iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003478

Ensembl Protein ID

ENSAPLP00000004456.1

UniProt Accession

U3IB34; U3IB34_ANAPL

Genbank Protein ID

ENSAPLP00000004456

Protein Name

Histone-lysine N-methyltransferase

Genbank Nucleotide ID

ADON01119126

Gene Name

KMT2A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000004837.1	ENSAPLT00000005072.1	ENSAPLP00000004456.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	5.30e-27	93.5	425	478

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsek..wiCpkCrsk 54
           k+C+vCg++++ +k+l+eC+kCr+ +Hp+Cl+++ ++++p+++k  wiC+kC ++
   Q: 425  KFCHVCGRQHQATKQLLECNKCRNSYHPECLGPN-YPTKPTKKKkvWICTKCVRC 478
           58********************************.*****99999*******876 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

GQESDSSETS VRGPRIKHVC RRAAVALGRK RAVFPDDMPT LSALPWEERE KILSSMGNDA 60
DKSSIAGSEE AEPLAPPIKP IKPVTRNKTQ QEPPVKKGRR SRRCGQCSGC QVPEDCGVCT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGACAAGAGA GCGATTCATC AGAAACGTCA GTCCGAGGAC CACGAATAAA ACATGTTTGC 60
AGGAGAGCAG CTGTTGCACT GGGTCGTAAG CGAGCCGTGT TTCCTGACGA CATGCCCACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001487--Bromodomain
IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR016569--MeTrfase_trithorax
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR002857--Znf_CXXC
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50014--BROMODOMAIN_2
PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS51058--ZF_CXXC
PS50016--ZF_PHD_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET
PF02008--zf-CXXC

SMART

SM00297--BROMO
SM00542--FYRC
SM00541--FYRN
SM00249--PHD
SM00508--PostSET
SM00317--SET

Gene Ontology

GO:0035097--C:histone methyltransferase complex
GO:0003677--F:DNA binding
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0008270--F:zinc ion binding
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001054	Aegilops tauschii	34.74	7.00e-13	68.90
IUUC-Aml-002274	Ailuropoda melanoleuca	79.73	0.00e+00	3950.00
IUUC-Atr-002455	Amborella trichopoda	48.10	2.00e-39	157.00
IUUC-Aca-005086	Anolis carolinensis	67.76	0.00e+00	3275.00
IUUC-Aly-006448	Arabidopsis lyrata	48.10	7.00e-40	159.00
IUUC-Ath-006690	Arabidopsis thaliana	47.40	1.00e-37	151.00
IUUC-Ame-011195	Astyanax mexicanus	44.40	0.00e+00	817.00
IUUC-Bta-012974	Bos taurus	79.78	0.00e+00	3960.00
IUUC-Bdi-014882	Brachypodium distachyon	33.17	1.00e-25	110.00
IUUC-Bol-016540	Brassica oleracea	48.05	4.00e-38	153.00
IUUC-Cja-019226	Callithrix jacchus	79.54	0.00e+00	4008.00
IUUC-Cfa-021049	Canis familiaris	79.67	0.00e+00	3989.00
IUUC-Cpo-021459	Cavia porcellus	80.67	0.00e+00	3605.00
IUUC-Cre-022891	Chlamydomonas reinhardtii	50.78	5.00e-39	157.00
IUUC-Csa-023434	Chlorocebus sabaeus	79.58	0.00e+00	3939.00
IUUC-Cho-024652	Choloepus hoffmanni	76.80	0.00e+00	3254.00
IUUC-Cin-025724	Ciona intestinalis	54.75	1.00e-95	344.00
IUUC-Csv-026268	Ciona savignyi	37.77	2.00e-130	460.00
IUUC-Cme-027224	Cyanidioschyzon merolae	34.18	4.00e-12	67.00
IUUC-Dre-028180	Danio rerio	67.79	0.00e+00	1135.00
IUUC-Dno-029068	Dasypus novemcinctus	87.79	0.00e+00	1176.00
IUUC-Dor-030550	Dipodomys ordii	74.35	0.00e+00	3613.00
IUUC-Dme-032023	Drosophila melanogaster	46.55	7.00e-89	323.00
IUUC-Ete-032834	Echinops telfairi	71.36	0.00e+00	2259.00
IUUC-Eca-033615	Equus caballus	79.59	0.00e+00	3901.00
IUUC-Eeu-035136	Erinaceus europaeus	76.05	0.00e+00	1035.00
IUUC-Fca-036453	Felis catus	72.20	0.00e+00	1985.00
IUUC-Fal-037256	Ficedula albicollis	91.18	0.00e+00	4741.00
IUUC-Gmo-038641	Gadus morhua	67.88	0.00e+00	1091.00
IUUC-Gga-040828	Gallus gallus	93.25	0.00e+00	4742.00
IUUC-Gac-041452	Gasterosteus aculeatus	70.70	0.00e+00	1157.00
IUUC-Gma-043554	Glycine max	49.02	7.00e-39	155.00
IUUC-Ggo-045124	Gorilla gorilla	76.49	0.00e+00	3663.00
IUUC-Hsa-046143	Homo sapiens	79.78	0.00e+00	3903.00
IUUC-Hvu-047762	Hordeum vulgare	28.89	1.00e-18	87.80
IUUC-Itr-049024	Ictidomys tridecemlineatus	76.83	0.00e+00	3335.00
IUUC-Lch-049704	Latimeria chalumnae	68.35	0.00e+00	3355.00
IUUC-Lpe-051476	Leersia perrieri	30.09	1.00e-21	98.60
IUUC-Loc-052181	Lepisosteus oculatus	78.61	0.00e+00	1278.00
IUUC-Laf-053946	Loxodonta africana	80.67	0.00e+00	3885.00
IUUC-Mcc-055508	Macaca mulatta	79.50	0.00e+00	3908.00
IUUC-Meu-056485	Macropus eugenii	77.22	0.00e+00	2828.00
IUUC-Mtr-058327	Medicago truncatula	41.96	1.00e-39	158.00
IUUC-Mga-059943	Meleagris gallopavo	89.24	0.00e+00	4486.00
IUUC-Mmr-061178	Microcebus murinus	77.47	0.00e+00	3959.00
IUUC-Mdo-063031	Monodelphis domestica	82.50	0.00e+00	3764.00
IUUC-Mmu-063650	Mus musculus	78.74	0.00e+00	3499.00
IUUC-Mpu-066495	Mustela putorius furo	80.03	0.00e+00	2658.00
IUUC-Mlu-068045	Myotis lucifugus	77.26	0.00e+00	3836.00
IUUC-Nle-069064	Nomascus leucogenys	79.90	0.00e+00	3978.00
IUUC-Opr-071043	Ochotona princeps	74.69	0.00e+00	3627.00
IUUC-Ont-072556	Oreochromis niloticus	66.25	0.00e+00	1119.00
IUUC-Oan-073324	Ornithorhynchus anatinus	77.08	0.00e+00	1631.00
IUUC-Ocu-074190	Oryctolagus cuniculus	79.11	0.00e+00	3939.00
IUUC-Oba-075647	Oryza barthii	49.36	7.00e-39	155.00
IUUC-Obr-076458	Oryza brachyantha	33.00	3.00e-25	110.00
IUUC-Ogl-077851	Oryza glaberrima	31.74	2.00e-24	107.00
IUUC-Ogu-078706	Oryza glumaepatula	31.84	3.00e-25	110.00
IUUC-Oin-079802	Oryza indica	27.75	1.00e-19	90.90
IUUC-Olo-080577	Oryza longistaminata	47.71	2.00e-36	147.00
IUUC-Ome-081214	Oryza meridionalis	49.36	7.00e-39	155.00
IUUC-Oni-083000	Oryza nivara	49.36	8.00e-39	155.00
IUUC-Opu-083842	Oryza punctata	49.36	7.00e-39	155.00
IUUC-Oru-084361	Oryza rufipogon	49.36	9.00e-39	155.00
IUUC-Osa-085421	Oryza sativa	32.49	4.00e-24	106.00
IUUC-Ola-087176	Oryzias latipes	65.99	0.00e+00	1137.00
IUUC-Olu-087718	Ostreococcus lucimarinus	37.50	7.00e-36	146.00
IUUC-Oga-088208	Otolemur garnettii	79.83	0.00e+00	3921.00
IUUC-Oar-090152	Ovis aries	79.22	0.00e+00	3971.00
IUUC-Ptr-091127	Pan troglodytes	79.78	0.00e+00	3878.00
IUUC-Pan-092679	Papio anubis	79.68	0.00e+00	3917.00
IUUC-Psi-094059	Pelodiscus sinensis	86.88	0.00e+00	4526.00
IUUC-Pma-094258	Petromyzon marinus	58.90	0.00e+00	670.00
IUUC-Pfo-096536	Poecilia formosa	67.90	0.00e+00	1120.00
IUUC-Pab-098262	Pongo abelii	79.94	0.00e+00	3958.00
IUUC-Pca-100358	Procavia capensis	75.85	0.00e+00	3692.00
IUUC-Pva-102522	Pteropus vampyrus	74.84	0.00e+00	3600.00
IUUC-Rno-105200	Rattus norvegicus	78.06	0.00e+00	3455.00
IUUC-Sce-106318	Saccharomyces cerevisiae	25.35	6.30e-02	33.10
IUUC-Sha-107174	Sarcophilus harrisii	81.25	0.00e+00	4139.00
IUUC-Smo-109164	Selaginella moellendorffii	51.30	1.00e-40	161.00
IUUC-Sit-110552	Setaria italica	32.19	4.00e-26	112.00
IUUC-Sly-111176	Solanum lycopersicum	48.37	1.00e-36	148.00
IUUC-Stu-112529	Solanum tuberosum	48.37	1.00e-38	154.00
IUUC-Sar-113503	Sorex araneus	71.69	0.00e+00	2598.00
IUUC-Sbi-114254	Sorghum bicolor	26.92	4.00e-10	59.70
IUUC-Ssc-115509	Sus scrofa	51.47	0.00e+00	750.00
IUUC-Tgu-117047	Taeniopygia guttata	92.20	0.00e+00	4798.00
IUUC-Tru-118328	Takifugu rubripes	66.15	0.00e+00	1139.00
IUUC-Tsy-118953	Tarsius syrichta	72.21	0.00e+00	2381.00
IUUC-Tni-120837	Tetraodon nigroviridis	66.71	0.00e+00	1125.00
IUUC-Tae-124647	Triticum aestivum	29.72	6.00e-19	88.60
IUUC-Tbe-127950	Tupaia belangeri	72.54	0.00e+00	2245.00
IUUC-Ttr-128643	Tursiops truncatus	78.06	0.00e+00	3801.00
IUUC-Vpa-130660	Vicugna pacos	75.95	0.00e+00	1521.00
IUUC-Vvi-131476	Vitis vinifera	46.75	6.00e-40	159.00
IUUC-Xtr-132869	Xenopus tropicalis	72.27	0.00e+00	1598.00
IUUC-Xma-133119	Xiphophorus maculatus	47.54	0.00e+00	745.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence