iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCJAG00000004298.3	ENSCJAT00000008268.1	ENSCJAP00000007822.1
ENSCJAG00000004298.3	ENSCJAT00000055112.1	ENSCJAP00000042505.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.00e-103	348.2	736	1067

Active Site

Position(s)	Description	Evidence
1041	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvg.....EegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqd 84
            dlkkr++v++++     E+g+d gG++refl++l+k  +np+ g+f++++++    +p+ ++ + +    ++++flGr+lgkal++
   Q: 736  PDLKKRIRVHLLNahgldEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAQMLVGD-SFARHYYFLGRMLGKALYE 821
           689**********99**9************************************9999999999965.999**************** PP
   S: 85   grlldlplsksfyklllgk..klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneN 169
           + l++lp++ +f+++llg+  ++++++l+++dpe+yk+l ++k++ e+d+e+lgl++t+   ++ lge++++eLk+gG++ipVt +N
   Q: 822  NMLVELPFAGFFLSKLLGTsaDVDIHHLASLDPEVYKNLLFLKSY-EDDVEDLGLNFTVV--NNDLGEAQVVELKSGGKDIPVTSAN 905
           ******************9666889********************.67898877666665..889********************** PP
   S: 170  keeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGe.eeidvedlkketkykggytedspaiqwFwevlee 255
           + +Y++lv++yrl+++i++++ afr+G+ +v++le+l++F+++e+++li+G    i++edlk++t+y ggy++d+p+i+ Fw+v+e+
   Q: 906  RIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAqVPISLEDLKSFTNYSGGYSADHPVIKVFWRVVEG 992
           ****************************************************899******************************** PP
   S: 256  fsseerkafLqFvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieet 330
           f+++e++++L+FvT++sr Pl Gf+el p  f+i++ +sd +rlP+++TC+n+LkLPe+  ++ l++kLlyAie +
   Q: 993  FTDDEKRKLLKFVTSCSRPPLLGFKELYPA-FCIHNGGSDlERLPTASTCMNLLKLPEFYDETLLRSKLLYAIECA 1067
           ****************************88.*****99999********************************986 PP

Organism

Callithrix jacchus

Protein Sequence
(Fasta)

MDFFEIRFYS SKTTEVLTCS RSEEKASLLH RTQEERRKRE EERRRLKNAI IIQSFIRGYR 60
DRKQQYSIQR SAFDRCATLS QSGGAFPIAS GPNLTLLVRQ LLFFYKQNED SKRLIWLYQN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATTTCT TCGTTGAAAT TTTTACTGAG ATAATTGTAG AGTTGTATCC AGCTGTTAGA 60
AATGATACAG GAGACCCTTC TTCACATGAC CCAGTTTCCC CTGGGGTGAT CGTTTACAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR000048--IQ_motif_EF-hand-BS

PROSITE

PS50237--HECT
PS50096--IQ

Pfam

PF00632--HECT

SMART

SM00119--HECTc
SM00015--IQ

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0000209--P:protein polyubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001355	Ailuropoda melanoleuca	93.67	0.00e+00	1915.00
IUUC-Apl-003731	Anas platyrhynchos	88.31	0.00e+00	1865.00
IUUC-Aca-005248	Anolis carolinensis	87.09	0.00e+00	1871.00
IUUC-Aly-005768	Arabidopsis lyrata	34.88	2.00e-106	380.00
IUUC-Ago-007748	Ashbya gossypii	41.20	4.00e-75	276.00
IUUC-Acl-008158	Aspergillus clavatus	37.85	7.00e-75	276.00
IUUC-Afl-008398	Aspergillus flavus	33.39	4.00e-76	280.00
IUUC-Afu-008937	Aspergillus fumigatus	38.33	2.00e-77	284.00
IUUC-Ani-009252	Aspergillus nidulans	37.63	1.00e-78	288.00
IUUC-Ang-009773	Aspergillus niger	33.56	8.00e-77	282.00
IUUC-Aor-009940	Aspergillus oryzae	33.39	5.00e-76	280.00
IUUC-Ate-010395	Aspergillus terreus	38.28	7.00e-75	275.00
IUUC-Ame-010769	Astyanax mexicanus	62.25	0.00e+00	1026.00
IUUC-Bgr-012269	Blumeria graminis	37.44	2.00e-73	269.00
IUUC-Bta-012841	Bos taurus	91.09	0.00e+00	1905.00
IUUC-Bci-013743	Botrytis cinerea	29.71	2.00e-84	307.00
IUUC-Bol-015390	Brassica oleracea	45.34	1.00e-98	354.00
IUUC-Bra-016853	Brassica rapa	34.88	2.00e-105	377.00
IUUC-Cel-018638	Caenorhabditis elegans	40.00	9.00e-90	325.00
IUUC-Cfa-021031	Canis familiaris	92.88	0.00e+00	1930.00
IUUC-Cpo-022401	Cavia porcellus	90.89	0.00e+00	1904.00
IUUC-Cre-022725	Chlamydomonas reinhardtii	43.26	2.00e-82	299.00
IUUC-Csa-024107	Chlorocebus sabaeus	96.56	0.00e+00	1994.00
IUUC-Cho-024750	Choloepus hoffmanni	82.14	0.00e+00	793.00
IUUC-Cin-025432	Ciona intestinalis	44.90	7.00e-98	350.00
IUUC-Cgl-026559	Colletotrichum gloeosporioides	34.15	5.00e-87	316.00
IUUC-Cne-026841	Cryptococcus neoformans	35.10	2.00e-92	333.00
IUUC-Cme-027265	Cyanidioschyzon merolae	47.16	5.00e-102	365.00
IUUC-Dre-028196	Danio rerio	75.58	0.00e+00	1547.00
IUUC-Dno-029024	Dasypus novemcinctus	93.59	0.00e+00	1956.00
IUUC-Dor-030483	Dipodomys ordii	91.91	0.00e+00	693.00
IUUC-Dse-031416	Dothistroma septosporum	33.62	3.00e-76	280.00
IUUC-Dme-031946	Drosophila melanogaster	36.56	0.00e+00	639.00
IUUC-Ete-032240	Echinops telfairi	85.30	1.00e-176	613.00
IUUC-Eca-033828	Equus caballus	94.23	0.00e+00	1953.00
IUUC-Eeu-034604	Erinaceus europaeus	85.38	5.00e-127	448.00
IUUC-Fca-035907	Felis catus	92.01	0.00e+00	1943.00
IUUC-Fal-037389	Ficedula albicollis	88.39	0.00e+00	1890.00
IUUC-Fox-037788	Fusarium oxysporum	36.79	2.00e-89	323.00
IUUC-Fso-038088	Fusarium solani	35.36	2.00e-86	314.00
IUUC-Gmo-039254	Gadus morhua	65.06	0.00e+00	1184.00
IUUC-Ggr-039941	Gaeumannomyces graminis	33.68	1.00e-81	298.00
IUUC-Gga-040310	Gallus gallus	88.21	0.00e+00	1882.00
IUUC-Gac-042054	Gasterosteus aculeatus	67.70	0.00e+00	1253.00
IUUC-Ggo-045031	Gorilla gorilla	96.93	0.00e+00	2002.00
IUUC-Hsa-045880	Homo sapiens	96.84	0.00e+00	2000.00
IUUC-Itr-048555	Ictidomys tridecemlineatus	87.89	0.00e+00	686.00
IUUC-Lch-050403	Latimeria chalumnae	79.94	0.00e+00	1630.00
IUUC-Loc-052218	Lepisosteus oculatus	79.43	0.00e+00	1649.00
IUUC-Lma-053096	Leptosphaeria maculans	38.26	4.00e-79	290.00
IUUC-Laf-054162	Loxodonta africana	90.18	0.00e+00	1683.00
IUUC-Mcc-055127	Macaca mulatta	96.47	0.00e+00	1993.00
IUUC-Meu-056187	Macropus eugenii	81.74	1.00e-104	374.00
IUUC-Mor-057021	Magnaporthe oryzae	35.09	2.00e-78	287.00
IUUC-Mpo-057570	Magnaporthe poae	35.90	2.00e-74	274.00
IUUC-Mla-059124	Melampsora laricipopulina	48.26	2.00e-100	359.00
IUUC-Mga-059581	Meleagris gallopavo	89.27	0.00e+00	1883.00
IUUC-Mvi-060445	Microbotryum violaceum	37.62	1.00e-102	368.00
IUUC-Mmr-061360	Microcebus murinus	91.17	0.00e+00	1861.00
IUUC-Mdo-062194	Monodelphis domestica	89.58	0.00e+00	1890.00
IUUC-Mmu-064189	Mus musculus	90.80	0.00e+00	1931.00
IUUC-Mpu-066439	Mustela putorius furo	92.63	0.00e+00	1898.00
IUUC-Mlu-068228	Myotis lucifugus	88.69	0.00e+00	1876.00
IUUC-Nfi-068280	Neosartorya fischeri	38.33	1.00e-77	285.00
IUUC-Ncr-068869	Neurospora crassa	35.34	5.00e-80	293.00
IUUC-Nle-069687	Nomascus leucogenys	97.45	0.00e+00	1978.00
IUUC-Opr-070592	Ochotona princeps	75.65	9.00e-121	427.00
IUUC-Ont-071836	Oreochromis niloticus	75.93	0.00e+00	1587.00
IUUC-Oan-072800	Ornithorhynchus anatinus	88.95	0.00e+00	1888.00
IUUC-Ocu-074587	Oryctolagus cuniculus	94.80	0.00e+00	1977.00
IUUC-Ola-087209	Oryzias latipes	76.02	0.00e+00	1570.00
IUUC-Olu-087699	Ostreococcus lucimarinus	42.78	1.00e-85	310.00
IUUC-Oga-088776	Otolemur garnettii	88.57	0.00e+00	1762.00
IUUC-Oar-089441	Ovis aries	89.99	0.00e+00	1883.00
IUUC-Ptr-091273	Pan troglodytes	96.75	0.00e+00	1998.00
IUUC-Pan-091981	Papio anubis	96.56	0.00e+00	1995.00
IUUC-Psi-093203	Pelodiscus sinensis	86.80	0.00e+00	1618.00
IUUC-Pma-094738	Petromyzon marinus	63.52	0.00e+00	1288.00
IUUC-Pno-095132	Phaeosphaeria nodorum	29.53	1.00e-60	228.00
IUUC-Ppa-095682	Physcomitrella patens	35.14	1.00e-109	391.00
IUUC-Pfo-097511	Poecilia formosa	75.84	0.00e+00	1599.00
IUUC-Pab-098634	Pongo abelii	93.69	0.00e+00	1917.00
IUUC-Pop-099574	Populus trichocarpa	41.37	3.00e-92	333.00
IUUC-Pca-100987	Procavia capensis	98.15	0.00e+00	782.00
IUUC-Pva-103034	Pteropus vampyrus	88.19	0.00e+00	1797.00
IUUC-Pgr-103513	Puccinia graminis	39.10	6.00e-105	375.00
IUUC-Ptt-103967	Puccinia triticina	41.25	1.00e-92	334.00
IUUC-Pte-104105	Pyrenophora teres	34.27	2.00e-80	294.00
IUUC-Pyt-104449	Pyrenophora triticirepentis	37.39	3.00e-77	284.00
IUUC-Rno-105380	Rattus norvegicus	89.99	0.00e+00	1672.00
IUUC-Sce-106446	Saccharomyces cerevisiae	39.86	4.00e-67	249.00
IUUC-Sha-107108	Sarcophilus harrisii	83.91	0.00e+00	1749.00
IUUC-Sja-107889	Schizosaccharomyces japonicus	42.89	2.00e-94	340.00
IUUC-Spo-108097	Schizosaccharomyces pombe	43.81	1.00e-92	334.00
IUUC-Ssl-108520	Sclerotinia sclerotiorum	30.11	2.00e-81	297.00
IUUC-Sar-113687	Sorex araneus	81.96	0.00e+00	911.00
IUUC-Sre-115038	Sporisorium reilianum	44.17	3.00e-96	347.00
IUUC-Ssc-115378	Sus scrofa	96.02	0.00e+00	752.00
IUUC-Tgu-116729	Taeniopygia guttata	88.13	0.00e+00	1877.00
IUUC-Tru-118068	Takifugu rubripes	74.91	0.00e+00	1553.00
IUUC-Tsy-118942	Tarsius syrichta	97.58	0.00e+00	728.00
IUUC-Tni-120732	Tetraodon nigroviridis	73.98	0.00e+00	1496.00
IUUC-Tre-121892	Trichoderma reesei	35.96	2.00e-85	310.00
IUUC-Tvi-122354	Trichoderma virens	35.06	5.00e-87	316.00
IUUC-Tme-127102	Tuber melanosporum	35.37	3.00e-89	323.00
IUUC-Tbe-127351	Tupaia belangeri	81.45	0.00e+00	1522.00
IUUC-Ttr-129061	Tursiops truncatus	89.32	0.00e+00	1842.00
IUUC-Uma-129343	Ustilago maydis	44.17	9.00e-97	348.00
IUUC-Vda-129748	Verticillium dahliae	38.27	2.00e-79	291.00
IUUC-Xtr-132094	Xenopus tropicalis	83.69	0.00e+00	1730.00
IUUC-Xma-133923	Xiphophorus maculatus	76.12	0.00e+00	1603.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence