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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045698
UUCD1 version UUC-HoS-00337
Ensembl Protein ID ENSP00000368982.3
UniProt Accession Q9BVA0; A6NCG6; O60620; KTNB1_HUMAN
Genbank Protein ID AAC09328.1; AAP35668.1; CAG33043.1; EAW82951.1; AAH01353.1
Protein Name Katanin p80 WD40 repeat-containing subunit B1; p80 katanin
Genbank Nucleotide ID AF052432; BT007022; CR456762; AC092118; BC001353
Gene Name KATNB1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000140854.12 ENST00000379661.7 ENSP00000368982.3
ENSG00000140854.12 ENST00000566726.5 ENSP00000455270.1
ENSG00000140854.12 ENST00000569627.1 ENSP00000457046.1
ENSG00000140854.12 ENST00000563462.1 ENSP00000457334.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDUniProtBioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 17588513
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 5.30e-45 151.0 145 180
UBD/Beta-Prp 1.20e-59 203.7 15 258
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgv 34
           gH+  v+cl+f +d + l+s++dD+t+k+WDl+ g+
   Q: 145  GHSQAVRCLRFsPDgKWLASAADDHTVKLWDLTAGK 180
           8***********999*****************9997 PP
   

   UBD/Beta-Prp
   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghed 95
           ++ +h ++v + v  + +++llatg++d ++ +w++ +++++ sl gh+++v +v+++  ++++v gs+ + i+vwdl++ k+++tl gh++
   Q: 15   EIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKA 106
           67788888999888899*************************************************************************** PP
   S: 96   svlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysls 187
           +++sl+f+p+g++++sGs+d  i++wd++ + c+    +gh+++v+c++++pdg+ l+s+++D tv+lWdl  gk++ ++ g ht++v+ ++
   Q: 107  NICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVF-RYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPG-HTGPVNVVE 196
           **********************************9.9********************************************9.********* PP
   S: 188  fdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWd 250
           f++n   l+sgs d+t+++wdl++ ++v   +g   +v+sv f p++  l+sg +D s+r++ 
   Q: 197  FHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRVYG 258
           *****************************************************766.556543 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
 Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
Protein Sequence
(Fasta)
MATPVVTKTA WKLQEIVAHA SNVSSLVLGK ASGRLLATGG DDCRVNLWSI NKPNCIMSLT 60
GHTSPVESVR LNTPEELIVA GSQSGSIRVW DLEAAKILRT LMGHKANICS LDFHPYGEFV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045698|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGCTCTGAG CCGGAGGTTT TGTTGTGAGG GTCGGTTGTC AAGCAGCGGC CAATCAAGGC 60
AGGGGATGGA GGCAAGTGGG GGTCGCGCCT GGAGCGGAGC CTCGGCCTCC GGAGCCGCAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045698|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0225--Disease mutation
KW-0451--Lissencephaly
KW-0493--Microtubule
KW-0498--Mitosis
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR003143--Cyt_cd1_C
IPR020472--G-protein_beta_WD-40_rep
IPR026962--Katanin_bsu1
IPR028021--Katanin_C-terminal
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF13925--Katanin_con80
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0030424--C:axon
GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0030426--C:growth cone
GO:0008352--C:katanin complex
GO:0016020--C:membrane
GO:0005874--C:microtubule
GO:0015630--C:microtubule cytoskeleton
GO:0030496--C:midbody
GO:0043025--C:neuronal cell body
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0000922--C:spindle pole
GO:0008017--F:microtubule binding
GO:0046982--F:protein heterodimerization activity
GO:0051301--P:cell division
GO:0051013--P:microtubule severing
GO:0007067--P:mitotic nuclear division
GO:0007026--P:negative regulation of microtubule depolymerization
GO:0010942--P:positive regulation of cell death
GO:0031117--P:positive regulation of microtubule depolymerization
GO:0010976--P:positive regulation of neuron projection development
GO:0006605--P:protein targeting
KEGG hsa:10300
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000954 Aegilops tauschii 46.30 2.00e-86 315.00
IUUC-Aml-002187 Ailuropoda melanoleuca 89.66 0.00e+00 1111.00
IUUC-Atr-002899 Amborella trichopoda 42.95 9.00e-103 368.00
IUUC-Apl-003305 Anas platyrhynchos 77.70 0.00e+00 1024.00
IUUC-Aca-004635 Anolis carolinensis 80.34 0.00e+00 971.00
IUUC-Aly-005711 Arabidopsis lyrata 51.50 1.00e-101 364.00
IUUC-Ath-007606 Arabidopsis thaliana 51.50 2.00e-101 363.00
IUUC-Ame-010870 Astyanax mexicanus 56.97 3.00e-98 352.00
IUUC-Bta-012527 Bos taurus 95.63 0.00e+00 1202.00
IUUC-Bdi-014652 Brachypodium distachyon 50.61 4.00e-104 373.00
IUUC-Bol-015242 Brassica oleracea 50.50 7.00e-100 358.00
IUUC-Bra-017390 Brassica rapa 50.83 2.00e-100 360.00
IUUC-Cja-019706 Callithrix jacchus 97.41 0.00e+00 1128.00
IUUC-Cfa-020139 Canis familiaris 81.12 0.00e+00 776.00
IUUC-Cpo-021710 Cavia porcellus 95.11 0.00e+00 1175.00
IUUC-Cre-022746 Chlamydomonas reinhardtii 41.47 6.00e-69 255.00
IUUC-Csa-023546 Chlorocebus sabaeus 99.24 0.00e+00 1090.00
IUUC-Cin-025156 Ciona intestinalis 42.11 2.00e-157 549.00
IUUC-Csv-025962 Ciona savignyi 49.66 1.00e-89 323.00
IUUC-Dre-028215 Danio rerio 62.29 0.00e+00 860.00
IUUC-Dno-029314 Dasypus novemcinctus 94.81 0.00e+00 1129.00
IUUC-Dor-030482 Dipodomys ordii 96.03 0.00e+00 1225.00
IUUC-Dme-032188 Drosophila melanogaster 39.81 1.00e-59 224.00
IUUC-Eca-034143 Equus caballus 95.73 0.00e+00 1199.00
IUUC-Fca-035924 Felis catus 96.79 0.00e+00 1174.00
IUUC-Fal-037387 Ficedula albicollis 79.21 0.00e+00 1005.00
IUUC-Gmo-038692 Gadus morhua 65.28 8.00e-155 540.00
IUUC-Gga-040597 Gallus gallus 79.18 0.00e+00 1053.00
IUUC-Gac-042004 Gasterosteus aculeatus 61.99 0.00e+00 834.00
IUUC-Gma-044134 Glycine max 33.38 5.00e-108 385.00
IUUC-Ggo-044761 Gorilla gorilla 99.69 0.00e+00 1134.00
IUUC-Hvu-047649 Hordeum vulgare 51.06 2.00e-104 373.00
IUUC-Itr-048697 Ictidomys tridecemlineatus 95.11 0.00e+00 1156.00
IUUC-Lch-049674 Latimeria chalumnae 68.14 0.00e+00 931.00
IUUC-Lpe-051554 Leersia perrieri 49.58 5.00e-107 382.00
IUUC-Loc-052623 Lepisosteus oculatus 66.81 0.00e+00 906.00
IUUC-Laf-054587 Loxodonta africana 96.50 0.00e+00 1181.00
IUUC-Mcc-055851 Macaca mulatta 99.54 0.00e+00 1134.00
IUUC-Meu-056704 Macropus eugenii 90.27 0.00e+00 1193.00
IUUC-Mtr-058053 Medicago truncatula 52.49 1.00e-104 374.00
IUUC-Mga-059608 Meleagris gallopavo 78.66 0.00e+00 1040.00
IUUC-Mmr-061154 Microcebus murinus 94.66 0.00e+00 1131.00
IUUC-Mdo-062365 Monodelphis domestica 86.52 0.00e+00 1123.00
IUUC-Mmu-063754 Mus musculus 95.14 0.00e+00 1160.00
IUUC-Mac-064667 Musa acuminata 52.38 7.00e-101 360.00
IUUC-Mpu-066245 Mustela putorius furo 96.18 0.00e+00 1128.00
IUUC-Mlu-067692 Myotis lucifugus 95.99 0.00e+00 1157.00
IUUC-Nle-070051 Nomascus leucogenys 96.34 0.00e+00 1112.00
IUUC-Opr-070855 Ochotona princeps 95.57 0.00e+00 1176.00
IUUC-Ont-071883 Oreochromis niloticus 59.26 0.00e+00 830.00
IUUC-Oan-073293 Ornithorhynchus anatinus 89.92 0.00e+00 1041.00
IUUC-Ocu-074644 Oryctolagus cuniculus 96.64 0.00e+00 1194.00
IUUC-Oba-075448 Oryza barthii 54.85 1.00e-106 381.00
IUUC-Obr-076385 Oryza brachyantha 50.76 5.00e-106 379.00
IUUC-Ogl-077427 Oryza glaberrima 51.66 2.00e-107 383.00
IUUC-Ogu-079022 Oryza glumaepatula 48.88 4.00e-98 352.00
IUUC-Oin-079811 Oryza indica 49.56 3.00e-104 373.00
IUUC-Olo-080245 Oryza longistaminata 49.56 2.00e-104 373.00
IUUC-Ome-081239 Oryza meridionalis 51.08 8.00e-104 371.00
IUUC-Oni-082640 Oryza nivara 54.85 1.00e-106 381.00
IUUC-Opu-083748 Oryza punctata 51.52 4.00e-107 382.00
IUUC-Oru-084609 Oryza rufipogon 54.85 1.00e-106 381.00
IUUC-Osa-086267 Oryza sativa 48.88 4.00e-98 353.00
IUUC-Ola-087483 Oryzias latipes 56.56 0.00e+00 640.00
IUUC-Oga-087964 Otolemur garnettii 95.73 0.00e+00 1197.00
IUUC-Oar-089483 Ovis aries 94.12 0.00e+00 1155.00
IUUC-Ptr-091387 Pan troglodytes 99.85 0.00e+00 1170.00
IUUC-Pan-092623 Papio anubis 99.54 0.00e+00 1134.00
IUUC-Psi-093830 Pelodiscus sinensis 81.69 0.00e+00 1058.00
IUUC-Pma-094135 Petromyzon marinus 46.00 2.00e-40 159.00
IUUC-Ppa-095379 Physcomitrella patens 54.79 6.00e-98 352.00
IUUC-Pfo-096755 Poecilia formosa 58.14 0.00e+00 807.00
IUUC-Pab-097564 Pongo abelii 98.28 0.00e+00 999.00
IUUC-Pop-099149 Populus trichocarpa 52.49 3.00e-104 373.00
IUUC-Pca-100357 Procavia capensis 99.52 3.00e-126 445.00
IUUC-Ppe-101237 Prunus persica 52.49 4.00e-104 372.00
IUUC-Pva-102397 Pteropus vampyrus 92.06 0.00e+00 1092.00
IUUC-Rno-105349 Rattus norvegicus 95.11 0.00e+00 1204.00
IUUC-Smo-109409 Selaginella moellendorffii 54.27 9.00e-102 364.00
IUUC-Sit-110360 Setaria italica 51.52 6.00e-107 382.00
IUUC-Sly-111307 Solanum lycopersicum 52.82 2.00e-99 357.00
IUUC-Stu-112462 Solanum tuberosum 52.40 8.00e-96 344.00
IUUC-Sar-112953 Sorex araneus 82.02 5.00e-109 388.00
IUUC-Sbi-114389 Sorghum bicolor 46.98 1.00e-94 340.00
IUUC-Ssc-115949 Sus scrofa 93.86 0.00e+00 886.00
IUUC-Tgu-117461 Taeniopygia guttata 78.38 0.00e+00 1033.00
IUUC-Tru-117865 Takifugu rubripes 58.29 0.00e+00 792.00
IUUC-Tsy-119036 Tarsius syrichta 84.08 3.00e-87 315.00
IUUC-Tni-120903 Tetraodon nigroviridis 60.88 0.00e+00 783.00
IUUC-Tca-121185 Theobroma cacao 51.50 3.00e-101 363.00
IUUC-Tae-125263 Triticum aestivum 51.36 1.00e-104 374.00
IUUC-Tur-126181 Triticum urartu 47.96 1.00e-94 341.00
IUUC-Tbe-127518 Tupaia belangeri 81.88 0.00e+00 646.00
IUUC-Ttr-128172 Tursiops truncatus 96.34 0.00e+00 1157.00
IUUC-Vvi-131489 Vitis vinifera 53.16 1.00e-104 374.00
IUUC-Xtr-132915 Xenopus tropicalis 73.17 0.00e+00 971.00
IUUC-Xma-134133 Xiphophorus maculatus 57.85 0.00e+00 796.00
Created Date 25-Jun-2017

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