iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
WBGene00016405	C34D4.14a	C34D4.14a
WBGene00016405	C34D4.14b	C34D4.14b
WBGene00016405	C34D4.14c	C34D4.14c
WBGene00016405	C34D4.14d	C34D4.14d
WBGene00016405	C34D4.14e	C34D4.14e
WBGene00016405	C34D4.14f	C34D4.14f
WBGene00016405	C34D4.14g	C34D4.14g
WBGene00016405	C34D4.14h	C34D4.14h

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.30e-100	336.0	2243	2650

Active Site

Position(s)	Description	Evidence
2619	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp..............................ehlk 69
           ++d+k++le+e+++Eeg++l G+t+ef+al+++elq+++l l++++++d++  +  +++ ++                                +  +
   Q: 2243 HADRKAVLEIEYTNEEGTGL-GPTLEFYALVAAELQRKSLALWVCDDDDTHASKSGEEREVD-LgegkkpigyyvrrvgglfpaplppgtdetkRAAD 2338
           57999***************.**************************988887777766653.2578889**************************** PP
   S: 70   lFeflGrllgkalqdgrlldlplsksfykll.............lgkklsledleevdpelykslkeikenaes........................ 130
           +F+ lG++l+k+l dgrl+dlpls++f+kll             l+k lsl+d+eev+p    +lke++++a++                        
   Q: 2339 MFRVLGVFLAKVLLDGRLVDLPLSRPFLKLLvhpqigddargpnLHKILSLDDFEEVNPVKGSFLKELRALAQRkrliendtsidsnskrrkiaelkl 2436
           *******************************66666666666666668**********************9944555566677777888899999999 PP
   S: 131  .......dieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGe 221
                   +e+l+l++t+ + ++++++++ e L+ gG++i+Vt++N e+Yv++  e+ l++gi+ q+ afr+Gf +v+pl+ l+++++ee++ l++Ge
   Q: 2437 hikgstcRVEDLALNFTVNPPSKVFQYAEME-LVDGGSDIDVTIDNVEQYVEKCEEFYLNTGIAYQMRAFRDGFDRVFPLRTLRAYSPEEVQRLLSGE 2533
           99999999*********99999888877776.****************************************************************** PP
   S: 222  ..eeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYssk 316
             +e++ +d+ + t+ k gyt++sp++ +F++v+e+++++erk+fLqF+Tg+s+lP+gG+a+l+prl+++rk ++ d ++Ps+nTC++yLkLPeYss 
   Q: 2534 qcPEWSRDDILNYTEPKLGYTRESPGFLRFVDVMEALTAQERKNFLQFATGCSSLPPGGLANLHPRLTIVRKvESGDGSYPSVNTCVHYLKLPEYSSS 2631
           5555555555555566********************************************************98999********************* PP
   S: 317  eilkekLlyAieetkgFels 336
            il+e+Ll+Ai+e kgF+l+
   Q: 2632 AILRERLLTAINE-KGFHLN 2650
           *************.****96 PP

Organism

Caenorhabditis elegans

Protein Sequence
(Fasta)

MDGIDPETLL EWLQTGIGDE RDLQLMALEQ LCMLLLMADN IDRCFESCPP RTFIPALCKI 60
FIDETAPDNV LEVTARAITY YLDVSNECTR RITQVDGAVK AICTRLAAAD ISDRSSKDLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTTTTAAGA AAAAAAAAAG TTTCTAAATT ATTGATTTTC AAACGATCCG GAACTTTTTC 60
ACACAACACT TTATATTTAG GGACTTTCGT ACTATTAAAC AGATTTTGAA CGCCCGTTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-0436--Ligase
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR012919--SUN_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT
PS51416--MIB_HERC2

Pfam

PF12796--Ank_2
PF00632--HECT
PF06701--MIB_HERC2
PF07738--Sad1_UNC

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0016874--F:ligase activity
GO:0046872--F:metal ion binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0031581--P:hemidesmosome assembly

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000750	Aegilops tauschii	36.96	8.00e-92	331.00
IUUC-Aml-001987	Ailuropoda melanoleuca	52.47	2.00e-176	613.00
IUUC-Atr-002821	Amborella trichopoda	35.74	3.00e-88	320.00
IUUC-Apl-003493	Anas platyrhynchos	52.39	6.00e-177	615.00
IUUC-Aca-004521	Anolis carolinensis	52.08	1.00e-173	603.00
IUUC-Aly-005962	Arabidopsis lyrata	36.78	2.00e-86	313.00
IUUC-Ath-006636	Arabidopsis thaliana	36.23	7.00e-87	315.00
IUUC-Ago-007875	Ashbya gossypii	32.21	8.00e-68	251.00
IUUC-Acl-008242	Aspergillus clavatus	34.43	1.00e-80	294.00
IUUC-Afl-008736	Aspergillus flavus	33.82	4.00e-77	282.00
IUUC-Afu-008812	Aspergillus fumigatus	33.64	3.00e-80	293.00
IUUC-Ani-009407	Aspergillus nidulans	32.54	4.00e-74	272.00
IUUC-Ang-009763	Aspergillus niger	33.03	5.00e-70	259.00
IUUC-Aor-009941	Aspergillus oryzae	34.00	3.00e-77	282.00
IUUC-Ate-010459	Aspergillus terreus	32.02	3.00e-64	239.00
IUUC-Ame-011258	Astyanax mexicanus	52.09	1.00e-174	607.00
IUUC-Bgr-012265	Blumeria graminis	32.97	1.00e-76	281.00
IUUC-Bta-012835	Bos taurus	52.47	2.00e-176	613.00
IUUC-Bci-013890	Botrytis cinerea	33.95	4.00e-77	282.00
IUUC-Bdi-014046	Brachypodium distachyon	37.39	4.00e-90	325.00
IUUC-Bol-015942	Brassica oleracea	36.65	4.00e-89	322.00
IUUC-Bra-016849	Brassica rapa	36.83	3.00e-89	323.00
IUUC-Cja-019174	Callithrix jacchus	52.31	6.00e-176	611.00
IUUC-Cfa-021115	Canis familiaris	51.85	3.00e-167	582.00
IUUC-Cpo-022382	Cavia porcellus	46.82	7.00e-143	501.00
IUUC-Cre-022767	Chlamydomonas reinhardtii	35.15	4.00e-68	251.00
IUUC-Csa-023230	Chlorocebus sabaeus	52.31	8.00e-176	611.00
IUUC-Cho-024711	Choloepus hoffmanni	48.64	4.00e-142	499.00
IUUC-Cin-025342	Ciona intestinalis	47.08	4.00e-164	572.00
IUUC-Csv-026031	Ciona savignyi	45.74	2.00e-161	563.00
IUUC-Cgl-026716	Colletotrichum gloeosporioides	33.94	8.00e-82	298.00
IUUC-Cne-026857	Cryptococcus neoformans	32.31	3.00e-65	243.00
IUUC-Cme-027226	Cyanidioschyzon merolae	33.81	8.00e-59	221.00
IUUC-Dre-027435	Danio rerio	52.09	6.00e-175	608.00
IUUC-Dno-029954	Dasypus novemcinctus	52.31	9.00e-176	610.00
IUUC-Dor-030734	Dipodomys ordii	46.82	4.00e-143	502.00
IUUC-Dse-031444	Dothistroma septosporum	33.52	5.00e-78	285.00
IUUC-Dme-031739	Drosophila melanogaster	43.69	6.00e-178	618.00
IUUC-Ete-033192	Echinops telfairi	55.90	2.00e-110	392.00
IUUC-Eca-033434	Equus caballus	52.47	2.00e-175	609.00
IUUC-Eeu-035031	Erinaceus europaeus	38.92	4.00e-101	361.00
IUUC-Fca-035998	Felis catus	52.47	3.00e-176	612.00
IUUC-Fal-037468	Ficedula albicollis	52.40	2.00e-176	613.00
IUUC-Fox-038035	Fusarium oxysporum	33.09	5.00e-77	281.00
IUUC-Fso-038320	Fusarium solani	32.54	3.00e-75	276.00
IUUC-Gmo-038495	Gadus morhua	51.78	2.00e-172	600.00
IUUC-Ggr-040057	Gaeumannomyces graminis	33.52	3.00e-78	286.00
IUUC-Gga-040736	Gallus gallus	52.40	4.00e-176	612.00
IUUC-Gac-041777	Gasterosteus aculeatus	51.24	6.00e-175	608.00
IUUC-Gma-043048	Glycine max	37.46	1.00e-90	327.00
IUUC-Ggo-044677	Gorilla gorilla	47.08	1.00e-147	517.00
IUUC-Hsa-045879	Homo sapiens	52.31	8.00e-176	611.00
IUUC-Hvu-047775	Hordeum vulgare	36.71	9.00e-90	324.00
IUUC-Itr-048664	Ictidomys tridecemlineatus	52.31	8.00e-176	610.00
IUUC-Kpa-049098	Komagataella pastoris	31.16	7.00e-66	245.00
IUUC-Lch-050444	Latimeria chalumnae	49.84	5.00e-158	552.00
IUUC-Lpe-051017	Leersia perrieri	35.93	1.00e-88	320.00
IUUC-Loc-051986	Lepisosteus oculatus	51.24	7.00e-175	608.00
IUUC-Lma-052990	Leptosphaeria maculans	35.24	1.00e-81	298.00
IUUC-Laf-054230	Loxodonta africana	52.23	1.00e-173	603.00
IUUC-Mcc-054787	Macaca mulatta	52.31	8.00e-176	611.00
IUUC-Meu-056502	Macropus eugenii	47.86	1.00e-133	471.00
IUUC-Mor-057054	Magnaporthe oryzae	32.04	3.00e-76	280.00
IUUC-Mpo-057417	Magnaporthe poae	33.58	1.00e-78	287.00
IUUC-Mtr-057849	Medicago truncatula	37.46	2.00e-89	323.00
IUUC-Mla-058870	Melampsora laricipopulina	32.37	3.00e-68	253.00
IUUC-Mga-059409	Meleagris gallopavo	52.31	1.00e-174	607.00
IUUC-Mvi-060507	Microbotryum violaceum	33.27	2.00e-79	290.00
IUUC-Mmr-061667	Microcebus murinus	52.31	6.00e-176	611.00
IUUC-Mdo-061960	Monodelphis domestica	52.55	5.00e-177	615.00
IUUC-Mmu-063941	Mus musculus	52.47	3.00e-175	608.00
IUUC-Mac-064675	Musa acuminata	35.26	4.00e-86	311.00
IUUC-Mpu-065939	Mustela putorius furo	52.47	3.00e-176	612.00
IUUC-Mlu-068112	Myotis lucifugus	52.47	4.00e-176	612.00
IUUC-Nfi-068482	Neosartorya fischeri	33.70	6.00e-80	292.00
IUUC-Ncr-068906	Neurospora crassa	33.33	4.00e-79	289.00
IUUC-Nle-069001	Nomascus leucogenys	52.31	6.00e-176	611.00
IUUC-Opr-071222	Ochotona princeps	52.62	2.00e-174	606.00
IUUC-Ont-072101	Oreochromis niloticus	51.93	2.00e-175	609.00
IUUC-Oan-072814	Ornithorhynchus anatinus	52.23	4.00e-176	612.00
IUUC-Ocu-074011	Oryctolagus cuniculus	51.93	2.00e-175	609.00
IUUC-Oba-075380	Oryza barthii	35.50	2.00e-77	283.00
IUUC-Obr-076915	Oryza brachyantha	35.14	3.00e-86	312.00
IUUC-Ogl-077055	Oryza glaberrima	34.15	5.00e-82	298.00
IUUC-Ogu-078892	Oryza glumaepatula	35.50	4.00e-77	282.00
IUUC-Oin-079256	Oryza indica	33.80	4.00e-80	292.00
IUUC-Olo-080343	Oryza longistaminata	33.97	1.00e-81	297.00
IUUC-Ome-081422	Oryza meridionalis	33.97	6.00e-82	298.00
IUUC-Oni-082469	Oryza nivara	33.10	4.00e-78	285.00
IUUC-Opu-083792	Oryza punctata	32.40	2.00e-70	260.00
IUUC-Oru-084439	Oryza rufipogon	35.69	8.00e-78	284.00
IUUC-Osa-085972	Oryza sativa	34.15	2.00e-81	295.00
IUUC-Ola-086412	Oryzias latipes	51.16	1.00e-173	603.00
IUUC-Olu-087871	Ostreococcus lucimarinus	31.51	6.00e-69	253.00
IUUC-Oga-087908	Otolemur garnettii	35.86	2.00e-82	300.00
IUUC-Oar-089668	Ovis aries	52.47	2.00e-176	613.00
IUUC-Ptr-090517	Pan troglodytes	52.31	4.00e-176	612.00
IUUC-Pan-091849	Papio anubis	47.38	2.00e-149	523.00
IUUC-Psi-093390	Pelodiscus sinensis	52.24	6.00e-177	614.00
IUUC-Pma-094628	Petromyzon marinus	36.09	5.00e-107	380.00
IUUC-Pno-094891	Phaeosphaeria nodorum	34.86	4.00e-84	305.00
IUUC-Ppa-095181	Physcomitrella patens	36.01	9.00e-83	300.00
IUUC-Pfo-097075	Poecilia formosa	50.77	1.00e-172	600.00
IUUC-Pab-098176	Pongo abelii	52.31	8.00e-176	611.00
IUUC-Pop-099190	Populus trichocarpa	36.76	2.00e-87	317.00
IUUC-Pca-101123	Procavia capensis	53.05	3.00e-155	542.00
IUUC-Ppe-101284	Prunus persica	36.51	2.00e-86	313.00
IUUC-Pva-103008	Pteropus vampyrus	52.47	2.00e-176	613.00
IUUC-Pgr-103694	Puccinia graminis	31.53	2.00e-73	270.00
IUUC-Ptt-103916	Puccinia triticina	31.05	1.00e-66	248.00
IUUC-Pte-104346	Pyrenophora teres	34.93	9.00e-84	305.00
IUUC-Pyt-104508	Pyrenophora triticirepentis	35.48	1.00e-84	308.00
IUUC-Rno-105885	Rattus norvegicus	52.70	3.00e-177	615.00
IUUC-Sce-106273	Saccharomyces cerevisiae	32.09	3.00e-57	216.00
IUUC-Sha-107048	Sarcophilus harrisii	52.31	1.00e-175	610.00
IUUC-Sja-107943	Schizosaccharomyces japonicus	30.18	3.00e-65	243.00
IUUC-Spo-108081	Schizosaccharomyces pombe	31.16	4.00e-63	236.00
IUUC-Ssl-108560	Sclerotinia sclerotiorum	33.33	4.00e-79	289.00
IUUC-Smo-108776	Selaginella moellendorffii	37.24	2.00e-90	327.00
IUUC-Sit-109757	Setaria italica	37.19	1.00e-89	324.00
IUUC-Sly-111557	Solanum lycopersicum	37.57	1.00e-88	320.00
IUUC-Stu-112896	Solanum tuberosum	37.64	6.00e-78	284.00
IUUC-Sar-113071	Sorex araneus	48.77	8.00e-156	542.00
IUUC-Sbi-113884	Sorghum bicolor	35.74	3.00e-90	325.00
IUUC-Sre-114993	Sporisorium reilianum	31.89	1.00e-70	261.00
IUUC-Ssc-115963	Sus scrofa	52.47	2.00e-176	612.00
IUUC-Tgu-117488	Taeniopygia guttata	52.39	7.00e-175	606.00
IUUC-Tru-118626	Takifugu rubripes	51.93	1.00e-175	610.00
IUUC-Tsy-119504	Tarsius syrichta	46.34	3.00e-140	493.00
IUUC-Tni-119877	Tetraodon nigroviridis	52.31	1.00e-174	607.00
IUUC-Tca-121779	Theobroma cacao	36.91	9.00e-89	321.00
IUUC-Tre-122195	Trichoderma reesei	34.19	4.00e-77	282.00
IUUC-Tvi-122650	Trichoderma virens	33.33	7.00e-76	278.00
IUUC-Tae-123580	Triticum aestivum	37.25	4.00e-91	327.00
IUUC-Tur-126295	Triticum urartu	36.71	2.00e-90	326.00
IUUC-Tme-126964	Tuber melanosporum	35.06	1.00e-83	304.00
IUUC-Tbe-127602	Tupaia belangeri	55.92	3.00e-164	570.00
IUUC-Ttr-128394	Tursiops truncatus	46.82	2.00e-142	500.00
IUUC-Uma-129365	Ustilago maydis	31.85	4.00e-62	233.00
IUUC-Vda-129725	Verticillium dahliae	34.44	3.00e-81	296.00
IUUC-Vpa-130280	Vicugna pacos	52.47	2.00e-176	613.00
IUUC-Vvi-131147	Vitis vinifera	35.96	2.00e-87	317.00
IUUC-Xtr-131787	Xenopus tropicalis	51.93	5.00e-179	621.00
IUUC-Xma-133497	Xiphophorus maculatus	36.48	6.00e-130	458.00
IUUC-Yli-134481	Yarrowia lipolytica	32.54	5.00e-70	259.00
IUUC-Zma-135782	Zea mays	37.17	8.00e-91	328.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence