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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063673
UUCD1 version UUC-MuM-01222
Ensembl Protein ID ENSMUSP00000031588.7
UniProt Accession Q3UN04; Q3TS48; Q3TSB9; Q8BVI3; Q8CHW7; UBP30_MOUSE
Genbank Protein ID BAC37154.1; BAE25944.1; BAE36756.1; BAE36827.1; AAH38606.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 30; Deubiquitinating enzyme 30; Ubiquitin thioesterase 30; Ubiquitin-specific-processing protease 30
Genbank Nucleotide ID AK078164; AK144578; AK162153; AK162269; BC038606
Gene Name Usp30
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000029592.11 ENSMUST00000202603.3 ENSMUSP00000144522.1
ENSMUSG00000029592.11 ENSMUST00000031588.11 ENSMUSP00000031588.7
ENSMUSG00000029592.11 ENSMUST00000200119.2 ENSMUSP00000142350.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 3.30e-71 241.3 69 501
Active Site
Position(s) Description Evidence
77 Nucleophile ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093,
ECO:0000269|PubMed:24513856}
452 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093,
ECO:0000269|PubMed:24513856}
Domain Profile

   DUB/USP
   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw...kskkkavsprellkalkkeaeefsgy 87
           Gl NlgNtC+mNS+LQ Ls++p + + l e +++  ++++ ++++++l+ +l +l+++l     +++++ + + ll++l+++  ++s++
   Q: 69   GLVNLGNTCFMNSLLQGLSACPAFVKWLEEFTTQYSRDQQGPHTHQCLSLTLLNLLKALScqeVTEDEVLDASCLLDVLRMYRWQISSF 157
           9*****************************6666666666688999*************888899999********************* PP
   S: 88   eqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde..........aeekkkkknkslisdlFqgqlksqikclecdnvs.sr 165
           e+qDa+E+++++ ++le+e    ++ +++++++ ++ e+++e          + + +++ n+   ++ F+g+l+s+++c++c+++s +r
   Q: 158  EEQDAHELFHVITSSLEDER--DRQPRVTHLFDVHSLEQQSEmaprqvtchtRGSPHPTTNHWKSQHPFHGRLTSNMVCKHCEHQSpVR 244
           *******************9..6788888999998888888889999999999999********************************* PP
   S: 166  eepfldlslpvpgkeetkkeslqdcLesftkeeelegenkyycekck...............kkqeaekklklkklPevLilhLkRfsf 239
           +++f +lsl++p  +  ++++l++cL++f + e++++   + c++c+               ++++ +k+lkl klP++L++hL+R s+
   Q: 245  FDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRD---VVCDNCTkieargtltgekvehQRSTFVKQLKLGKLPQCLCIHLQRLSW 330
           ***********************************97...9******7777777777777666666*********************** PP
   S: 240  seeqksrekinkkvefpleLdlspfcts...............................peekqke....................... 274
           s++ + + k +++v+f++ L ++ +  +                               p                             
   Q: 331  SSH-GTPLKRHEHVQFNEFLMMDFYKYRllghkpsqhgpkatenpgsapevqdaqaapkP-----Glsqpgapktqiflngacspsllp 413
           998.8888*********9999986666677778777777777766666665555555550.....055555555556666666666666 PP
   S: 275  ...................kkkYeLiavvvHsGslssGHYvayvkn.........ekgkWllfdDskVtevkeeevleetgstaYvlfY 335
                              ++ ++L+avvvH+G ++sGH+v+y ++         ++++Wl ++D++V++ + +evl+   s+aY+lfY
   Q: 414  alpspvafplpvvpdysssTYLFRLMAVVVHHGDMHSGHFVTYRRSppsaknplsTSNQWLWISDDTVRKASLQEVLS---SSAYLLFY 499
           66666666666666666559999***********************9999888888999*******************...******** PP
   S: 336  kr 337
           +r
   Q: 500  ER 501
           98 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PARK2): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy. Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate in mitophagic signaling. Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (By similarity). Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (PubMed:24513856).
 Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PARK2): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy. Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate in mitophagic signaling. Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (By similarity). Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (PubMed:24513856).
Protein Sequence
(Fasta)
MLSSRAQAAR TAADKALQRF LRTGAAVRYK VMKNWGVIGG IAAALAAGIY VIWGPITERK 60
KRRKGLVPGL VNLGNTCFMN SLLQGLSACP AFVKWLEEFT TQYSRDQQGP HTHQCLSLTL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063673|DUB,USP|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TTGGTACTCA GAGCCTTCCC AACTGCTCCT CCTCAAGAAC TTTCTACCAC CAGGGCTTTT 60
CTCACCATCA GTGGGATTGG CAAACTCCTT GGGGACAGCG GCTCCATCAT CCAGCTCGAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063673|DUB,USP|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0496--Mitochondrion
KW-1000--Mitochondrion outer membrane
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
Pfam

PF00443--UCH
Gene Ontology

GO:0016021--C:integral component of membrane
GO:0005741--C:mitochondrial outer membrane
GO:0005739--C:mitochondrion
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008053--P:mitochondrial fusion
GO:0000422--P:mitophagy
GO:0016579--P:protein deubiquitination
GO:0035871--P:protein K11-linked deubiquitination
GO:0044313--P:protein K6-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG mmu:100756
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000204 Aegilops tauschii 28.96 3.00e-15 76.60
IUUC-Aml-001733 Ailuropoda melanoleuca 89.04 0.00e+00 838.00
IUUC-Atr-002510 Amborella trichopoda 24.38 7.00e-21 95.50
IUUC-Apl-003645 Anas platyrhynchos 71.12 2.00e-106 378.00
IUUC-Aca-004583 Anolis carolinensis 68.42 2.00e-24 103.00
IUUC-Aly-005754 Arabidopsis lyrata 26.42 8.00e-27 115.00
IUUC-Ath-007622 Arabidopsis thaliana 26.87 2.00e-23 103.00
IUUC-Ame-010896 Astyanax mexicanus 61.44 2.00e-154 538.00
IUUC-Bta-012321 Bos taurus 87.62 0.00e+00 826.00
IUUC-Bci-013590 Botrytis cinerea 21.97 2.00e-12 67.80
IUUC-Bdi-014795 Brachypodium distachyon 27.27 2.00e-16 80.50
IUUC-Bol-015637 Brassica oleracea 27.51 8.00e-24 105.00
IUUC-Bra-016801 Brassica rapa 26.15 2.00e-23 103.00
IUUC-Cel-018308 Caenorhabditis elegans 28.79 4.00e-38 152.00
IUUC-Cja-018826 Callithrix jacchus 89.58 0.00e+00 894.00
IUUC-Cfa-021206 Canis familiaris 87.31 0.00e+00 844.00
IUUC-Cpo-021343 Cavia porcellus 89.02 0.00e+00 840.00
IUUC-Csa-023419 Chlorocebus sabaeus 89.36 0.00e+00 894.00
IUUC-Cho-024475 Choloepus hoffmanni 87.27 2.00e-133 469.00
IUUC-Cgl-026621 Colletotrichum gloeosporioides 21.39 5.00e-14 73.20
IUUC-Cne-027061 Cryptococcus neoformans 26.07 5.00e-09 56.20
IUUC-Dre-027563 Danio rerio 58.45 2.00e-156 545.00
IUUC-Dno-029929 Dasypus novemcinctus 87.81 0.00e+00 858.00
IUUC-Dor-030166 Dipodomys ordii 81.43 0.00e+00 736.00
IUUC-Dse-031517 Dothistroma septosporum 23.00 2.00e-12 67.80
IUUC-Dme-031627 Drosophila melanogaster 33.21 6.00e-34 139.00
IUUC-Ete-032634 Echinops telfairi 77.95 0.00e+00 674.00
IUUC-Eca-033968 Equus caballus 89.59 0.00e+00 813.00
IUUC-Eeu-035279 Erinaceus europaeus 80.49 1.00e-56 214.00
IUUC-Fca-036525 Felis catus 89.56 0.00e+00 869.00
IUUC-Fal-036606 Ficedula albicollis 71.99 2.00e-157 548.00
IUUC-Gmo-038726 Gadus morhua 56.67 4.00e-142 497.00
IUUC-Gga-040718 Gallus gallus 72.43 6.00e-160 556.00
IUUC-Gac-042645 Gasterosteus aculeatus 56.97 3.00e-151 528.00
IUUC-Gma-042890 Glycine max 25.98 2.00e-25 110.00
IUUC-Ggo-045021 Gorilla gorilla 89.75 0.00e+00 893.00
IUUC-Hsa-045832 Homo sapiens 89.75 0.00e+00 893.00
IUUC-Itr-048392 Ictidomys tridecemlineatus 91.43 0.00e+00 836.00
IUUC-Lch-050662 Latimeria chalumnae 69.49 1.00e-176 612.00
IUUC-Lpe-051078 Leersia perrieri 25.90 3.00e-28 120.00
IUUC-Loc-052611 Lepisosteus oculatus 65.69 2.00e-179 622.00
IUUC-Lma-053048 Leptosphaeria maculans 20.44 2.00e-14 74.70
IUUC-Laf-053752 Loxodonta africana 88.57 0.00e+00 809.00
IUUC-Mcc-054892 Macaca mulatta 89.75 0.00e+00 897.00
IUUC-Meu-056673 Macropus eugenii 72.32 6.00e-159 553.00
IUUC-Mor-057143 Magnaporthe oryzae 21.87 1.00e-08 55.50
IUUC-Mtr-057976 Medicago truncatula 25.00 5.00e-32 132.00
IUUC-Mga-059543 Meleagris gallopavo 74.17 0.00e+00 654.00
IUUC-Mmr-061534 Microcebus murinus 90.14 0.00e+00 868.00
IUUC-Mdo-062140 Monodelphis domestica 69.15 4.00e-164 571.00
IUUC-Mpu-066328 Mustela putorius furo 88.59 0.00e+00 834.00
IUUC-Mlu-067938 Myotis lucifugus 88.97 0.00e+00 873.00
IUUC-Nle-069426 Nomascus leucogenys 88.01 0.00e+00 793.00
IUUC-Opr-070796 Ochotona princeps 82.88 2.00e-119 422.00
IUUC-Ont-072248 Oreochromis niloticus 58.06 2.00e-155 542.00
IUUC-Oan-072916 Ornithorhynchus anatinus 79.14 0.00e+00 758.00
IUUC-Ocu-074459 Oryctolagus cuniculus 85.13 0.00e+00 658.00
IUUC-Oba-075765 Oryza barthii 26.45 1.00e-26 114.00
IUUC-Obr-076005 Oryza brachyantha 26.69 4.00e-29 122.00
IUUC-Ogl-077916 Oryza glaberrima 26.69 3.00e-30 126.00
IUUC-Ogu-078263 Oryza glumaepatula 26.83 2.00e-27 117.00
IUUC-Oin-080096 Oryza indica 26.84 2.00e-21 97.10
IUUC-Ome-081928 Oryza meridionalis 26.85 2.00e-28 120.00
IUUC-Oni-082424 Oryza nivara 26.85 1.00e-27 117.00
IUUC-Oru-085117 Oryza rufipogon 26.85 1.00e-27 117.00
IUUC-Ola-087429 Oryzias latipes 56.16 1.00e-147 516.00
IUUC-Oga-087981 Otolemur garnettii 89.17 0.00e+00 852.00
IUUC-Oar-089927 Ovis aries 87.62 0.00e+00 826.00
IUUC-Ptr-090878 Pan troglodytes 89.75 0.00e+00 893.00
IUUC-Pan-092698 Papio anubis 89.75 0.00e+00 897.00
IUUC-Psi-093451 Pelodiscus sinensis 76.02 0.00e+00 709.00
IUUC-Ppa-096015 Physcomitrella patens 23.10 4.00e-12 67.00
IUUC-Pfo-096096 Poecilia formosa 58.55 4.00e-154 538.00
IUUC-Pab-098676 Pongo abelii 88.39 0.00e+00 872.00
IUUC-Pca-100418 Procavia capensis 92.34 6.00e-126 444.00
IUUC-Ppe-101898 Prunus persica 24.48 1.00e-22 101.00
IUUC-Pva-103018 Pteropus vampyrus 86.85 0.00e+00 837.00
IUUC-Pgr-103423 Puccinia graminis 27.32 4.00e-10 60.50
IUUC-Pte-104330 Pyrenophora teres 21.19 2.00e-14 73.90
IUUC-Pyt-104518 Pyrenophora triticirepentis 21.25 3.00e-16 80.50
IUUC-Rno-105708 Rattus norvegicus 96.32 0.00e+00 901.00
IUUC-Sha-106971 Sarcophilus harrisii 79.24 0.00e+00 752.00
IUUC-Sit-110442 Setaria italica 26.93 2.00e-27 116.00
IUUC-Stu-112223 Solanum tuberosum 24.86 3.00e-15 76.60
IUUC-Ssc-116397 Sus scrofa 87.81 0.00e+00 828.00
IUUC-Tgu-117446 Taeniopygia guttata 68.74 0.00e+00 636.00
IUUC-Tru-118268 Takifugu rubripes 55.98 4.00e-142 498.00
IUUC-Tsy-119484 Tarsius syrichta 90.55 4.00e-52 199.00
IUUC-Tni-119735 Tetraodon nigroviridis 57.87 7.00e-122 430.00
IUUC-Tca-121660 Theobroma cacao 26.77 1.00e-27 118.00
IUUC-Tae-125383 Triticum aestivum 28.04 5.00e-28 119.00
IUUC-Tur-126458 Triticum urartu 27.52 1.00e-23 104.00
IUUC-Tbe-127740 Tupaia belangeri 83.37 0.00e+00 770.00
IUUC-Ttr-129273 Tursiops truncatus 86.85 0.00e+00 817.00
IUUC-Vda-129789 Verticillium dahliae 22.80 5.00e-09 56.60
IUUC-Vvi-131177 Vitis vinifera 25.14 8.00e-26 111.00
IUUC-Xtr-132374 Xenopus tropicalis 67.70 1.00e-172 599.00
IUUC-Xma-133267 Xiphophorus maculatus 60.28 7.00e-156 543.00
IUUC-Yli-134571 Yarrowia lipolytica 24.04 2.00e-11 64.30
IUUC-Zma-135796 Zea mays 25.61 1.00e-24 107.00
Created Date 25-Jun-2017

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