iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-131933

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

HECT and RLD domain-containing E3 ubiquitin protein ligase family member 1

Genbank Nucleotide ID

AAMC01035297

Gene Name

herc1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000009734.4	ENSXETT00000021476.4	ENSXETP00000021476.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	9.50e-13	48.0	3408	3438
E3 activity/HECT	4.90e-93	312.3	4488	4822

Active Site

Position(s)	Description	Evidence
4791	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDl 30
           H+++vt+  + s  +ll++++ Dgt++vW++
   Q: 3408 HQNRVTASVWcSKkDLLATSGSDGTVRVWNV 3438
           999999977*97789***************7 PP

E3 activity/HECT

   S: 6    kkrle.vefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgr 86
            +r++ v++vgE + d+gGv+ ++++++++el++  + l+  s+n ++++ +n+d++l np     ehl  F+flG+l+g+a+++++
   Q: 4488 PSRAWkVKLVGEGADDAGGVFDDTITEMCQELETGVVDLLIPSPNATAEVGYNRDRFLLNPssgldEHLMQFKFLGILMGVAIRTKK 4574
           466666********************************************************************************* PP
   S: 87   lldlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeee..LkpgGenipVtneNke 171
           +ldl+l++ ++k+l+  +l+ledleevd  ++++l++i++ ++s i+e++++ ++  ++ + ++++ ++  ++pgG++ip t +N++
   Q: 4575 PLDLHLAPLVWKQLCCIPLTLEDLEEVDLLYVQTLNSILHIEDSGITEENFHEMIPLDSFVGQSADGKMvpIIPGGNSIPLTFSNRK 4661
           *******************************************************9999887777766666**************** PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefss 258
           eYv++ ++yrl+e +++qv+a+reG++++ip  llsl+t+++le+++cG++ei+v+ lkk  +y++ + e+++ +qwFw++leefs+
   Q: 4662 EYVDRAIDYRLHE-MDRQVAAVREGMSWIIPVPLLSLLTARQLEQMVCGMPEISVDVLKKVVRYRE-VDEQHQLVQWFWQTLEEFSN 4746
           *************.**************************************************88.******************** PP
   S: 259  eerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           eer  f++Fv+g+srlP+ + a+++ ++f+i k d+ +d+lP+s+TCf++L+LP+Yss+ ++ e+L+yAi++++++++
   Q: 4747 EERVLFMRFVSGRSRLPA-NTADIS-QRFQIMKvDRPHDSLPTSQTCFFQLRLPPYSSQPVMAERLRYAINNCRSIDM 4822
           *****************6.899999.678888878888***********************************99987 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MAGMMPPVKL KWLEHLNSSW ITEDSESIAT REGVSLLYAK LISNKEVVPL PQQVLCLKGP 60
QLPDFERESL SCDEQDHYLD ALLSSQLALA KVVCSDSPFA GALRKRLLVL QRVFYALSNK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTGGTA TGATGCCCCC TGTGAAGCTA AAGTGGCTGG AGCATTTGAA CAGCTCCTGG 60
ATTACAGAGG ACAGCGAATC CATTGCCACC CGGGAAGGAG TGTCACTTCT GTATGCCAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR001870--B30.2/SPRY
IPR013320--ConA-like_dom
IPR000569--HECT_dom
IPR016106--Pyr-dep_his-deCO2ase_subdom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR003877--SPRY_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50188--B302_SPRY
PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00632--HECT
PF00415--RCC1
PF00622--SPRY
PF00400--WD40

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc
SM00449--SPRY
SM00320--WD40

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001830	Ailuropoda melanoleuca	84.72	0.00e+00	7651.00
IUUC-Atr-003065	Amborella trichopoda	34.66	3.00e-48	187.00
IUUC-Apl-003461	Anas platyrhynchos	85.16	0.00e+00	7686.00
IUUC-Aca-004452	Anolis carolinensis	81.77	0.00e+00	7059.00
IUUC-Aly-006545	Arabidopsis lyrata	36.95	8.00e-50	192.00
IUUC-Ame-011268	Astyanax mexicanus	60.57	0.00e+00	2210.00
IUUC-Bta-013213	Bos taurus	85.26	0.00e+00	7660.00
IUUC-Bdi-014791	Brachypodium distachyon	36.08	6.00e-51	194.00
IUUC-Bol-015203	Brassica oleracea	36.66	3.00e-52	200.00
IUUC-Bra-017584	Brassica rapa	33.94	7.00e-47	182.00
IUUC-Cja-019298	Callithrix jacchus	84.94	0.00e+00	7652.00
IUUC-Cfa-021213	Canis familiaris	84.85	0.00e+00	7708.00
IUUC-Cpo-021674	Cavia porcellus	83.90	0.00e+00	5163.00
IUUC-Cre-023014	Chlamydomonas reinhardtii	38.31	8.00e-50	190.00
IUUC-Csa-023341	Chlorocebus sabaeus	84.54	0.00e+00	7620.00
IUUC-Cho-024567	Choloepus hoffmanni	81.86	0.00e+00	1517.00
IUUC-Dre-028289	Danio rerio	77.23	0.00e+00	6860.00
IUUC-Dno-029988	Dasypus novemcinctus	84.50	0.00e+00	7629.00
IUUC-Dor-030636	Dipodomys ordii	84.54	0.00e+00	1937.00
IUUC-Ete-032598	Echinops telfairi	81.23	0.00e+00	1329.00
IUUC-Eca-033754	Equus caballus	84.91	0.00e+00	7666.00
IUUC-Eeu-034702	Erinaceus europaeus	80.50	0.00e+00	1347.00
IUUC-Fca-035900	Felis catus	85.01	0.00e+00	7686.00
IUUC-Fal-037034	Ficedula albicollis	83.62	0.00e+00	6589.00
IUUC-Gmo-038634	Gadus morhua	90.26	0.00e+00	1209.00
IUUC-Gga-040321	Gallus gallus	85.22	0.00e+00	7726.00
IUUC-Gac-042444	Gasterosteus aculeatus	58.27	0.00e+00	2216.00
IUUC-Gma-043808	Glycine max	34.94	4.00e-45	176.00
IUUC-Ggo-045134	Gorilla gorilla	79.39	0.00e+00	4021.00
IUUC-Hsa-046516	Homo sapiens	84.89	0.00e+00	7622.00
IUUC-Hvu-047529	Hordeum vulgare	35.15	4.00e-50	193.00
IUUC-Itr-048914	Ictidomys tridecemlineatus	86.74	0.00e+00	2305.00
IUUC-Lch-049903	Latimeria chalumnae	83.32	0.00e+00	7532.00
IUUC-Lpe-051165	Leersia perrieri	36.61	4.00e-48	185.00
IUUC-Loc-052149	Lepisosteus oculatus	80.91	0.00e+00	7172.00
IUUC-Laf-053426	Loxodonta africana	84.67	0.00e+00	7692.00
IUUC-Mcc-055826	Macaca mulatta	84.83	0.00e+00	7663.00
IUUC-Meu-056521	Macropus eugenii	75.38	0.00e+00	1974.00
IUUC-Mtr-058277	Medicago truncatula	34.44	8.00e-52	197.00
IUUC-Mga-059567	Meleagris gallopavo	91.87	0.00e+00	2034.00
IUUC-Mmr-061512	Microcebus murinus	84.48	0.00e+00	7578.00
IUUC-Mdo-062177	Monodelphis domestica	83.07	0.00e+00	7466.00
IUUC-Mmu-064373	Mus musculus	85.07	0.00e+00	7653.00
IUUC-Mpu-066148	Mustela putorius furo	84.67	0.00e+00	7621.00
IUUC-Mlu-067680	Myotis lucifugus	84.59	0.00e+00	7587.00
IUUC-Nle-069633	Nomascus leucogenys	84.48	0.00e+00	7580.00
IUUC-Opr-070609	Ochotona princeps	83.98	0.00e+00	1207.00
IUUC-Ont-071249	Oreochromis niloticus	78.77	0.00e+00	7144.00
IUUC-Oan-073157	Ornithorhynchus anatinus	84.72	0.00e+00	7573.00
IUUC-Ocu-074841	Oryctolagus cuniculus	84.81	0.00e+00	7693.00
IUUC-Oba-075262	Oryza barthii	34.93	3.00e-48	185.00
IUUC-Obr-076115	Oryza brachyantha	34.85	4.00e-47	181.00
IUUC-Ogl-077586	Oryza glaberrima	34.93	3.00e-48	185.00
IUUC-Ogu-078796	Oryza glumaepatula	34.93	3.00e-48	185.00
IUUC-Oin-079298	Oryza indica	34.93	3.00e-48	186.00
IUUC-Olo-080768	Oryza longistaminata	34.94	1.00e-51	197.00
IUUC-Ome-081908	Oryza meridionalis	34.94	6.00e-48	184.00
IUUC-Oni-082049	Oryza nivara	34.93	3.00e-48	185.00
IUUC-Opu-083608	Oryza punctata	34.83	4.00e-47	182.00
IUUC-Oru-084712	Oryza rufipogon	34.93	3.00e-48	185.00
IUUC-Osa-086078	Oryza sativa	34.93	3.00e-48	185.00
IUUC-Ola-086889	Oryzias latipes	77.41	0.00e+00	6989.00
IUUC-Oga-088459	Otolemur garnettii	84.14	0.00e+00	7593.00
IUUC-Oar-089888	Ovis aries	85.32	0.00e+00	7653.00
IUUC-Ptr-091114	Pan troglodytes	84.89	0.00e+00	7648.00
IUUC-Pan-092442	Papio anubis	84.71	0.00e+00	7641.00
IUUC-Psi-093833	Pelodiscus sinensis	84.69	0.00e+00	5017.00
IUUC-Pma-094275	Petromyzon marinus	76.55	0.00e+00	1715.00
IUUC-Ppa-095790	Physcomitrella patens	36.36	6.00e-54	204.00
IUUC-Pfo-097262	Poecilia formosa	78.20	0.00e+00	6915.00
IUUC-Pab-097760	Pongo abelii	84.09	0.00e+00	4296.00
IUUC-Pop-099121	Populus trichocarpa	35.97	9.00e-53	202.00
IUUC-Pca-100465	Procavia capensis	84.43	0.00e+00	3994.00
IUUC-Ppe-101345	Prunus persica	36.23	6.00e-51	196.00
IUUC-Pva-102950	Pteropus vampyrus	84.88	0.00e+00	3674.00
IUUC-Rno-104892	Rattus norvegicus	85.10	0.00e+00	7598.00
IUUC-Sha-106633	Sarcophilus harrisii	84.29	0.00e+00	7503.00
IUUC-Smo-108827	Selaginella moellendorffii	35.51	1.00e-53	204.00
IUUC-Sit-110415	Setaria italica	34.83	2.00e-51	196.00
IUUC-Sly-111155	Solanum lycopersicum	37.68	2.00e-53	203.00
IUUC-Stu-112166	Solanum tuberosum	34.69	5.00e-49	189.00
IUUC-Sar-113251	Sorex araneus	76.87	0.00e+00	2195.00
IUUC-Ssc-116391	Sus scrofa	85.06	0.00e+00	7677.00
IUUC-Tgu-116554	Taeniopygia guttata	84.90	0.00e+00	7676.00
IUUC-Tru-118695	Takifugu rubripes	78.51	0.00e+00	7150.00
IUUC-Tsy-119647	Tarsius syrichta	76.46	0.00e+00	4673.00
IUUC-Tni-120707	Tetraodon nigroviridis	78.25	0.00e+00	7085.00
IUUC-Tca-121094	Theobroma cacao	34.80	2.00e-50	194.00
IUUC-Tae-124157	Triticum aestivum	33.07	5.00e-48	186.00
IUUC-Tur-126300	Triticum urartu	35.15	2.00e-50	194.00
IUUC-Tbe-127346	Tupaia belangeri	77.79	0.00e+00	2272.00
IUUC-Ttr-128542	Tursiops truncatus	78.92	0.00e+00	4956.00
IUUC-Vpa-130611	Vicugna pacos	85.76	0.00e+00	3580.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence