iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-012699

Ensembl Protein ID

ENSBTAP00000022686.3

UniProt Accession

F1MD09; F1MD09_BOVIN

Genbank Protein ID

ENSBTAP00000022686

Protein Name

Inhibitor of growth protein

Genbank Nucleotide ID

DAAA02014462

Gene Name

ING4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000017064.3	ENSBTAT00000022686.3	ENSBTAP00000022686.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	7.60e-10	39.0	196	243

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCek..Cr.ewfHpaClklsveeelpnsekwiCpkCrs 53
           ++C +C++ + +e  ++ C++  C+ ewfH+aC++l+   ++p+ + w+Cp+C++
   Q: 196  TYC-LCHQVSYGE--MIGCDNpdCSiEWFHFACVGLT---TKPRGK-WFCPRCSQ 243
           69*.*******99..********999***********...899996.******97 PP

Organism

Bos taurus

Protein Sequence
(Fasta)

MAAGMYLEHY LDSIENLPFE LQRNFQLMRD LDQRTEDLKA EIDKLASEYM SSARSRSSEE 60
KLALLRQIQE AYGKCKEFGD DKVQLAMQTY EMVDKHIRRL DTDLARFEAD LKEKQIESSD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTTTGTTTT GCTTCAAGAT GGCTGCGGGG ATGTATTTGG AACATTATCT GGACAGTAAG 60
AGCAGGCTGG AGGAGCGGGT CAGGGGTTAC AGAGGGGTAG GGGTGGGGGT TCGGGCTGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR028647--ING4
IPR028651--ING_fam
IPR024610--ING_N_histone_binding
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF12998--ING

SMART

SM01408--ING
SM00249--PHD

Gene Ontology

GO:0000123--C:histone acetyltransferase complex
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0007050--P:cell cycle arrest
GO:0006978--P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0006260--P:DNA replication
GO:0043966--P:histone H3 acetylation
GO:0043983--P:histone H4-K12 acetylation
GO:0043981--P:histone H4-K5 acetylation
GO:0043982--P:histone H4-K8 acetylation
GO:0008285--P:negative regulation of cell proliferation
GO:0045926--P:negative regulation of growth
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0043065--P:positive regulation of apoptotic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001338	Ailuropoda melanoleuca	98.79	5.00e-127	446.00
IUUC-Apl-004097	Anas platyrhynchos	89.11	5.00e-111	393.00
IUUC-Aca-004593	Anolis carolinensis	91.97	9.00e-117	412.00
IUUC-Ame-011133	Astyanax mexicanus	79.68	3.00e-112	397.00
IUUC-Bdi-014504	Brachypodium distachyon	35.20	6.00e-39	154.00
IUUC-Bol-015245	Brassica oleracea	38.15	2.00e-29	122.00
IUUC-Bra-017027	Brassica rapa	31.85	8.00e-30	123.00
IUUC-Cja-019988	Callithrix jacchus	95.18	6.00e-118	416.00
IUUC-Cfa-021282	Canis familiaris	95.18	6.00e-118	416.00
IUUC-Cpo-022011	Cavia porcellus	95.98	3.00e-123	434.00
IUUC-Cre-022920	Chlamydomonas reinhardtii	31.35	3.00e-28	118.00
IUUC-Csa-023203	Chlorocebus sabaeus	95.18	6.00e-118	416.00
IUUC-Cin-025479	Ciona intestinalis	62.03	5.00e-77	280.00
IUUC-Csv-026288	Ciona savignyi	54.68	2.00e-71	261.00
IUUC-Dre-028264	Danio rerio	79.28	2.00e-110	391.00
IUUC-Dno-029766	Dasypus novemcinctus	92.34	2.00e-111	394.00
IUUC-Dor-031136	Dipodomys ordii	81.36	1.00e-91	328.00
IUUC-Dme-032200	Drosophila melanogaster	74.19	3.00e-40	158.00
IUUC-Eca-033565	Equus caballus	95.18	1.00e-122	432.00
IUUC-Eeu-034948	Erinaceus europaeus	79.67	6.00e-99	353.00
IUUC-Fca-036368	Felis catus	95.58	2.00e-118	417.00
IUUC-Fal-037120	Ficedula albicollis	89.11	1.00e-109	389.00
IUUC-Gmo-038982	Gadus morhua	81.20	5.00e-110	390.00
IUUC-Gga-040771	Gallus gallus	91.97	9.00e-117	412.00
IUUC-Gac-042184	Gasterosteus aculeatus	80.89	4.00e-107	380.00
IUUC-Gma-044339	Glycine max	29.08	3.00e-33	135.00
IUUC-Ggo-045559	Gorilla gorilla	95.18	6.00e-118	416.00
IUUC-Hsa-046852	Homo sapiens	95.18	6.00e-118	416.00
IUUC-Hvu-047046	Hordeum vulgare	35.71	6.00e-36	144.00
IUUC-Itr-047978	Ictidomys tridecemlineatus	95.58	4.00e-123	433.00
IUUC-Kpa-049229	Komagataella pastoris	59.18	2.00e-16	79.00
IUUC-Lpe-050822	Leersia perrieri	34.00	6.00e-37	147.00
IUUC-Laf-054057	Loxodonta africana	95.58	2.00e-118	417.00
IUUC-Mcc-055212	Macaca mulatta	90.44	4.00e-113	400.00
IUUC-Meu-056511	Macropus eugenii	91.95	1.00e-113	401.00
IUUC-Mga-059967	Meleagris gallopavo	89.88	2.00e-110	391.00
IUUC-Mmr-060843	Microcebus murinus	97.18	1.00e-125	442.00
IUUC-Mdo-062357	Monodelphis domestica	94.78	3.00e-122	430.00
IUUC-Mmu-064093	Mus musculus	95.98	3.00e-123	434.00
IUUC-Mac-064625	Musa acuminata	33.60	6.00e-37	147.00
IUUC-Mpu-066923	Mustela putorius furo	81.93	3.00e-95	340.00
IUUC-Mlu-067754	Myotis lucifugus	87.70	1.00e-110	392.00
IUUC-Nle-069062	Nomascus leucogenys	95.18	6.00e-118	416.00
IUUC-Opr-070207	Ochotona princeps	88.56	1.00e-106	378.00
IUUC-Ont-072446	Oreochromis niloticus	81.60	6.00e-109	386.00
IUUC-Ocu-074235	Oryctolagus cuniculus	95.18	6.00e-118	416.00
IUUC-Obr-076266	Oryza brachyantha	34.40	2.00e-37	149.00
IUUC-Oin-079049	Oryza indica	33.33	5.00e-36	144.00
IUUC-Ome-081291	Oryza meridionalis	35.27	1.00e-36	145.00
IUUC-Oni-082218	Oryza nivara	33.33	5.00e-36	144.00
IUUC-Opu-084171	Oryza punctata	35.06	2.00e-36	146.00
IUUC-Osa-085563	Oryza sativa	35.27	1.00e-36	145.00
IUUC-Ola-086429	Oryzias latipes	77.20	1.00e-100	358.00
IUUC-Olu-087851	Ostreococcus lucimarinus	34.16	4.00e-20	90.90
IUUC-Oga-089123	Otolemur garnettii	95.58	2.00e-118	417.00
IUUC-Oar-089524	Ovis aries	100.00	1.00e-127	448.00
IUUC-Ptr-090908	Pan troglodytes	94.78	2.00e-117	414.00
IUUC-Pan-092837	Papio anubis	98.39	2.00e-126	444.00
IUUC-Psi-093828	Pelodiscus sinensis	91.85	3.00e-106	377.00
IUUC-Ppa-096009	Physcomitrella patens	33.59	4.00e-32	131.00
IUUC-Pfo-096617	Poecilia formosa	81.20	4.00e-109	387.00
IUUC-Pab-097978	Pongo abelii	94.49	2.00e-107	381.00
IUUC-Pop-099415	Populus trichocarpa	73.68	3.00e-26	112.00
IUUC-Pca-100475	Procavia capensis	64.66	5.00e-80	290.00
IUUC-Ppe-101441	Prunus persica	32.27	1.00e-36	145.00
IUUC-Pva-102325	Pteropus vampyrus	95.18	1.00e-122	432.00
IUUC-Rno-105178	Rattus norvegicus	97.98	2.00e-130	457.00
IUUC-Sha-106773	Sarcophilus harrisii	94.78	2.00e-122	431.00
IUUC-Sit-109827	Setaria italica	35.60	8.00e-36	143.00
IUUC-Sly-111750	Solanum lycopersicum	34.26	3.00e-35	141.00
IUUC-Stu-112250	Solanum tuberosum	34.26	3.00e-35	141.00
IUUC-Sbi-114826	Sorghum bicolor	36.00	1.00e-36	146.00
IUUC-Sre-115124	Sporisorium reilianum	58.21	3.00e-22	100.00
IUUC-Ssc-115797	Sus scrofa	88.62	1.00e-102	365.00
IUUC-Tgu-117270	Taeniopygia guttata	91.97	9.00e-117	412.00
IUUC-Tru-118253	Takifugu rubripes	81.27	4.00e-110	390.00
IUUC-Tca-121597	Theobroma cacao	69.84	4.00e-28	117.00
IUUC-Tae-123043	Triticum aestivum	35.04	3.00e-37	148.00
IUUC-Tbe-127558	Tupaia belangeri	98.79	5.00e-127	446.00
IUUC-Ttr-128300	Tursiops truncatus	100.00	3.00e-65	241.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence