iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000005158.4	ENSCAFT00000008320.4	ENSCAFP00000007711.3
ENSCAFG00000005158.4	ENSCAFT00000047945.1	ENSCAFP00000036771.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.70e-105	352.3	751	1088

Active Site

Position(s)	Description	Evidence
1056	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvg.....EegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqd 84
            dlkkr++v++++     E+g+d gG++refl++l+k  +np+ g+f++++++    +p+ ++ + +    ++++flGr+lgkal++
   Q: 751  PDLKKRIRVHLLNahgldEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPSPAAQMLVGD-SFARHYYFLGRMLGKALYE 836
           689**********99**9*********************************************9965.99***************** PP
   S: 85   grlldlplsksfyklllgk..klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneN 169
           + l++lp++ +f+++llg+  ++++++l+++dpe+yk+l ++k++ e d+eelgl++t+   ++ lge++++eLk gG++ipVt +N
   Q: 837  NMLVELPFAGFFLSKLLGTsaDVDIHHLASLDPEVYKNLLFLKSY-EGDVEELGLNFTVV--NNDLGEAQVVELKFGGKDIPVTSAN 920
           ******************9666889******************99.78999987777765..888********************** PP
   S: 170  keeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGe.eeidvedlkketkykggytedspaiqwFwevlee 255
           + +Y++lv++yrl+++i++++ afr+G+ +v++le+l++F+++e+++li+G    i++edlk++t+y ggy++d+p+i+ Fw+v+e+
   Q: 921  RIAYIHLVADYRLNRQIRQHCLAFRQGLANVVNLEWLRMFDQQEIQVLISGAqVPISLEDLKSFTNYSGGYSADHPVIKVFWRVVEG 1007
           ****************************************************899******************************** PP
   S: 256  fsseerkafLqFvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           f++ee++++L+FvT++sr Pl Gf+el p  f+i++ +sd +rlP+++TC+n+LkLPe+  ++ l++kLlyAie ++gFels
   Q: 1008 FTDEEKRKLLKFVTSCSRPPLLGFKELYPA-FCIHNGGSDlERLPTASTCMNLLKLPEFYDETLLRSKLLYAIECAAGFELS 1088
           ****************************88.*****99999**************************************985 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MFSFEGDFKT RPKVSLGGAS RKEEKASLLH RTQEERRKRE EERRRLKNAI IIQSFIRGYR 60
DRKQQHAIQR SAFDRCASAS QSGGTFSIAS GPNLTLLVRQ LLFFYKQNED SKRLIWMYQN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTTTAGTT TTGAAGGGGA TTTCAAAACG AGGCCCAAAG TGTCTCTCGG CGGCGCCAGC 60
AGGAAGGTAA GAGCGGCCTG CGTTGGTGCG GCGTCGGCTG GGCCTCCGGG GCGAGCCGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR000048--IQ_motif_EF-hand-BS

PROSITE

PS50237--HECT
PS50096--IQ

Pfam

PF00632--HECT
PF00612--IQ

SMART

SM00119--HECTc
SM00015--IQ

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0000209--P:protein polyubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001355	Ailuropoda melanoleuca	96.66	0.00e+00	1998.00
IUUC-Apl-003731	Anas platyrhynchos	89.53	0.00e+00	1927.00
IUUC-Aca-005248	Anolis carolinensis	88.69	0.00e+00	1921.00
IUUC-Aly-005768	Arabidopsis lyrata	34.30	5.00e-108	385.00
IUUC-Ath-006576	Arabidopsis thaliana	33.29	3.00e-108	386.00
IUUC-Ago-007748	Ashbya gossypii	42.08	2.00e-77	283.00
IUUC-Acl-008158	Aspergillus clavatus	38.17	2.00e-76	280.00
IUUC-Afl-008398	Aspergillus flavus	33.85	8.00e-78	285.00
IUUC-Afu-008937	Aspergillus fumigatus	38.64	1.00e-78	288.00
IUUC-Ani-009252	Aspergillus nidulans	38.59	2.00e-81	297.00
IUUC-Ang-009773	Aspergillus niger	34.19	6.00e-79	289.00
IUUC-Aor-009940	Aspergillus oryzae	33.85	8.00e-78	285.00
IUUC-Ate-010395	Aspergillus terreus	38.81	1.00e-76	281.00
IUUC-Ame-010769	Astyanax mexicanus	63.55	0.00e+00	1040.00
IUUC-Bgr-012269	Blumeria graminis	37.77	3.00e-75	275.00
IUUC-Bta-012841	Bos taurus	92.19	0.00e+00	1939.00
IUUC-Bci-013743	Botrytis cinerea	29.57	5.00e-85	309.00
IUUC-Bdi-014123	Brachypodium distachyon	46.32	3.00e-101	363.00
IUUC-Bol-015390	Brassica oleracea	33.72	8.00e-101	362.00
IUUC-Bra-016853	Brassica rapa	34.59	9.00e-108	385.00
IUUC-Cel-018638	Caenorhabditis elegans	39.61	7.00e-90	325.00
IUUC-Cja-019743	Callithrix jacchus	91.67	0.00e+00	1921.00
IUUC-Cpo-022401	Cavia porcellus	91.64	0.00e+00	1942.00
IUUC-Cre-022725	Chlamydomonas reinhardtii	43.73	1.00e-83	303.00
IUUC-Csa-024107	Chlorocebus sabaeus	94.85	0.00e+00	1988.00
IUUC-Cho-024750	Choloepus hoffmanni	83.33	0.00e+00	810.00
IUUC-Cin-025432	Ciona intestinalis	44.42	3.00e-97	348.00
IUUC-Cgl-026559	Colletotrichum gloeosporioides	34.08	3.00e-87	317.00
IUUC-Cne-026841	Cryptococcus neoformans	35.20	4.00e-94	339.00
IUUC-Cme-027265	Cyanidioschyzon merolae	46.62	4.00e-102	365.00
IUUC-Dre-028196	Danio rerio	77.57	0.00e+00	1611.00
IUUC-Dno-029024	Dasypus novemcinctus	94.21	0.00e+00	1997.00
IUUC-Dor-030483	Dipodomys ordii	91.12	0.00e+00	687.00
IUUC-Dse-031416	Dothistroma septosporum	33.56	1.00e-77	285.00
IUUC-Dme-031946	Drosophila melanogaster	37.04	0.00e+00	674.00
IUUC-Ete-032240	Echinops telfairi	83.65	3.00e-176	612.00
IUUC-Eca-033828	Equus caballus	94.84	0.00e+00	1975.00
IUUC-Eeu-034604	Erinaceus europaeus	85.38	3.00e-127	449.00
IUUC-Fca-035907	Felis catus	96.14	0.00e+00	2043.00
IUUC-Fal-037389	Ficedula albicollis	90.17	0.00e+00	1947.00
IUUC-Fox-037788	Fusarium oxysporum	31.38	1.00e-92	334.00
IUUC-Fso-038088	Fusarium solani	36.38	7.00e-90	325.00
IUUC-Gmo-039254	Gadus morhua	66.80	0.00e+00	1238.00
IUUC-Ggr-039941	Gaeumannomyces graminis	33.80	3.00e-83	303.00
IUUC-Gga-040310	Gallus gallus	90.07	0.00e+00	1939.00
IUUC-Gac-042054	Gasterosteus aculeatus	69.25	0.00e+00	1293.00
IUUC-Gma-042836	Glycine max	33.55	6.00e-102	365.00
IUUC-Ggo-045031	Gorilla gorilla	95.22	0.00e+00	1995.00
IUUC-Hsa-045880	Homo sapiens	95.13	0.00e+00	1994.00
IUUC-Hvu-047770	Hordeum vulgare	47.30	1.00e-102	367.00
IUUC-Itr-048555	Ictidomys tridecemlineatus	82.67	0.00e+00	669.00
IUUC-Kpa-049307	Komagataella pastoris	36.28	5.00e-64	239.00
IUUC-Lch-050403	Latimeria chalumnae	81.44	0.00e+00	1673.00
IUUC-Lpe-051428	Leersia perrieri	45.91	3.00e-94	340.00
IUUC-Loc-052218	Lepisosteus oculatus	81.56	0.00e+00	1716.00
IUUC-Lma-053096	Leptosphaeria maculans	38.36	4.00e-80	293.00
IUUC-Laf-054162	Loxodonta africana	89.91	0.00e+00	1684.00
IUUC-Mcc-055127	Macaca mulatta	94.94	0.00e+00	1989.00
IUUC-Meu-056187	Macropus eugenii	82.61	1.00e-105	377.00
IUUC-Mor-057021	Magnaporthe oryzae	34.49	3.00e-78	287.00
IUUC-Mpo-057570	Magnaporthe poae	36.46	5.00e-76	279.00
IUUC-Mtr-058154	Medicago truncatula	29.98	1.00e-104	374.00
IUUC-Mla-059124	Melampsora laricipopulina	48.03	1.00e-101	363.00
IUUC-Mga-059581	Meleagris gallopavo	89.83	0.00e+00	1922.00
IUUC-Mvi-060445	Microbotryum violaceum	37.54	5.00e-104	372.00
IUUC-Mmr-061360	Microcebus murinus	90.30	0.00e+00	1848.00
IUUC-Mdo-062194	Monodelphis domestica	86.93	0.00e+00	1929.00
IUUC-Mmu-064189	Mus musculus	91.73	0.00e+00	1972.00
IUUC-Mac-065275	Musa acuminata	49.14	3.00e-108	386.00
IUUC-Mpu-066439	Mustela putorius furo	95.15	0.00e+00	1966.00
IUUC-Mlu-068228	Myotis lucifugus	89.14	0.00e+00	1910.00
IUUC-Nfi-068280	Neosartorya fischeri	38.64	7.00e-79	289.00
IUUC-Ncr-068869	Neurospora crassa	35.79	1.00e-81	298.00
IUUC-Nle-069687	Nomascus leucogenys	94.47	0.00e+00	1935.00
IUUC-Opr-070592	Ochotona princeps	76.60	1.00e-121	431.00
IUUC-Ont-071836	Oreochromis niloticus	77.87	0.00e+00	1645.00
IUUC-Oan-072800	Ornithorhynchus anatinus	90.72	0.00e+00	1942.00
IUUC-Ocu-074587	Oryctolagus cuniculus	95.13	0.00e+00	2009.00
IUUC-Oba-075006	Oryza barthii	48.66	2.00e-106	381.00
IUUC-Obr-076133	Oryza brachyantha	48.17	9.00e-106	378.00
IUUC-Ogl-077003	Oryza glaberrima	48.66	1.00e-106	381.00
IUUC-Ogu-078947	Oryza glumaepatula	48.66	1.00e-106	381.00
IUUC-Olo-080475	Oryza longistaminata	48.66	1.00e-106	381.00
IUUC-Ome-081342	Oryza meridionalis	45.66	5.00e-94	339.00
IUUC-Oni-082385	Oryza nivara	48.66	1.00e-106	381.00
IUUC-Opu-083176	Oryza punctata	48.41	5.00e-106	379.00
IUUC-Oru-084554	Oryza rufipogon	45.66	7.00e-94	339.00
IUUC-Osa-085355	Oryza sativa	48.66	1.00e-106	381.00
IUUC-Ola-087209	Oryzias latipes	77.39	0.00e+00	1612.00
IUUC-Olu-087699	Ostreococcus lucimarinus	42.59	1.00e-86	313.00
IUUC-Oga-088776	Otolemur garnettii	88.60	0.00e+00	1811.00
IUUC-Oar-089441	Ovis aries	91.56	0.00e+00	1921.00
IUUC-Ptr-091273	Pan troglodytes	95.04	0.00e+00	1991.00
IUUC-Pan-091981	Papio anubis	94.85	0.00e+00	1989.00
IUUC-Psi-093203	Pelodiscus sinensis	88.75	0.00e+00	1672.00
IUUC-Pma-094738	Petromyzon marinus	65.18	0.00e+00	1339.00
IUUC-Pno-095132	Phaeosphaeria nodorum	29.38	1.00e-59	224.00
IUUC-Ppa-095682	Physcomitrella patens	35.64	4.00e-113	402.00
IUUC-Pfo-097511	Poecilia formosa	77.67	0.00e+00	1654.00
IUUC-Pab-098634	Pongo abelii	91.09	0.00e+00	1910.00
IUUC-Pop-098928	Populus trichocarpa	34.49	6.00e-98	352.00
IUUC-Pca-100987	Procavia capensis	99.22	0.00e+00	798.00
IUUC-Ppe-102040	Prunus persica	37.10	5.00e-95	342.00
IUUC-Pva-103034	Pteropus vampyrus	88.93	0.00e+00	1835.00
IUUC-Pgr-103513	Puccinia graminis	38.83	9.00e-106	378.00
IUUC-Ptt-103967	Puccinia triticina	41.12	5.00e-94	339.00
IUUC-Pte-104105	Pyrenophora teres	34.38	2.00e-81	297.00
IUUC-Pyt-104449	Pyrenophora triticirepentis	37.50	5.00e-78	286.00
IUUC-Rno-105380	Rattus norvegicus	89.56	0.00e+00	1706.00
IUUC-Sce-106446	Saccharomyces cerevisiae	41.01	4.00e-68	253.00
IUUC-Sha-107108	Sarcophilus harrisii	83.58	0.00e+00	1765.00
IUUC-Sja-107889	Schizosaccharomyces japonicus	43.19	8.00e-96	345.00
IUUC-Spo-108097	Schizosaccharomyces pombe	44.12	5.00e-94	339.00
IUUC-Ssl-108520	Sclerotinia sclerotiorum	29.74	4.00e-83	303.00
IUUC-Smo-109537	Selaginella moellendorffii	37.06	1.00e-103	371.00
IUUC-Sit-110457	Setaria italica	48.28	4.00e-98	353.00
IUUC-Sly-111362	Solanum lycopersicum	35.48	4.00e-100	359.00
IUUC-Sar-113687	Sorex araneus	82.47	0.00e+00	910.00
IUUC-Sre-115038	Sporisorium reilianum	43.76	2.00e-98	354.00
IUUC-Ssc-116168	Sus scrofa	87.32	0.00e+00	808.00
IUUC-Tgu-116729	Taeniopygia guttata	89.99	0.00e+00	1934.00
IUUC-Tru-118068	Takifugu rubripes	76.84	0.00e+00	1610.00
IUUC-Tsy-118942	Tarsius syrichta	92.75	0.00e+00	716.00
IUUC-Tni-120732	Tetraodon nigroviridis	75.80	0.00e+00	1558.00
IUUC-Tca-121737	Theobroma cacao	34.53	3.00e-105	376.00
IUUC-Tre-121892	Trichoderma reesei	37.66	6.00e-88	319.00
IUUC-Tvi-122354	Trichoderma virens	35.87	6.00e-89	322.00
IUUC-Tae-125580	Triticum aestivum	47.06	3.00e-102	366.00
IUUC-Tme-127102	Tuber melanosporum	35.99	8.00e-92	332.00
IUUC-Tbe-127351	Tupaia belangeri	81.05	0.00e+00	1521.00
IUUC-Ttr-129061	Tursiops truncatus	90.99	0.00e+00	1894.00
IUUC-Uma-129343	Ustilago maydis	44.72	3.00e-99	356.00
IUUC-Vda-129748	Verticillium dahliae	38.60	3.00e-80	293.00
IUUC-Vvi-131234	Vitis vinifera	35.59	1.00e-101	365.00
IUUC-Xtr-132094	Xenopus tropicalis	85.41	0.00e+00	1778.00
IUUC-Xma-133923	Xiphophorus maculatus	77.94	0.00e+00	1659.00
IUUC-Yli-134496	Yarrowia lipolytica	39.43	6.00e-89	322.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence