iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062788

UUCD1 version

UUC-MoD-00581

Ensembl Protein ID

ENSMODP00000028411.1

UniProt Accession

F7AZP2; F7AZP2_MONDO

Protein Name

Uncharacterized protein

Gene Name

SOCS5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000023104.1	ENSMODT00000029993.1	ENSMODP00000028411.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	7.30e-16	57.9	478	523

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 5    wllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
            l r+ p+SLq++CR +I+rc++++++   d+LPLP++L+d+L++++y+
   Q: 478  SLNRTFPFSLQYICRAVICRCTTYDGI---DGLPLPSMLQDFLKEYHYK 523
           577899*********************...****************985 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MDKVGKMWNN FKYRCQNLFN HEGGNNNENT VVNSNRCLSV KERNISIGDL APQQQSSPLR 60
ENVALQLEIS PSKNSSRRNQ NCATDIPQIV EISIEKESDS CITTTGTRLA RRDSYSRHAP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATAAAG TGGGGAAGAT GTGGAACAAC TTCAAATACA GGTGTCAGAA TCTTTTTAAC 60
CACGAAGGAG GAAACAACAA TGAAAATACA GTTGTGAACT CTAACAGGTG TTTATCTGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR022252--SOCS4/SOCS5_dom
IPR028420--SOCS5
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF12610--SOCS
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004860--F:protein kinase inhibitor activity
GO:0071404--P:cellular response to low-density lipoprotein particle stimulus
GO:0019221--P:cytokine-mediated signaling pathway
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0007259--P:JAK-STAT cascade
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0050728--P:negative regulation of inflammatory response
GO:0032715--P:negative regulation of interleukin-6 production
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0071638--P:negative regulation of monocyte chemotactic protein-1 production
GO:0006469--P:negative regulation of protein kinase activity
GO:0045629--P:negative regulation of T-helper 2 cell differentiation
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0045627--P:positive regulation of T-helper 1 cell differentiation
GO:0016567--P:protein ubiquitination
GO:0097699--P:vascular endothelial cell response to fluid shear stress

KEGG

mdo:100032188

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000371	Aegilops tauschii	34.69	2.00e-02	32.00
IUUC-Aml-001789	Ailuropoda melanoleuca	54.08	1.00e-111	396.00
IUUC-Apl-003815	Anas platyrhynchos	90.91	0.00e+00	981.00
IUUC-Aca-004504	Anolis carolinensis	85.34	0.00e+00	848.00
IUUC-Ame-010677	Astyanax mexicanus	62.43	0.00e+00	630.00
IUUC-Bta-012338	Bos taurus	92.21	0.00e+00	975.00
IUUC-Bol-016597	Brassica oleracea	41.03	4.50e-01	29.60
IUUC-Cja-019828	Callithrix jacchus	92.02	0.00e+00	952.00
IUUC-Cfa-020369	Canis familiaris	91.65	0.00e+00	974.00
IUUC-Cpo-021397	Cavia porcellus	90.54	0.00e+00	988.00
IUUC-Csa-023856	Chlorocebus sabaeus	91.84	0.00e+00	973.00
IUUC-Cho-024700	Choloepus hoffmanni	53.15	1.00e-116	413.00
IUUC-Dre-028262	Danio rerio	62.65	2.00e-168	585.00
IUUC-Dno-029019	Dasypus novemcinctus	92.02	0.00e+00	1001.00
IUUC-Dor-030273	Dipodomys ordii	54.03	5.00e-112	397.00
IUUC-Dme-031965	Drosophila melanogaster	67.44	2.00e-69	257.00
IUUC-Ete-032972	Echinops telfairi	57.19	1.00e-99	356.00
IUUC-Eca-033867	Equus caballus	90.54	0.00e+00	984.00
IUUC-Eeu-035208	Erinaceus europaeus	53.83	2.00e-110	392.00
IUUC-Fca-035806	Felis catus	92.02	0.00e+00	969.00
IUUC-Fal-037117	Ficedula albicollis	90.72	0.00e+00	972.00
IUUC-Gmo-039066	Gadus morhua	84.98	2.00e-108	385.00
IUUC-Gga-040876	Gallus gallus	90.35	0.00e+00	961.00
IUUC-Gac-042149	Gasterosteus aculeatus	66.54	0.00e+00	638.00
IUUC-Ggo-045169	Gorilla gorilla	90.72	0.00e+00	968.00
IUUC-Hsa-045805	Homo sapiens	91.84	0.00e+00	973.00
IUUC-Hvu-047122	Hordeum vulgare	36.59	8.50e-02	30.80
IUUC-Itr-049048	Ictidomys tridecemlineatus	90.72	0.00e+00	991.00
IUUC-Lch-049686	Latimeria chalumnae	79.11	0.00e+00	825.00
IUUC-Lpe-051639	Leersia perrieri	29.23	7.70e-01	28.90
IUUC-Loc-051745	Lepisosteus oculatus	71.48	0.00e+00	714.00
IUUC-Lma-053042	Leptosphaeria maculans	25.00	8.50e-02	34.70
IUUC-Laf-054124	Loxodonta africana	90.72	0.00e+00	985.00
IUUC-Mcc-055175	Macaca mulatta	91.84	0.00e+00	973.00
IUUC-Meu-056557	Macropus eugenii	97.03	0.00e+00	1049.00
IUUC-Mga-059214	Meleagris gallopavo	89.98	0.00e+00	972.00
IUUC-Mvi-060418	Microbotryum violaceum	29.63	7.50e-01	27.30
IUUC-Mmr-060613	Microcebus murinus	76.99	0.00e+00	758.00
IUUC-Mmu-064333	Mus musculus	90.54	0.00e+00	958.00
IUUC-Mpu-066048	Mustela putorius furo	92.21	0.00e+00	975.00
IUUC-Mlu-067430	Myotis lucifugus	91.84	0.00e+00	951.00
IUUC-Nle-069086	Nomascus leucogenys	91.84	0.00e+00	996.00
IUUC-Opr-070312	Ochotona princeps	88.31	0.00e+00	934.00
IUUC-Ont-072299	Oreochromis niloticus	63.96	0.00e+00	633.00
IUUC-Ocu-074123	Oryctolagus cuniculus	86.83	0.00e+00	921.00
IUUC-Ola-086934	Oryzias latipes	67.22	0.00e+00	657.00
IUUC-Oga-088535	Otolemur garnettii	92.39	0.00e+00	1004.00
IUUC-Oar-089875	Ovis aries	91.84	0.00e+00	972.00
IUUC-Ptr-090541	Pan troglodytes	91.84	0.00e+00	973.00
IUUC-Pan-092416	Papio anubis	91.84	0.00e+00	973.00
IUUC-Psi-092960	Pelodiscus sinensis	89.24	0.00e+00	964.00
IUUC-Pma-094222	Petromyzon marinus	52.52	4.00e-137	481.00
IUUC-Pfo-096930	Poecilia formosa	64.77	0.00e+00	655.00
IUUC-Pab-098659	Pongo abelii	91.84	0.00e+00	973.00
IUUC-Pop-098820	Populus trichocarpa	41.18	1.70e-01	30.40
IUUC-Pca-100222	Procavia capensis	89.05	0.00e+00	971.00
IUUC-Pva-102387	Pteropus vampyrus	91.09	0.00e+00	967.00
IUUC-Rno-105698	Rattus norvegicus	90.35	0.00e+00	962.00
IUUC-Sha-107234	Sarcophilus harrisii	95.92	0.00e+00	1002.00
IUUC-Sar-113698	Sorex araneus	85.71	0.00e+00	867.00
IUUC-Ssc-115985	Sus scrofa	91.28	0.00e+00	989.00
IUUC-Tgu-116676	Taeniopygia guttata	90.91	0.00e+00	979.00
IUUC-Tru-118441	Takifugu rubripes	58.90	2.00e-151	529.00
IUUC-Tsy-119163	Tarsius syrichta	86.09	0.00e+00	929.00
IUUC-Tni-120436	Tetraodon nigroviridis	66.30	0.00e+00	642.00
IUUC-Tca-121188	Theobroma cacao	31.43	1.00e+00	27.70
IUUC-Tae-124846	Triticum aestivum	34.69	3.90e-02	31.20
IUUC-Tbe-127353	Tupaia belangeri	92.21	0.00e+00	975.00
IUUC-Ttr-128907	Tursiops truncatus	92.21	0.00e+00	956.00
IUUC-Vpa-130140	Vicugna pacos	92.58	0.00e+00	981.00
IUUC-Vvi-131327	Vitis vinifera	43.75	1.40e-01	30.80
IUUC-Xtr-132817	Xenopus tropicalis	78.70	0.00e+00	848.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence