iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Mmu-063937

Ensembl Protein ID

ENSMUSP00000071589.5

UniProt Accession

O35226; Q91V59; Q9JJM0; Q9JJM1; Q9JJM2; Q9JJM3; PSMD4_MOUSE

Genbank Protein ID

AAC53547.1; BAA97572.1; BAA97573.1; BAA97574.1; BAA97575.1; BAA97576.1; BAA97577.1; AAG09199.1; AAH09005.1

Protein Name

26S proteasome non-ATPase regulatory subunit 4; 26S proteasome regulatory subunit RPN10; 26S proteasome regulatory subunit S5A; Multiubiquitin chain-binding protein

Genbank Nucleotide ID

AF013099; AB029090; AB029142; AB029143; AB029144; AB029145; AB029146; AF175574; BC009005

Gene Name

Psmd4; Mcb1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000005625.15	ENSMUST00000107237.7	ENSMUSP00000102857.1
ENSMUSG00000005625.15	ENSMUST00000071664.11	ENSMUSP00000071589.5
ENSMUSG00000005625.15	ENSMUST00000140348.7	ENSMUSP00000114545.1
ENSMUSG00000005625.15	ENSMUST00000117355.1	ENSMUSP00000113554.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
Phospho.ELM	UniProt	PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UIM	41.86	4.00e-65	245.00	IUUC-Ath-007436
UBD/Alpha-Helix/UIM	56.05	9.00e-104	374.00	IUUC-Dme-032000

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains.

Protein Sequence
(Fasta)

MVLESTMVCV DNSEYMRNGD FLPTRLQAQQ DAVNIVCHSK TRSNPENNVG LITLANDCEV 60
LTTLTPDTGR ILSKLHTVQP KGKITFCTGI RVAHLALKHR QGKNHKMRII AFVGSPVEDN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATTGGTGAT GAGCACCAGG CCAATCGGAG GTGCTGTTGT TTGTCAGTCC CGGAGCCGGT 60
CCGCAGAGGG AAGGAGGCAA GATGGTGTTG GAGAGCACTA TGGTTTGGTG AGGAGCTTCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR027040--Proteasome_su_Rpn10
IPR003903--UIM_dom
IPR002035--VWF_A

PROSITE

PS50330--UIM
PS50234--VWFA

Pfam

PF02809--UIM
PF13519--VWA_2

SMART

SM00726--UIM
SM00327--VWA

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0022624--C:proteasome accessory complex
GO:0000502--C:proteasome complex
GO:0008540--C:proteasome regulatory particle, base subcomplex
GO:0042802--F:identical protein binding
GO:0031593--F:polyubiquitin binding
GO:0003723--F:RNA binding
GO:0043248--P:proteasome assembly
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process

KEGG

mmu:19185

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001241	Ailuropoda melanoleuca	94.26	1.00e-175	608.00
IUUC-Atr-002938	Amborella trichopoda	42.79	1.00e-65	243.00
IUUC-Apl-003881	Anas platyrhynchos	97.13	5.00e-110	389.00
IUUC-Aca-004397	Anolis carolinensis	97.32	3.00e-120	424.00
IUUC-Aly-005564	Arabidopsis lyrata	50.85	3.00e-53	202.00
IUUC-Ath-007436	Arabidopsis thaliana	50.85	4.00e-53	201.00
IUUC-Ago-007858	Ashbya gossypii	51.30	1.00e-58	219.00
IUUC-Acl-008094	Aspergillus clavatus	45.45	2.00e-38	152.00
IUUC-Afl-008689	Aspergillus flavus	46.75	6.00e-39	154.00
IUUC-Afu-008959	Aspergillus fumigatus	46.29	6.00e-39	154.00
IUUC-Ani-009344	Aspergillus nidulans	43.01	1.00e-23	102.00
IUUC-Ang-009602	Aspergillus niger	45.45	3.00e-37	148.00
IUUC-Aor-009906	Aspergillus oryzae	44.74	1.00e-24	106.00
IUUC-Ate-010267	Aspergillus terreus	44.50	3.00e-30	125.00
IUUC-Ame-011018	Astyanax mexicanus	86.03	5.00e-172	597.00
IUUC-Bgr-012200	Blumeria graminis	50.00	5.00e-49	187.00
IUUC-Bta-013066	Bos taurus	95.91	2.00e-174	604.00
IUUC-Bci-013904	Botrytis cinerea	51.90	2.00e-49	189.00
IUUC-Bdi-014537	Brachypodium distachyon	49.58	7.00e-53	201.00
IUUC-Bol-015474	Brassica oleracea	50.42	2.00e-52	199.00
IUUC-Bra-018039	Brassica rapa	50.42	1.00e-52	200.00
IUUC-Cel-018187	Caenorhabditis elegans	43.06	8.00e-66	244.00
IUUC-Cja-019738	Callithrix jacchus	96.46	2.00e-177	615.00
IUUC-Cfa-020362	Canis familiaris	94.26	1.00e-175	608.00
IUUC-Cpo-021297	Cavia porcellus	95.25	5.00e-167	581.00
IUUC-Cre-022783	Chlamydomonas reinhardtii	49.58	4.00e-46	177.00
IUUC-Cho-024800	Choloepus hoffmanni	88.07	4.00e-50	191.00
IUUC-Cin-025469	Ciona intestinalis	54.60	6.00e-89	320.00
IUUC-Csv-026297	Ciona savignyi	55.65	3.00e-99	355.00
IUUC-Cgl-026657	Colletotrichum gloeosporioides	48.95	2.00e-39	155.00
IUUC-Cne-027027	Cryptococcus neoformans	47.14	5.00e-49	188.00
IUUC-Cme-027212	Cyanidioschyzon merolae	41.03	6.00e-47	181.00
IUUC-Dre-027759	Danio rerio	84.66	4.00e-167	580.00
IUUC-Dno-029528	Dasypus novemcinctus	96.46	2.00e-177	615.00
IUUC-Dor-030255	Dipodomys ordii	96.09	9.00e-173	599.00
IUUC-Dse-031464	Dothistroma septosporum	49.79	2.00e-53	202.00
IUUC-Dme-032000	Drosophila melanogaster	68.44	2.00e-87	315.00
IUUC-Ete-032762	Echinops telfairi	95.91	8.00e-178	616.00
IUUC-Eca-034399	Equus caballus	93.70	4.00e-174	605.00
IUUC-Eeu-035072	Erinaceus europaeus	96.14	5.00e-143	500.00
IUUC-Fca-035993	Felis catus	94.96	1.00e-169	588.00
IUUC-Fal-037623	Ficedula albicollis	64.44	1.00e-117	416.00
IUUC-Fox-037746	Fusarium oxysporum	47.03	2.00e-49	189.00
IUUC-Fso-038431	Fusarium solani	49.15	3.00e-50	191.00
IUUC-Gmo-039290	Gadus morhua	81.15	3.00e-141	494.00
IUUC-Ggr-039821	Gaeumannomyces graminis	48.70	4.00e-41	161.00
IUUC-Gga-040288	Gallus gallus	91.55	5.00e-169	587.00
IUUC-Gac-042587	Gasterosteus aculeatus	82.55	1.00e-161	563.00
IUUC-Gma-044042	Glycine max	52.17	2.00e-57	216.00
IUUC-Ggo-044628	Gorilla gorilla	96.46	2.00e-177	615.00
IUUC-Hsa-045850	Homo sapiens	95.64	0.00e+00	627.00
IUUC-Hvu-047715	Hordeum vulgare	49.58	4.00e-52	198.00
IUUC-Itr-048388	Ictidomys tridecemlineatus	95.29	1.00e-172	598.00
IUUC-Kpa-049158	Komagataella pastoris	54.79	4.00e-56	211.00
IUUC-Lch-050472	Latimeria chalumnae	88.48	1.00e-160	560.00
IUUC-Lpe-051233	Leersia perrieri	48.73	4.00e-49	190.00
IUUC-Loc-052437	Lepisosteus oculatus	76.59	3.00e-90	327.00
IUUC-Lma-053295	Leptosphaeria maculans	52.50	3.00e-48	185.00
IUUC-Laf-053504	Loxodonta africana	95.91	5.00e-177	613.00
IUUC-Mcc-054877	Macaca mulatta	96.46	3.00e-177	614.00
IUUC-Meu-056114	Macropus eugenii	94.82	9.00e-180	622.00
IUUC-Mor-057212	Magnaporthe oryzae	45.99	5.00e-44	171.00
IUUC-Mpo-057587	Magnaporthe poae	49.74	4.00e-42	165.00
IUUC-Mtr-058520	Medicago truncatula	39.75	4.00e-57	215.00
IUUC-Mla-059105	Melampsora laricipopulina	41.84	7.00e-19	87.80
IUUC-Mga-059537	Meleagris gallopavo	91.55	4.00e-173	600.00
IUUC-Mvi-060277	Microbotryum violaceum	37.15	2.00e-39	156.00
IUUC-Mmr-061736	Microcebus murinus	95.37	2.00e-172	598.00
IUUC-Mdo-062403	Monodelphis domestica	94.40	2.00e-172	599.00
IUUC-Mac-065456	Musa acuminata	39.33	4.00e-57	215.00
IUUC-Mpu-065901	Mustela putorius furo	94.26	8.00e-176	609.00
IUUC-Mlu-067994	Myotis lucifugus	94.82	1.00e-179	622.00
IUUC-Nfi-068540	Neosartorya fischeri	46.29	8.00e-39	153.00
IUUC-Ncr-068760	Neurospora crassa	49.58	1.00e-52	199.00
IUUC-Nle-069463	Nomascus leucogenys	96.46	2.00e-177	614.00
IUUC-Opr-070298	Ochotona princeps	95.91	7.00e-177	613.00
IUUC-Ont-072615	Oreochromis niloticus	84.76	2.00e-171	594.00
IUUC-Ocu-074141	Oryctolagus cuniculus	95.64	7.00e-178	616.00
IUUC-Oba-075955	Oryza barthii	48.73	9.00e-50	190.00
IUUC-Obr-076545	Oryza brachyantha	48.31	2.00e-48	186.00
IUUC-Ogl-077252	Oryza glaberrima	48.31	2.00e-47	183.00
IUUC-Ogu-078986	Oryza glumaepatula	48.73	1.00e-49	190.00
IUUC-Oin-080166	Oryza indica	47.64	1.00e-47	184.00
IUUC-Olo-080390	Oryza longistaminata	48.05	2.00e-46	181.00
IUUC-Ome-082015	Oryza meridionalis	48.73	8.00e-50	191.00
IUUC-Oni-082397	Oryza nivara	48.73	9.00e-50	190.00
IUUC-Opu-083674	Oryza punctata	48.73	6.00e-50	191.00
IUUC-Oru-085199	Oryza rufipogon	48.73	9.00e-50	190.00
IUUC-Osa-085911	Oryza sativa	48.73	9.00e-50	190.00
IUUC-Ola-087383	Oryzias latipes	85.15	6.00e-164	571.00
IUUC-Olu-087857	Ostreococcus lucimarinus	48.42	2.00e-45	175.00
IUUC-Oga-088882	Otolemur garnettii	94.41	7.00e-171	593.00
IUUC-Oar-089311	Ovis aries	95.91	2.00e-174	604.00
IUUC-Ptr-090931	Pan troglodytes	95.64	0.00e+00	627.00
IUUC-Pan-092286	Papio anubis	95.64	0.00e+00	627.00
IUUC-Psi-093908	Pelodiscus sinensis	91.16	3.00e-163	567.00
IUUC-Pma-094737	Petromyzon marinus	77.15	6.00e-139	487.00
IUUC-Pno-094807	Phaeosphaeria nodorum	52.10	5.00e-54	204.00
IUUC-Ppa-095749	Physcomitrella patens	48.35	2.00e-52	199.00
IUUC-Pfo-097212	Poecilia formosa	84.34	2.00e-168	584.00
IUUC-Pab-097708	Pongo abelii	95.53	1.00e-175	608.00
IUUC-Pop-099138	Populus trichocarpa	41.79	3.00e-64	239.00
IUUC-Pca-100722	Procavia capensis	100.00	3.00e-63	235.00
IUUC-Ppe-101877	Prunus persica	41.35	2.00e-70	259.00
IUUC-Pva-103185	Pteropus vampyrus	96.19	1.00e-178	619.00
IUUC-Pgr-103361	Puccinia graminis	39.83	3.00e-31	129.00
IUUC-Ptt-103848	Puccinia triticina	35.54	7.00e-15	74.30
IUUC-Pte-104114	Pyrenophora teres	50.43	4.00e-49	188.00
IUUC-Pyt-104662	Pyrenophora triticirepentis	51.05	1.00e-52	199.00
IUUC-Rno-104906	Rattus norvegicus	96.73	0.00e+00	642.00
IUUC-Sce-106427	Saccharomyces cerevisiae	48.73	3.00e-55	208.00
IUUC-Sha-106574	Sarcophilus harrisii	94.31	4.00e-178	617.00
IUUC-Sja-107706	Schizosaccharomyces japonicus	48.85	5.00e-49	187.00
IUUC-Spo-108378	Schizosaccharomyces pombe	46.51	2.00e-51	195.00
IUUC-Smo-109639	Selaginella moellendorffii	48.98	7.00e-53	201.00
IUUC-Sit-110284	Setaria italica	50.85	1.00e-49	190.00
IUUC-Sly-111246	Solanum lycopersicum	38.27	4.00e-60	225.00
IUUC-Stu-112695	Solanum tuberosum	37.78	2.00e-60	226.00
IUUC-Sar-113015	Sorex araneus	98.81	8.00e-98	350.00
IUUC-Sbi-114495	Sorghum bicolor	50.85	6.00e-50	191.00
IUUC-Sre-114891	Sporisorium reilianum	53.88	2.00e-58	219.00
IUUC-Ssc-116142	Sus scrofa	95.37	1.00e-180	625.00
IUUC-Tgu-116946	Taeniopygia guttata	85.90	4.00e-123	434.00
IUUC-Tru-118485	Takifugu rubripes	83.01	4.00e-162	565.00
IUUC-Tsy-119004	Tarsius syrichta	94.21	5.00e-145	507.00
IUUC-Tni-120074	Tetraodon nigroviridis	85.71	3.00e-169	587.00
IUUC-Tca-121251	Theobroma cacao	39.09	3.00e-55	208.00
IUUC-Tre-122168	Trichoderma reesei	49.79	8.00e-54	203.00
IUUC-Tvi-122655	Trichoderma virens	49.36	5.00e-50	191.00
IUUC-Tae-124568	Triticum aestivum	49.58	5.00e-52	198.00
IUUC-Tur-126420	Triticum urartu	49.58	7.00e-52	197.00
IUUC-Tme-126937	Tuber melanosporum	54.01	4.00e-55	208.00
IUUC-Tbe-128080	Tupaia belangeri	94.28	4.00e-173	600.00
IUUC-Ttr-128811	Tursiops truncatus	96.46	2.00e-177	615.00
IUUC-Uma-129436	Ustilago maydis	54.31	2.00e-59	223.00
IUUC-Vda-129920	Verticillium dahliae	48.35	4.00e-43	168.00
IUUC-Vpa-130762	Vicugna pacos	100.00	4.00e-65	241.00
IUUC-Vvi-130840	Vitis vinifera	40.00	8.00e-58	217.00
IUUC-Xtr-131967	Xenopus tropicalis	87.50	2.00e-110	391.00
IUUC-Xma-134224	Xiphophorus maculatus	84.07	4.00e-167	580.00
IUUC-Yli-134643	Yarrowia lipolytica	54.04	2.00e-53	202.00
IUUC-Zma-135870	Zea mays	41.44	4.00e-55	208.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence