iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pab-097989

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ABGA01085157

Gene Name

UBR2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000016616.2	ENSPPYT00000019322.2	ENSPPYP00000018583.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	2.80e-09	37.4	1108	1212
E3 activity/N-recognin/N-domain	8.10e-39	131.7	227	302
E3 activity/N-recognin/UBR-box	8.70e-32	109.6	97	167

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiC.....................................ledf........kdgplvlpCgHvfhadClqkw............. 29
           C++C                                     +           ++g+++ +CgH++ha+C+q++             
   Q: 1108 CILCqeeqevkvesrkqgiaafvqrstvlsknrsfiqdpekY--DplfmhpdlSCGTHTSSCGHIMHAHCWQRYfdsvqakeqrrqq 1192
           888833333333333333333333333333333333333321..023444444558999**************************** PP
   S: 30   ....pglknssskefrCPlC 45
               + +++++++ef+CPlC
   Q: 1193 rlrlHTSYDVENGEFLCPLC 1212
           ******************** PP

E3 activity/N-recognin/N-domain

   S: 1    YylvLfNDEkHsyeqviyslqkAleleqkeakkfatiidkeGRravkaGdyavceeakkeilknseklaqipLkVev 77
           Yy++LfNDE+H+yeqviy+lqkA++++qkea++fat++d++GRr+v++Gd+++ce+ak++i++n+ ++++ pLkV+v
   Q: 227  YYCMLFNDEVHTYEQVIYTLQKAVNCTQKEAIGFATTVDRDGRRSVRYGDFQYCEQAKSVIVRNTIRQTK-PLKVQV 302
           9*********************************************************************.****98 PP

E3 activity/N-recognin/UBR-box

   S: 1    slCgrvfkvgetiyeCrtCsvdetlvlCteCfakvvHkdHeyklkksggggfCdCGdteAwedgskCkkll 71
           +lCgrvfkvge +y+Cr+C+vd+t+vlC+eCf  ++H+dH+y++++sggggfCdCGdteAw++g++C+k++
   Q: 97   HLCGRVFKVGEPTYSCRDCAVDPTCVLCMECFLGSIHRDHRYRMTTSGGGGFCDCGDTEAWKEGPYCQKHE 167
           68******************************************************************996 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

MASELEPEVQ AIDRSLLECS AEEIAGKWLQ ATDLTREVYQ HLAHYVPKIY CRGPNPFPQK 60
EDMLAQHVLL GPMEWYLCGE DPAFGFPKLE QANKPSHLCG RVFKVGEPTY SCRDCAVDPT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTTCCTGGC TGTGCTGTAC CTACAGTACC CAGAACTACA GTACCCACAA CGCTCCGCTT 60
CGCCTCCTGG GTGTTATTGC CCCTTTCCCG GTGCAGGACG CGGTAGTGGC CACCGAGAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003769--ClpS_core
IPR014719--Ribosomal_L7/12_C/ClpS-like
IPR011991--WHTH_DNA-bd_dom
IPR013083--Znf_RING/FYVE/PHD
IPR003126--Znf_UBR

PROSITE

PS51157--ZF_UBR

Pfam

PF02617--ClpS
PF02207--zf-UBR

SMART

SM00396--ZnF_UBR1

Gene Ontology

GO:0000785--C:chromatin
GO:0000151--C:ubiquitin ligase complex
GO:0070728--F:leucine binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0071233--P:cellular response to leucine
GO:0006342--P:chromatin silencing
GO:0033522--P:histone H2A ubiquitination
GO:0007141--P:male meiosis I
GO:0032007--P:negative regulation of TOR signaling
GO:0007283--P:spermatogenesis
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000949	Aegilops tauschii	27.37	3.00e-21	98.60
IUUC-Aml-001876	Ailuropoda melanoleuca	82.53	0.00e+00	2647.00
IUUC-Atr-002501	Amborella trichopoda	28.67	1.00e-27	120.00
IUUC-Apl-003828	Anas platyrhynchos	85.74	0.00e+00	2986.00
IUUC-Aca-005189	Anolis carolinensis	83.88	0.00e+00	2960.00
IUUC-Aly-005901	Arabidopsis lyrata	32.39	6.00e-26	114.00
IUUC-Ath-007148	Arabidopsis thaliana	30.99	1.00e-24	110.00
IUUC-Ago-007946	Ashbya gossypii	22.66	9.00e-31	130.00
IUUC-Afl-008479	Aspergillus flavus	23.22	9.00e-49	189.00
IUUC-Afu-008929	Aspergillus fumigatus	24.32	6.00e-56	214.00
IUUC-Ani-009334	Aspergillus nidulans	23.98	1.00e-50	196.00
IUUC-Ang-009550	Aspergillus niger	23.86	2.00e-49	191.00
IUUC-Aor-010124	Aspergillus oryzae	23.22	5.00e-49	191.00
IUUC-Ame-011917	Astyanax mexicanus	72.10	0.00e+00	2422.00
IUUC-Bta-012768	Bos taurus	90.95	0.00e+00	3169.00
IUUC-Bdi-014635	Brachypodium distachyon	25.87	3.00e-31	131.00
IUUC-Bol-015669	Brassica oleracea	31.45	2.00e-30	129.00
IUUC-Bra-017776	Brassica rapa	31.45	5.00e-31	130.00
IUUC-Cel-018476	Caenorhabditis elegans	32.20	4.00e-85	310.00
IUUC-Cja-019797	Callithrix jacchus	96.07	0.00e+00	2612.00
IUUC-Cfa-020950	Canis familiaris	94.47	0.00e+00	3276.00
IUUC-Cpo-022385	Cavia porcellus	91.28	0.00e+00	3202.00
IUUC-Csa-024082	Chlorocebus sabaeus	97.61	0.00e+00	3375.00
IUUC-Cho-025029	Choloepus hoffmanni	86.70	0.00e+00	2174.00
IUUC-Cin-025148	Ciona intestinalis	35.59	1.00e-137	483.00
IUUC-Cgl-026605	Colletotrichum gloeosporioides	23.09	2.00e-55	212.00
IUUC-Cne-026823	Cryptococcus neoformans	22.19	1.00e-39	159.00
IUUC-Dre-028343	Danio rerio	71.14	0.00e+00	2422.00
IUUC-Dno-030002	Dasypus novemcinctus	89.77	0.00e+00	1892.00
IUUC-Dor-030207	Dipodomys ordii	79.48	0.00e+00	1583.00
IUUC-Dse-031531	Dothistroma septosporum	24.18	8.00e-56	213.00
IUUC-Dme-031910	Drosophila melanogaster	34.47	0.00e+00	677.00
IUUC-Ete-033162	Echinops telfairi	84.90	0.00e+00	1385.00
IUUC-Eca-033454	Equus caballus	92.94	0.00e+00	3215.00
IUUC-Eeu-034783	Erinaceus europaeus	77.10	0.00e+00	1506.00
IUUC-Fca-036588	Felis catus	94.25	0.00e+00	3255.00
IUUC-Fal-036919	Ficedula albicollis	85.87	0.00e+00	2931.00
IUUC-Fso-038463	Fusarium solani	24.24	4.00e-43	171.00
IUUC-Gmo-039698	Gadus morhua	69.11	0.00e+00	1600.00
IUUC-Ggr-040070	Gaeumannomyces graminis	22.88	1.00e-43	173.00
IUUC-Gga-041123	Gallus gallus	87.24	0.00e+00	3047.00
IUUC-Gac-042622	Gasterosteus aculeatus	64.85	0.00e+00	2148.00
IUUC-Gma-043622	Glycine max	30.39	5.00e-26	114.00
IUUC-Ggo-045583	Gorilla gorilla	96.26	0.00e+00	3342.00
IUUC-Hsa-046343	Homo sapiens	96.75	0.00e+00	3341.00
IUUC-Hvu-047626	Hordeum vulgare	29.33	9.00e-28	119.00
IUUC-Kpa-049088	Komagataella pastoris	23.47	6.00e-47	183.00
IUUC-Lch-049649	Latimeria chalumnae	73.29	0.00e+00	2521.00
IUUC-Lpe-051516	Leersia perrieri	25.82	2.00e-31	132.00
IUUC-Loc-052818	Lepisosteus oculatus	74.18	0.00e+00	2572.00
IUUC-Lma-053059	Leptosphaeria maculans	23.25	1.00e-49	192.00
IUUC-Laf-054142	Loxodonta africana	91.63	0.00e+00	3204.00
IUUC-Mcc-055677	Macaca mulatta	97.21	0.00e+00	3348.00
IUUC-Meu-056204	Macropus eugenii	67.56	0.00e+00	719.00
IUUC-Mor-057051	Magnaporthe oryzae	23.22	2.00e-50	195.00
IUUC-Mpo-057372	Magnaporthe poae	23.98	1.00e-44	176.00
IUUC-Mtr-058538	Medicago truncatula	30.39	1.00e-28	123.00
IUUC-Mla-058963	Melampsora laricipopulina	24.39	6.00e-64	240.00
IUUC-Mga-059698	Meleagris gallopavo	87.46	0.00e+00	3022.00
IUUC-Mvi-060535	Microbotryum violaceum	24.82	1.00e-50	196.00
IUUC-Mmr-060901	Microcebus murinus	91.45	0.00e+00	3157.00
IUUC-Mdo-062014	Monodelphis domestica	89.97	0.00e+00	3150.00
IUUC-Mmu-063699	Mus musculus	88.21	0.00e+00	3073.00
IUUC-Mpu-066153	Mustela putorius furo	94.53	0.00e+00	3278.00
IUUC-Mlu-068151	Myotis lucifugus	91.51	0.00e+00	3157.00
IUUC-Nfi-068403	Neosartorya fischeri	23.87	2.00e-55	212.00
IUUC-Ncr-068864	Neurospora crassa	22.23	1.00e-51	199.00
IUUC-Nle-069529	Nomascus leucogenys	97.83	0.00e+00	3382.00
IUUC-Opr-071107	Ochotona princeps	83.97	0.00e+00	1273.00
IUUC-Ont-072189	Oreochromis niloticus	65.03	0.00e+00	2107.00
IUUC-Oan-072893	Ornithorhynchus anatinus	87.29	0.00e+00	3046.00
IUUC-Ocu-074082	Oryctolagus cuniculus	90.84	0.00e+00	3166.00
IUUC-Obr-076117	Oryza brachyantha	25.88	5.00e-27	117.00
IUUC-Ome-081738	Oryza meridionalis	22.68	1.00e-14	76.60
IUUC-Opu-083202	Oryza punctata	26.82	2.00e-27	119.00
IUUC-Ola-087460	Oryzias latipes	63.30	0.00e+00	2081.00
IUUC-Oga-088432	Otolemur garnettii	92.37	0.00e+00	3237.00
IUUC-Oar-090206	Ovis aries	91.04	0.00e+00	3192.00
IUUC-Ptr-091180	Pan troglodytes	96.52	0.00e+00	3341.00
IUUC-Pan-092375	Papio anubis	97.49	0.00e+00	3371.00
IUUC-Psi-093049	Pelodiscus sinensis	86.45	0.00e+00	2994.00
IUUC-Pma-094152	Petromyzon marinus	45.58	4.00e-175	608.00
IUUC-Pno-094877	Phaeosphaeria nodorum	22.36	2.00e-42	169.00
IUUC-Pfo-096524	Poecilia formosa	62.28	0.00e+00	1991.00
IUUC-Pca-100207	Procavia capensis	77.08	0.00e+00	1226.00
IUUC-Ppe-101802	Prunus persica	28.90	3.00e-26	115.00
IUUC-Pva-102538	Pteropus vampyrus	89.13	0.00e+00	1155.00
IUUC-Pgr-103372	Puccinia graminis	24.23	5.00e-53	204.00
IUUC-Ptt-103878	Puccinia triticina	24.08	9.00e-50	193.00
IUUC-Rno-105567	Rattus norvegicus	89.07	0.00e+00	3054.00
IUUC-Sce-106272	Saccharomyces cerevisiae	20.83	1.00e-24	109.00
IUUC-Sha-106980	Sarcophilus harrisii	89.31	0.00e+00	2999.00
IUUC-Sja-107980	Schizosaccharomyces japonicus	23.64	1.00e-49	192.00
IUUC-Spo-108183	Schizosaccharomyces pombe	25.20	4.00e-52	201.00
IUUC-Smo-108719	Selaginella moellendorffii	31.18	4.00e-30	127.00
IUUC-Sit-110716	Setaria italica	26.56	3.00e-32	135.00
IUUC-Sly-111701	Solanum lycopersicum	30.04	4.00e-26	114.00
IUUC-Sar-113332	Sorex araneus	86.81	0.00e+00	2176.00
IUUC-Sbi-114577	Sorghum bicolor	28.73	2.00e-30	129.00
IUUC-Sre-115045	Sporisorium reilianum	26.79	1.00e-47	186.00
IUUC-Ssc-115525	Sus scrofa	94.81	0.00e+00	2560.00
IUUC-Tgu-116943	Taeniopygia guttata	87.08	0.00e+00	3036.00
IUUC-Tru-117673	Takifugu rubripes	64.18	0.00e+00	2119.00
IUUC-Tsy-119032	Tarsius syrichta	93.64	0.00e+00	1850.00
IUUC-Tni-119987	Tetraodon nigroviridis	63.95	0.00e+00	2074.00
IUUC-Tca-121077	Theobroma cacao	32.70	4.00e-26	114.00
IUUC-Tre-122137	Trichoderma reesei	24.45	2.00e-59	225.00
IUUC-Tvi-122272	Trichoderma virens	23.04	9.00e-56	213.00
IUUC-Tae-125501	Triticum aestivum	28.65	2.00e-28	122.00
IUUC-Tur-126562	Triticum urartu	30.36	6.00e-28	120.00
IUUC-Tme-127156	Tuber melanosporum	23.25	6.00e-52	200.00
IUUC-Tbe-128103	Tupaia belangeri	86.76	0.00e+00	1233.00
IUUC-Ttr-128253	Tursiops truncatus	87.35	0.00e+00	2991.00
IUUC-Uma-129344	Ustilago maydis	26.74	9.00e-52	200.00
IUUC-Vda-129778	Verticillium dahliae	22.67	3.00e-54	208.00
IUUC-Vpa-130540	Vicugna pacos	88.94	0.00e+00	2882.00
IUUC-Vvi-131290	Vitis vinifera	33.02	4.00e-28	121.00
IUUC-Xtr-132690	Xenopus tropicalis	78.60	0.00e+00	2759.00
IUUC-Xma-133748	Xiphophorus maculatus	64.72	0.00e+00	2021.00
IUUC-Yli-134662	Yarrowia lipolytica	23.66	1.00e-30	129.00
IUUC-Zma-135553	Zea mays	23.26	4.00e-16	81.60

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence