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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063871
UUCD1 version UUC-MuM-00939
Ensembl Protein ID ENSMUSP00000023455.5
UniProt Accession Q9D787; Q542A2; Q9CZL1; PPIL2_MOUSE
Genbank Protein ID BAB26301.1; BAC41068.1; BAE36483.1; AAH28899.1
Protein Name Peptidyl-prolyl cis-trans isomerase-like 2; CYC4; Cyclophilin-60; Cyclophilin-like protein Cyp-60; RING-type E3 ubiquitin transferase isomerase-like 2; Rotamase PPIL2
Genbank Nucleotide ID AK009460; AK090052; AK161596; BC028899
Gene Name Ppil2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000022771.15 ENSMUST00000023455.11 ENSMUSP00000023455.5
ENSMUSG00000022771.15 ENSMUST00000115719.1 ENSMUSP00000111384.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarmiRNAMap
RAID2
Protein-protein Interaction
IIDiRefIndexMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/U-box 9.00e-13 49.2 39 104
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/U-box
   S: 5    eflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqawcee 71
           + +C++sl+++  Pv++p G+++d  +I  wl+++g+ +P t+++l+ ++l+  ++ ++   ++++ 
   Q: 39   FDHCSLSLQPFVYPVCTPEGVVFDLLNIVPWLKKYGT-NPSTGEKLDGKSLIKLNFAKNSEGQYHCP 104
           568*********************************9.**********************9999875 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in transport to the cell membrane of BSG for instance. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation.
 May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in transport to the cell membrane of BSG for instance. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation.
Protein Sequence
(Fasta)
MGKRQHQKDK MYITCAEYTH FYGGRKPDIS QTSFRRLPFD HCSLSLQPFV YPVCTPEGVV 60
FDLLNIVPWL KKYGTNPSTG EKLDGKSLIK LNFAKNSEGQ YHCPVLYSVF TDNTHIVAIR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063871|E3,U-box|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGTGCGTCGA TCTCCGGAAG TAGTTGAGAA AGCGGAGGCG CCATAGTCAG TGTCTGCTGT 60
GGTCTCTTCG GTTTGTTGCC ACCATGGGGA AGCGACAGCA CCAGAAGGAC AAGATGTAAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063871|E3,U-box|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0413--Isomerase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0697--Rotamase
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR029000--Cyclophilin-like_dom
IPR024936--Cyclophilin-type_PPIase
IPR020892--Cyclophilin-type_PPIase_CS
IPR002130--Cyclophilin-type_PPIase_dom
IPR003613--Ubox_domain
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS00170--CSA_PPIASE_1
PS50072--CSA_PPIASE_2
PS51698--U_BOX
Pfam

PF00160--Pro_isomerase
PRINTS

PR00153--CSAPPISMRASE
SMART

SM00504--Ubox
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0003755--F:peptidyl-prolyl cis-trans isomerase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0006457--P:protein folding
GO:0072659--P:protein localization to plasma membrane
GO:0000209--P:protein polyubiquitination
KEGG mmu:66053
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000982 Aegilops tauschii 53.17 6.00e-54 205.00
IUUC-Aml-002351 Ailuropoda melanoleuca 85.23 0.00e+00 934.00
IUUC-Atr-002724 Amborella trichopoda 45.78 5.00e-61 229.00
IUUC-Apl-003515 Anas platyrhynchos 80.00 0.00e+00 753.00
IUUC-Aca-004802 Anolis carolinensis 79.54 0.00e+00 854.00
IUUC-Aly-005928 Arabidopsis lyrata 48.64 6.00e-59 221.00
IUUC-Ath-007574 Arabidopsis thaliana 48.82 2.00e-58 220.00
IUUC-Acl-008183 Aspergillus clavatus 45.08 4.00e-107 382.00
IUUC-Afl-008382 Aspergillus flavus 44.79 4.00e-104 372.00
IUUC-Afu-008952 Aspergillus fumigatus 46.04 8.00e-105 374.00
IUUC-Ani-009146 Aspergillus nidulans 42.39 1.00e-108 387.00
IUUC-Ang-009743 Aspergillus niger 43.45 1.00e-103 370.00
IUUC-Aor-010027 Aspergillus oryzae 46.65 3.00e-104 372.00
IUUC-Ate-010569 Aspergillus terreus 43.61 2.00e-107 382.00
IUUC-Ame-010783 Astyanax mexicanus 77.19 0.00e+00 833.00
IUUC-Bgr-012172 Blumeria graminis 37.12 9.00e-76 277.00
IUUC-Bta-012459 Bos taurus 83.39 0.00e+00 915.00
IUUC-Bci-013693 Botrytis cinerea 42.99 2.00e-107 382.00
IUUC-Bdi-014623 Brachypodium distachyon 49.66 2.00e-61 230.00
IUUC-Bol-015781 Brassica oleracea 49.66 2.00e-59 223.00
IUUC-Bra-016624 Brassica rapa 49.66 4.00e-60 226.00
IUUC-Cel-018328 Caenorhabditis elegans 49.62 2.00e-132 465.00
IUUC-Cja-019427 Callithrix jacchus 90.21 0.00e+00 931.00
IUUC-Cfa-020829 Canis familiaris 90.82 0.00e+00 982.00
IUUC-Cpo-022189 Cavia porcellus 91.55 0.00e+00 951.00
IUUC-Cre-022723 Chlamydomonas reinhardtii 46.92 1.00e-56 214.00
IUUC-Csa-024212 Chlorocebus sabaeus 89.80 0.00e+00 951.00
IUUC-Cin-025720 Ciona intestinalis 60.73 2.00e-179 622.00
IUUC-Csv-026137 Ciona savignyi 59.69 3.00e-180 624.00
IUUC-Cgl-026532 Colletotrichum gloeosporioides 42.51 2.00e-104 373.00
IUUC-Cne-026830 Cryptococcus neoformans 38.59 4.00e-99 355.00
IUUC-Dre-028561 Danio rerio 73.95 0.00e+00 785.00
IUUC-Dno-029029 Dasypus novemcinctus 79.46 0.00e+00 871.00
IUUC-Dor-030683 Dipodomys ordii 76.47 7.00e-105 374.00
IUUC-Dse-031506 Dothistroma septosporum 45.15 1.00e-108 387.00
IUUC-Dme-032058 Drosophila melanogaster 52.83 4.00e-157 548.00
IUUC-Ete-033157 Echinops telfairi 71.79 0.00e+00 694.00
IUUC-Eca-033753 Equus caballus 81.69 4.00e-63 233.00
IUUC-Eeu-034470 Erinaceus europaeus 80.47 5.00e-176 610.00
IUUC-Fca-036571 Felis catus 90.82 0.00e+00 962.00
IUUC-Fal-037613 Ficedula albicollis 80.62 0.00e+00 799.00
IUUC-Fox-037795 Fusarium oxysporum 38.75 2.00e-97 350.00
IUUC-Fso-038213 Fusarium solani 40.11 5.00e-93 335.00
IUUC-Gmo-039609 Gadus morhua 70.72 0.00e+00 719.00
IUUC-Ggr-039825 Gaeumannomyces graminis 43.50 3.00e-95 342.00
IUUC-Gga-041191 Gallus gallus 80.46 0.00e+00 816.00
IUUC-Gac-041524 Gasterosteus aculeatus 73.55 0.00e+00 770.00
IUUC-Gma-042936 Glycine max 52.05 3.00e-63 236.00
IUUC-Ggo-045352 Gorilla gorilla 90.40 0.00e+00 953.00
IUUC-Hsa-045709 Homo sapiens 90.21 0.00e+00 952.00
IUUC-Hvu-047058 Hordeum vulgare 57.62 8.00e-59 221.00
IUUC-Itr-048483 Ictidomys tridecemlineatus 93.92 0.00e+00 856.00
IUUC-Lch-049681 Latimeria chalumnae 77.33 0.00e+00 754.00
IUUC-Lpe-050799 Leersia perrieri 59.80 8.00e-60 224.00
IUUC-Loc-052566 Lepisosteus oculatus 74.48 7.00e-107 381.00
IUUC-Lma-053028 Leptosphaeria maculans 46.19 3.00e-101 362.00
IUUC-Laf-054547 Loxodonta africana 89.85 0.00e+00 941.00
IUUC-Mcc-054753 Macaca mulatta 86.82 0.00e+00 924.00
IUUC-Meu-056855 Macropus eugenii 59.48 2.00e-111 394.00
IUUC-Mor-056941 Magnaporthe oryzae 41.78 3.00e-98 352.00
IUUC-Mpo-057306 Magnaporthe poae 40.51 4.00e-100 358.00
IUUC-Mtr-058349 Medicago truncatula 50.93 9.00e-63 234.00
IUUC-Mla-058842 Melampsora laricipopulina 41.32 3.00e-106 379.00
IUUC-Mga-060099 Meleagris gallopavo 75.63 0.00e+00 725.00
IUUC-Mvi-060413 Microbotryum violaceum 39.14 2.00e-96 346.00
IUUC-Mmr-061530 Microcebus murinus 91.17 0.00e+00 988.00
IUUC-Mdo-062668 Monodelphis domestica 87.89 0.00e+00 827.00
IUUC-Mac-064559 Musa acuminata 50.00 3.00e-62 233.00
IUUC-Mpu-065919 Mustela putorius furo 90.04 0.00e+00 939.00
IUUC-Mlu-067846 Myotis lucifugus 79.64 0.00e+00 848.00
IUUC-Nfi-068507 Neosartorya fischeri 45.62 8.00e-106 377.00
IUUC-Ncr-068805 Neurospora crassa 41.43 6.00e-84 305.00
IUUC-Nle-070125 Nomascus leucogenys 86.21 0.00e+00 901.00
IUUC-Opr-070486 Ochotona princeps 89.10 0.00e+00 749.00
IUUC-Ont-071597 Oreochromis niloticus 74.57 0.00e+00 810.00
IUUC-Oan-073439 Ornithorhynchus anatinus 77.78 4.00e-27 112.00
IUUC-Ocu-074411 Oryctolagus cuniculus 88.51 0.00e+00 892.00
IUUC-Oba-075040 Oryza barthii 60.29 6.00e-60 225.00
IUUC-Obr-076727 Oryza brachyantha 61.76 2.00e-60 226.00
IUUC-Ogl-077605 Oryza glaberrima 60.29 6.00e-60 225.00
IUUC-Ogu-078177 Oryza glumaepatula 60.29 6.00e-60 225.00
IUUC-Oin-079549 Oryza indica 48.13 4.00e-59 222.00
IUUC-Olo-081090 Oryza longistaminata 60.29 5.00e-60 225.00
IUUC-Ome-081979 Oryza meridionalis 60.29 6.00e-60 225.00
IUUC-Oni-082819 Oryza nivara 60.29 6.00e-60 225.00
IUUC-Opu-083212 Oryza punctata 60.78 8.00e-59 221.00
IUUC-Oru-084412 Oryza rufipogon 60.29 6.00e-60 225.00
IUUC-Osa-085431 Oryza sativa 52.31 5.00e-38 149.00
IUUC-Ola-086602 Oryzias latipes 68.33 0.00e+00 664.00
IUUC-Olu-087682 Ostreococcus lucimarinus 40.73 9.00e-98 350.00
IUUC-Oga-088999 Otolemur garnettii 82.73 0.00e+00 919.00
IUUC-Oar-089338 Ovis aries 76.97 0.00e+00 728.00
IUUC-Ptr-091185 Pan troglodytes 90.40 0.00e+00 953.00
IUUC-Pan-092321 Papio anubis 89.83 0.00e+00 974.00
IUUC-Psi-094018 Pelodiscus sinensis 77.93 8.00e-130 456.00
IUUC-Pma-094111 Petromyzon marinus 65.17 3.00e-137 481.00
IUUC-Pno-094782 Phaeosphaeria nodorum 41.29 4.00e-104 372.00
IUUC-Ppa-095335 Physcomitrella patens 47.99 2.00e-65 243.00
IUUC-Pfo-097393 Poecilia formosa 75.05 0.00e+00 805.00
IUUC-Pab-098263 Pongo abelii 85.80 0.00e+00 890.00
IUUC-Pop-099316 Populus trichocarpa 49.54 2.00e-105 376.00
IUUC-Pca-100387 Procavia capensis 73.64 6.00e-86 311.00
IUUC-Ppe-101275 Prunus persica 50.93 3.00e-62 233.00
IUUC-Pva-102150 Pteropus vampyrus 77.65 0.00e+00 800.00
IUUC-Pgr-103378 Puccinia graminis 46.65 2.00e-112 399.00
IUUC-Ptt-103908 Puccinia triticina 39.63 2.00e-98 352.00
IUUC-Pte-104248 Pyrenophora teres 41.58 7.00e-105 374.00
IUUC-Pyt-104645 Pyrenophora triticirepentis 41.11 2.00e-106 379.00
IUUC-Rno-105162 Rattus norvegicus 97.31 0.00e+00 1016.00
IUUC-Sha-107123 Sarcophilus harrisii 74.91 1.00e-112 400.00
IUUC-Sja-107828 Schizosaccharomyces japonicus 39.74 9.00e-91 327.00
IUUC-Spo-108368 Schizosaccharomyces pombe 41.34 5.00e-96 344.00
IUUC-Smo-109263 Selaginella moellendorffii 41.77 4.00e-115 408.00
IUUC-Sit-110821 Setaria italica 60.78 2.00e-59 223.00
IUUC-Sly-111803 Solanum lycopersicum 51.36 2.00e-62 233.00
IUUC-Stu-112730 Solanum tuberosum 47.35 8.00e-63 234.00
IUUC-Sar-113618 Sorex araneus 87.85 0.00e+00 873.00
IUUC-Sbi-114487 Sorghum bicolor 59.05 2.00e-59 224.00
IUUC-Sre-115009 Sporisorium reilianum 37.96 3.00e-90 325.00
IUUC-Ssc-115984 Sus scrofa 89.46 0.00e+00 924.00
IUUC-Tgu-117410 Taeniopygia guttata 81.64 0.00e+00 827.00
IUUC-Tru-118537 Takifugu rubripes 69.66 0.00e+00 762.00
IUUC-Tsy-119318 Tarsius syrichta 74.58 2.00e-129 456.00
IUUC-Tni-120514 Tetraodon nigroviridis 69.16 5.00e-169 587.00
IUUC-Tca-121620 Theobroma cacao 50.47 5.00e-62 232.00
IUUC-Tre-121904 Trichoderma reesei 44.19 1.00e-84 307.00
IUUC-Tvi-122585 Trichoderma virens 38.79 6.00e-85 308.00
IUUC-Tae-125342 Triticum aestivum 58.82 7.00e-59 221.00
IUUC-Tme-126960 Tuber melanosporum 43.04 1.00e-109 390.00
IUUC-Tbe-127839 Tupaia belangeri 69.84 7.00e-97 347.00
IUUC-Ttr-129173 Tursiops truncatus 75.86 0.00e+00 769.00
IUUC-Uma-129595 Ustilago maydis 38.43 4.00e-82 298.00
IUUC-Vda-130012 Verticillium dahliae 40.86 3.00e-103 369.00
IUUC-Vvi-131156 Vitis vinifera 49.49 3.00e-67 249.00
IUUC-Xtr-132807 Xenopus tropicalis 72.04 0.00e+00 799.00
IUUC-Xma-133940 Xiphophorus maculatus 70.56 2.00e-65 241.00
IUUC-Yli-134361 Yarrowia lipolytica 32.67 2.00e-48 186.00
IUUC-Zma-135759 Zea mays 58.74 3.00e-58 219.00
Created Date 25-Jun-2017

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