iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-091116

UUCD1 version

UUC-PaT-00456

Ensembl Protein ID

ENSPTRP00000022412.3

UniProt Accession

H2QJQ3; H2QJQ3_PANTR

Genbank Protein ID

JAA02580.1; JAA15842.1; JAA24704.1; JAA43254.1

Protein Name

Histone deacetylase

Genbank Nucleotide ID

AACZ03021132; GABF01006303; GABD01008396; GABE01001485

Gene Name

HDAC4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000013097.4	ENSPTRT00000024291.3	ENSPTRP00000022412.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/Other	99.53	0.00e+00	1926.00	IUUC-Hsa-046925

Active Site

Position(s)	Description	Evidence
803	N/A	{ECO:0000256\|PIRSR:PIRSR037911-1}

Organism

Pan troglodytes

Functional Description
(View)

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

Protein Sequence
(Fasta)

MSSQSHPDGL SGRDQPVELL NPARVNHMPS TVDVAAALPL QVAPSAVPMD LRLDHQFSLP 60
VAEPALREQQ LQQELLALKQ KQQIQRQILI AEFQRQHEQL SRQHEAQLHE HIKQQQEMLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAGGTTGTG GGGCCGCCGC CGCGGAGCAC CGTCCCCGCC GCCGCCCGAG CCCGAGCCCG 60
AGCCCGCGCA CCCGCCCGCG CCGCCGCCGC CGCCGCCCGA ACAGCCTCCC AGCCTGGGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc

Interpro

IPR033660--HDAC4
IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom
IPR024643--Hist_deacetylase_Gln_rich_N
IPR017320--Histone_deAcase_II_euk

Pfam

PF12203--HDAC4_Gln
PF00850--Hist_deacetyl

PRINTS

PR01270--HDASUPER

Gene Ontology

GO:0042641--C:actomyosin
GO:0005829--C:cytosol
GO:0000118--C:histone deacetylase complex
GO:0031594--C:neuromuscular junction
GO:0017053--C:transcriptional repressor complex
GO:0003682--F:chromatin binding
GO:0001047--F:core promoter binding
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0030955--F:potassium ion binding
GO:0043565--F:sequence-specific DNA binding
GO:0003714--F:transcription corepressor activity
GO:0008270--F:zinc ion binding
GO:0006338--P:chromatin remodeling
GO:0070933--P:histone H4 deacetylation
GO:0008285--P:negative regulation of cell proliferation
GO:0045820--P:negative regulation of glycolytic process
GO:0010832--P:negative regulation of myotube differentiation
GO:0045668--P:negative regulation of osteoblast differentiation
GO:1902894--P:negative regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0002076--P:osteoblast development
GO:0034983--P:peptidyl-lysine deacetylation
GO:0008284--P:positive regulation of cell proliferation
GO:0033235--P:positive regulation of protein sumoylation
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0010882--P:regulation of cardiac muscle contraction by calcium ion signaling
GO:0040029--P:regulation of gene expression, epigenetic
GO:0043393--P:regulation of protein binding
GO:0048742--P:regulation of skeletal muscle fiber development
GO:0014894--P:response to denervation involved in regulation of muscle adaptation
GO:0070555--P:response to interleukin-1
GO:0001501--P:skeletal system development
GO:0006351--P:transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002279	Ailuropoda melanoleuca	92.73	0.00e+00	1756.00
IUUC-Apl-003250	Anas platyrhynchos	87.55	0.00e+00	1603.00
IUUC-Aca-004668	Anolis carolinensis	83.20	0.00e+00	1658.00
IUUC-Aly-006432	Arabidopsis lyrata	43.63	5.00e-70	258.00
IUUC-Ath-007355	Arabidopsis thaliana	42.97	4.00e-76	279.00
IUUC-Ago-007972	Ashbya gossypii	39.50	6.00e-71	261.00
IUUC-Afl-008399	Aspergillus flavus	43.65	1.00e-41	164.00
IUUC-Ang-009522	Aspergillus niger	29.26	1.00e-33	138.00
IUUC-Ate-010291	Aspergillus terreus	40.76	2.00e-75	276.00
IUUC-Bta-013215	Bos taurus	92.78	0.00e+00	1774.00
IUUC-Bci-013789	Botrytis cinerea	36.79	1.00e-66	248.00
IUUC-Bol-015468	Brassica oleracea	42.11	2.00e-76	279.00
IUUC-Bra-016680	Brassica rapa	42.36	2.00e-76	280.00
IUUC-Cja-019816	Callithrix jacchus	98.13	0.00e+00	1894.00
IUUC-Cfa-020861	Canis familiaris	93.54	0.00e+00	1769.00
IUUC-Cpo-021562	Cavia porcellus	93.16	0.00e+00	1806.00
IUUC-Cre-022561	Chlamydomonas reinhardtii	52.25	6.00e-53	200.00
IUUC-Csa-023612	Chlorocebus sabaeus	98.51	0.00e+00	1869.00
IUUC-Csv-026359	Ciona savignyi	55.41	2.00e-95	341.00
IUUC-Cgl-026709	Colletotrichum gloeosporioides	36.12	1.00e-68	253.00
IUUC-Cne-026978	Cryptococcus neoformans	39.19	1.00e-72	268.00
IUUC-Dre-028284	Danio rerio	77.32	0.00e+00	1368.00
IUUC-Dno-029951	Dasypus novemcinctus	90.31	0.00e+00	1613.00
IUUC-Dor-030362	Dipodomys ordii	83.16	0.00e+00	1502.00
IUUC-Dme-031766	Drosophila melanogaster	58.22	4.00e-159	555.00
IUUC-Fca-036187	Felis catus	94.28	0.00e+00	1744.00
IUUC-Fox-038067	Fusarium oxysporum	38.33	2.00e-68	253.00
IUUC-Fso-038263	Fusarium solani	38.82	1.00e-70	261.00
IUUC-Gmo-038473	Gadus morhua	76.69	0.00e+00	740.00
IUUC-Ggr-040062	Gaeumannomyces graminis	38.54	1.00e-66	247.00
IUUC-Gga-040501	Gallus gallus	90.42	0.00e+00	1691.00
IUUC-Gac-042335	Gasterosteus aculeatus	69.55	0.00e+00	1255.00
IUUC-Ggo-045380	Gorilla gorilla	99.16	0.00e+00	1883.00
IUUC-Hsa-046925	Homo sapiens	99.53	0.00e+00	1883.00
IUUC-Itr-048036	Ictidomys tridecemlineatus	94.13	0.00e+00	1726.00
IUUC-Kpa-049281	Komagataella pastoris	38.76	2.00e-71	263.00
IUUC-Lch-050325	Latimeria chalumnae	83.85	0.00e+00	1554.00
IUUC-Loc-052231	Lepisosteus oculatus	80.44	0.00e+00	1460.00
IUUC-Laf-054490	Loxodonta africana	85.96	0.00e+00	1652.00
IUUC-Mcc-055265	Macaca mulatta	98.51	0.00e+00	1880.00
IUUC-Meu-056676	Macropus eugenii	85.84	0.00e+00	761.00
IUUC-Mor-057095	Magnaporthe oryzae	37.47	2.00e-70	260.00
IUUC-Mpo-057389	Magnaporthe poae	37.56	3.00e-65	243.00
IUUC-Mmr-061633	Microcebus murinus	86.35	0.00e+00	1572.00
IUUC-Mmu-063089	Mus musculus	93.47	0.00e+00	1726.00
IUUC-Mac-064630	Musa acuminata	41.36	9.00e-73	268.00
IUUC-Mpu-065887	Mustela putorius furo	92.70	0.00e+00	1764.00
IUUC-Mlu-067470	Myotis lucifugus	93.93	0.00e+00	1764.00
IUUC-Ncr-068672	Neurospora crassa	37.59	5.00e-70	259.00
IUUC-Nle-069099	Nomascus leucogenys	95.93	0.00e+00	1262.00
IUUC-Ont-071613	Oreochromis niloticus	71.88	0.00e+00	1277.00
IUUC-Oan-073275	Ornithorhynchus anatinus	88.96	0.00e+00	1675.00
IUUC-Ola-087031	Oryzias latipes	66.76	0.00e+00	1195.00
IUUC-Oga-088201	Otolemur garnettii	89.19	0.00e+00	1548.00
IUUC-Oar-089997	Ovis aries	85.15	0.00e+00	1438.00
IUUC-Pan-092132	Papio anubis	99.23	0.00e+00	1236.00
IUUC-Psi-093734	Pelodiscus sinensis	89.21	0.00e+00	1587.00
IUUC-Pma-094347	Petromyzon marinus	70.33	0.00e+00	703.00
IUUC-Pno-095131	Phaeosphaeria nodorum	45.49	1.00e-66	247.00
IUUC-Pfo-096293	Poecilia formosa	69.21	0.00e+00	1202.00
IUUC-Pab-098491	Pongo abelii	96.26	0.00e+00	1820.00
IUUC-Pop-099174	Populus trichocarpa	40.26	9.00e-73	268.00
IUUC-Pca-101004	Procavia capensis	83.72	0.00e+00	937.00
IUUC-Ppe-101644	Prunus persica	40.34	3.00e-73	269.00
IUUC-Pva-102961	Pteropus vampyrus	71.86	0.00e+00	897.00
IUUC-Rno-105005	Rattus norvegicus	93.28	0.00e+00	1701.00
IUUC-Sce-106274	Saccharomyces cerevisiae	37.29	3.00e-67	249.00
IUUC-Sha-107646	Sarcophilus harrisii	66.82	0.00e+00	985.00
IUUC-Smo-109615	Selaginella moellendorffii	43.12	8.00e-77	281.00
IUUC-Sly-111164	Solanum lycopersicum	39.90	8.00e-77	281.00
IUUC-Sre-115013	Sporisorium reilianum	40.56	6.00e-69	255.00
IUUC-Ssc-115428	Sus scrofa	92.44	0.00e+00	1659.00
IUUC-Tgu-116776	Taeniopygia guttata	90.08	0.00e+00	1674.00
IUUC-Tru-118180	Takifugu rubripes	70.14	0.00e+00	1288.00
IUUC-Tsy-119468	Tarsius syrichta	90.85	0.00e+00	781.00
IUUC-Tni-120196	Tetraodon nigroviridis	69.84	0.00e+00	1276.00
IUUC-Tca-121312	Theobroma cacao	40.79	4.00e-76	279.00
IUUC-Tre-121930	Trichoderma reesei	39.36	3.00e-74	273.00
IUUC-Tvi-122373	Trichoderma virens	38.57	4.00e-71	262.00
IUUC-Ttr-128360	Tursiops truncatus	83.72	0.00e+00	999.00
IUUC-Uma-129408	Ustilago maydis	43.53	6.00e-69	255.00
IUUC-Vda-129994	Verticillium dahliae	42.12	4.00e-64	239.00
IUUC-Xtr-132956	Xenopus tropicalis	80.22	0.00e+00	1469.00
IUUC-Xma-134265	Xiphophorus maculatus	67.94	0.00e+00	1207.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence