iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
PINA	HINT
Post-translational Modifications (PTMs)
dbPPT
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	9.90e-16	58.8	568	632

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkld 66
           +Dv++ ++g++f ahki L asS+ F+a+f++  +e++    vei  +  evf+ ++kF+Y+g+++
   Q: 568  SDVTFLIDGKQFYAHKIGLVASSDIFRAMFDGLYKERN-AQNVEIPNIRWEVFELMMKFIYSGRIN 632
           6*****************************99999998.************************987 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). In association with TCP24, exerts a negative role in cell proliferation in leaves, possibly by inhibiting mitotic DNA replication.

Protein Sequence
(Fasta)

MIISKSFKAP LKFSVKSSTA PVISNHPPME NHPKRQRTTR LAARNLKRKL SHNTDGAPIV 60
TQLIDIDDEP IDLVVAIRRH VEVLNSSFSD PDFDHEAVKE AAADIADLAK IDENVEIIVE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCCAAATAG GCTTTGGTAT TATAAAGAAA ACGCTCTCTC CACTCCTGAT GATAATCTCA 60
AAATCGTTCA AAGCACCGCT CAAATTCTCC GTCAAATCTT CTACTGCGCC GGTGATATCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR000225--Armadillo
IPR011987--ATPase_V1-cplx_hsu_C
IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ

PROSITE

PS50176--ARM_REPEAT
PS50097--BTB

Pfam

PF00514--Arm
PF00651--BTB

SMART

SM00185--ARM
SM00225--BTB

Gene Ontology

GO:0005737--C:cytoplasm
GO:0031261--C:DNA replication preinitiation complex
GO:0005634--C:nucleus
GO:0006261--P:DNA-dependent DNA replication
GO:0008285--P:negative regulation of cell proliferation
GO:2000104--P:negative regulation of DNA-dependent DNA replication
GO:0016567--P:protein ubiquitination
GO:0042127--P:regulation of cell proliferation

KEGG

ath:AT5G13060

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003858	Anas platyrhynchos	31.78	7.00e-24	105.00
IUUC-Aca-004669	Anolis carolinensis	35.22	2.00e-23	103.00
IUUC-Aly-005450	Arabidopsis lyrata	92.72	0.00e+00	1304.00
IUUC-Bgr-012235	Blumeria graminis	35.00	1.00e-20	94.40
IUUC-Bta-013089	Bos taurus	33.33	1.00e-21	98.60
IUUC-Bci-013587	Botrytis cinerea	35.24	1.00e-21	97.40
IUUC-Bol-015177	Brassica oleracea	83.68	0.00e+00	1220.00
IUUC-Bra-017604	Brassica rapa	81.33	0.00e+00	1158.00
IUUC-Cgl-026537	Colletotrichum gloeosporioides	33.81	3.00e-21	95.90
IUUC-Cme-027156	Cyanidioschyzon merolae	24.85	2.00e-12	67.40
IUUC-Dme-032128	Drosophila melanogaster	36.65	2.00e-22	101.00
IUUC-Eca-034033	Equus caballus	30.37	3.00e-22	100.00
IUUC-Fal-037448	Ficedula albicollis	35.85	6.00e-24	105.00
IUUC-Fox-037811	Fusarium oxysporum	30.51	2.00e-21	96.30
IUUC-Fso-038217	Fusarium solani	32.86	4.00e-19	89.00
IUUC-Gga-040135	Gallus gallus	35.48	8.00e-24	103.00
IUUC-Lch-050679	Latimeria chalumnae	34.59	6.00e-22	99.40
IUUC-Loc-052388	Lepisosteus oculatus	35.53	1.00e-21	98.60
IUUC-Lma-053243	Leptosphaeria maculans	35.24	2.00e-22	100.00
IUUC-Mga-059390	Meleagris gallopavo	30.81	4.00e-24	105.00
IUUC-Mvi-060440	Microbotryum violaceum	25.76	3.00e-10	59.30
IUUC-Mlu-067661	Myotis lucifugus	32.90	4.00e-21	96.70
IUUC-Oan-072689	Ornithorhynchus anatinus	30.37	2.00e-23	103.00
IUUC-Oga-087929	Otolemur garnettii	29.91	2.00e-21	97.80
IUUC-Psi-092948	Pelodiscus sinensis	30.33	7.00e-23	102.00
IUUC-Pno-095110	Phaeosphaeria nodorum	34.76	1.00e-22	100.00
IUUC-Pfo-097492	Poecilia formosa	36.11	5.00e-23	102.00
IUUC-Pva-103017	Pteropus vampyrus	30.19	2.00e-22	100.00
IUUC-Pte-104314	Pyrenophora teres	35.24	6.00e-23	101.00
IUUC-Pyt-104569	Pyrenophora triticirepentis	27.60	3.00e-17	82.80
IUUC-Rno-105357	Rattus norvegicus	30.66	5.00e-22	99.40
IUUC-Ssl-108596	Sclerotinia sclerotiorum	35.24	1.00e-21	97.10
IUUC-Tgu-117412	Taeniopygia guttata	35.85	6.00e-24	105.00
IUUC-Tru-118635	Takifugu rubripes	34.72	4.00e-21	96.70
IUUC-Tni-120593	Tetraodon nigroviridis	33.78	2.00e-21	96.30
IUUC-Tre-122117	Trichoderma reesei	34.76	3.00e-22	99.40
IUUC-Tvi-122426	Trichoderma virens	33.81	5.00e-21	95.10
IUUC-Uma-129348	Ustilago maydis	27.14	2.00e-12	66.60
IUUC-Xtr-132590	Xenopus tropicalis	33.33	1.00e-21	98.20

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence