666666666**********************9.6788885.******************************* PP
   S: 168  eNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleef 256
           +N++eYv+l+v++ l+++i +q++af+ Gf++v+  + l l+++ee+e+l+cG++e+d+++l+k ++y+ gy++++ +++ Fw+v+ +f
   Q: 597  QNRKEYVQLYVDFLLNKSIYKQFAAFYHGFHSVCASDALMLLRPEEVEMLVCGSPELDMSALQKAAQYE-GYSKTDATVRCFWDVVLAF 684
           ********************************************************************5.5****************** PP
   S: 257  sseerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
             e +k++L+F+Tgs+r+P+gG+a+l+   f i k d  +d+lP s+TCfn+++LP+Y + ++lk+kL++Ai++++gF+l+
   Q: 685  PLELQKKLLHFATGSDRVPVGGMADLN---FKIAKiDVPTDWLPISHTCFNQICLPPYRTRKELKQKLTIAISNAEGFGLE 762
           ***************************...8888878899**************************************985 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

MDGEHSALSG VERERERLPP IYNSSPPAGF GRGAKQPFPS LGTFISTLSQ RRDMAGRGLA 60
GGIMGNLTCN PGLRHGRELP PICSDVRQKQ RLSIDTLPPE VKAPFPSDPI IPLRTKTTKE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTAACATATT GAAATTCAGT TTCTGATGGC ACAGATTTCT GCCCATACTA AAGCTGCTGT 60
TGCCCACTGT TTGCCGTTAT TTCCTCCTCT CTCTAGCTCT TTCTCTCCCC TGTGTGTGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001266	Ailuropoda melanoleuca	73.58	0.00e+00	1162.00
IUUC-Apl-003589	Anas platyrhynchos	75.37	0.00e+00	1157.00
IUUC-Aca-004350	Anolis carolinensis	74.20	0.00e+00	1091.00
IUUC-Ago-007908	Ashbya gossypii	35.33	5.00e-83	302.00
IUUC-Acl-008288	Aspergillus clavatus	35.03	3.00e-95	343.00
IUUC-Afl-008402	Aspergillus flavus	34.16	1.00e-89	324.00
IUUC-Afu-008762	Aspergillus fumigatus	34.32	5.00e-94	339.00
IUUC-Ani-009176	Aspergillus nidulans	34.55	2.00e-91	330.00
IUUC-Ang-009791	Aspergillus niger	34.75	9.00e-93	335.00
IUUC-Aor-009921	Aspergillus oryzae	34.00	5.00e-89	322.00
IUUC-Ate-010295	Aspergillus terreus	35.71	4.00e-98	353.00
IUUC-Ame-010660	Astyanax mexicanus	84.28	3.00e-157	547.00
IUUC-Bgr-011981	Blumeria graminis	33.06	2.00e-87	317.00
IUUC-Bta-012945	Bos taurus	73.07	0.00e+00	1134.00
IUUC-Bci-013697	Botrytis cinerea	37.39	3.00e-78	287.00
IUUC-Cja-019263	Callithrix jacchus	72.40	0.00e+00	1120.00
IUUC-Cfa-020486	Canis familiaris	78.57	0.00e+00	1095.00
IUUC-Cpo-021755	Cavia porcellus	73.36	0.00e+00	1153.00
IUUC-Csa-023814	Chlorocebus sabaeus	72.99	0.00e+00	1065.00
IUUC-Cho-024980	Choloepus hoffmanni	60.95	0.00e+00	903.00
IUUC-Cgl-026526	Colletotrichum gloeosporioides	40.22	1.00e-91	331.00
IUUC-Dre-028551	Danio rerio	79.09	0.00e+00	1227.00
IUUC-Dno-029497	Dasypus novemcinctus	75.18	0.00e+00	1071.00
IUUC-Dor-030867	Dipodomys ordii	63.47	0.00e+00	949.00
IUUC-Dse-031239	Dothistroma septosporum	28.94	6.00e-87	316.00
IUUC-Ete-032902	Echinops telfairi	65.74	0.00e+00	947.00
IUUC-Eca-033678	Equus caballus	73.57	0.00e+00	1147.00
IUUC-Eeu-035262	Erinaceus europaeus	65.16	0.00e+00	914.00
IUUC-Fca-035590	Felis catus	73.98	0.00e+00	1165.00
IUUC-Fal-037123	Ficedula albicollis	71.50	0.00e+00	1108.00
IUUC-Fox-037941	Fusarium oxysporum	38.12	3.00e-96	347.00
IUUC-Fso-038388	Fusarium solani	39.33	2.00e-98	354.00
IUUC-Gmo-039553	Gadus morhua	74.41	0.00e+00	948.00
IUUC-Ggr-040110	Gaeumannomyces graminis	39.01	4.00e-93	336.00
IUUC-Gga-040406	Gallus gallus	75.41	0.00e+00	1191.00
IUUC-Gac-042141	Gasterosteus aculeatus	94.78	0.00e+00	1353.00
IUUC-Ggo-045504	Gorilla gorilla	71.90	0.00e+00	1129.00
IUUC-Hsa-045786	Homo sapiens	72.42	0.00e+00	1134.00
IUUC-Itr-048050	Ictidomys tridecemlineatus	71.95	0.00e+00	1034.00
IUUC-Kpa-049152	Komagataella pastoris	31.33	5.00e-73	269.00
IUUC-Lch-049824	Latimeria chalumnae	75.40	0.00e+00	1029.00
IUUC-Loc-052173	Lepisosteus oculatus	78.04	0.00e+00	1199.00
IUUC-Laf-054017	Loxodonta africana	77.55	0.00e+00	1136.00
IUUC-Mcc-055713	Macaca mulatta	75.57	0.00e+00	1114.00
IUUC-Meu-056212	Macropus eugenii	63.00	2.00e-102	367.00
IUUC-Mor-057045	Magnaporthe oryzae	38.00	1.00e-86	315.00
IUUC-Mla-059187	Melampsora laricipopulina	40.43	5.00e-82	298.00
IUUC-Mga-059884	Meleagris gallopavo	69.43	0.00e+00	1048.00
IUUC-Mmr-061344	Microcebus murinus	75.72	0.00e+00	1140.00
IUUC-Mdo-062653	Monodelphis domestica	72.78	0.00e+00	1131.00
IUUC-Mmu-063775	Mus musculus	71.74	0.00e+00	1066.00
IUUC-Mpu-066069	Mustela putorius furo	77.19	0.00e+00	1105.00
IUUC-Mlu-067925	Myotis lucifugus	76.73	0.00e+00	1134.00
IUUC-Nfi-068439	Neosartorya fischeri	34.15	5.00e-93	336.00
IUUC-Ncr-068903	Neurospora crassa	38.28	1.00e-92	335.00
IUUC-Nle-070046	Nomascus leucogenys	72.17	0.00e+00	1137.00
IUUC-Opr-071085	Ochotona princeps	65.44	9.00e-114	404.00
IUUC-Oan-072933	Ornithorhynchus anatinus	77.16	0.00e+00	1057.00
IUUC-Ocu-073800	Oryctolagus cuniculus	77.19	0.00e+00	1091.00
IUUC-Ola-086988	Oryzias latipes	94.03	0.00e+00	1355.00
IUUC-Oga-088117	Otolemur garnettii	78.10	0.00e+00	963.00
IUUC-Oar-089371	Ovis aries	73.16	0.00e+00	1115.00
IUUC-Ptr-090551	Pan troglodytes	75.54	0.00e+00	1110.00
IUUC-Pan-092067	Papio anubis	76.01	0.00e+00	1120.00
IUUC-Psi-092963	Pelodiscus sinensis	73.49	0.00e+00	1110.00
IUUC-Pfo-096562	Poecilia formosa	91.87	0.00e+00	1425.00
IUUC-Pab-098680	Pongo abelii	72.29	0.00e+00	1130.00
IUUC-Pca-100986	Procavia capensis	62.00	0.00e+00	749.00
IUUC-Pva-102219	Pteropus vampyrus	69.50	0.00e+00	861.00
IUUC-Pgr-103315	Puccinia graminis	35.61	2.00e-92	334.00
IUUC-Ptt-103736	Puccinia triticina	39.61	8.00e-91	328.00
IUUC-Rno-105270	Rattus norvegicus	75.87	0.00e+00	1073.00
IUUC-Sce-106306	Saccharomyces cerevisiae	35.04	4.00e-76	280.00
IUUC-Sha-106819	Sarcophilus harrisii	74.73	0.00e+00	1171.00
IUUC-Spo-108271	Schizosaccharomyces pombe	32.08	6.00e-89	322.00
IUUC-Ssl-108657	Sclerotinia sclerotiorum	37.14	9.00e-80	292.00
IUUC-Sar-113134	Sorex araneus	66.49	0.00e+00	997.00
IUUC-Ssc-115441	Sus scrofa	73.63	0.00e+00	1130.00
IUUC-Tgu-117166	Taeniopygia guttata	73.49	0.00e+00	1117.00
IUUC-Tsy-118898	Tarsius syrichta	67.35	0.00e+00	892.00
IUUC-Tre-122108	Trichoderma reesei	36.47	6.00e-86	313.00
IUUC-Tvi-122644	Trichoderma virens	36.90	4.00e-91	330.00
IUUC-Tme-127004	Tuber melanosporum	34.77	3.00e-103	370.00
IUUC-Tbe-127292	Tupaia belangeri	62.43	0.00e+00	876.00
IUUC-Ttr-128352	Tursiops truncatus	70.84	0.00e+00	1085.00
IUUC-Vda-129969	Verticillium dahliae	38.90	7.00e-89	322.00
IUUC-Vpa-130218	Vicugna pacos	70.53	0.00e+00	797.00
IUUC-Xtr-132594	Xenopus tropicalis	70.24	0.00e+00	1072.00
IUUC-Xma-134157	Xiphophorus maculatus	93.04	0.00e+00	1259.00
IUUC-Yli-134470	Yarrowia lipolytica	31.50	1.00e-76	281.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence