iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tni-119852

Ensembl Protein ID

ENSTNIP00000005614.1

UniProt Accession

H3CBJ2; H3CBJ2_TETNG

Protein Name

Presenilin

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTNIG00000003044.1	ENSTNIT00000005762.1	ENSTNIP00000005614.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	1.30e-07	31.7	266	296

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgsl 32
           +eta+e++++iFP+l+ys+++v+L++ ++s+
   Q: 266  VETAQERNEPIFPALIYSSTMVWLVNVADSD 296
           89**********************9888776 PP

Organism

Tetraodon nigroviridis

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

MNQETGGVPE PAVQPQEVSV TRARSRGGGG GGGGGGGHGG GGPEQNGQPP APHAAHAVET 60
DEDEDEELTL KYGAKNVIML FVPVTLCMVV VVATIKSVSY YTKNDEQRLI YTPFPENTDT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAAGTGTCCG GGCTTTAAAC TCACTCCGGC AACCTTCAGA TTTAGAATTT AACCGTTTTA 60
CATTGTGGGT AAGATCTTTT ATTTTGTGCT CAGTGACCTG GGAACTTTAT TTAATCCCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR002031--Pept_A22A_PS1
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN

SMART

SM00730--PSN

Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0004190--F:aspartic-type endopeptidase activity
GO:0035556--P:intracellular signal transduction
GO:0007219--P:Notch signaling pathway
GO:0016485--P:protein processing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000686	Aegilops tauschii	33.23	7.00e-23	102.00
IUUC-Aml-001648	Ailuropoda melanoleuca	67.49	1.00e-115	409.00
IUUC-Atr-003039	Amborella trichopoda	29.60	7.00e-35	141.00
IUUC-Apl-003727	Anas platyrhynchos	71.72	4.00e-138	484.00
IUUC-Aca-004582	Anolis carolinensis	73.42	4.00e-141	494.00
IUUC-Aly-005455	Arabidopsis lyrata	29.44	7.00e-17	81.60
IUUC-Ath-006730	Arabidopsis thaliana	31.80	1.00e-17	84.30
IUUC-Ame-011500	Astyanax mexicanus	75.71	6.00e-150	523.00
IUUC-Bta-013026	Bos taurus	68.61	2.00e-135	475.00
IUUC-Bdi-014196	Brachypodium distachyon	31.32	8.00e-28	118.00
IUUC-Bol-015841	Brassica oleracea	33.77	2.00e-29	122.00
IUUC-Bra-017580	Brassica rapa	58.62	2.00e-17	83.60
IUUC-Cel-018553	Caenorhabditis elegans	49.00	2.00e-93	335.00
IUUC-Cja-019994	Callithrix jacchus	70.82	7.00e-136	476.00
IUUC-Cfa-020074	Canis familiaris	71.65	1.00e-136	479.00
IUUC-Cpo-022237	Cavia porcellus	71.39	2.00e-135	475.00
IUUC-Cre-022747	Chlamydomonas reinhardtii	33.03	8.00e-28	118.00
IUUC-Csa-023537	Chlorocebus sabaeus	70.82	3.00e-136	478.00
IUUC-Cho-024735	Choloepus hoffmanni	65.74	3.00e-126	444.00
IUUC-Cin-025780	Ciona intestinalis	56.78	3.00e-115	407.00
IUUC-Csv-025967	Ciona savignyi	57.11	6.00e-113	400.00
IUUC-Dre-028689	Danio rerio	76.63	8.00e-145	506.00
IUUC-Dno-029758	Dasypus novemcinctus	71.90	2.00e-138	485.00
IUUC-Dor-031127	Dipodomys ordii	64.86	3.00e-85	308.00
IUUC-Dme-031929	Drosophila melanogaster	50.47	5.00e-102	364.00
IUUC-Ete-033081	Echinops telfairi	48.20	7.00e-31	128.00
IUUC-Eca-034387	Equus caballus	67.34	1.00e-91	329.00
IUUC-Eeu-035134	Erinaceus europaeus	72.38	4.00e-104	370.00
IUUC-Fca-036243	Felis catus	71.65	5.00e-137	480.00
IUUC-Fal-036600	Ficedula albicollis	72.91	3.00e-140	491.00
IUUC-Gmo-039665	Gadus morhua	73.10	3.00e-121	427.00
IUUC-Gga-040993	Gallus gallus	72.91	7.00e-141	493.00
IUUC-Gac-042342	Gasterosteus aculeatus	78.97	4.00e-145	507.00
IUUC-Gma-043822	Glycine max	36.33	3.00e-21	95.90
IUUC-Ggo-045338	Gorilla gorilla	67.34	7.00e-92	330.00
IUUC-Hsa-046822	Homo sapiens	70.82	4.00e-136	478.00
IUUC-Hvu-047141	Hordeum vulgare	33.12	6.00e-24	105.00
IUUC-Itr-048731	Ictidomys tridecemlineatus	67.34	1.00e-91	330.00
IUUC-Lch-049946	Latimeria chalumnae	65.80	2.00e-117	415.00
IUUC-Lpe-051132	Leersia perrieri	51.49	5.00e-15	75.50
IUUC-Loc-052469	Lepisosteus oculatus	62.66	6.00e-130	457.00
IUUC-Laf-053979	Loxodonta africana	68.30	4.00e-125	441.00
IUUC-Mcc-055682	Macaca mulatta	70.82	4.00e-136	478.00
IUUC-Meu-056004	Macropus eugenii	60.76	8.00e-109	386.00
IUUC-Mtr-058392	Medicago truncatula	33.07	7.00e-26	111.00
IUUC-Mga-059466	Meleagris gallopavo	73.16	8.00e-141	493.00
IUUC-Mmr-060890	Microcebus murinus	66.94	2.00e-91	329.00
IUUC-Mdo-062122	Monodelphis domestica	69.91	2.00e-138	485.00
IUUC-Mmu-063176	Mus musculus	70.63	4.00e-130	457.00
IUUC-Mac-064858	Musa acuminata	36.04	2.00e-17	82.80
IUUC-Mpu-065927	Mustela putorius furo	71.65	8.00e-136	476.00
IUUC-Mlu-067079	Myotis lucifugus	71.39	4.00e-144	504.00
IUUC-Nle-070180	Nomascus leucogenys	70.82	4.00e-136	478.00
IUUC-Opr-070847	Ochotona princeps	69.37	4.00e-128	451.00
IUUC-Ont-071846	Oreochromis niloticus	77.21	2.00e-171	594.00
IUUC-Oan-072783	Ornithorhynchus anatinus	68.48	2.00e-109	389.00
IUUC-Ocu-074527	Oryctolagus cuniculus	71.65	6.00e-135	474.00
IUUC-Oba-075256	Oryza barthii	58.33	2.00e-15	76.60
IUUC-Obr-076302	Oryza brachyantha	44.80	3.00e-15	76.30
IUUC-Ogl-077097	Oryza glaberrima	58.33	2.00e-15	77.00
IUUC-Ogu-078570	Oryza glumaepatula	58.33	2.00e-15	76.60
IUUC-Oin-079244	Oryza indica	58.33	2.00e-15	76.60
IUUC-Olo-080484	Oryza longistaminata	60.49	7.00e-16	77.40
IUUC-Ome-081814	Oryza meridionalis	58.33	2.00e-15	77.00
IUUC-Oni-082057	Oryza nivara	58.33	2.00e-15	76.60
IUUC-Opu-084176	Oryza punctata	58.33	3.00e-15	76.30
IUUC-Oru-084618	Oryza rufipogon	58.33	2.00e-15	76.60
IUUC-Osa-085602	Oryza sativa	58.33	2.00e-15	76.60
IUUC-Ola-086707	Oryzias latipes	73.95	2.00e-84	305.00
IUUC-Olu-087811	Ostreococcus lucimarinus	32.91	2.00e-39	155.00
IUUC-Oga-088560	Otolemur garnettii	67.21	5.00e-91	327.00
IUUC-Oar-090348	Ovis aries	70.38	3.00e-138	484.00
IUUC-Ptr-091060	Pan troglodytes	70.82	4.00e-136	478.00
IUUC-Pan-091855	Papio anubis	65.37	4.00e-120	424.00
IUUC-Psi-093505	Pelodiscus sinensis	70.56	2.00e-139	488.00
IUUC-Pma-094612	Petromyzon marinus	63.89	1.00e-110	392.00
IUUC-Ppa-095431	Physcomitrella patens	31.19	7.00e-24	104.00
IUUC-Pfo-097396	Poecilia formosa	81.17	0.00e+00	633.00
IUUC-Pab-098591	Pongo abelii	70.82	4.00e-136	477.00
IUUC-Pop-099661	Populus trichocarpa	31.95	4.00e-31	129.00
IUUC-Pca-101029	Procavia capensis	68.09	4.00e-128	451.00
IUUC-Ppe-101495	Prunus persica	30.67	1.00e-19	90.90
IUUC-Pva-102244	Pteropus vampyrus	68.10	5.00e-131	460.00
IUUC-Rno-105861	Rattus norvegicus	69.52	4.00e-131	461.00
IUUC-Sha-107045	Sarcophilus harrisii	70.62	9.00e-140	489.00
IUUC-Smo-109325	Selaginella moellendorffii	35.74	2.00e-32	133.00
IUUC-Sit-110624	Setaria italica	31.10	2.00e-23	103.00
IUUC-Sly-110865	Solanum lycopersicum	55.56	5.00e-07	45.80
IUUC-Stu-112433	Solanum tuberosum	30.95	6.00e-30	124.00
IUUC-Sar-113169	Sorex araneus	65.17	2.00e-104	372.00
IUUC-Sbi-114305	Sorghum bicolor	55.95	9.00e-15	74.70
IUUC-Ssc-115766	Sus scrofa	71.90	2.00e-136	478.00
IUUC-Tgu-117280	Taeniopygia guttata	62.74	1.00e-116	412.00
IUUC-Tru-117732	Takifugu rubripes	83.82	0.00e+00	627.00
IUUC-Tsy-119624	Tarsius syrichta	67.09	8.00e-121	426.00
IUUC-Tca-121865	Theobroma cacao	34.07	3.00e-19	89.40
IUUC-Tae-125925	Triticum aestivum	34.82	3.00e-26	112.00
IUUC-Tur-126237	Triticum urartu	32.91	1.00e-23	103.00
IUUC-Tbe-128148	Tupaia belangeri	63.04	4.00e-96	344.00
IUUC-Ttr-128793	Tursiops truncatus	70.63	9.00e-132	463.00
IUUC-Vpa-130625	Vicugna pacos	57.86	2.00e-104	372.00
IUUC-Vvi-131312	Vitis vinifera	32.10	5.00e-32	132.00
IUUC-Xtr-131790	Xenopus tropicalis	72.41	1.00e-130	459.00
IUUC-Xma-133377	Xiphophorus maculatus	78.66	1.00e-176	612.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence