iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-059608

UUCD1 version

UUC-MeG-00178

Ensembl Protein ID

ENSMGAP00000003265.2

UniProt Accession

G1MWV4; G1MWV4_MELGA

Protein Name

Katanin p80 WD40 repeat-containing subunit B1; p80 katanin

Gene Name

KATNB1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000003513.2	ENSMGAT00000003964.2	ENSMGAP00000003265.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.90e-41	136.7	146	181
UBD/Beta-Prp	2.90e-61	207.0	13	229

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvl 35
           Ht  v+cl+f +d + l+s++dD+t+k+WDl+ g++
   Q: 146  HTQAVRCLRFsPDgKWLASAADDHTVKLWDLTAGKV 181
           99*********999******************9975 PP

UBD/Beta-Prp

   S: 45   lrslsgheaevtavkfspdgk.ilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleet 132
           l+++  h++ v+++ + +++  +l+tg++D  ++vw+++++ cv++l+gh+  + sl++s++ + +v+Gs+   irvwdle  + l+ t
   Q: 13   LEEIVAHSSNVSSLVLGKKSGrLLATGGDDCRVNVWSVNKPNCVMSLSGHTTPIESLQISAKEELIVAGSQSGSIRVWDLEAAKILR-T 100
           6677889999999887554444****************************************************************9.* PP
   S: 133  lsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlngh 221
           l gh++ ++++ +hp g+ ++sGslD+ ++lWd++++ ++ ++++ ht++v++l f+++gk l+s+++d tvklwdl +g+++ +++gh
   Q: 101  LLGHKANICSLDFHPYGSFVASGSLDTDIKLWDVRRKGCIFKWQS-HTQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKVMFEFTGH 188
           ********************************************9.******************************************* PP
   S: 222  tdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlql 262
           + +v++v+f+p + +l+sgssD++ir+Wdl++  ++++++ 
   Q: 189  SGPVNVVEFHPSEYLLASGSSDRTIRFWDLEKFHVVSCIEE 229
           *******************************9998888765 PP

Organism

Meleagris gallopavo

Functional Description
(View)

Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.

Protein Sequence
(Fasta)

YCLPLLQQIS YLLEEIVAHS SNVSSLVLGK KSGRLLATGG DDCRVNVWSV NKPNCVMSLS 60
GHTTPIESLQ ISAKEELIVA GSQSGSIRVW DLEAAKILRT LLGHKANICS LDFHPYGSFV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TACTGCCTGC CCCTTTTACA ACAAATTTCA TACCTATTAG GGCAGCAAAT GCAGTAAACT 60
CTCAAAGAAG AGAGCAGTCG GGAAGAAATT GGTAAATACA TCTGCCAAAA GCTCCTGCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR026962--Katanin_bsu1
IPR028021--Katanin_C-terminal
IPR023302--Pept_S9A_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF13925--Katanin_con80
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030424--C:axon
GO:0005813--C:centrosome
GO:0005829--C:cytosol
GO:0008352--C:katanin complex
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0000922--C:spindle pole
GO:0008568--F:microtubule-severing ATPase activity
GO:0051013--P:microtubule severing
GO:0007026--P:negative regulation of microtubule depolymerization
GO:0031117--P:positive regulation of microtubule depolymerization

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000873	Aegilops tauschii	46.74	5.00e-83	301.00
IUUC-Aml-002187	Ailuropoda melanoleuca	73.49	0.00e+00	912.00
IUUC-Atr-002899	Amborella trichopoda	53.77	1.00e-101	363.00
IUUC-Apl-003305	Anas platyrhynchos	85.38	0.00e+00	1123.00
IUUC-Aca-004635	Anolis carolinensis	81.29	0.00e+00	986.00
IUUC-Aly-005711	Arabidopsis lyrata	51.01	3.00e-99	356.00
IUUC-Ath-007606	Arabidopsis thaliana	51.01	2.00e-99	356.00
IUUC-Ame-010870	Astyanax mexicanus	54.91	4.00e-94	337.00
IUUC-Bta-012527	Bos taurus	77.76	0.00e+00	991.00
IUUC-Bdi-014652	Brachypodium distachyon	50.68	2.00e-99	357.00
IUUC-Bol-016374	Brassica oleracea	50.00	6.00e-97	348.00
IUUC-Bra-017390	Brassica rapa	45.45	9.00e-98	351.00
IUUC-Cja-019706	Callithrix jacchus	77.59	0.00e+00	916.00
IUUC-Cfa-020139	Canis familiaris	66.73	9.00e-179	619.00
IUUC-Cpo-021710	Cavia porcellus	77.93	0.00e+00	979.00
IUUC-Cre-022746	Chlamydomonas reinhardtii	38.84	2.00e-67	250.00
IUUC-Csa-023546	Chlorocebus sabaeus	78.51	0.00e+00	889.00
IUUC-Cin-025156	Ciona intestinalis	41.11	1.00e-148	519.00
IUUC-Csv-025962	Ciona savignyi	46.10	2.00e-83	301.00
IUUC-Dre-028215	Danio rerio	60.87	0.00e+00	822.00
IUUC-Dno-029314	Dasypus novemcinctus	77.29	0.00e+00	930.00
IUUC-Dor-030482	Dipodomys ordii	78.69	0.00e+00	1007.00
IUUC-Dme-032188	Drosophila melanogaster	37.27	5.00e-58	219.00
IUUC-Eca-034143	Equus caballus	77.74	0.00e+00	976.00
IUUC-Fca-035924	Felis catus	78.35	0.00e+00	966.00
IUUC-Fal-037387	Ficedula albicollis	85.71	0.00e+00	1085.00
IUUC-Gmo-038692	Gadus morhua	62.07	2.00e-147	515.00
IUUC-Gga-040597	Gallus gallus	93.58	0.00e+00	1221.00
IUUC-Gac-042004	Gasterosteus aculeatus	59.91	0.00e+00	801.00
IUUC-Gma-044322	Glycine max	51.01	6.00e-97	348.00
IUUC-Ggo-044761	Gorilla gorilla	78.51	0.00e+00	913.00
IUUC-Hsa-045698	Homo sapiens	78.66	0.00e+00	934.00
IUUC-Hvu-047649	Hordeum vulgare	50.00	7.00e-99	355.00
IUUC-Itr-048697	Ictidomys tridecemlineatus	78.05	0.00e+00	962.00
IUUC-Lch-049674	Latimeria chalumnae	65.58	0.00e+00	886.00
IUUC-Lpe-051597	Leersia perrieri	31.12	4.00e-101	362.00
IUUC-Loc-052623	Lepisosteus oculatus	64.72	0.00e+00	879.00
IUUC-Laf-054587	Loxodonta africana	78.69	0.00e+00	986.00
IUUC-Mcc-055851	Macaca mulatta	78.51	0.00e+00	913.00
IUUC-Meu-056704	Macropus eugenii	79.39	0.00e+00	1058.00
IUUC-Mtr-058053	Medicago truncatula	51.35	3.00e-101	362.00
IUUC-Mmr-061154	Microcebus murinus	77.96	0.00e+00	936.00
IUUC-Mdo-062365	Monodelphis domestica	75.46	0.00e+00	991.00
IUUC-Mmu-063754	Mus musculus	78.42	0.00e+00	967.00
IUUC-Mac-064667	Musa acuminata	50.16	4.00e-99	354.00
IUUC-Mpu-066245	Mustela putorius furo	77.90	0.00e+00	928.00
IUUC-Mlu-067692	Myotis lucifugus	78.66	0.00e+00	966.00
IUUC-Nle-070051	Nomascus leucogenys	77.16	0.00e+00	908.00
IUUC-Opr-070855	Ochotona princeps	77.93	0.00e+00	965.00
IUUC-Ont-071883	Oreochromis niloticus	57.24	0.00e+00	813.00
IUUC-Oan-073293	Ornithorhynchus anatinus	78.92	0.00e+00	926.00
IUUC-Ocu-074644	Oryctolagus cuniculus	79.15	0.00e+00	979.00
IUUC-Oba-075448	Oryza barthii	52.12	2.00e-103	369.00
IUUC-Obr-076385	Oryza brachyantha	51.35	2.00e-101	363.00
IUUC-Ogl-077427	Oryza glaberrima	52.36	8.00e-103	367.00
IUUC-Ogu-078062	Oryza glumaepatula	48.46	2.00e-93	336.00
IUUC-Oin-079811	Oryza indica	52.20	3.00e-102	366.00
IUUC-Olo-080245	Oryza longistaminata	52.20	3.00e-102	365.00
IUUC-Ome-081239	Oryza meridionalis	52.72	1.00e-101	363.00
IUUC-Oni-082640	Oryza nivara	52.12	2.00e-103	369.00
IUUC-Opu-083748	Oryza punctata	52.03	5.00e-102	365.00
IUUC-Oru-084609	Oryza rufipogon	52.12	2.00e-103	369.00
IUUC-Osa-085801	Oryza sativa	47.49	8.00e-94	337.00
IUUC-Ola-087483	Oryzias latipes	54.28	2.00e-179	621.00
IUUC-Oga-087964	Otolemur garnettii	78.39	0.00e+00	988.00
IUUC-Oar-089483	Ovis aries	76.40	0.00e+00	941.00
IUUC-Ptr-091387	Pan troglodytes	78.81	0.00e+00	936.00
IUUC-Pan-092623	Papio anubis	78.51	0.00e+00	913.00
IUUC-Psi-093830	Pelodiscus sinensis	84.71	0.00e+00	1084.00
IUUC-Pma-094135	Petromyzon marinus	45.54	2.00e-40	158.00
IUUC-Ppa-095379	Physcomitrella patens	54.11	2.00e-96	346.00
IUUC-Pfo-096755	Poecilia formosa	58.13	0.00e+00	809.00
IUUC-Pab-097564	Pongo abelii	76.20	0.00e+00	790.00
IUUC-Pop-099149	Populus trichocarpa	52.36	1.00e-102	367.00
IUUC-Pca-100357	Procavia capensis	81.16	2.00e-105	376.00
IUUC-Ppe-101237	Prunus persica	51.69	1.00e-100	360.00
IUUC-Pva-102397	Pteropus vampyrus	74.39	0.00e+00	899.00
IUUC-Rno-105349	Rattus norvegicus	78.54	0.00e+00	1007.00
IUUC-Smo-109409	Selaginella moellendorffii	51.97	7.00e-100	357.00
IUUC-Sit-110360	Setaria italica	52.36	4.00e-102	365.00
IUUC-Sly-111307	Solanum lycopersicum	51.69	1.00e-97	350.00
IUUC-Stu-112462	Solanum tuberosum	51.70	3.00e-96	345.00
IUUC-Sar-112953	Sorex araneus	68.86	2.00e-91	328.00
IUUC-Sbi-114389	Sorghum bicolor	46.15	2.00e-92	333.00
IUUC-Ssc-115949	Sus scrofa	76.76	0.00e+00	724.00
IUUC-Tgu-117461	Taeniopygia guttata	84.52	0.00e+00	1091.00
IUUC-Tru-117865	Takifugu rubripes	58.76	0.00e+00	800.00
IUUC-Tsy-119036	Tarsius syrichta	64.52	2.00e-60	226.00
IUUC-Tni-120903	Tetraodon nigroviridis	60.33	0.00e+00	769.00
IUUC-Tca-121185	Theobroma cacao	51.35	7.00e-100	358.00
IUUC-Tae-125307	Triticum aestivum	49.51	5.00e-100	358.00
IUUC-Tur-126181	Triticum urartu	46.76	7.00e-92	331.00
IUUC-Tbe-127518	Tupaia belangeri	66.45	1.00e-149	523.00
IUUC-Ttr-128172	Tursiops truncatus	77.29	0.00e+00	957.00
IUUC-Vvi-131489	Vitis vinifera	52.70	2.00e-102	366.00
IUUC-Xtr-132915	Xenopus tropicalis	69.57	0.00e+00	925.00
IUUC-Xma-134133	Xiphophorus maculatus	57.83	0.00e+00	801.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence