iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Ath-007280

UUCD1 version

UUC-ArT-01609

Ensembl Protein ID

AT4G39910.1

UniProt Accession

O24454; UBP3_ARATH

Genbank Protein ID

AAB67966.1; CAB38904.1; CAB80654.1; AEE87136.1; AAL24275.1; AAL79594.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase 3; Deubiquitinating enzyme 3; Ubiquitin thioesterase 3; Ubiquitin-specific-processing protease 3

Genbank Nucleotide ID

U76845; AL035708; AL161596; CP002687; AY058889; AY079044

Gene Name

UBP3; At4g39910; T5J17.80

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT4G39910	AT4G39910.1	AT4G39910.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Post-translational Modifications (PTMs)
dbPTM
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	10898935; 9268021

Classification

Family	E-value	Score	Start	End
DUB/USP	1.20e-98	331.3	23	366

Active Site

Position(s)	Description	Evidence
32	Nucleophile
315	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsgyeqqDaqEfl 96
           +G++N+gNtCY+NSvLQ+L+++ ++re+lle +  + +     + +++l+++l++lf+++   k+k+++++p+++++ lkk +e f++y++qDa+Efl
   Q: 23   FGFENFGNTCYCNSVLQALYFCVPFREQLLE-YYTSNKSV--ADAEENLMTCLADLFSQISsqKKKTGVIAPKRFVQRLKKQNELFRSYMHQDAHEFL 117
           69*****************************.44443333..6899**************98899999****************************** PP
   S: 97   aflldqleeelkkeknkpkeeeeeedkselsde..........aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkk 184
           ++ll+++ + l+ke++ +k+e e +++s+ + +          +   +k+   ++++++Fqg l+++++cl+c++v+ r+e+fldlsl++++++    
   Q: 118  NYLLNEVVDILEKEAKATKTEHETSSSSSPE-KianglkvpqaNGVVHKEPIVTWVHNIFQGILTNETRCLRCETVTARDETFLDLSLDIEQNS---- 210
           ***********77555555555555544444.359999998888888888888*****************************************.... PP
   S: 185  eslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqkekkkYeLia 282
            s+++cL++f+++e+l+ e+k++c+kc+++qea+k++k+kk P++L++hLkRf++ e+ ++ +k++ +v fpleL+ls+ ++        +++Y+L+a
   Q: 211  -SITSCLKNFSSTETLHAEDKFFCDKCCSLQEAQKRMKIKKPPHILVIHLKRFKYIEQLGRYKKLSYRVVFPLELKLSNTVEP-Y----ADVEYSLFA 302
           .9****************************************************************************77766.3....279****** PP
   S: 283  vvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetg.........staYvlfYkr 337
           vvvH G ++++GHYv++vk+ +++Wl fdD++V+ ++e+ v+++ g         + +Y+lfY++
   Q: 303  VVVHVGsGPNHGHYVSLVKS-HNHWLFFDDENVEMIEESAVQTFFGssqeyssntDHGYILFYES 366
           ********************.889*******************999*****************85 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Required for the correct development of pollen.

Protein Sequence
(Fasta)

MGAAGSKLEK ALGDQFPEGE RYFGFENFGN TCYCNSVLQA LYFCVPFREQ LLEYYTSNKS 60
VADAEENLMT CLADLFSQIS SQKKKTGVIA PKRFVQRLKK QNELFRSYMH QDAHEFLNYL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATAGTTTTT GATAATCAAA TCCACATCTT CCTTCGTTGC TTCGTCGCTT TGGACAGAAA 60
AGAAGAGAAA AAGTTTAATA GTAAAATAAT CGATCCTCTT CTCTTCTCTT CTCTGAGGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0449--Lipoprotein
KW-0519--Myristate
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005634--C:nucleus
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ath:AT4G39910

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-002650	Amborella trichopoda	88.83	0.00e+00	662.00
IUUC-Aly-005830	Arabidopsis lyrata	99.73	0.00e+00	731.00
IUUC-Ame-011015	Astyanax mexicanus	59.08	2.00e-125	441.00
IUUC-Bci-013837	Botrytis cinerea	43.21	3.00e-75	275.00
IUUC-Bol-015138	Brassica oleracea	96.23	0.00e+00	707.00
IUUC-Bra-016956	Brassica rapa	97.04	0.00e+00	732.00
IUUC-Cel-018379	Caenorhabditis elegans	49.63	1.00e-110	392.00
IUUC-Cfa-020534	Canis familiaris	58.81	3.00e-123	434.00
IUUC-Cre-022711	Chlamydomonas reinhardtii	62.37	2.00e-123	434.00
IUUC-Cho-024902	Choloepus hoffmanni	49.18	7.00e-94	336.00
IUUC-Cin-025659	Ciona intestinalis	47.87	1.00e-100	359.00
IUUC-Cgl-026611	Colletotrichum gloeosporioides	43.34	3.00e-76	279.00
IUUC-Dre-027845	Danio rerio	59.08	3.00e-125	441.00
IUUC-Dor-030972	Dipodomys ordii	56.60	4.00e-83	300.00
IUUC-Dse-031470	Dothistroma septosporum	47.62	3.00e-73	269.00
IUUC-Ete-033125	Echinops telfairi	48.71	3.00e-72	264.00
IUUC-Eca-033721	Equus caballus	58.15	4.00e-122	430.00
IUUC-Fal-036833	Ficedula albicollis	59.14	2.00e-122	431.00
IUUC-Fox-037682	Fusarium oxysporum	43.12	1.00e-74	273.00
IUUC-Fso-038299	Fusarium solani	38.33	4.00e-78	285.00
IUUC-Gmo-038763	Gadus morhua	58.27	1.00e-124	438.00
IUUC-Ggr-039806	Gaeumannomyces graminis	45.09	2.00e-78	286.00
IUUC-Gac-041967	Gasterosteus aculeatus	59.08	1.00e-125	442.00
IUUC-Gma-043828	Glycine max	91.03	0.00e+00	682.00
IUUC-Hvu-047692	Hordeum vulgare	82.43	4.00e-178	616.00
IUUC-Lpe-051368	Leersia perrieri	82.34	2.00e-179	620.00
IUUC-Mor-057072	Magnaporthe oryzae	43.96	6.00e-77	281.00
IUUC-Mpo-057424	Magnaporthe poae	45.26	1.00e-78	287.00
IUUC-Mtr-057715	Medicago truncatula	88.62	0.00e+00	672.00
IUUC-Mmr-060751	Microcebus murinus	58.81	2.00e-123	434.00
IUUC-Mac-065323	Musa acuminata	83.97	0.00e+00	634.00
IUUC-Ncr-068699	Neurospora crassa	43.03	2.00e-75	276.00
IUUC-Ont-072658	Oreochromis niloticus	59.08	1.00e-125	442.00
IUUC-Oan-073372	Ornithorhynchus anatinus	58.70	4.00e-122	430.00
IUUC-Olo-080882	Oryza longistaminata	82.34	2.00e-179	620.00
IUUC-Ome-081549	Oryza meridionalis	82.34	2.00e-179	620.00
IUUC-Oni-082982	Oryza nivara	82.34	2.00e-179	620.00
IUUC-Ola-087418	Oryzias latipes	59.08	8.00e-126	442.00
IUUC-Oga-088073	Otolemur garnettii	58.15	4.00e-122	430.00
IUUC-Pma-094388	Petromyzon marinus	58.40	1.00e-123	435.00
IUUC-Pno-095044	Phaeosphaeria nodorum	47.73	2.00e-73	269.00
IUUC-Pfo-097052	Poecilia formosa	58.81	2.00e-125	441.00
IUUC-Pop-099016	Populus trichocarpa	89.73	0.00e+00	679.00
IUUC-Pca-100835	Procavia capensis	53.96	4.00e-99	353.00
IUUC-Ppe-101474	Prunus persica	90.00	0.00e+00	684.00
IUUC-Pte-104356	Pyrenophora teres	48.18	2.00e-74	273.00
IUUC-Pyt-104709	Pyrenophora triticirepentis	48.18	4.00e-74	271.00
IUUC-Spo-108095	Schizosaccharomyces pombe	45.34	2.00e-72	266.00
IUUC-Smo-109064	Selaginella moellendorffii	80.27	7.00e-168	582.00
IUUC-Sly-111210	Solanum lycopersicum	88.83	0.00e+00	664.00
IUUC-Stu-112398	Solanum tuberosum	85.71	0.00e+00	653.00
IUUC-Sar-113216	Sorex araneus	58.42	3.00e-120	424.00
IUUC-Tru-118613	Takifugu rubripes	59.08	9.00e-126	442.00
IUUC-Tsy-119520	Tarsius syrichta	49.81	6.00e-67	246.00
IUUC-Tni-120293	Tetraodon nigroviridis	59.08	9.00e-126	442.00
IUUC-Tca-121329	Theobroma cacao	90.84	0.00e+00	688.00
IUUC-Tre-122226	Trichoderma reesei	43.75	6.00e-76	278.00
IUUC-Tvi-122330	Trichoderma virens	43.75	2.00e-76	279.00
IUUC-Tbe-127783	Tupaia belangeri	58.31	1.00e-119	422.00
IUUC-Ttr-129083	Tursiops truncatus	58.54	8.00e-123	432.00
IUUC-Uma-129409	Ustilago maydis	49.47	9.00e-76	278.00
IUUC-Vvi-131371	Vitis vinifera	91.03	0.00e+00	685.00
IUUC-Xtr-132082	Xenopus tropicalis	57.84	2.00e-121	427.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence